Leukocyte adhesion glycoprotein LFA-1 alpha Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	5-[[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl]thiophene-3-carboxylic acid	IC50	18.0 [1], 276.0 [2], 280.0 [3]
	Bms-688521	IC50	2.5 [1], 60.0 [2], 276.0 [3]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrimidine-5-carboxylic acid	IC50	11.0 [1], 260.0 [2]
	5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrazine-2-carboxylic acid	IC50	19.0 [1], 1260.0 [2]
	6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridazine-3-carboxylic acid	IC50	13.0 [1], 270.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-4-carboxylic acid	IC50	3.6 [1], 50.0 [2]
	4-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-2-carboxylic acid	IC50	56.0 [1], 140.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrimidine-4-carboxylic acid	IC50	26.0 [1], 310.0 [2]
	6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrimidine-4-carboxylic acid	IC50	8.0 [1], 100.0 [2]
	6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-2-methylpyridine-3-carboxylic acid	IC50	12.0 [1], 280.0 [2]
	6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-4-methylpyridine-3-carboxylic acid	IC50	11.0 [1], 240.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-thiazole-5-carboxylic acid	IC50	5.0 [1], 170.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzoxazole-7-carboxylic acid	IC50	4.8 [1], 70.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzoxazole-6-carboxylic acid	IC50	6.0 [1], 410.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzoxazole-5-carboxylic acid	IC50	4.0 [1], 400.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzothiazole-7-carboxylic acid	IC50	1.8 [1], 80.0 [2]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzothiazole-6-carboxylic acid	IC50	4.4 [1], 280.0 [2]
	4-[(5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-pyridin-2-yl-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrile	IC50	11.0 [1], 200.0 [2]
	6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-3-carbonitrile	IC50	11.0 [1], 80.0 [2]
	5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-2-carbonitrile	IC50	12.0 [1], 140.0 [2]
	4-[(5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-[5-(2H-tetrazol-5-yl)pyridin-2-yl]-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrile	IC50	1.8 [1], 80.0 [2]
	Cucurbitacin I	IC50	950.0 [1]
	Cucurbitacin E	IC50	180.0 [1]
	Cucurbitacin D	IC50	1360.0 [1]
	[(E,6R)-6-[(2S,8S,9R,10S,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate	IC50	300.0 [1]
	2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-(4-((2-(1-methylethyl)phenyl)thio)-3-nitrophenyl)-	IC50	44.0 [1]
	23,24-Dihydrocucurbitacin D	IC50	50000.0 [1]
	Unii-nug7541qvz	IC50	40.0 [1]
	3-[3-Chloro-4-(2,4-dichlorophenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-one	IC50	140.0 [1]
	1-[(E)-3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	50.0 [1]
	(2S)-2-[[2-(1-Benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	260.0 [1]
	(2S)-2-[[5,7-Dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	430.0 [1]
	3-[3-Nitro-4-(2,3-dichlorophenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-one	IC50	105.0 [1]
	(2S)-2-[[2,6-Dichloro-4-[3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	1.4 [1]
	1-[(E)-3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	3.0 [1]
	3-[2,3-Bis(trifluoromethyl)-4-(2-methoxyphenylthio)phenyl]-1-(4-carboxypiperidino)-2-propene-1-one	IC50	5.0 [1]
	3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylthio)-1-naphthyl]-1-(4-carboxypiperidino)-2-propene-1-one	IC50	295.0 [1]
	(Benzodioxan-6-yl)[2,3-dichloro-4-(E-((4-carboxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide	IC50	7.0 [1]
	1-[(E)-3-[3-Chloro-4-(2-methoxyphenyl)sulfanyl-2-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	6.0 [1]
	1-[(E)-3-[3-Chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-5-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	20000.0 [1]
	1-[(E)-3-[3-Chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	145.0 [1]
	1-{3-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phenyl]-acryloyl}-piperidine-4-carboxylic acid	IC50	10.0 [1]
	5-[(E)-3-(4-Acetylpiperazin-1-yl)-3-oxoprop-1-enyl]-2-(2,3-dichlorophenyl)sulfanyl-N,N-dimethylbenzenesulfonamide	IC50	3750.0 [1]
	1-{3-[4-(2-Methoxy-phenylsulfanyl)-2-methyl-phenyl]-acryloyl}-piperidine-4-carboxylic acid	IC50	20000.0 [1]
	1-{3-[2,3-Dichloro-4-(2-methoxy-phenylsulfanyl)-phenyl]-acryloyl}-piperidine-4-carboxylic acid	IC50	8.0 [1]
	(E)-1-(4-Acetylpiperazin-1-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-(trifluoromethyl)phenyl]prop-2-en-1-one	IC50	55.0 [1]
	1-[(E)-3-[4-(1-Methylindol-5-yl)sulfanyl-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	5.0 [1]
	3-[2,3-Dichloro-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-one	IC50	10.0 [1]
	1-{3-[2-Chloro-4-(2-methoxy-phenylsulfanyl)-phenyl]-acryloyl}-piperidine-4-carboxylic acid	IC50	1400.0 [1]
	(E)-3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-(trifluoromethyl)phenyl]-1-morpholin-4-ylprop-2-en-1-one	IC50	30.0 [1]
	(E)-1-(4-Acetylpiperazin-1-yl)-3-[2,3-dichloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]prop-2-en-1-one	IC50	7.0 [1]
