Lethal(3)malignant brain tumor-like protein 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone	IC50	2800.0 [1], 3100.0 [2], 4700.0 [3], 4800.0 [4], 35000.0 [5]
	(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)	IC50	24.0 [1], 49.0 [2], 64.0 [3]
	1,4-Phenylenebis(1,4'-bipiperidin-1'-ylmethanone)	IC50	8000.0 [1], 10000.0 [2]
	1,4-Bis(4-(pyrrolidinyl)piperidinyl)benzamide	IC50	48.0 [1], 71.0 [2]
	UNC 926 hydrochloride	IC50	3200.0 [1], 4100.0 [2]
	(3-Bromophenyl)-(4-pyrrolidin-2-ylpiperidin-1-yl)methanone	IC50	30000.0 [1]
	[6-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)naphthalen-2-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	450.0 [1], 690.0 [2]
	[5-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)furan-2-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	310.0 [1], 530.0 [2]
	[5-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)thiophen-2-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	68.0 [1], 96.0 [2]
	[3-(Benzylamino)-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	39.0 [1], 50.0 [2]
	[3-Benzyl-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	48.0 [1], 51.0 [2]
	[3-Phenoxy-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	53.0 [1], 58.0 [2]
	[3-Phenyl-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	61.0 [1], 66.0 [2]
	N-(2-Ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)benzamide	IC50	350.0 [1], 370.0 [2]
	2-Anilino-N-(2-ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-2-ylpiperidine-1-carbonyl)benzamide	IC50	160.0 [1], 170.0 [2]
	3-Anilino-N-(2-ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-2-ylpiperidine-1-carbonyl)benzamide	IC50	130.0 [1], 140.0 [2]
	N-(2-Ethyl-1,3-dihydroisoindol-5-yl)-4-(4-pyrrolidin-2-ylpiperidine-1-carbonyl)benzamide	IC50	160.0 [1], 170.0 [2]
	[3-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	290.0 [1], 360.0 [2]
	[2-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	350.0 [1], 1100.0 [2]
	[3,4-Bis(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	110.0 [1], 120.0 [2]
	(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)sulfonylphenyl]methanone	IC50	97.0 [1], 99.0 [2]
	(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]methanone	IC50	150.0 [1], 170.0 [2]
	(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-[(4-pyrrolidin-1-ylpiperidin-1-yl)methyl]phenyl]methanone	IC50	130.0 [1], 140.0 [2]
	(4-Piperidin-1-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	160.0 [1], 230.0 [2]
	[4-(Azepan-1-yl)piperidin-1-yl]-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	210.0 [1], 270.0 [2]
	[4-(4-Morpholin-4-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	1100.0 [1], 1500.0 [2]
	(4-Cyclohexylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	1600.0 [1], 2400.0 [2]
	[4-[4-(Dimethylamino)piperidine-1-carbonyl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	180.0 [1], 310.0 [2]
	[4-[4-(1-Methylpyrrolidin-1-ium-1-yl)piperidine-1-carbonyl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	81.0 [1], 140.0 [2]
	[4-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-2-ylpiperidin-1-yl)methanone	IC50	92.0 [1], 120.0 [2]
	(4-Piperidin-4-ylpiperidin-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	740.0 [1], 800.0 [2]
	[4-(4-Cyclopentylpiperazine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	3200.0 [1], 3800.0 [2]
	[4-[4-(1-Methylpiperidin-4-yl)piperazine-1-carbonyl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	770.0 [1], 830.0 [2]
