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Macrophage-stimulating protein receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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ForetinibIC503.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5012.0 [1]
StaurosporineIC50102.7 [1], 326.0 [2], 442.5 [3]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-N-methyl-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC50575.0 [1], 580.0 [2]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5016.0 [1], 80.0 [2]
4-[6-Amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamideIC5025.0 [1], 200.0 [2]
Infigratinib phosphateIC502891.0 [1], 10000.0 [2]
CrizotinibIC50300.0 [1]
VandetanibIC503370.0 [1]
VatalanibIC5010000.0 [1]
SemaxanibIC5010000.0 [1]
CabozantinibIC5069.0 [1]
DoramapimodIC5030000.0 [1]
Pha-665752IC5068.0 [1]
Nvp-tae 684IC501634.0 [1]
Bms-777607IC501.8 [1]
Amg-458IC5010.0 [1]
2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamideIC5010000.0 [1]
MK-2461IC507.0 [1]
Pyrimidone, 22Ki195.0 [1]
MK-8033IC507.0 [1]
2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-oneKi28.0 [1]
5'-FluoroindirubinoximeIC5010000.0 [1]
CID 44155856IC503.0 [1]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamideKi1.0 [1]
4-Tert-Butyl-N-[6-(1h-Imidazol-1-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamideIC5019952.62 [1]
CID 44814409IC5010000.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2-oxo-3-phenylimidazolidine-1-carboxamideIC50170.0 [1]
2-Benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-oneKi581.0 [1]
6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC5093.4 [1]
5-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-2-(4-fluoroanilino)-3-methylpyrimidin-4-oneKi80.0 [1]
5-[3-Fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-2-[(4-fluorophenyl)methyl]-3-methylpyrimidin-4-oneKi706.0 [1]
14-(Dimethylsulfamoylamino)-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaeneIC507.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
4,4,4-Trifluoro-3-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyanilino]-N-phenylbutanamideIC501030.0 [1]
3-Anilino-4,4,4-trifluoro-N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]butanamideIC50410.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
3-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolineIC5010000.0 [1]
N-[5-Amino-1-[(4-methoxyphenyl)methyl]pyrazol-4-yl]-5-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-2-methylbenzamideIC50277.1 [1]
Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylateIC5010000.0 [1]
1-(4-Fluorophenyl)-N-[3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yl)oxyphenyl]-2-oxopyridine-3-carboxamideIC5050.4 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC5010000.0 [1]
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC5050000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
6-(6-Fluoroindol-1-yl)-2-[2-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyethyl]pyridazin-3-oneIC501000.0 [1]
1-(2-Chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]triazole-4-carboxamideIC50345.7 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
4-[4-(6-Benzyl-pyridazin-3-yl)-2-fluoro-phenoxy]-6,7-dimethoxy-quinolineKi79.0 [1]
2-[3-Fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]acetamideIC5028.6 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-2-(trifluoromethyl)pyrrole-3-carboxamideIC5010.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)imidazole-4-carboxamideIC5013.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)triazole-4-carboxamideIC5017.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-3-(trifluoromethyl)pyrazole-4-carboxamideIC5095.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-(4-fluorophenyl)-5-(trifluoromethyl)pyrazole-4-carboxamideIC5044.0 [1]
4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrileIC506100.0 [1]
2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acidIC505000.0 [1]
1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC504800.0 [1]
