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Lysyl-tRNA synthetase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
Nvp-tae 684IC50286.0 [1], 1474.0 [2], 286000.0 [3]
StaurosporineIC500.86 [1], 9.0 [2]
CladosporinIC5020000.0 [1], 105000.0 [2]
CrizotinibIC5010000.0 [1]
Dehydroabietic acidIC5027.7 [1]
IsocladosporinIC50100000.0 [1]
Syk Inhibitor IIIC5041.0 [1]
DehydroabietolIC5046.4 [1]
15-Hydroxydehydroabietic acidIC5049.1 [1]
5-(4-Aminobutylamino)-7-[4-(dimethylamino)phenyl]-1,6-naphthyridineIC5034.0 [1]
3-N-[4-(4-Morpholin-4-ylcyclohexyl)phenyl]-1-pyridin-2-yl-1,2,4-triazole-3,5-diamineKi220.0 [1]
(1R,4As,10aR)-6-hydroxy-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbaldehydeIC5034.1 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamideIC509.0 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamideIC504.0 [1]
(3R)-6,8-Dihydroxy-3-[[(2S,6R)-6-methyloxan-2-yl]methyl]-3,4-dihydroisochromen-1-oneIC50100000.0 [1]
(1S,4As,10aR)-1-(hydroxymethyl)-4a-methyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC507.2 [1]
(E)-3-[4-[[[8-Carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]prop-2-enoic acidIC50690.0 [1]
5-(2-Aminoethylamino)-7-(3,5-dimethoxyphenylamino)-1,2,4-triazolo[4,3-c]pyrimidine-8-carboxamideIC509.0 [1]
5-Amino-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC507100.0 [1]
7-(3,5-Dimethoxyanilino)-5-(2-hydroxyethylamino)imidazo[1,2-c]pyrimidine-8-carboxamideIC504300.0 [1]
5-(2-Aminoethylamino)-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC50230.0 [1]
1,2,4-Oxadiazole Analogue 12dIC50500000.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC50720.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
7-(3,5-Dimethoxyanilino)-5-(pyridin-4-ylmethylamino)imidazo[1,2-c]pyrimidine-8-carboxamideIC502300.0 [1]
Ethyl (E)-3-[4-[[[8-carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]prop-2-enoateIC5010000.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(4-methoxyphenyl)methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC5011200.0 [1]
1-[(6-Fluoro-4H-1,3-benzodioxin-8-yl)methyl]-6-methyl-3-nitrosoindol-2-olKi30000.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
6-[[1-[4-(Cyclohexylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5013500.0 [1]
6-[[1-[4-(3-Methoxypropylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5050000.0 [1]
6-[[1-[4-(4-Methylanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5020900.0 [1]
6-[[1-[4-(Hexylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC509700.0 [1]
6-[[1-[4-(3-Ethoxypropylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5050000.0 [1]
6-[[1-[4-(Heptylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5011400.0 [1]
6-[[1-[4-(3,5-Dimethoxyanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5020900.0 [1]
6-[[1-[4-(4-Ethylanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5019200.0 [1]
6-[[1-[4-(Pentylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5050000.0 [1]
6-[[1-[4-(3,4-Dimethylanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5015600.0 [1]
6-[[1-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylamino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5020300.0 [1]
(1S,4As,10aR)-1-(hydroxymethyl)-4a-methyl-7-prop-1-en-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC5085.3 [1]
(1S,4As,10aR)-7-acetyl-1-(2-methoxy-2-oxoethyl)-4a-methyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC50100.0 [1]
6-[[1-[4-(4-Methoxyanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5032100.0 [1]
6-[[1-[4-(3,4,5-Trimethoxyanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5014200.0 [1]
6-[[1-[4-(3,4-Dimethoxyanilino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]pyridine-3-carboxylic acidIC5023700.0 [1]
4-[[1-[4-(3,4-Dimethoxyanilino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]benzoic acidIC5025300.0 [1]
Methyl 4-[[1-[4-(3,4-dimethoxyanilino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]pyrrolidin-3-yl]carbamoyl]benzoateIC5050000.0 [1]
(1S,4As,10aR)-1-(2-methoxy-2-oxoethyl)-4a-methyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC5022.4 [1]
(1S,4As,10aR)-7-hydroxy-1-(2-methoxy-2-oxoethyl)-4a-methyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC50100.0 [1]
(1S,4As,10aR)-1-(2-methoxy-2-oxoethyl)-4a-methyl-7-prop-1-en-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC5010.7 [1]
(1S,4As,10aR)-7-(2-hydroxypropan-2-yl)-1-(2-methoxy-2-oxoethyl)-4a-methyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC50100.0 [1]
(1S,4As,10aR)-7-acetyl-1-(hydroxymethyl)-4a-methyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acidIC50100.0 [1]
Isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamateIC5010000.0 [1]
(S)-(2-Aminopyridin-3-yl)(6-(3-isobutylpiperazin-1-yl)-3-(trifluoromethyl)pyridin-2-yl)methanoneKi4000.0 [1]
7-(3,5-Dimethoxyanilino)-5-methylsulfanylimidazo[1,2-c]pyrimidine-8-carboxamideIC5010000.0 [1]
5-(Benzylamino)-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC504300.0 [1]
