Lysine-specific histone demethylase 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amine	IC50	27800.0 [1]
	(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amine	Ki	21000.0 [1], 25000.0 [2], 357000.0 [3]
	Parnate	IC50	25000.0 [1]
	Parnate	Ki	28100.0 [1], 243000.0 [2], 284000.0 [3]
	(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide	IC50	13.0 [1]
	(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide	Ki	13.5 [1], 31.92 [2], 35.17 [3], 35.32 [4], 54.66 [5]
	N-[(2S)-4-[3-(2-Aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide	IC50	2500.0 [1]
	N-[(2S)-4-[3-(2-Aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide	Ki	5700.0 [1]
	Benzyl N-[1-[4-(2-aminocyclopropyl)anilino]-1-oxo-3-phenylpropan-2-yl]carbamate	IC50	150.0 [1], 1300.0 [2]
	Benzyl N-[1-[4-(2-aminocyclopropyl)anilino]-1-oxo-3-phenylpropan-2-yl]carbamate	Ki	1000.0 [1], 1300.0 [2], 2100.0 [3]
	trans-2-Phenylcyclopropylamine	IC50	3600.0 [1], 6300.0 [2], 6500.0 [3]
	trans-2-Phenylcyclopropylamine	Ki	28100.0 [1], 284000.0 [2]
	N-[(2S)-4-[4-[(1S,2R)-2-Aminocyclopropyl]phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide	IC50	1900.0 [1], 2000.0 [2]
	N-[(2S)-4-[4-[(1S,2R)-2-Aminocyclopropyl]phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide	Ki	3100.0 [1]
	2-(3,5-Difluoro-2-phenylmethoxyphenyl)cyclopropan-1-amine	IC50	990.0 [1]
	2-(3,5-Difluoro-2-phenylmethoxyphenyl)cyclopropan-1-amine	Ki	610.0 [1], 2000.0 [2]
	[[5-Cyano-2-prop-2-ynylsulfanyl-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea	IC50	650.0 [1], 650.13 [2]
	CID 46830247	IC50	19.0 [1]
	CID 46830247	Ki	1000.0 [1], 1100.0 [2]
	Phenelzine	Ki	5600.0 [1], 17600.0 [2], 18000.0 [3]
	4-((4-((((1R,2S)-2-Phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid	IC50	24.0 [1], 41.0 [2]
	4-((4-((((1R,2S)-2-Phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid	Ki	1700.0 [1]
	Iadademstat	IC50	14.0 [1], 15.0 [2], 33.0 [3]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-(prop-2-ynylamino)hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	290.0 [1], 16600.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-hydrazinylhexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	4.35 [1], 4400.0 [2]
	3-Chloro-6-nitro-2-(trifluoromethyl)chromone	IC50	51000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-(aziridin-1-yl)hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	IC50	15600.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-(aziridin-1-yl)hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	15600.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	40.0 [1], 50.0 [2]
	Benzyl 4-(2-Aminocyclopropyl)Phenylcarbamate	Ki	1000.0 [1], 1900.0 [2], 2000.0 [3]
	1-(4-Methylpiperazin-1-yl)-2-[[(1S,2R)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]ethanone	IC50	8.0 [1], 70.0 [2]
	1-(4-Methylpiperazin-1-yl)-2-[[(1S,2R)-2-(4-phenylmethoxyphenyl)cyclopropyl]amino]ethanone	Ki	30.0 [1]
	4-[3-[(3R)-3-Aminopiperidine-1-carbonyl]-5-(pyridin-2-ylmethoxy)pyrazol-1-yl]benzonitrile	IC50	100.0 [1], 230.0 [2], 2300.0 [3]
	(2S)-1-[(17S,20S,23S,26S,29S,32S,35S,38S)-29-Benzyl-20,35-bis[3-(diaminomethylideneamino)propyl]-32-(hydroxymethyl)-26-(2-methylpropyl)-2,11,19,22,25,28,31,34,37-nonaoxo-23-propan-2-yl-3,10-dioxa-6,7-dithia-1,12,18,21,24,27,30,33,36-nonazabicyclo[36.3.0]hentetracontane-17-carbonyl]pyrrolidine-2-carboxamide	Ki	1600.0 [1], 37000.0 [2], 44000.0 [3]
	4-[2-(4-Methylphenyl)-5-[[(3R)-pyrrolidin-3-yl]methoxy]pyridin-3-yl]benzonitrile	IC50	30.0 [1], 41.0 [2], 1400.0 [3]
	4-N-[(1S,2R)-2-[4-[3-(Trifluoromethyl)phenyl]phenyl]cyclopropyl]cyclohexane-1,4-diamine	IC50	48.0 [1], 86.0 [2], 94.0 [3]
	Tranylcypromine	IC50	22300.0 [1], 29310.0 [2]
	Tranylcypromine hydrochloride	IC50	2100.0 [1], 27800.0 [2]
