 | 2-Amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)butan-2-yl]-2-methylpropanamide | IC50 | 1.0 [1] |
 | [(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-3-methylphenyl)-5-methyl-1,2,4-triazol-3-yl]piperidin-1-yl]methanone | IC50 | 0.9 [1] |
 | Dizocilpine | IC50 | 5.3 [1] |
 | Phencyclidine | IC50 | 91.0 [1] |
 | 1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(1-methyl-5-pyridin-4-ylpyrazol-3-yl)piperidin-1-yl]propan-1-one | IC50 | 1.1 [1], 1.4 [2] |
 | 1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]propan-1-one | IC50 | 12.0 [1] |
 | 1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-(4-phenylpiperidin-1-yl)propan-1-one | IC50 | 10.0 [1] |
 | CID 54670056 | IC50 | 0.08 [1], 0.16 [2] |
 | [(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone | IC50 | 0.3 [1] |
 | 1-[(2S)-2-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-(4-phenylphenyl)propan-1-one | IC50 | 158.0 [1], 3314.0 [2] |
 | 1-[(2S)-2-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-2,2-dimethyl-3-(4-phenylphenyl)propan-1-one | IC50 | 79.0 [1], 1460.0 [2] |
 | 1-[(1R,2S,5S)-2-(4-Methyl-1H-benzimidazol-2-yl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-(4-phenylphenoxy)ethanone | IC50 | 308.0 [1], 1970.0 [2] |
 | 2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-methylpropanamide | IC50 | 4.0 [1], 356.0 [2] |
 | 2-Amino-N-[(2S)-3-(4-chlorophenyl)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl]-2-methylpropanamide | IC50 | 54.0 [1], 114.0 [2] |
 | 2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)azetidin-1-yl]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-2-methylpropanamide | IC50 | 9.0 [1], 829.0 [2] |
 | 3-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2,2-dimethylpropanamide | IC50 | 3.0 [1], 42.0 [2] |
 | 3-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-3-methylbutanamide | IC50 | 5.0 [1], 71.0 [2] |
 | 2-Amino-N-[(2S)-1-[(2S)-2-(5-tert-butyl-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-methylpropanamide | IC50 | 2.0 [1], 7.0 [2] |
 | N-[(2S)-1-[(2S)-2-(5-Tert-butyl-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-hydroxy-2-methylpropanamide | IC50 | 4.0 [1] |
 | 2-Amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)azetidin-1-yl]-1-oxo-3-phenylbutan-2-yl]-2-methylpropanamide | IC50 | 37.0 [1], 67.0 [2] |
 | 2-Amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-yl]-2-methylpropanamide | IC50 | 5.0 [1], 10.0 [2] |
 | N-[(2S,3S)-1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(4-fluorophenyl)phenyl]-1-oxobutan-2-yl]-2-hydroxy-2-methylpropanamide | IC50 | 2.0 [1] |
 | N-[(2S,3S)-1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-yl]-2-hydroxy-2-methylpropanamide | IC50 | 21.0 [1], 59.0 [2] |
 | 2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-1-oxopropan-2-yl]-2-methylpropanamide | IC50 | 5.0 [1], 7.0 [2] |
 | 2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-methyl-1-oxo-3-phenylbutan-2-yl]-2-methylpropanamide | IC50 | 12.0 [1], 39.0 [2] |
 | 1-[(2S)-2-[5-(3-Bromophenyl)-1H-imidazol-2-yl]-4,4-difluoropyrrolidin-1-yl]-3-[4-(2,3-dichlorophenyl)phenyl]-2,2-dimethylpropan-1-one | IC50 | 22.0 [1], 20000.0 [2] |
 | 1-(4-Chloropyridin-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine] | IC50 | 0.44 [1], 0.66 [2] |
 | 1-(4-Chloro-1-oxidopyridin-1-ium-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine] | IC50 | 1.2 [1], 1.3 [2] |
 | (1R,2R,4R)-N-[Bis(4-fluorophenyl)methyl]-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexane-1-carboxamide | IC50 | 0.66 [1], 1.4 [2] |
 | (1R,2R,4R)-N-[Bis(4-chlorophenyl)methyl]-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexane-1-carboxamide | IC50 | 2.6 [1] |
 | (1R,2R,4R)-N-[Bis(4-fluorophenyl)methyl]-2-(4-bromophenyl)-4-[[2-(diethylamino)acetyl]amino]cyclohexane-1-carboxamide | IC50 | 16.7 [1], 17.0 [2] |
 | [(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone | IC50 | 0.5 [1] |
 | [4-[2-(3-Chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone | IC50 | 10.7 [1], 11.0 [2] |
 | [(1R,2R,4S)-4-Amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone | IC50 | 6.4 [1], 8.1 [2] |
 | [(1S,2S,4S)-4-Amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone | IC50 | 18.0 [1] |
 | (2S)-N-Dodecyl-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide | Ki | 34100.0 [1], 43100.0 [2] |
 | 5-(4-Chloropyridin-2-yl)-1'-[2-[4-(trifluoromethoxy)phenyl]propan-2-yl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine] | IC50 | 0.49 [1] |
 | 5-(3,5-Dichlorophenyl)-1'-[4-(trifluoromethoxy)phenyl]sulfonylspiro[5H-furo[3,4-b]pyridine-7,4'-piperidine] | IC50 | 1.6 [1] |
 | 5-(3,5-Dichlorophenyl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine] | IC50 | 3.2 [1], 5.2 [2] |
 | (1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-(3-chloropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide | IC50 | 2.7 [1] |
 | (1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-pyridin-4-ylmethyl]-4-morpholin-4-ylcyclohexane-1-carboxamide | IC50 | 0.18 [1] |
 | (1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-(5-fluoropyridin-2-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide | IC50 | 0.95 [1] |
 | (1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-(2-methylpyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide | IC50 | 2.2 [1], 3.1 [2] |