3-(2-Chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-methyl-2-oxo-1H-imidazole-5-carboxamideIC50270.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1,5-diphenylpyrazole-4-carboxamideIC5023.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1,3-diphenylpyrazole-4-carboxamideIC5032.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2,4-diphenyl-1,3-thiazole-5-carboxamideIC5045.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1,5-diphenylpyrrole-3-carboxamideIC50101.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(2-fluorophenyl)-1-phenylpyrazole-4-carboxamideIC5025.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-pyridin-2-ylpyrazole-4-carboxamideIC5023.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(3-methoxyphenyl)-1-phenylpyrazole-4-carboxamideIC5027.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-pyridin-3-ylpyrazole-4-carboxamideIC5014.0 [1]
5-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-6H-pyrazolo[4,3-c]azepin-4-oneIC5049.0 [1]
5-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-7,8-dihydro-6H-pyrazolo[4,3-c]azepin-4-oneIC5034.0 [1]
5-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-6,7-dihydropyrazolo[4,3-c]pyridin-4-oneIC5030.0 [1]
6-(1-Methylpyrazol-4-yl)-2-[[3-[[5-(1-methylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]methyl]pyridazin-3-oneIC501000.0 [1]
N-[3-Fluoro-4-[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-(4-fluorophenyl)-3-oxoquinoxaline-2-carboxamideIC5082.56 [1]
N-[3-Fluoro-4-[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-1-(2-fluorophenyl)-4-methyl-5-oxo-1,2,4-triazole-3-carboxamideIC50140.72 [1]
c-Met-IN-2IC50731.0 [1]
1-[3-Fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]ureaIC5014.5 [1]
5-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepine-4,7-dioneIC50361.0 [1]
N-[1-(2-Methoxyethyl)pyrazol-4-yl]-2-(4-propan-2-yl-1,2,4-triazol-3-yl)-1,3-thiazole-4-carboxamideIC5019952.62 [1]
1-[2-(2,6-Difluorophenyl)-4-oxo-1,3-thiazolidin-3-yl]-3-[2-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]ureaIC503.1 [1]
2-Methyl-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC5025000.0 [1]
2-(4-Fluoroanilino)-5-[5-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxypyridin-2-yl]-3-methylpyrimidin-4-oneKi1.3 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-2-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5060.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-methyl-1-phenylpyrazole-4-carboxamideIC50150.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenylpyrazole-4-carboxamideIC50590.0 [1]
N-[3-Fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-methyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC501000.0 [1]
5-Amino-N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenylpyrazole-4-carboxamideIC501000.0 [1]
N-[4-[2-[4-[[Acetyl-[(2S)-1-methoxypropan-2-yl]amino]methyl]phenyl]thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5060.0 [1]
N-(3-Isoquinolin-4-yl-phenyl)-2-[(pyridin-4-ylmethyl)-amino]-benzamideIC5010000.0 [1]
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolineIC503600.0 [1]
(E)-3-[6-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enamideIC50450.0 [1]
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamideIC50230.0 [1]
1-Tert-butyl-N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(trifluoromethyl)pyrazole-4-carboxamideIC50200.0 [1]
N-[3-Fluoro-4-[2-[4-[(2-methylsulfonylethylamino)methyl]phenyl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5080.0 [1]
N-[4-[2-[4-(Dimethylcarbamoyl)phenyl]thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5030.0 [1]
N-[4-[2-[4-[2-(Dimethylamino)ethyl-methylcarbamoyl]phenyl]thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5090.0 [1]
N-[4-[2-[4-[(3S)-3-(Dimethylamino)pyrrolidine-1-carbonyl]phenyl]thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC50100.0 [1]
6-[7-[2-Fluoro-4-[[1-phenyl-5-(trifluoromethyl)pyrazole-4-carbonyl]amino]phenoxy]thieno[3,2-b]pyridin-2-yl]-N,N-dimethylpyridine-3-carboxamideIC5030.0 [1]
6-[7-[2-Fluoro-4-[[1-phenyl-5-(trifluoromethyl)pyrazole-4-carbonyl]amino]phenoxy]thieno[3,2-b]pyridin-2-yl]-N-(2-methoxyethyl)pyridine-3-carboxamideIC5040.0 [1]
N-[4-[2-(1-Acetyl-3,6-dihydro-2H-pyridin-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5090.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Macrophage-stimulating protein receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/macrophage-stimulating-protein-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Macrophage-stimulating protein receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/macrophage-stimulating-protein-receptor-inhibitors-ic50-ki.
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