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Leukotriene B4 receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
BioMed 101IC50200.0 [1], 1790.0 [2], 2300.0 [3]
BioMed 101Ki12.0 [1], 15.0 [2], 93.0 [3]
1-(3-(4-Phenylbenzyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acidIC506.4 [1]
1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanoneIC5085.0 [1], 2900.0 [2]
1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanoneKi77.0 [1], 78.0 [2], 85.0 [3]
Sodium;2-ethoxy-4-ethyl-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]phenolIC508.4 [1], 206.0 [2]
Sodium;2-ethoxy-4-ethyl-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]phenolKi14.2 [1]
2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-4-chlorobenzoic acidIC5012.0 [1], 26.0 [2], 59.0 [3], 265.0 [4], 1300.0 [5]
Leukotriene B4IC501.9 [1]
Leukotriene B4Ki0.12 [1], 1.9 [2]
CP-195543IC507.0 [1], 13.0 [2], 280.0 [3], 660.0 [4]
5-(2-Carboxyethyl)-6-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9-oxoxanthene-2-carboxylic acidIC501.2 [1]
5-(2-Carboxyethyl)-6-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9-oxoxanthene-2-carboxylic acidKi0.04 [1], 0.47 [2]
6-[3-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)propoxy]-5-(2-carboxyethyl)-9-oxoxanthene-2-carboxylic acidIC5047.0 [1]
6-[3-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)propoxy]-5-(2-carboxyethyl)-9-oxoxanthene-2-carboxylic acidKi1.2 [1], 4.0 [2]
3-[3-(2-Ethyl-4-phenyl-5-hydroxyphenoxy)propoxy]-7-carboxy-9-oxo-9H-xanthene-4-propanoic acidIC503.4 [1]
3-[3-(2-Ethyl-4-phenyl-5-hydroxyphenoxy)propoxy]-7-carboxy-9-oxo-9H-xanthene-4-propanoic acidKi0.11 [1], 0.57 [2]
3-[3-(2-Ethyl-4-phenyl-5-hydroxyphenoxy)propoxy]-9-oxo-9H-xanthene-4-propanoic acidIC505.4 [1]
3-[3-(2-Ethyl-4-phenyl-5-hydroxyphenoxy)propoxy]-9-oxo-9H-xanthene-4-propanoic acidKi12.0 [1], 22.0 [2]
3-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9-oxoxanthen-4-yl]propanoic acidIC501.8 [1]
3-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9-oxoxanthen-4-yl]propanoic acidKi4.0 [1], 36.0 [2]
Sodium;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]phenyl]ethanoneIC5085.1 [1], 2874.0 [2]
Sodium;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]phenyl]ethanoneKi77.9 [1]
2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-4-fluorobenzenesulfonamideIC5017.0 [1], 37.0 [2], 540.0 [3], 10000.0 [4]
4-Fluoro-2-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]benzoic acidIC505.0 [1], 14.0 [2], 700.0 [3], 5100.0 [4]
2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-6-(trifluoromethyl)benzoic acidIC5024.0 [1], 46.0 [2], 750.0 [3], 890.0 [4]
2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-4,6-difluorobenzoic acidIC505.0 [1], 40.0 [2], 200.0 [3], 300.0 [4]
2-[(3S,4R)-4-Hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]-4-(trifluoromethyl)benzoic acidIC507.0 [1], 27.0 [2], 820.0 [3], 4000.0 [4]
Sodium;4-ethyl-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]-2-propylphenolIC509.3 [1], 161.0 [2]
Sodium;4-ethyl-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]-2-propylphenolKi14.2 [1]
2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-6-fluorobenzoic acidIC50240.0 [1], 400.0 [2], 650.0 [3], 1000.0 [4]
4-Chloro-2-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]benzoic acidIC504.0 [1], 6.0 [2], 520.0 [3], 1700.0 [4]
N-[2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-4-fluorophenyl]-1,1,1-trifluoromethanesulfonamideIC503.8 [1], 15.0 [2], 3000.0 [3]
2-[(3S,4R)-3-Benzyl-4-hydroxy-3,4-dihydro-2H-chromen-7-yl]-4-fluorobenzoic acidIC505.0 [1], 27.0 [2], 3000.0 [3], 3500.0 [4]
EtalocibIC503.3 [1]
EtalocibKi6.6 [1], 17.0 [2]
4-(2-(Methyl(2-phenylethyl)amino)-2-oxoethyl)-8-(phenylmethoxy)-2-naphthalenecarboxylic acidIC500.36 [1], 4.7 [2]
2-[2-Propyl-3-[5-[2-ethyl-5-hydroxy-4-(4-fluorophenyl) phenoxy]pentoxy]phenoxy]benzoic acidIC509.5 [1]
2-[2-Propyl-3-[5-[2-ethyl-5-hydroxy-4-(4-fluorophenyl) phenoxy]pentoxy]phenoxy]benzoic acidKi6.8 [1], 150.0 [2]
3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acidIC5031.0 [1]
3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acidKi3.8 [1], 8.0 [2]
4-Ethyl-2-(4-fluorophenyl)-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolIC5013.0 [1]
4-Ethyl-2-(4-fluorophenyl)-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolKi2.8 [1], 3.7 [2]
2-(4-Chlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolIC5012.0 [1]
2-(4-Chlorophenyl)-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolKi5.0 [1], 25.0 [2]
2-[2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]phenyl]acetic acidIC507.8 [1]
2-[2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]phenyl]acetic acidKi8.4 [1], 210.0 [2]
2-Ethoxy-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolIC50210.0 [1]
2-Ethoxy-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolKi8.4 [1], 14.0 [2]
2-[3-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-2-propylphenoxy]-6-fluorobenzoic acidIC503.2 [1]