	1-[N'-[3-[7-[3-[[Amino-[[N'-(3,3-diphenylpropyl)carbamimidoyl]amino]methylidene]amino]propylamino]heptylamino]propyl]carbamimidoyl]-2-(3,3-diphenylpropyl)guanidine	IC50	500.0 [1], 1000.0 [2]
	CID 6476700	IC50	500.0 [1], 5000.0 [2]
	4-(4-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	125000.0 [1], 125025.9 [2]
	1-[2-(2-Chloroanilino)thiazole-4-yl]ethanone	IC50	188000.0 [1], 437000.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-[methyl(prop-2-ynyl)amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	107.0 [1]
	4-Hydroxybenzoic (2-hydroxybenzylidene)hydrazide	IC50	218.0 [1]
	3-N-[(2-Chloro-6-phenoxyphenyl)methyl]-1H-1,2,4-triazole-3,5-diamine	IC50	1200.0 [1]
	3-N-[(2-Chloro-6-phenoxyphenyl)methyl]-1H-1,2,4-triazole-3,5-diamine	Ki	2200.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	1800.0 [1]
	Tert-butyl 4-[[1-[(4-methylphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	IC50	2100.0 [1]
	4-[[4-[[[(1S,2R)-2-Phenylcyclopropyl]amino]methyl]piperidin-1-yl]methyl]benzoic acid	IC50	610.0 [1], 1700.0 [2]
	[[5-Cyano-6-(4-fluorophenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	1820.0 [1], 1823.9 [2]
	4-(4-Fluoroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	125000.0 [1], 125025.9 [2]
	4-(4-Nitroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	123310.48 [1], 125000.0 [2]
	4-Chloro-2-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanyl]-6-phenylpyrimidine-5-carbonitrile	IC50	97274.72 [1], 125000.0 [2]
	4-Chloro-6-(4-chlorophenyl)-2-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanyl]pyrimidine-5-carbonitrile	IC50	125000.0 [1], 125025.9 [2]
	[[5-Cyano-2-[(3,4-dichlorophenyl)methylsulfanyl]-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea	IC50	98174.79 [1], 98570.0 [2]
	[[5-Cyano-2-[(4-fluorophenyl)methylsulfanyl]-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea	IC50	125000.0 [1], 125025.9 [2]
	4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzonitrile	Ki	29.0 [1]
	N-[(2S)-1-[(3-Chlorophenyl)methylamino]-1-oxo-6-[[(1R,2S)-2-phenylcyclopropyl]amino]hexan-2-yl]-4-phenylbenzamide	IC50	132.0 [1], 770.0 [2]
	(2S)-1-[(2S)-6-Amino-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]pentanoyl]amino]hexanoyl]pyrrolidine-2-carboxamide	Ki	140.0 [1], 1900.0 [2]
	N-[(E)-(5-Chloro-2-hydroxyphenyl)methylideneamino]-4-hydroxybenzamide	IC50	275.0 [1]
	4-[3-[(3R)-3-Aminopiperidine-1-carbonyl]-5-[(3-ethyl-1,2-oxazol-5-yl)methoxy]pyrazol-1-yl]benzonitrile	IC50	79.0 [1], 520.0 [2]
	N-[(2S)-4-[3-[(1R,2S)-2-Aminocyclopropyl]phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide	IC50	1600.0 [1], 1900.0 [2]
	2-(Perfluorophenyl)Cyclopropanamine	IC50	9000.0 [1]
	2-(Perfluorophenyl)Cyclopropanamine	Ki	8900.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-6-(cyclopropylamino)hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Ki	2700.0 [1], 2800.0 [2]
	(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S,5S,8S,11S,14S,23S)-11-(4-aminobutyl)-23-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-8-(3-carbamimidamidopropyl)-2-[(1R)-1-hydroxyethyl]-5-methyl-3,6,9,12,17,24-hexaoxo-1,4,7,10,13,18-hexazacyclotetracosane-14-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide	IC50	2100.0 [1]
	(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S,5S,8S,11S,14S,23S)-11-(4-aminobutyl)-23-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-8-(3-carbamimidamidopropyl)-2-[(1R)-1-hydroxyethyl]-5-methyl-3,6,9,12,17,24-hexaoxo-1,4,7,10,13,18-hexazacyclotetracosane-14-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide	Ki	385.0 [1]
	N-[(2S)-1-(Benzylamino)-1-oxo-6-[(2-phenylcyclopropyl)amino]hexan-2-yl]benzamide	IC50	300.0 [1]
	Tert-butyl [4-[(1S,2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropyl]phenyl] carbonate	IC50	21250.0 [1]
	[[6-(4-Bromophenyl)-5-cyano-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]urea	IC50	41495.4 [1], 41510.0 [2]
