Macrophage migration inhibitory factor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester	IC50	25000.0 [1]
	6-[alpha-Morpholino-4-(trifluoromethyl)benzyl]-1,3-benzodioxole-5-ol	IC50	360.0 [1], 570.0 [2], 2400.0 [3], 6120.0 [4]
	6-[alpha-Morpholino-4-(trifluoromethyl)benzyl]-1,3-benzodioxole-5-ol	Ki	52.0 [1], 570.0 [2]
	3',4',7-Trihydroxyisoflavone	IC50	38.0 [1]
	3',4',7-Trihydroxyisoflavone	Ki	38.0 [1], 15000.0 [2]
	3-Acetyl-7-hydroxy-2H-chromen-2-one	IC50	45200.0 [1], 103200.0 [2]
	3-Acetyl-7-hydroxy-2H-chromen-2-one	Ki	4300.0 [1]
	Benzyl isothiocyanate	IC50	530.0 [1], 540.0 [2], 790.0 [3]
	6-[2-(2-Morpholinoethoxy)ethoxy]-2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazole-4-yl]quinoline	Ki	160.0 [1], 161.0 [2], 410.0 [3]
	(S)-Methyl 2-(4-hydroxybenzylideneamino)-3-(1H-indol-3-yl)propanoate	IC50	1600.0 [1], 1650.0 [2]
	Methyl (5R)-3-(4-hydroxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate	Ki	24000.0 [1], 27300.0 [2], 30100.0 [3]
	4-{4-[6-(2-Methoxyethoxy)quinolin-2-Yl]-1h-1,2,3-Triazol-1-Yl}phenol	Ki	200.0 [1], 550.0 [2], 650.0 [3]
	4-Hydroxybenzaldehyde O-(Cyclohexylcarbonyl)oxime	IC50	1300.0 [1], 1570.0 [2]
	2-[2-[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]ethyl]isoindole-1,3-dione	IC50	500.0 [1], 800.0 [2], 1500.0 [3]
	1-[2-[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]ethyl]pyrrolidine-2,5-dione	IC50	15000.0 [1], 20000.0 [2], 50000.0 [3]
	2-Fluoro-4-[5-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]methyl]-4,5-dihydro-1,2-oxazol-3-yl]phenol	IC50	15000.0 [1], 48000.0 [2], 60000.0 [3]
	2,2,2-Trifluoro-N-[2-[3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]ethyl]acetamide	IC50	15000.0 [1], 49000.0 [2], 100000.0 [3]
	N-[2-[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]ethyl]-2,2-dimethylpropanamide	IC50	15000.0 [1], 22000.0 [2], 28000.0 [3]
	4-Fluoro-N-[2-[3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]ethyl]benzamide	IC50	10000.0 [1], 15000.0 [2], 20000.0 [3]
	N-[2-[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]ethyl]-3-methylbutanamide	IC50	20000.0 [1], 22000.0 [2], 29000.0 [3]
	3-Fluorobenzyl isothiocyanate	IC50	1500.0 [1], 11000.0 [2], 54000.0 [3]
	3-[3-[3-(3-Fluoro-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1,2,4-oxadiazol-5-yl]propanoic acid	IC50	12000.0 [1], 60000.0 [2], 100000.0 [3]
	5-Amino-3-dodecyl-1H-chromeno[3,4-c]pyridine-2,4(3H,10bH)-dione	IC50	13500.0 [1], 13800.0 [2], 18000.0 [3]
	4-Fluorobenzyl isothiocyanate	IC50	540.0 [1], 9600.0 [2], 31000.0 [3]
	Sulforaphane	IC50	2200.0 [1], 11000.0 [2]
	Hexachlorophene	IC50	6000.0 [1]
	Hexachlorophene	Ki	5550.0 [1]
	Phenethyl isothiocyanate	IC50	1600.0 [1], 16000.0 [2]
	Allyl isothiocyanate	IC50	250.0 [1], 1100.0 [2]
	Ebselen	IC50	2400.0 [1]
	Ebselen	Ki	570.0 [1]
	Epoxyazadiradione	IC50	6000.0 [1], 6400.0 [2]
	Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate	Ki	7400.0 [1]