	3-[2,3-Dimethyl-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-one	IC50	90.0 [1]
	1-[(E)-3-[4-(2-Methoxyphenyl)sulfanyl-2-methyl-5-nitrophenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	20000.0 [1]
	1-[(E)-3-[2,5-Dichloro-4-(2-methoxyphenyl)sulfanylphenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	20000.0 [1]
	3-[2-(Trifluoromethyl)-3-chloro-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-one	IC50	8.0 [1]
	1-[(E)-3-[5-Chloro-4-(2-methoxyphenyl)sulfanyl-2-methylphenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	20000.0 [1]
	3-[2-Fluoro-4-(2-methoxyphenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-one	IC50	3900.0 [1]
	1-[(E)-3-[3-Chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-2-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	5.0 [1]
	3-[3-Methoxy-4-(2-methoxyphenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-one	IC50	10700.0 [1]
	1-[(E)-3-[4-(2-Methoxyphenyl)sulfanyl-2-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	265.0 [1]
	3-[3-Chloro-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-one	IC50	150.0 [1]
	3-[4-(2,4-Dichlorophenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-one	IC50	4300.0 [1]
	(E)-1-(4-Acetylpiperazin-1-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-nitrophenyl]prop-2-en-1-one	IC50	139.0 [1]
	(1-Methylindol-5-yl)[2,3-dichloro-4-(E-((4-carboxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide	IC50	6.0 [1]
	3-[4-(2,3-Dichlorophenylthio)phenyl]-1-morpholino-2-propene-1-one	IC50	9100.0 [1]
	(2S)-2-[[5,7-Dichloro-2-(2,3-dihydro-1-benzofuran-6-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	650.0 [1]
	1-[(E)-3-[5,6-Difluoro-4-(2-propan-2-ylphenyl)sulfanylcyclohexa-1,3-dien-1-yl]prop-2-enoyl]piperidine-4-carboxylic acid	IC50	115.0 [1]
	(2S)-2-[[2-(1-Benzofuran-2-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	69.0 [1]
	(2S)-3-Benzamido-2-[[5,7-dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]propanoic acid	IC50	550.0 [1]
	(8S,9R,13R,14S,16R)-17-[(2S)-2,6-Dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione	IC50	50000.0 [1]
	2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-oxazole-4-carboxylic acid	IC50	58.0 [1]
	4-[(5S,9R)-7-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrile	IC50	60.0 [1]
	(2S)-2-[(2-Benzoyl-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl)amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	1200.0 [1]
	(2S)-2-[[5,7-Dichloro-2-(4-methylbenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	1600.0 [1]
	(2S)-2-[[5,7-Dichloro-2-(3-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acid	IC50	240.0 [1]
	(2S)-2-[[5,7-Dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(furan-2-carbonylamino)propanoic acid	IC50	3800.0 [1]
	N-Ethyl-2-[[4-[[(1R)-1-phenylethyl]amino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamide	IC50	10000.0 [1]
	2-[[4-(Benzylamino)-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-N-ethyl-1,3-dihydroindene-2-carboxamide	IC50	7900.0 [1]
	N-Ethyl-2-[[4-(2-phenylethylamino)-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamide	IC50	488.0 [1]
	N-Ethyl-2-[[4-(ethylamino)-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamide	IC50	10000.0 [1]
	2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxylic acid	IC50	37.0 [1]
	[5-[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-(2,3-dihydro-1H-inden-2-ylamino)-1,3,5-triazin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-[3-(trifluoromethyl)phenyl]methanone	IC50	358.0 [1]
	[5-[4-(Cyclopentylamino)-6-[2-(3,4-dichlorophenyl)ethylamino]-1,3,5-triazin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-[3-(trifluoromethyl)phenyl]methanone	IC50	10000.0 [1]
	2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)phenyl]sulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxylic acid	IC50	65.0 [1]
	(2E)-2-[(E)-3-[1-[6-[4-[[2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carbonyl]amino]butylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]prop-2-enylidene]-1-ethyl-3,3-dimethylindole-5-sulfonic acid	IC50	100.0 [1]
	(2E)-2-[(E)-3-[1-[6-[4-[[2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)phenyl]sulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carbonyl]amino]butylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]prop-2-enylidene]-1-ethyl-3,3-dimethylindole-5-sulfonic acid	IC50	28.0 [1]
	2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]-N-ethyl-1,3-dihydroindene-2-carboxamide	IC50	12900.0 [1]
	N-Ethyl-2-[[4-[[(1S)-1-phenylethyl]amino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamide	IC50	180.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 88 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Leukocyte adhesion glycoprotein LFA-1 alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/leukocyte-adhesion-glycoprotein-lfa-1-alpha-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Leukocyte adhesion glycoprotein LFA-1 alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leukocyte-adhesion-glycoprotein-lfa-1-alpha-inhibitors-ic50-ki.
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