 | Lrrk2-IN-1 | IC50 | 13.0 [1] |
| Lrrk2-IN-1 | Ki | 6.0 [1] |
 | 6-Azanyl-4-(3-Methylphenyl)-1~{h}-Pyrrolo[2,3-B]pyridine-3-Carbonitrile | IC50 | 61.66 [1] |
| 6-Azanyl-4-(3-Methylphenyl)-1~{h}-Pyrrolo[2,3-B]pyridine-3-Carbonitrile | Ki | 0.5 [1], 2.0 [2] |
 | CID 58539301 | IC50 | 20.3 [1] |
| CID 58539301 | Ki | 3.0 [1] |
 | Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl- | IC50 | 10.9 [1] |
 | 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 3.0 [1], 11.0 [2], 15.0 [3], 25.0 [4] |
 | 5-(1-Methyl-1H-pyrazol-4-yl)-4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine | IC50 | 12.0 [1], 36.0 [2], 50.0 [3], 278.0 [4] |
 | 3-[4-(Dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 5.0 [1], 15.0 [2], 42.0 [3], 89.0 [4] |
 | 5-[4-(Morpholin-4-Ylmethyl)phenyl]-3-(1-Propan-2-Yl-1,2,3-Triazol-4-Yl)pyridin-2-Amine | IC50 | 160.0 [1], 300.0 [2], 920.0 [3], 2100.0 [4] |
 | 4-(3-Methylphenyl)-6-[(1-Methylpyrazol-3-Yl)amino]-1~{h}-Pyrrolo[2,3-B]pyridine-3-Carbonitrile | IC50 | 1.0 [1], 2.0 [2], 17.0 [3], 18.0 [4] |
| 4-(3-Methylphenyl)-6-[(1-Methylpyrazol-3-Yl)amino]-1~{h}-Pyrrolo[2,3-B]pyridine-3-Carbonitrile | Ki | 0.06 [1], 0.1 [2] |
 | 6-[(1,4-Dimethylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 108.0 [1], 210.0 [2], 215.0 [3], 580.0 [4] |
 | 6-[(1-Methylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 27.0 [1], 37.0 [2], 70.0 [3], 90.0 [4] |
 | 6-[(1,4-Dimethylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 36.0 [1], 50.0 [2], 130.0 [3], 170.0 [4] |
 | 6-[(1-Methylpyrazol-3-yl)amino]-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 85.0 [1], 99.0 [2], 100.0 [3], 112.0 [4] |
 | CID 58539171 | IC50 | 9.0 [1], 46.0 [2], 97.0 [3] |
| CID 58539171 | Ki | 1.0 [1], 2.0 [2] |
 | CID 44252884 | IC50 | 1.3 [1], 1.9 [2], 4.0 [3], 7.0 [4] |
| CID 44252884 | Ki | 7.0 [1] |
 | 4-[5-(1-Methylpyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine | IC50 | 53.0 [1], 90.0 [2], 2570.0 [3] |
 | 2-Fluoro-3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile | IC50 | 2.0 [1], 3.0 [2], 7.0 [3], 9.0 [4], 20.0 [5] |
 | 3-(4-Pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile | IC50 | 8.0 [1], 64.0 [2], 432.0 [3] |
 | 3-[4-(Diethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 13.0 [1], 20.0 [2], 119.0 [3], 151.0 [4], 443.0 [5] |
 | 4-[5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine | IC50 | 28.0 [1], 46.0 [2], 882.0 [3] |
 | 4-(5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine | IC50 | 9.0 [1], 14.0 [2], 198.0 [3] |
 | 4-[5-(3-Chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine | IC50 | 8.0 [1], 13.0 [2], 144.0 [3] |
 | 6-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]pyridine-2-carbonitrile | IC50 | 9.0 [1], 26.0 [2], 298.0 [3] |
 | 3-(4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile | IC50 | 6.0 [1], 28.0 [2], 182.0 [3] |
 | 3-[4-[(3S)-3-Methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 16.0 [1], 45.0 [2], 49.0 [3], 210.0 [4] |
 | 4-[6-(5-Propan-2-yloxy-1H-indazol-3-yl)pyrimidin-4-yl]morpholine | IC50 | 5.95 [1], 7.12 [2], 7.2 [3], 41.0 [4], 96.0 [5] |
 | 4-[5-(5-Methylpyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine | IC50 | 18.0 [1], 30.0 [2], 211.0 [3] |
 | Nvp-tae 684 | IC50 | 6.1 [1], 7.8 [2], 21.9 [3], 93.3 [4] |