	7-Hydroxy-3-phenyl-2H-chromen-2-one	Ki	470.0 [1]
	3-Benzyl-5-methyl-3H-benzooxazol-2-one	IC50	500.0 [1]
	Butyl 1,3-benzoxazol-2-ylsulfanylformate	IC50	80.0 [1], 150.0 [2]
	4-Methoxybenzyl isothiocyanate	IC50	700.0 [1], 3900.0 [2]
	3-({[(4-Biphenylylcarbonyl)amino]carbonothioyl}amino)benzoic acid	Ki	348.0 [1], 4270.0 [2]
	4-(2-Isothiocyanatoethyl)phenol	IC50	1200.0 [1], 3600.0 [2]
	3-({2-[1-(3-Fluoro-4-Hydroxyphenyl)-1h-1,2,3-Triazol-4-Yl]quinolin-5-Yl}oxy)benzoic Acid	Ki	14.0 [1], 57.0 [2]
	1-(2-Chlorophenyl)-3-pyridin-2-ylthiourea	IC50	1010.0 [1], 1040.0 [2]
	2-(4-Chlorophenyl)-6-fluoro-1,2-benzothiazol-3-one	IC50	4200.0 [1]
	6-Phenylpyridazin-3-yl thiophene-2-carboxylate	IC50	50.0 [1]
	3,4-Dihydroxyphenethyl isothiocyanate	IC50	4000.0 [1], 29000.0 [2]
	4-(Isothiocyanatomethyl)benzene-1-sulfonamide	IC50	500.0 [1], 750.0 [2]
	2-Fluoro-4-[4-[6-[2-(2-morpholin-4-ylethoxy)ethoxy]quinolin-2-yl]triazol-1-yl]phenol	Ki	74.0 [1]
	2-[2-[1-(3-Fluoro-4-hydroxyphenyl)triazol-4-yl]quinolin-6-yl]oxyacetic acid	Ki	48.0 [1]
	4-[2-[1-(3-Fluoro-4-hydroxyphenyl)triazol-4-yl]quinolin-6-yl]oxybutanoic acid	Ki	39.0 [1]
	2-[2-[1-(4-Hydroxyphenyl)triazol-4-yl]quinolin-6-yl]oxyacetic acid	Ki	200.0 [1]
	3-{[(1-Benzofuran-2-ylcarbonyl)carbamothioyl]amino}-4-methoxybenzoic acid	Ki	5141.0 [1], 26790.0 [2]
	4-[4-[6-(2-Hydroxyethoxy)quinolin-2-yl]triazol-1-yl]phenol	Ki	530.0 [1]
	4-[4-[6-[2-(2-Aminoethoxy)ethoxy]quinolin-2-yl]triazol-1-yl]phenol;2,2,2-trifluoroacetic acid	Ki	360.0 [1]
	4-[4-[6-[2-(2-Aminoethoxy)ethoxy]quinolin-2-yl]triazol-1-yl]-2-fluorophenol;2,2,2-trifluoroacetic acid	Ki	144.0 [1]
	Neopentyl 2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate	IC50	750.0 [1], 1070.0 [2]
	7-Hydroxy-3-pyrazolo[1,5-a]pyridin-2-yl-chromen-2-one	Ki	500.0 [1]
	2-[4-(1,3-Benzothiazol-2-yl)-2-bromo-6-methoxyphenoxy]acetic acid	Ki	4521.0 [1], 10900.0 [2]
	2-(4-Chlorophenyl)-6-hydroxy-1,2-benzothiazol-3-one	IC50	1000.0 [1]
	2-(4-Chlorophenyl)-6-hydroxy-1,2-benzothiazol-3-one	Ki	10000.0 [1]
	7-Hydroxy-3-(2-methyl-thiazol-4-yl)-chromen-2-one	Ki	2100.0 [1]
	2-(4-Chlorophenyl)-6-methoxy-1,2-benzothiazol-3-one	IC50	1900.0 [1]
	2-(4-Chlorophenyl)-6-methoxy-1,2-benzothiazol-3-one	Ki	5370.0 [1]
	Ethyl 2-cyano-3-(2,4-dihydroxyphenyl)acrylate	IC50	62100.0 [1], 110200.0 [2]
	1-Phenyl-3-(1,3,4-thiadiazol-2-yl)thiourea	IC50	300.0 [1], 420.0 [2]
	1-(2-Methoxybenzoyl)-1H-1,2,3-benzotriazole	IC50	6900.0 [1], 12200.0 [2]
	4-[4-(Quinolin-2-Yl)-1h-1,2,3-Triazol-1-Yl]phenol	Ki	230.0 [1]
	4-Imidazo[1,2-a]pyridin-3-ylbenzene-1,2-diol	IC50	110.0 [1]
	4-Imidazo[1,2-a]pyridin-3-ylbenzene-1,2-diol	Ki	45200.0 [1]
	N-(2-Bromobenzoyloxy)-4-chlorobenzamide	IC50	2800.0 [1], 4200.0 [2]
	2-Fluoro-4-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1,2-oxazol-3-yl]phenol	IC50	60000.0 [1], 100000.0 [2]
	2-[[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl]isoindole-1,3-dione	IC50	29000.0 [1], 36000.0 [2]