5-[Benzyl(methyl)amino]-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC5013400.0 [1]
7-(3,5-Dimethoxyanilino)-5-(2-phenylethylamino)imidazo[1,2-c]pyrimidine-8-carboxamideIC504800.0 [1]
7-(3,5-Dimethoxyanilino)-5-[[(1R)-1-phenylethyl]amino]imidazo[1,2-c]pyrimidine-8-carboxamideIC5010000.0 [1]
7-(3,5-Dimethoxyanilino)-5-[[(1S)-1-phenylethyl]amino]imidazo[1,2-c]pyrimidine-8-carboxamideIC503300.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(4-fluorophenyl)methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC501900.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(3-methoxyphenyl)methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC506700.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(2-methoxyphenyl)methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC505800.0 [1]
5-[(3,5-Difluorophenyl)methylamino]-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC509800.0 [1]
5-[(2,4-Difluorophenyl)methylamino]-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC503700.0 [1]
7-(3,5-Dimethoxyanilino)-5-(furan-2-ylmethylamino)imidazo[1,2-c]pyrimidine-8-carboxamideIC502500.0 [1]
5-(1H-Benzimidazol-2-ylmethylamino)-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC509800.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(4-sulfamoylphenyl)methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC5010000.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(4-methylsulfonylphenyl)methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC5011300.0 [1]
Methyl 4-[[[8-carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]benzoateIC504800.0 [1]
4-[[[8-Carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]benzoic acidIC508100.0 [1]
5-[(4-Carbamoylphenyl)methylamino]-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC508700.0 [1]
7-(3,5-Dimethoxyanilino)-5-[[4-(hydroxymethyl)phenyl]methylamino]imidazo[1,2-c]pyrimidine-8-carboxamideIC508500.0 [1]
Tert-butyl 2-[4-[[[8-carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]acetateIC5010000.0 [1]
2-[4-[[[8-Carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]acetic acidIC50760.0 [1]
5-[[4-(2-Amino-2-oxoethyl)phenyl]methylamino]-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC501900.0 [1]
7-(3,5-Dimethoxyanilino)-5-(2-hydroxyethylamino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamideIC506100.0 [1]
Tert-butyl 2-[[8-carbamoyl-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl]amino]acetateIC5079100.0 [1]
5-[(2-Amino-2-methylpropyl)amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamideIC50150.0 [1]
5-(3-Aminopropylamino)-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamideIC507700.0 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-3-phenyl-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamideIC5015200.0 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-2-phenyl-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamideIC5083.0 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-2-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamideIC50120.0 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-2-(2-chlorophenyl)-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamideIC5050.0 [1]
Cdk4-IN-1IC5010000.0 [1]
N-[5-[4-(Dimethylamino)piperidin-1-yl]pyridin-2-yl]-4-[5-propan-2-yl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrimidin-2-amineIC5010000.0 [1]
N-{6-[3-(Piperazin-1-Yl)phenyl]pyridin-2-Yl}-4-(Trifluoromethyl)pyridin-2-AmineIC500.6 [1]
6-(2-Piperazin-1-ylpyridin-4-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]pyridin-2-amineIC501.8 [1]
N-[6-(3-Piperazin-1-ylphenyl)pyridin-2-yl]pyrazin-2-amineIC5043.0 [1]
N-[6-(2-Piperazin-1-ylpyridin-4-yl)pyridin-2-yl]pyrazin-2-amineIC5062.0 [1]
4-N-Methyl-6-(2-piperazin-1-ylpyridin-4-yl)-2-N-pyrazin-2-ylpyridine-2,4-diamineIC504.0 [1]
6-[3-(Aminomethyl)phenyl]-N-(4-methylpyridin-2-yl)pyridin-2-amineIC501671.0 [1]
6-[3-(2-Aminoethyl)phenyl]-N-(4-methylpyridin-2-yl)pyridin-2-amineIC50160.0 [1]
6-(3-Aminophenyl)-N-(4-methylpyridin-2-yl)pyridin-2-amineIC503242.0 [1]
N'-[3-[6-[(4-Methylpyridin-2-yl)amino]pyridin-2-yl]phenyl]ethane-1,2-diamineIC5091.0 [1]
N'-[4-[6-[(4-Methylpyridin-2-yl)amino]pyridin-2-yl]pyridin-2-yl]ethane-1,2-diamineIC50200.0 [1]
6-[2-(3-Aminopyrrolidin-1-yl)pyridin-4-yl]-N-(4-methylpyridin-2-yl)pyridin-2-amineIC50450.0 [1]
6-[2-(4-Aminopiperidin-1-yl)pyridin-4-yl]-N-(4-methylpyridin-2-yl)pyridin-2-amineIC50114.0 [1]
N-(4-Methylpyridin-2-yl)-6-(2-piperazin-1-ylpyridin-4-yl)pyridin-2-amineIC5014.0 [1]
6-[2-(1,4-Diazepan-1-yl)pyridin-4-yl]-N-(4-methylpyridin-2-yl)pyridin-2-amineIC5027.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Lysyl-tRNA synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/lysyl-trna-synthetase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Lysyl-tRNA synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysyl-trna-synthetase-inhibitors-ic50-ki.
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