	[4-[1-(4-Methylpiperazin-1-yl)ethyl]piperidin-1-yl]-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	250.0 [1], 300.0 [2]
	(4-Pyrrolidin-1-ylazepan-1-yl)-[4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	74.0 [1], 96.0 [2]
	[4-(3-Pyrrolidin-1-ylazetidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	300.0 [1], 330.0 [2]
	(4-Pyrrolidin-1-ylpiperidin-1-yl)-[4-(3-pyrrolidin-1-ylpyrrolidine-1-carbonyl)phenyl]methanone	IC50	220.0 [1], 250.0 [2]
	4-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)-N-(3-pyrrolidin-1-ylpropyl)benzamide	IC50	340.0 [1], 680.0 [2]
	[4-(2,7-Diazaspiro[3.4]octane-2-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	2700.0 [1], 3600.0 [2]
	[4-(2,7-Diazaspiro[4.4]nonane-2-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	1800.0 [1], 2200.0 [2]
	[4-(2,8-Diazaspiro[4.5]decane-8-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	560.0 [1], 620.0 [2]
	[4-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	3100.0 [1], 3500.0 [2]
	N-(2-Methyl-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-yl)-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)benzamide	IC50	4500.0 [1], 4600.0 [2]
	[4-(4-Pyrrolidin-1-ylazepane-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylazepan-1-yl)methanone	IC50	110.0 [1]
	[4-[4-(Azetidin-1-yl)piperidine-1-carbonyl]phenyl]-[4-(azetidin-1-yl)piperidin-1-yl]methanone	IC50	350.0 [1], 400.0 [2]
	[4-(4-Pyrrolidin-2-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-2-ylpiperidin-1-yl)methanone	IC50	640.0 [1], 800.0 [2]
	[4-[4-(1-Methylpyrrolidin-2-yl)piperidine-1-carbonyl]phenyl]-[4-(1-methylpyrrolidin-2-yl)piperidin-1-yl]methanone	IC50	1700.0 [1], 1900.0 [2]
	[4-[4-(Dimethylamino)piperidine-1-carbonyl]phenyl]-[4-(dimethylamino)piperidin-1-yl]methanone	IC50	8000.0 [1], 10000.0 [2]
	[6-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)pyridin-3-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	61.0 [1], 110.0 [2]
	[3-Nitro-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	88.0 [1], 160.0 [2]
	[3-Amino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	220.0 [1], 230.0 [2]
	(4-Pyrrolidin-1-ylpiperidin-1-yl)-[2,3,5,6-tetrafluoro-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]methanone	IC50	130.0 [1], 210.0 [2]
	[2,5-Dimethyl-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	210.0 [1], 240.0 [2]
	[4-(4-Pyrrolidin-1-ylpiperidine-1-carbonyl)naphthalen-1-yl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	43.0 [1], 72.0 [2]
	(3-Bromophenyl)-(8-pyrrolidin-1-yl-3-azabicyclo[3.2.1]octan-3-yl)methanone	IC50	3200.0 [1], 3600.0 [2]
	N-(2-Ethyl-1,3-dihydroisoindol-5-yl)-4-(8-pyrrolidin-1-yl-3-azabicyclo[3.2.1]octane-3-carbonyl)benzamide	IC50	150.0 [1], 240.0 [2]
	[4-(8-Pyrrolidin-1-yl-3-azabicyclo[3.2.1]octane-3-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	92.0 [1], 160.0 [2]
	[4-(8-Pyrrolidin-1-yl-3-azabicyclo[3.2.1]octane-3-carbonyl)phenyl]-(8-pyrrolidin-1-yl-3-azabicyclo[3.2.1]octan-3-yl)methanone	IC50	280.0 [1], 400.0 [2]
	[3-Bromo-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone	IC50	74.0 [1], 120.0 [2]
	Chlorpheniramine	IC50	42000.0 [1]
	Oxybutynin	IC50	54000.0 [1]
	Maprotiline	IC50	85000.0 [1]
	4-Methyl-N-[3-(1-pyrrolidinyl)propyl]benzenesulfonamide	IC50	57000.0 [1]
	N,N-Dimethyl-4-(1-methyl-9H-pyrido[3,4-b]indol-4-yl)butan-1-amine	IC50	5700.0 [1]
	1-(N-Methylamino)-4-phenylbutane	IC50	100000.0 [1]