 | 6-(2,5-Dimethoxyphenyl)sulfanyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine | IC50 | 40.0 [1], 82.0 [2], 173.0 [3], 1380.0 [4] |
 | 2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5-carbonitrile | IC50 | 105.0 [1] |
| 2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5-carbonitrile | Ki | 2.4 [1], 11.0 [2], 13.0 [3] |
 | [3-Methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | IC50 | 9.0 [1] |
| [3-Methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | Ki | 1.0 [1], 2.0 [2], 2.7 [3] |
 | 6-[(1-Methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 55.0 [1], 102.0 [2], 130.0 [3], 700.0 [4] |
 | 6-[(1-Methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 28.0 [1], 41.0 [2], 76.0 [3], 160.0 [4] |
 | 6-[(4-Chloro-1-methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 158.0 [1], 180.0 [2], 210.0 [3], 1300.0 [4] |
 | 6-[(4-Chloro-1-methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 44.0 [1], 57.0 [2], 94.0 [3], 110.0 [4] |
 | 6-[(4-Chloro-1-methylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 67.0 [1], 68.0 [2], 93.0 [3], 190.0 [4] |
 | 6-[(1,4-Dimethylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 43.0 [1], 48.0 [2], 160.0 [3], 170.0 [4] |
 | 3-{4-[(2S)-2-Methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | IC50 | 7.0 [1], 18.0 [2], 69.0 [3], 122.0 [4] |
 | 3-[4-[3-(Methoxymethyl)piperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 95.0 [1], 219.0 [2] |
 | 3-[4-(3-Methoxypiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 79.0 [1], 154.0 [2] |
 | 3-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-5-(1-methyl-2,3-dihydroindol-5-yl)pyridin-2-amine | IC50 | 710.0 [1], 970.0 [2] |
 | 3-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-5-[4-(morpholin-4-ylmethyl)phenyl]pyridin-2-amine | IC50 | 390.0 [1], 490.0 [2] |
 | 5-(1-Methylindol-5-yl)-3-(1-propan-2-yltriazol-4-yl)pyridin-2-amine | IC50 | 540.0 [1], 550.0 [2] |
 | 5-(4-Morpholin-4-ylphenyl)-3-(1-propan-2-yltriazol-4-yl)pyridin-2-amine | IC50 | 280.0 [1], 340.0 [2] |
 | 5-[4-(2-Morpholin-4-ylethyl)phenyl]-3-(1-propan-2-yltriazol-4-yl)pyridin-2-amine | IC50 | 340.0 [1], 600.0 [2] |
 | 3-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-5-(1H-indol-5-yl)pyridin-2-amine | IC50 | 570.0 [1], 1000.0 [2], 1300.0 [3], 1600.0 [4] |
 | 6-Amino-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 216.0 [1], 240.0 [2] |
| 6-Amino-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | Ki | 3.0 [1], 12.0 [2] |
 | 4-Thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 851.0 [1], 1279.0 [2] |
| 4-Thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | Ki | 31.0 [1], 60.0 [2] |
 | CID 86287875 | IC50 | 170.0 [1], 195.0 [2] |
| CID 86287875 | Ki | 4.0 [1], 13.0 [2] |
 | 4-(3-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | IC50 | 201.0 [1], 247.0 [2] |
| 4-(3-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | Ki | 6.0 [1], 24.0 [2] |
 | 3-[4-[2-(3-Methyl-1,2,4-oxadiazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 20.0 [1], 176.0 [2], 390.0 [3] |
 | 3-[4-[(2R)-2-Methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 18.0 [1], 69.0 [2], 377.0 [3] |
 | 3-[4-[2-(1,2-Oxazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 37.0 [1], 234.0 [2], 1467.0 [3] |
 | 1-[5-Chloro-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyrazol-1-yl]-2-methylpropan-2-ol | IC50 | 28.0 [1] |
