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LXR-beta Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideKi17.0 [1]
3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acidIC507.94 [1], 12.0 [2], 30.0 [3], 39.81 [4]
2-[2-(2-Phenylethyl)phenyl]-2,3-dihydro-1H-isoindole-1,3-dioneIC5030000.0 [1], 44000.0 [2]
3-Methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)quinolineIC501.0 [1], 2.4 [2]
2-{4-[({3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acidIC501.9 [1], 2.0 [2]
F3MethylAAIC5024.9 [1], 28.0 [2]
N-(4-(2-Phenylethyl)phenyl)phthalimideIC5030000.0 [1]
N-{2-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl}phthalimideIC5030000.0 [1]
CID 122192273IC501800.0 [1], 4300.0 [2]
N-[3-(2-Phenylethyl)phenyl]phthalimideIC5030000.0 [1]
2-Hydroxy-5-methyl-11-methylidenebenzo[c][1]benzazepin-6-oneIC5011000.0 [1]
2-(2-Hexylphenyl)-2,3-dihydro-1H-isoindole-1,3-dioneIC5065000.0 [1]
2-{4-[({3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}methyl)amino]phenyl}acetic acidIC507.0 [1]
[3-[3-[3-Methyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy]phenyl]methanolIC502.1 [1], 12.0 [2]
2-(4-(3-(3-Benzyl-8-(trifluoromethyl)quinolin-4-yl)benzylamino)-2,3-dimethylphenyl)acetic acidIC504.0 [1], 4000.0 [2]
2-Methyl-1-{3-[3-(methylsulfonyl)phenoxy]phenyl}-4-(trifluoromethyl)-1H-benzimidazoleIC50111.0 [1], 128.0 [2]
[(1S,4As,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl] (4aS,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylateIC502.0 [1]
(4As,10aR)-N-[(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl]-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxamideIC501.0 [1]
Methyl 3-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}benzoateIC5053.0 [1]
Methyl 3-[3-(8-chloro-3-methylquinolin-4-yl)phenoxy]benzoateIC50230.0 [1], 231.0 [2]
3-[3-(8-Chloro-3-methylquinolin-4-yl)phenoxy]-N-methylbenzamideIC509.0 [1], 125.0 [2]
4-(3-(3-Chloro-5-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)quinoline-3-carboxamideIC5061.0 [1], 62.0 [2]
[4-[(3R)-4-[5-(Hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-yl]-3-propan-2-ylpiperazin-1-yl]-2-methylsulfonylphenyl]methanolKi3.0 [1]
N-(2-Methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-4-pyridin-2-ylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC503800.0 [1], 10000.0 [2]
N-[4-[4-(1-Ethylpyrazol-4-yl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC501700.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50600.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50600.0 [1], 2000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-[4-(trifluoromethyl)phenyl]but-3-yn-2-yl]phenyl]benzenesulfonamideIC502500.0 [1], 10000.0 [2]
N-[4-[4-(2,4-Difluorophenyl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC50800.0 [1], 8000.0 [2]
N-[4-[4-(4-Chlorophenyl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-3-cyano-N-(2-methylpropyl)benzenesulfonamideIC50600.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-4-phenylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC50600.0 [1], 8000.0 [2]
N-[4-(1,1,1,5,5,5-Hexafluoro-2-hydroxypent-3-yn-2-yl)phenyl]-N-methylbenzenesulfonamideIC504100.0 [1], 10000.0 [2]
N-Methyl-N-[4-(1,1,1-trifluoro-2-hydroxy-4-phenylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC501400.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-4-pyridin-3-ylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC50400.0 [1], 10000.0 [2]
3-Cyano-N-(2-methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-4-phenylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC50300.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-5-phenylpent-3-yn-2-yl)phenyl]benzenesulfonamideIC50600.0 [1], 10000.0 [2]
N-[4-[4-(Cyclohexen-1-yl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC501100.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methoxyphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50700.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-5,5-dimethylhex-3-yn-2-yl)phenyl]benzenesulfonamideIC501100.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(3-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50600.0 [1], 5000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-[3-(trifluoromethyl)phenyl]but-3-yn-2-yl]phenyl]benzenesulfonamideIC50500.0 [1], 10000.0 [2]
2,5-Dichloro-N-(2-methylpropyl)-N-[4-(1,1,1-trifluoro-2-hydroxy-4-phenylbut-3-yn-2-yl)phenyl]benzenesulfonamideIC501400.0 [1], 10000.0 [2]
3-Cyano-N-(2-methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50600.0 [1], 2000.0 [2]
N-(Cyclopropylmethyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50500.0 [1], 2000.0 [2]
N-Benzyl-N-[[5-[4-(hydroxymethyl)-3-methylsulfonylphenyl]thiophen-2-yl]methyl]-2-(trifluoromethyl)benzenesulfonamideIC500.6 [1]
N-Benzyl-N-[[5-[4-(hydroxymethyl)-3-methylsulfonylphenyl]thiophen-2-yl]methyl]-2-(trifluoromethyl)benzenesulfonamideKi1.3 [1]
N-(Cyclobutylmethyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50300.0 [1], 7000.0 [2]