	4-(2-Methoxy-4-methylphenoxy)-N-methylbutan-1-amine	IC50	84000.0 [1]
	4-(4-Benzylphenoxy)-N-methylbutan-1-amine	IC50	100000.0 [1]
	1-(7-Bromo-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-3-(dimethylamino)propan-1-one	IC50	100000.0 [1]
	2-Isopropyl-5-(methylamino)-2-o-tolylpentanenitrile	IC50	100000.0 [1]
	3-Chloro-N-(3-(diethylamino)propyl)-4-fluorobenzenesulfonamide	IC50	30000.0 [1]
	5-Bromo-N-(5-(pyrrolidin-1-YL)pentyl)nicotinamide	IC50	28000.0 [1]
	1-Phenyl-4-pyrrolidin-1-ylpiperidine	IC50	13000.0 [1]
	4-(Dimethylamino)butan-2-yl 5-(1-phenylethyl)furan-2-carboxylate	IC50	75000.0 [1]
	4-(Pyrrolidin-1-Yl)-1-{4-[2-(Pyrrolidin-1-Yl)ethyl]phenyl}piperidine	IC50	62.0 [1]
	3-Bromo-N-(2-ethyl-1,3-dihydroisoindol-5-yl)benzamide	IC50	1200.0 [1]
	7-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]-1,4-dioxa-7-azaspiro[4.4]nonane	IC50	650.0 [1]
	6-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]-2-oxa-6-azaspiro[3.3]heptane	IC50	270.0 [1]
	1-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]pyrrolidine-3-carbonitrile	IC50	360.0 [1]
	1-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]azepane	IC50	100.0 [1]
	1-[3-Chloro-4-(2-pyrrolidin-1-ylethyl)phenyl]-4-pyrrolidin-1-ylpiperidine	IC50	37.0 [1]
	4-Piperidin-1-yl-1-[4-(2-pyrrolidin-1-ylethyl)phenyl]piperidine	IC50	580.0 [1]
	4-Pyrrolidin-1-yl-1-[4-(3-pyrrolidin-1-ylpropyl)phenyl]piperidine	IC50	70.0 [1]
	4-Pyrrolidin-1-yl-1-[3-(2-pyrrolidin-1-ylethyl)phenyl]piperidine	IC50	120.0 [1]
	[3-(Hydroxymethyl)-1-[2-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]azetidin-3-yl]methanol	IC50	59.0 [1]
	4-Pyrrolidin-1-yl-1-[4-(pyrrolidin-1-ylmethyl)phenyl]piperidine	IC50	350.0 [1]
	1-[[4-(2-Pyrrolidin-1-ylethyl)phenyl]methyl]pyrrolidine	IC50	1300.0 [1]
	4-Pyrrolidin-1-yl-1-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]piperidine	IC50	320.0 [1]
	4-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]morpholine	IC50	850.0 [1]
	1-[4-[2-(Azetidin-1-yl)ethyl]phenyl]-4-pyrrolidin-1-ylpiperidine	IC50	48.0 [1]
	1-[4-[2-(3,3-Difluoroazetidin-1-yl)ethyl]phenyl]-4-pyrrolidin-1-ylpiperidine	IC50	1000.0 [1]
	1-[4-(2-Piperidin-1-ylethyl)phenyl]-4-pyrrolidin-1-ylpiperidine	IC50	80.0 [1]
	4-Pyrrolidin-1-yl-1-[3-(pyrrolidin-1-ylmethyl)phenyl]piperidine	IC50	120.0 [1]
	1-Pyrrolidin-1-yl-3-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]propan-1-one	IC50	2400.0 [1]
	Pyrrolidin-1-yl-[3-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]methanone	IC50	2400.0 [1]
	1-[2-[4-(4-Pyrrolidin-1-ylpiperidin-1-yl)phenyl]ethyl]pyrrolidin-3-one	IC50	390.0 [1]
	N-(3-(Diethylamino)propyl)-2,5-dimethoxybenzenesulfonamide	IC50	48000.0 [1]
	(3-Bromophenyl)-[4-(dimethylamino)piperidin-1-yl]methanone	IC50	30000.0 [1]
	(3-Bromophenyl)-(4-piperidin-1-ylpiperidin-1-yl)methanone	IC50	30000.0 [1]
	1-(3-Bromophenyl)sulfonyl-4-pyrrolidin-1-ylpiperidine	IC50	3700.0 [1]
	(3-Bromophenyl)-(4-cyclopentylpiperazin-1-yl)methanone	IC50	30000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Lethal(3)malignant brain tumor-like protein 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/lethal-3-malignant-brain-tumor-like-protein-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Lethal(3)malignant brain tumor-like protein 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lethal-3-malignant-brain-tumor-like-protein-3-inhibitors-ic50-ki.
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