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Lysosomal alpha-glucosidase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
1-DeoxynojirimycinIC5060.0 [1], 1000.0 [2], 1500.0 [3], 91900.0 [4]
1-DeoxynojirimycinKi150.0 [1], 25000.0 [2]
PrecoseIC505000.0 [1], 42000.0 [2], 102000.0 [3], 446700.0 [4]
MiglustatIC50100.0 [1], 158000.0 [2]
MiglitolIC50350.0 [1], 1000.0 [2], 2000.0 [3]
5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraolIC501340.0 [1], 162000.0 [2], 300000.0 [3]
VogliboseIC5070.0 [1], 5600.0 [2]
N-Methyl-1-deoxynojirimycinKi54000.0 [1], 369000.0 [2]
AMP-DeoxynojirimycinIC50400.0 [1]
(2r,3r,5s,6r)-2,6-Bis(hydroxymethyl)piperidine-3,4,5-triolIC50100.0 [1], 1000.0 [2]
5-[[4-(4-Acetylphenyl)-1-piperazinyl]sulfonyl]-1,3-dihydroindol-2-oneIC50750.0 [1], 940.0 [2]
5-[(4-Acetylpiperazin-1-yl)sulfonyl]-2,3-dihydro-1H-indol-2-oneIC5011870.0 [1], 14940.0 [2]
5-[4-(4-Hydroxyphenyl)piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-oneIC501880.0 [1], 2370.0 [2]
5-[[4-(4-Acetylphenyl)-1-piperazinyl]sulfonyl]-3,3-dichloro-1H-indol-2-oneIC5032610.0 [1], 41050.0 [2]
4-[4-[(2-Oxo-1,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzaldehydeIC503660.0 [1], 4110.0 [2]
4-[4-[(2-Oxo-1,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzoic acidIC501300.0 [1], 1460.0 [2]
5-[4-(4-Acetylphenyl)piperazin-1-yl]sulfonyl-6-chloro-1,3-dihydroindol-2-oneIC501630.0 [1]
5-[4-(4-Nitrophenyl)piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-oneIC503260.0 [1], 3660.0 [2]
4-[4-[(2-Oxo-1,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzonitrileIC502910.0 [1], 3260.0 [2]
5-[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-oneIC5018820.0 [1], 23690.0 [2]
5-[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-oneIC5094310.0 [1]
5-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-oneIC5014940.0 [1]
Methyl 4-[4-[(2-oxo-1,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzoateIC5025900.0 [1], 36610.0 [2]
5-[4-[4-(Hydroxymethyl)phenyl]piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-oneIC5012980.0 [1]
5-Amino-cyclopentane-1,2,3,4-tetraolIC50300000.0 [1]
2-Anilino-6a-(hydroxymethyl)-3a,4,5,6-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triolIC50300000.0 [1]
2-Anilino-6-(hydroxymethyl)-3a,4,5,6a-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triolIC502930.0 [1], 300000.0 [2]
2-Anilino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]oxazole-4,5,6-triolIC50300000.0 [1]
3-Anilino-5,7a-bis(hydroxymethyl)-2,4a,6,7-tetrahydrocyclopenta[b][1,4]oxazine-5,6,7-triolIC50118000.0 [1], 300000.0 [2]
2-Anilino-4-(hydroxymethyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]oxazole-5,6-diolIC502320.0 [1], 300000.0 [2]
BaicaleinIC50500000.0 [1]
AcarboseIC50817380.0 [1]
OrcinolIC50100000.0 [1]
MigalastatIC506000.0 [1]
LucerastatIC501500.0 [1]
2,4-Dihydroxy-6-methylbenzoic acidIC50100000.0 [1]
N-MethyldeoxynojirimycinKi420.0 [1]
3-O-MethylfuniconeIC50100000.0 [1]
ValiolamineIC5057000.0 [1]
2,5-Dideoxy-2,5-Imino-D-GlucitolIC50300000.0 [1]
Piperidine-3,4,5-triolIC501000000.0 [1]
Unii-pugmwu0AL6IC5018000.0 [1]
(2S,3R,4R,5S)-1-[5-(1-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC501000000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4R,5S)-IC501000000.0 [1]
(2S,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triolIC501000000.0 [1]
5-Epi-IsofagomineKi86000.0 [1]
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5S)-IC501000000.0 [1]
Pinazaphilone AIC5081700.0 [1]
2-BenzyliminopiperidineKi3700000.0 [1]
[(7S,8S)-7-Hydroxy-7-methyl-6-oxo-3-[(E)-prop-1-enyl]-8H-isochromen-8-yl] 2,4-dihydroxy-6-methylbenzoateIC5016600.0 [1]
(2R,3S,4R,5S)-1-[5-(1-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50500.0 [1]
(1S,3R,4S,5R,6R,7S)-7-Amino-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptane-4,5-diolIC501000000.0 [1]
(2S,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triolIC50500000.0 [1]
(E)-3-[(7R,8S,8As)-8-(2,4-dihydroxy-6-methylbenzoyl)oxy-7-hydroxy-7-methyl-6-oxo-8,8a-dihydro-1H-isochromen-3-yl]prop-2-enoic acidIC5028000.0 [1]