2-[3-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-2-propylphenoxy]-6-fluorobenzoic acidKi10.0 [1], 14.0 [2]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]sulfonyl]benzoic acidIC50160.0 [1]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]sulfonyl]benzoic acidKi11.0 [1], 15.0 [2]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]carbonyl]benzoic acidIC5013.0 [1]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]carbonyl]benzoic acidKi11.0 [1], 35.0 [2]
2-[3-[4-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]butoxy]-2-propylphenoxy]benzoic acidIC505.1 [1]
2-[3-[4-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]butoxy]-2-propylphenoxy]benzoic acidKi19.0 [1], 39.0 [2]
2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]-6-fluorobenzoic acidIC502.5 [1]
2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]-6-fluorobenzoic acidKi4.4 [1], 9.5 [2]
7-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acidIC50110.0 [1]
7-[3-(2-Ethyl-5-hydroxy-4-phenylphenoxy)propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acidKi2.8 [1], 3.3 [2]
2-[2-Butyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acidIC5014.0 [1]
2-[2-Butyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acidKi16.0 [1], 34.0 [2]
2-[2-Benzyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acidIC50220.0 [1]
2-[2-Benzyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acidKi55.0 [1], 390.0 [2]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]methyl]benzoic acidIC502.8 [1]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]methyl]benzoic acidKi11.0 [1], 99.0 [2]
2-[3-[3-(2-Ethyl-4-phenyl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy]benzoic acidIC5011.0 [1]
2-[3-[3-(2-Ethyl-4-phenyl-5-hydroxyphenoxy)propoxy]-2-propylphenoxy]benzoic acidKi16.0 [1], 19.0 [2]
2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-(2-methylpropyl)phenoxy]benzoic acidIC508.5 [1]
2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-(2-methylpropyl)phenoxy]benzoic acidKi14.0 [1], 36.0 [2]
2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfinyl]benzoic acidIC5095.0 [1]
2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenylsulfinyl]benzoic acidKi1.4 [1], 14.0 [2]
2-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-6-methoxybenzenepropanoic acidIC5064.0 [1]
2-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-6-methoxybenzenepropanoic acidKi6.4 [1], 8.3 [2]
Sodium;4-ethyl-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]-2-phenylphenolIC503.0 [1], 31.5 [2]
Sodium;4-ethyl-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]-2-phenylphenolKi4.4 [1]
Sodium;4-ethyl-2-(4-fluorophenyl)-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]phenolIC502.8 [1], 13.1 [2]
Sodium;4-ethyl-2-(4-fluorophenyl)-5-[6-methyl-6-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)heptoxy]phenolKi3.7 [1]
2-Phenyl-4-ethyl-5-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]phenolIC5032.0 [1]
2-Phenyl-4-ethyl-5-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]phenolKi3.0 [1], 4.4 [2]
4-Ethyl-2-(3-fluorophenyl)-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolIC5017.0 [1]
4-Ethyl-2-(3-fluorophenyl)-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolKi3.0 [1], 6.2 [2]
3-[2-[5-(Dimethylamino)-5-oxopentyl]-6-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]propanoic acidIC507.8 [1]
3-[2-[5-(Dimethylamino)-5-oxopentyl]-6-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]propanoic acidKi3.1 [1], 8.6 [2]
5-[2-(2-Carboxyethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]pentanoic acidIC5013.0 [1]
5-[2-(2-Carboxyethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]pentanoic acidKi0.71 [1], 2.3 [2]
2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]-4-fluorobenzoic acidIC502.7 [1]
2-[3-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]-4-fluorobenzoic acidKi19.0 [1], 48.0 [2]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]thio]benzoic acidIC507.4 [1]
2-[[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenyl]thio]benzoic acidKi11.0 [1], 350.0 [2]
7-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acidIC5017.0 [1]
7-[3-[2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acidKi3.8 [1], 4.4 [2]
4-Ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]-2-propylphenolIC50160.0 [1]
4-Ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]-2-propylphenolKi9.3 [1], 14.0 [2]
7-[3-[2-(Cyclopropylmethyl)-3-methoxy-4-(1,3-thiazol-4-yl)phenoxy]propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acidIC50188.0 [1]
7-[3-[2-(Cyclopropylmethyl)-3-methoxy-4-(1,3-thiazol-4-yl)phenoxy]propoxy]-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acidKi5.0 [1]
2-(1H-Pyrazol-3-yl)-4-ethyl-5-[6-(1H-tetrazol-5-yl)-6-methylheptyloxy]phenolKi4.2 [1], 42.0 [2]
(2E)-2-[[1-[2-[Methyl(2-phenylethyl)amino]-2-oxoethyl]-5-phenylmethoxyindol-3-yl]methylidene]butanoic acidIC501.3 [1], 7.6 [2]
4-Ethyl-2-(2-methylphenyl)-5-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenolKi11.0 [1], 70.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Leukotriene B4 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/leukotriene-b4-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Leukotriene B4 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leukotriene-b4-receptor-inhibitors-ic50-ki.
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