| 1-[5-Chloro-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyrazol-1-yl]-2-methylpropan-2-ol | Ki | 9.0 [1] |
 | 4-(4-Isopropoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-isopropyl-N-(oxetan-3-yl)-1H-pyrrole-2-carboxaMide | Ki | 2.4 [1] |
 | [2-Fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | IC50 | 16.0 [1] |
| [2-Fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | Ki | 2.9 [1], 6.0 [2] |
 | (4-(5-Bromo-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanone | IC50 | 13.0 [1] |
| (4-(5-Bromo-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanone | Ki | 1.0 [1], 2.0 [2] |
 | (4-(5-Fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanone | IC50 | 418.0 [1] |
| (4-(5-Fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanone | Ki | 58.0 [1], 71.0 [2] |
 | 4-[[(1R)-1-Cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamide | IC50 | 2.0 [1], 6.0 [2] |
 | 7-(4-Methylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carboxamide | IC50 | 35.0 [1], 39.0 [2], 41.0 [3] |
 | (2S)-2-Methyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine | IC50 | 3.8 [1], 5.8 [2], 76.0 [3] |
 | (7R)-3-(Cyclopropylmethylsulfanyl)-7-methyl-1-(1H-pyrazol-5-yl)-6,7-dihydro-5H-thieno[3,4-c]pyridin-4-one | IC50 | 31.0 [1] |
| (7R)-3-(Cyclopropylmethylsulfanyl)-7-methyl-1-(1H-pyrazol-5-yl)-6,7-dihydro-5H-thieno[3,4-c]pyridin-4-one | Ki | 34.0 [1], 83.0 [2] |
 | 3-[4-(Azetidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | IC50 | 115.0 [1], 325.0 [2], 7687.0 [3] |
 | 2-Fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile | IC50 | 117.0 [1], 920.0 [2], 2460.0 [3] |
 | 3-Fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile | IC50 | 80.0 [1], 688.0 [2], 2082.0 [3] |
 | 3-[2-[(3R,4R)-3,4-Difluoropyrrolidin-1-yl]pyridin-4-yl]-5-propan-2-yloxy-1H-indazole | IC50 | 6.6 [1], 128.0 [2], 341.0 [3] |
 | [5-Fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | IC50 | 63.0 [1] |
| [5-Fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | Ki | 4.8 [1], 7.0 [2] |
 | [4-[(5-Chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone | IC50 | 69.0 [1] |
| [4-[(5-Chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone | Ki | 9.0 [1], 10.4 [2] |
 | [5-Chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | IC50 | 24.0 [1] |
| [5-Chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | Ki | 2.0 [1], 4.0 [2] |
 | [2-Chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | IC50 | 7.0 [1] |
| [2-Chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | Ki | 2.0 [1] |
 | [2-Fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | IC50 | 35.0 [1] |
| [2-Fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone | Ki | 12.0 [1], 14.5 [2] |
 | [5-Chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanone | IC50 | 27.0 [1] |
| [5-Chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanone | Ki | 3.0 [1], 3.4 [2] |
 | 2-N-(5-Fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine | IC50 | 27.0 [1] |
| 2-N-(5-Fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine | Ki | 2.0 [1], 3.0 [2] |
 | 5-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-one | IC50 | 22.0 [1] |
| 5-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-one | Ki | 3.0 [1], 4.0 [2] |
 | 2-N-[2-Chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine | IC50 | 100.0 [1] |
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