(5S)-2-(3,5-Dihydroxyphenyl)-5-hydroxy-3-methylcyclopent-2-en-1-oneIC50100000.0 [1]
4-(3,5-Dihydroxyphenyl)-5-methylbenzene-1,2-diolIC502200.0 [1]
Penicidone DIC50100000.0 [1]
Methyl 3,5-dimethoxy-2-(5-methyl-7-oxo-5,6-dihydrofuro[3,2-b]pyran-3-carbonyl)benzoateIC5014400.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamideIC5014450.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(4-methylphenyl)acetamideIC5018220.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(4-fluorophenyl)acetamideIC5021000.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(3-methylphenyl)acetamideIC5020170.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(4-ethoxyphenyl)acetamideIC5016940.0 [1]
N-(2,4-Dichlorophenyl)-2-[4-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]acetamideIC5019130.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-phenylacetamideIC5027710.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(4-methoxyphenyl)acetamideIC5017020.0 [1]
N-(4-Chlorophenyl)-2-[4-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]acetamideIC5015970.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(2-ethoxyphenyl)acetamideIC5015240.0 [1]
N-(2,5-Dichlorophenyl)-2-[4-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]acetamideIC5011630.0 [1]
2-[4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]-N-(2-methylphenyl)acetamideIC5037440.0 [1]
N-(2,4-Dimethylphenyl)-2-[4-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanylmethyl]triazol-1-yl]acetamideIC5025690.0 [1]
(2Z)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one O-(anilinocarbonyl)oximeKi75000.0 [1]
(2S,3S,4R,5S)-1-[5-(1-Adamantylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triolIC50500000.0 [1]
(1S,3R,4S,5R,6R,7S)-7-[5-(1-Adamantylmethoxy)pentylamino]-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptane-4,5-diolIC501000000.0 [1]
5-(1-Adamantylmethoxy)-N-[(1S,3R,4S,5R,6R,7S)-4,5-dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-yl]pentanamideIC501000000.0 [1]
(1S,3R,4S,5R,6R,7S)-7-(Butylamino)-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptane-4,5-diolIC501000000.0 [1]
N-[(1S,3R,4S,5R,6R,7S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-yl]butanamideIC501000000.0 [1]
(E)-3-(1,3-Benzothiazol-2-ylamino)-1-(4-methylphenyl)-3-methylsulfanylprop-2-en-1-oneIC5021050.0 [1]
5-Methylpiperidine-3,4-diolIC501000000.0 [1]
(2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsilanyl-allyl)-piperidine-3,4,5-triolKi1000.0 [1]
(3s,4r,5r,6s)-Azepane-3,4,5,6-TetrolKi29400.0 [1]
(5-Benzyliminopyrrolidin-2-yl)methanolKi4000000.0 [1]
(6-Benzyliminopiperidin-2-yl)methanolKi700000.0 [1]
(3R,4S,5R,6S)-2-Benzylimino-6-(hydroxymethyl)piperidine-3,4,5-triolKi5000.0 [1]
(2S,3R,4S,5R)-2-(Hydroxymethyl)-6-[[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methylimino]piperidine-3,4,5-triolKi100000.0 [1]
(2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilanyl-propyl)-piperidine-3,4,5-triolKi2500.0 [1]
(2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilanyl-benzyl)-piperidine-3,4,5-triolKi2600.0 [1]
5-Methylene-piperidine-3,4-diolIC501000000.0 [1]
1-Butyl-5-methyl-piperidine-3,4-diolIC501000000.0 [1]
5-Methoxy-piperidine-3,4-diolIC501000000.0 [1]
1-Butyl-piperidine-3,4,5-triolIC501000000.0 [1]
[(2S,3S,4S,5R,6S)-6-(2,3-Diacetyloxypropoxy)-3,4,5-trihydroxyoxan-2-yl]methanesulfonic acidKi2900.0 [1]
[(2R,3R)-4-[(2S,3S,4S)-3,4-Dihydroxy-2-(hydroxymethyl)thiolan-1-ium-1-yl]-1,3-dihydroxybutan-2-yl] hydrogen sulfateIC503400000.0 [1]
Items per page: 1 - 10 of 93
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References

This online tool may be cited as follows

MLA

"Quest Database™ Lysosomal alpha-glucosidase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/lysosomal-alpha-glucosidase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Lysosomal alpha-glucosidase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysosomal-alpha-glucosidase-inhibitors-ic50-ki.
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