N-[4-[4-(4-Ethoxyphenyl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC50700.0 [1], 10000.0 [2]
N-[4-[1,1,1-Trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]-N-(3,3,3-trifluoropropyl)benzenesulfonamideIC50500.0 [1], 4000.0 [2]
3-Cyano-N-[4-[4-(4-cyanophenyl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC50600.0 [1], 10000.0 [2]
N-(2,2-Dimethylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC501200.0 [1], 6000.0 [2]
N-(Cyclopentylmethyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50150.0 [1], 1500.0 [2]
N-(2,2,2-Trifluoroethyl)-N-[4-[1,1,1-trifluoro-4-(4-fluorophenyl)-2-hydroxybut-3-yn-2-yl]phenyl]benzenesulfonamideIC501100.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(3-methylimidazol-4-yl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC505100.0 [1], 10000.0 [2]
N-[4-[4-[4-(Benzenesulfonyl)phenyl]-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-3-cyano-N-(2-methylpropyl)benzenesulfonamideIC5010000.0 [1]
3-[3-[4-[Benzenesulfonyl(2-methylpropyl)amino]phenyl]-4,4,4-trifluoro-3-hydroxybut-1-ynyl]benzoic acidIC501800.0 [1], 10000.0 [2]
3-Cyano-N-(2-methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(3-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC50400.0 [1], 7000.0 [2]
N-(2,2,2-Trifluoroethyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(4-methylsulfonylphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC501000.0 [1], 9000.0 [2]
N-[4-[4-(3,5-Dimethyl-1,2-oxazol-4-yl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC503200.0 [1], 10000.0 [2]
3-Cyano-N-(2-methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-[4-(trifluoromethylsulfonyl)phenyl]but-3-yn-2-yl]phenyl]benzenesulfonamideIC504300.0 [1], 10000.0 [2]
4-[3-[4-[(3-Cyanophenyl)sulfonyl-(2-methylpropyl)amino]phenyl]-4,4,4-trifluoro-3-hydroxybut-1-ynyl]benzoic acidIC50500.0 [1], 10000.0 [2]
N-[4-[4-(4-Butylphenyl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC503500.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(3-methoxyphenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC501000.0 [1], 10000.0 [2]
N-(2-Methylpropyl)-N-[4-[1,1,1-trifluoro-2-hydroxy-4-(2-methyl-4-nitrophenyl)but-3-yn-2-yl]phenyl]benzenesulfonamideIC502800.0 [1], 10000.0 [2]
N-[4-[4-(3-Cyanophenyl)-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl]phenyl]-N-(2-methylpropyl)benzenesulfonamideIC50600.0 [1], 10000.0 [2]
GenisteinIC5022000.0 [1]
1-DeoxynojirimycinIC50100000.0 [1]
Podocarpic acidIC5050000.0 [1]
2-(2-Chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazoleIC5024.0 [1]
Riccardin CIC506600.0 [1]
CID 46203250IC5031.62 [1]
CID 71478195IC5043.0 [1]
N-[4-(1,1,1,3,3,3-Hexafluoro-2-Hydroxypropan-2-Yl)phenyl]-N-MethylbenzenesulfonamideIC5020.0 [1]
(1R,3E,5S,6R,7S)-3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6-methyl-1,5-bis(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trioneIC5015000.0 [1]
3-Methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxalineIC5053.0 [1]
2-[2,6-Di(propan-2-yl)phenyl]-3-sulfanylideneisoindol-1-oneIC5018000.0 [1]
4-Dehydroxyriccardin CIC5010000.0 [1]
4,5,6,7-Tetrachloro-2-[2-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC503000.0 [1]
N-{2-[2-(3,4-Dihydroxyphenyl)ethyl]phenyl}phthalimideIC5030000.0 [1]
N-{3-[2-(3,4-Dihydroxyphenyl)ethyl]phenyl}phthalimideIC507600.0 [1]
4-[[N-Butyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]methyl]-2,6-dichlorophenolIC5030.0 [1]
N-Methyl-N-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)benzenesulfonamideIC5010000.0 [1]
17-Dehydroxyriccardin CIC5013000.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
N-{4-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl}phthalimideIC504300.0 [1]
4,5,6,7-Tetrachloro-2-[2-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC507700.0 [1]
4,5,6,7-Tetrachloro-2-[2-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5017000.0 [1]
4,5,6,7-Tetrachloro-2-[3-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5021000.0 [1]
N-{3-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl}phthalimideIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[4-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
(1S,4As,10aR)-N-(1-adamantylmethyl)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxamideIC50190.0 [1]
5,16,24-Trimethoxy-14-oxapentacyclo[20.2.2.210,13.115,19.02,7]nonacosa-1(24),2(7),3,5,10(29),11,13(28),15,17,19(27),22,25-dodecaeneIC5014000.0 [1]
3-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)propanoic acidIC506.0 [1]
2-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)acetic acidIC5016.0 [1]
1,1,1,3,3,3-Hexafluoro-2-{4-[methyl(phenylmethyl)amino]phenyl}-2-propanolIC50170.0 [1]
2-(4-(Dibenzylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-olIC50175.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ LXR-beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/lxr-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ LXR-beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lxr-beta-inhibitors-ic50-ki.
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