	2-Fluoro-4-[5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-4,5-dihydro-1,2-oxazol-3-yl]phenol	IC50	60000.0 [1], 100000.0 [2]
	2-[3-[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propyl]isoindole-1,3-dione	IC50	2000.0 [1], 7000.0 [2]
	N-Cyclohexyl-3-[3-[3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1,2,4-oxadiazol-5-yl]propanamide	IC50	25000.0 [1], 100000.0 [2]
	Methyl 3-[3-[3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1,2,4-oxadiazol-5-yl]propanoate	IC50	50000.0 [1], 100000.0 [2]
	3-[3-[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1,2,4-oxadiazol-5-yl]benzene-1,2-diol	IC50	19000.0 [1], 100000.0 [2]
	Methyl (5S)-3-(4-hydroxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate	IC50	7000.0 [1], 11300.0 [2]
	[(E)-(3-Fluoro-4-hydroxyphenyl)methylideneamino] pyridine-3-carboxylate	IC50	410.0 [1]
	[(E)-(3-Fluoro-4-hydroxyphenyl)methylideneamino] pyridine-3-carboxylate	Ki	3300.0 [1]
	1-Chloro-4-(2-isothiocyanatoethyl)benzene	IC50	1100.0 [1], 1600.0 [2]
	N-[(2-Chlorophenyl)carbamothioyl]-4-nitrothiophene-2-carboxamide	IC50	7080.0 [1]
	N-[(2-Chlorophenyl)carbamothioyl]-4-nitrothiophene-2-carboxamide	Ki	2470.0 [1]
	(1-Isothiocyanatoethyl)benzene	IC50	1000.0 [1], 2800.0 [2]
	5-(Isothiocyanatomethyl)-1,3-benzodioxole	IC50	2900.0 [1], 5000.0 [2]
	3-[[3-(3-Fluoro-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl]-5-(trifluoromethyl)-1,2,4-oxadiazole	IC50	55000.0 [1], 100000.0 [2]
	5-(2,3-Dimethoxyphenyl)-3-[3-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1,2,4-oxadiazole	IC50	20000.0 [1], 32000.0 [2]
	3-[3-(3-Fluoro-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole	IC50	95000.0 [1], 100000.0 [2]
	N-Cyclohexyl-3-[3-[3-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]-1,2,4-oxadiazol-5-yl]propanamide	IC50	9500.0 [1], 30000.0 [2]
	4-(1-Isothiocyanatopropan-2-yl)phenol	IC50	4800.0 [1], 28000.0 [2]
	Methyl 2-(4-methyl-5-(2-thienyl)-1,2,4-triazol-3-ylthio)acetate	IC50	18600.0 [1], 28400.0 [2]
	1-(2-Isothiocyanatoethyl)-4-(trifluoromethyl)benzene	IC50	7100.0 [1], 40000.0 [2]
	3-(2-Isothiocyanatoethyl)phenol	IC50	7800.0 [1], 62000.0 [2]
	4-[4-[6-(2-Aminoethoxy)quinolin-2-yl]triazol-1-yl]phenol	Ki	260.0 [1]
	Sodium	IC50	810.0 [1]
	DL-Thyroxine	IC50	15800.0 [1]
	Ellagic acid	Ki	1950.0 [1]
	Phenyl isothiocyanate	IC50	11000.0 [1]
	Acetimidoquinone	IC50	40000.0 [1]
	s-Hexylglutathione	IC50	3300000.0 [1]
	6-Phenylhexyl isothiocyanate	IC50	4200.0 [1]
	1-Hexanethiol	IC50	17400000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Macrophage migration inhibitory factor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/macrophage-migration-inhibitory-factor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Macrophage migration inhibitory factor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/macrophage-migration-inhibitory-factor-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan