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Lysine-specific demethylase 2B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-{5-[(4-Chloro-2-Methylphenyl)methoxy]-1h-Pyrazol-1-Yl}pyridine-4-Carboxylic AcidIC50100.0 [1], 630.0 [2]
2-[5-(4-Methoxyphenyl)-1-methylimidazol-4-yl]pyridine-4-carboxylic acidIC50100.0 [1]
2-(1-Methylimidazol-4-yl)pyridine-4-carboxylic acidIC50100.0 [1]
2-(1-Methylimidazol-4-yl)-4-(2H-tetrazol-5-yl)pyridineIC50100.0 [1]
2-[5-[4-(Cyclopropylmethoxy)phenyl]-1-methylimidazol-4-yl]pyridine-4-carboxylic acidIC50100.0 [1]
2-[1-(2-Naphthalen-1-ylethyl)imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(5-fluoro-2H-triazol-4-yl)pyridineIC50100.0 [1], 1000.0 [2]
Kdm5A-IN-1IC5025000.0 [1]
3-[[(1R)-6-(N-Methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acidIC504000.0 [1]
2-(((2-((2-(Dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acidIC50100.0 [1]
[3-[6-Methyl-4-(1-methylpyrazol-4-yl)pyridin-2-yl]pyrrolidin-1-yl]-(5-propan-2-yl-1H-pyrazol-3-yl)methanoneIC5025000.0 [1]
2-[[(1-Ethyl-2-oxopyrrolidin-3-yl)methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3R)-1-Ethyl-2-oxopiperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[(2-Methyl-5,6,8,9-tetrahydroimidazo[1,2-d][1,4]diazepin-7-yl)methyl]pyridine-4-carboxylic acidIC502500.0 [1]
2-[[[(3S)-2-Oxo-1-[(1R)-1-phenylethyl]piperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3S)-2-Oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3S)-1-[(1R)-1-(4-Methoxyphenyl)ethyl]-2-oxopiperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
Kdm4D-IN-1IC5010000.0 [1]
N-[[2-[[[2-[2-(Dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridin-4-yl]methyl]-2,2,2-trifluoroacetamideIC502500.0 [1]
2-[[4-(Diethylamino)butylamino]methyl]pyridine-4-carbaldehydeIC502500.0 [1]
2-[5-[(4-Cyanophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1]
Methyl 2-[[[2-[2-(dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxylateIC501000.0 [1]
2-[5-[[4-Chloro-2-(cyclopropylmethoxy)phenyl]methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1]
2-[5-[(4-Methylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1]
2-[5-[(4-Ethylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1]
2-[5-[(4-Fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5010000.0 [1]
2-[5-[(4-Chloro-2-phenylmethoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1]
2-[5-(4-Fluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC5010000.0 [1]
2-[[[(3R)-2-Oxo-1-[(1R)-1-phenylethyl]piperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
4-(5-Iodo-2H-triazol-4-yl)-2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-(2-Chlorophenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Ethoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
4-(2H-Triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroethoxy)phenyl]ethyl]imidazol-4-yl]pyridineIC50100.0 [1]
4-(5-Chloro-2H-triazol-4-yl)-2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyridineIC50100.0 [1]
6-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[1-(2-Naphthalen-1-ylethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
4-(2H-Triazol-4-yl)-2-[1-[2-[2-(trifluoromethyl)phenyl]ethyl]imidazol-4-yl]pyridineIC50100.0 [1]
2-[1-(1-Phenylethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-(1,2,3,4-Tetrahydronaphthalen-1-ylmethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-(2-Chlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
6-(1-Benzylimidazol-4-yl)-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2,3-Dichlorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[[2-Fluoro-3-(trifluoromethoxy)phenyl]methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-(1-Phenylpropan-2-yl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-(2,2,2-Trifluoroethyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
5-[2-[1-(1,2,3,4-Tetrahydronaphthalen-1-ylmethyl)imidazol-4-yl]pyridin-4-yl]-2H-triazole-4-carbonitrileIC50100.0 [1]
4-(5-Chloro-2H-triazol-4-yl)-2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]pyridineIC50100.0 [1]
6-[1-[(3-Chlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[1-[(2,3-Dichlorophenyl)methyl]imidazol-4-yl]-4-(5-iodo-2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-[(4-Chlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-(1-Methylimidazol-4-yl)-4-(1H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Methoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Phenoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-[(2-Chlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[1-[2-(2-Phenylmethoxyphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(3-Chloro-2-fluorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
5-[2-[1-(2-Naphthalen-1-ylethyl)imidazol-4-yl]pyridin-4-yl]-2H-triazole-4-carbonitrileIC50100.0 [1]
2-[1-[(2-Chlorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2-Fluoro-3-methylphenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
5-(4-Fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazoleIC50100.0 [1]
4-(2H-Triazol-4-yl)-2-[1-[2-[2-(trifluoromethoxy)phenyl]ethyl]imidazol-4-yl]pyridineIC50100.0 [1]
2-[5-(4-Fluoro-3-methoxyphenyl)-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2,3-Dichlorophenyl)methyl]imidazol-4-yl]-4-(5-fluoro-2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-[(3,4-Dichlorophenyl)methyl]imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[1-[2-(2-Phenylphenyl)ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Chlorophenyl)-2-methylpropyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-(4-Chlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
1-(Cyclopropylmethyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazoleIC50100.0 [1]
6-[1-(3,5-Dichlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
2-[5-Bromo-1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[(2-Fluoro-3-methoxyphenyl)methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
5-[2-[5-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]pyridin-4-yl]-2H-triazole-4-carbonitrileIC50100.0 [1]
2-[5-(3-Ethoxy-4-fluorophenyl)-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-(3,4-Dihydro-2H-chromen-4-ylmethyl)imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
6-[1-(3-Chlorophenyl)imidazol-4-yl]-2H-triazolo[4,5-c]pyridineIC50100.0 [1]
4-(5-Fluoro-2H-triazol-4-yl)-2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyridineIC50100.0 [1]
2-[1-(1-Phenylpropyl)imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-(2-Methyl-1-phenylpropyl)imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-[2-(Cyclopropylmethoxy)phenyl]ethyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[5-(4-Fluorophenyl)-1-methylimidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[[2-Chloro-3-(trifluoromethyl)phenyl]methyl]imidazol-4-yl]-4-(2H-triazol-4-yl)pyridineIC50100.0 [1]
2-[1-[2-(2-Ethoxyphenyl)ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-[2-(Trifluoromethyl)phenyl]ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(2-Fluoro-4-methylphenyl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-(2,4-Difluorophenyl)ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-(2,6-Difluorophenyl)ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-(1-Benzylimidazol-4-yl)-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(2,6-Difluorophenyl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(7-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[(6-Methyl-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC501000.0 [1]
2-[1-[2-(3-Fluorophenyl)ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-(3,4-Dihydro-2H-chromen-4-ylmethyl)imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-(1-Phenylethyl)imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-(4-Fluorophenyl)ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
2-[1-[2-[4-(Trifluoromethyl)phenyl]ethyl]imidazol-4-yl]-4-[5-(trifluoromethyl)-2H-triazol-4-yl]pyridineIC50100.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Lysine-specific demethylase 2B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/lysine-specific-demethylase-2b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Lysine-specific demethylase 2B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysine-specific-demethylase-2b-inhibitors-ic50-ki.
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