 | Benzyl (2S)-2-[(2S)-2-(hexadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 61000.0 [1], 141400.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[[2-(trifluoromethyl)phenyl]methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 135400.0 [1], 488600.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[(4-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 257100.0 [1], 264600.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[(2,6-difluorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 541500.0 [1], 835700.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[(3-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 467700.0 [1], 900000.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[(2-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 289200.0 [1], 771400.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[(3-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 393800.0 [1], 450000.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-[2-(4-bromophenyl)ethylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 110800.0 [1], 282900.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-(pentylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 289200.0 [1], 565700.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-(heptylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 80000.0 [1], 437100.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-(dodecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 61500.0 [1], 64300.0 [2] |
 | Benzyl (2S)-2-[[4-[(2-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate | Ki | 332300.0 [1], 694300.0 [2] |
 | Benzyl (2S)-2-[[4-[(3-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate | Ki | 227700.0 [1], 565700.0 [2] |
 | Benzyl (2S)-2-[[4-[(4-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate | Ki | 258500.0 [1], 668600.0 [2] |
 | Benzyl (2S)-2-[[4-[(2,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate | Ki | 147700.0 [1], 604300.0 [2] |
 | Benzyl (2S)-2-[[4-[(3,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate | Ki | 110800.0 [1], 456400.0 [2] |
 | Benzyl (2S)-2-[[4-[3-[2-(2-ethoxyethoxy)ethoxy]propylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate | Ki | 192900.0 [1], 350800.0 [2] |
 | N-Dodecylazetidine-2-carboxamide | Ki | 50140.0 [1], 195100.0 [2] |
 | N-Dodecyl-1-(pyrrolidine-2-carbonyl)azetidine-2-carboxamide | Ki | 50400.0 [1], 84900.0 [2] |
 | Benzyl (2S)-2-[(2S)-2-(pentadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | Ki | 61500.0 [1], 64200.0 [2] |
 | 1-(Azetidine-2-carbonyl)-N-dodecylazetidine-2-carboxamide | Ki | 29600.0 [1], 108900.0 [2] |
 | (2S)-1-[(2S)-Azetidine-2-carbonyl]-N-dodecylpyrrolidine-2-carboxamide | Ki | 17400.0 [1], 43700.0 [2] |
 | (2S)-N-[4-(Dodecylamino)-4-oxobutyl]pyrrolidine-2-carboxamide | Ki | 6400.0 [1], 36900.0 [2] |
 | (2S)-N-Dodecylpyrrolidine-2-carboxamide | Ki | 61500.0 [1], 477000.0 [2] |
 | Tenocyclidine | IC50 | 20.0 [1] |
 | Caramiphen | Ki | 26.0 [1] |
 | 2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate | IC50 | 100000.0 [1] |
 | Carbetapentane | IC50 | 32.0 [1] |
 | Metaphit | Ki | 16.0 [1] |
 | 1-Benzyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 1000.0 [1] |
 | (2S)-N-Benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide | IC50 | 100000.0 [1] |
 | (R)-Preclamol | IC50 | 100000.0 [1] |
 | 4-Phenyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 30000.0 [1] |
 | 1-Phenyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 1900.0 [1] |
 | 2-Methyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 30000.0 [1] |
 | 1,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 30000.0 [1] |
 | 3-Phenyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 3900.0 [1] |
 | 1-Isopropyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 11000.0 [1] |
 | 1-Cyclohexyl-1,2,3,4-tetrahydro-isoquinoline | IC50 | 12000.0 [1] |
 | 1-(1-Tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl)piperidine | IC50 | 117500.0 [1] |
 | 1-(4-Chlorophenyl)-1,2,3,4-tetrahydroisoquinoline | IC50 | 5300.0 [1] |
 | 1-Isobutyl-1,2,3,4-tetrahydro-isoquinoline | IC50 | 20000.0 [1] |
 | 1-Phenyl-2,3-dihydro-1H-isoindole | IC50 | 30000.0 [1] |
 | 1-Phenyl-2-prop-2-enyl-3,4-dihydro-1H-isoquinoline | IC50 | 2300.0 [1] |
 | 1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline | IC50 | 4900.0 [1] |
 | 1-(4-Methylphenyl)-1,2,3,4-tetrahydroisoquinoline | IC50 | 9500.0 [1] |
 | 1-Naphthalen-2-yl-1,2,3,4-tetrahydro-isoquinoline | IC50 | 30000.0 [1] |
 | 2-Allyl-1-cyclohexyl-1,2,3,4-tetrahydro-isoquinoline | IC50 | 6200.0 [1] |
 | 2-Benzyl-3-methyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 30000.0 [1] |
 | 2-Allyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline | IC50 | 5400.0 [1] |
 | 1-Phenyl-2-ethyl-1,2,3,4-tetrahydroisoquinoline | IC50 | 3800.0 [1] |
 | 2-Methyl-1-phenyl-3,4-dihydro-1H-isoquinoline | IC50 | 24000.0 [1] |
 | Isoquinoline, 1,2,3,4-tetrahydro-2,3-dimethyl- | IC50 | 30000.0 [1] |
 | (1S,13R)-1,13-Dimethyl-10-prop-2-enyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-triene | IC50 | 760.0 [1] |
 | 1-(3,4-Dihydro-2H-1,4-methano-naphthalen-1-yl)-piperidine | IC50 | 107000.0 [1] |
 | 3-[4-(3-Aminophenyl)phenyl]-1-[(2S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one | IC50 | 4090.0 [1] |
 | 3-[4-(2-Methylphenyl)phenyl]-1-[(2S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one | IC50 | 352.0 [1] |
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