	[[5-Cyano-6-(4-methylphenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]urea	IC50	3160.0 [1], 3162.28 [2]
	[[5-Cyano-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]urea	IC50	11190.0 [1], 11194.38 [2]
	[[6-(3-Chlorophenyl)-5-cyano-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]urea	IC50	5060.0 [1], 5069.91 [2]
	4-Chloro-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	45708.82 [1], 45750.0 [2]
	4-Chloro-6-(4-chlorophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	8330.0 [1], 8336.81 [2]
	4-Chloro-2-prop-2-ynylsulfanyl-6-(3,4,5-trimethoxyphenyl)pyrimidine-5-carbonitrile	IC50	3130.0 [1], 3133.29 [2]
	4-Chloro-6-(3,4-difluorophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	24370.0 [1], 24378.11 [2]
	4-(4-Bromophenyl)-6-chloro-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	24710.0 [1], 24717.24 [2]
	4-Chloro-6-(4-fluorophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	21820.0 [1], 21827.3 [2]
	4-Chloro-6-(4-methylphenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	59160.0 [1], 59292.53 [2]
	4-Chloro-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	IC50	125000.0 [1], 125025.9 [2]
	[(5-Cyano-6-phenyl-2-prop-2-ynylsulfanylpyrimidin-4-yl)amino]thiourea	IC50	1590.0 [1], 1592.21 [2]
	[[6-(4-Chlorophenyl)-5-cyano-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	1590.0 [1], 1592.21 [2]
	[[5-Cyano-6-(3,4-difluorophenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	1660.0 [1], 1663.41 [2]
	[[6-(4-Bromophenyl)-5-cyano-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	1590.0 [1], 1592.21 [2]
	[[5-Cyano-6-(4-methylphenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	1100.0 [1], 1101.54 [2]
	[[5-Cyano-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	2580.0 [1], 2582.26 [2]
	[[6-(3-Chlorophenyl)-5-cyano-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	3580.0 [1], 3580.96 [2]
	[[5-Cyano-6-(3-methoxyphenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]thiourea	IC50	2610.0 [1], 2612.16 [2]
	[[6-(4-Chlorophenyl)-5-cyano-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]urea	IC50	2640.0 [1], 2642.41 [2]
	4-[5-(4-Methylphenyl)-2-[[(3S)-pyrrolidin-3-yl]methylamino]pyrimidin-4-yl]benzonitrile	IC50	10.0 [1]
	1-(3,3-Diphenylpropyl)-3-[3-[5-[3-(3,3-diphenylpropylcarbamothioylamino)propylamino]pentylamino]propyl]thiourea;hydrochloride	IC50	4800.0 [1]
	1-(3,3-Diphenylpropyl)-3-[3-[5-[3-(3,3-diphenylpropylcarbamothioylamino)propylamino]pentylamino]propyl]thiourea;hydrochloride	Ki	2400.0 [1]
	4-[2-Phenyl-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzonitrile	Ki	1800.0 [1], 2300.0 [2]
	(2S)-1-[(17S,20S,23S,26S,29S,32S,35S,38S)-29-Benzyl-20,35-bis[3-(diaminomethylideneamino)propyl]-32-(hydroxymethyl)-26-(2-methylpropyl)-2,11,19,22,25,28,31,34,37-nonaoxo-23-propan-2-yl-3,10-dioxa-1,12,18,21,24,27,30,33,36-nonazabicyclo[36.3.0]hentetracontane-17-carbonyl]pyrrolidine-2-carboxamide	Ki	300000.0 [1]
	(E)-4-Bromo-N'-(2-hydroxybenzylidene)benzohydrazide	IC50	196.0 [1]
	4-Hydroxy-N-[(E)-1-(2-hydroxyphenyl)ethylideneamino]benzamide	IC50	291.0 [1]
	3-Chloro-N'-(2-hydroxybenzylidene)benzohydrazide	IC50	333.0 [1]
	N'-[(1E)-1-(5-Chloro-2-hydroxyphenyl)ethylidene]benzohydrazide	IC50	128.0 [1]
	(1S,2R)-N-[(2-Methoxypyridin-3-yl)methyl]-2-phenylcyclopropan-1-amine	IC50	65.5 [1], 98.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Lysine-specific histone demethylase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 7 May. 2024, https://www.aatbio.com/data-sets/lysine-specific-histone-demethylase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 7). Quest Database™ Lysine-specific histone demethylase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysine-specific-histone-demethylase-1-inhibitors-ic50-ki.
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