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MAP kinase ERK1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
StaurosporineIC505089.0 [1]
SeliciclibIC5034000.0 [1]
OlomoucineIC5025000.0 [1], 30000.0 [2]
DoramapimodIC5020000.0 [1], 30000.0 [2]
Purvalanol BIC503300.0 [1], 3333.0 [2]
Purvalanol AIC509000.0 [1]
CID 24866313IC504.0 [1], 8.0 [2]
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amineKi310.0 [1]
TanzisertibIC50480.0 [1]
SorafenibIC5018.1 [1]
(Z)-3-Amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrileIC5010000.0 [1]
KenpaulloneIC5020000.0 [1]
Tak-285IC5010000.0 [1]
1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)ureaIC5010000.0 [1]
Amg-458IC50100000.0 [1]
CID 46209401IC5010000.0 [1]
CID 6918852Ki50000.0 [1]
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-IC5010000.0 [1]
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolIC5018000.0 [1]
JNK Inhibitor VIC5010000.0 [1]
JNK Inhibitor VIIIKi9200.0 [1]
Bms-509744IC5050000.0 [1]
RavoxertinibIC501.2 [1]
Pyrimidone, 22IC50100000.0 [1]
(2S,3S)-3-((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)butane-1,2,4-triolIC503730.0 [1]
3-Phenyl-1H-benzofuro[3,2-c]pyrazoleIC5010000.0 [1]
2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-oneIC50100000.0 [1]
1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5010000.0 [1]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamideIC5025000.0 [1]
MEK Inhibitor IIIC5082900.0 [1]
N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)ureaIC5010000.0 [1]
CID 46203864IC50980.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi1000.0 [1]
CID 58282870IC5020.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi9200.0 [1]
Lck InhibitorIC50100000.0 [1]
1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-(4-piperidinyl)-1,2,3,4-tetrahydroquinazoline-2-oneIC5010000.0 [1]
2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-oneIC501000.0 [1]
Methyl 6-bromo-2-[(4-methylsulfonylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylateIC5011000.0 [1]
Meridianin EIC50100000.0 [1]
(E)-3-[4-[[[8-Carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]prop-2-enoic acidIC5010000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi9200.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9200.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9200.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi9200.0 [1]
3-[2-(Pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetrahydroquinazolin-2-oneIC5010000.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
3-[[[5-[1-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrileIC5010000.0 [1]
[4-[[4-(3H-Benzimidazol-5-ylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(cyanoamino)phenyl]cyanamideIC50300.0 [1]
2-N-(3H-Benzimidazol-5-yl)-4-N-(2-chlorophenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamineIC501000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
3-[1-(2-Imidazol-1-ylethyl)pyrazolo[3,4-b]pyridin-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dioneIC5040000.0 [1]
4-(4-Fluorophenyl)-N-[4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]phthalazin-1-amineIC5025000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
(3S)-N-[3-(4-Fluorophenyl)-1H-indazol-5-yl]-3-methylsulfanyl-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]pyrrolidine-3-carboxamideIC5025.0 [1]
Erk2 IN-1IC5041.0 [1]
N-[4-Chloro-3-(pyridin-3-yloxymethyl)phenyl]-3-fluoro-5-morpholin-4-ylbenzamideIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
TilfrinibIC5010000.0 [1]
[4-Amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,3-dihydro-1,4-benzodioxin-6-yl)methanoneIC50100000000.0 [1]
Ethyl (E)-3-[4-[[[8-carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]prop-2-enoateIC5010000.0 [1]
7-(Morpholin-4-ylmethyl)-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetrahydroquinazolin-2-oneIC5010000.0 [1]
(4S,6Z,9S,10R,12E)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dioneIC501400.0 [1]
3-[5-Chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamideIC5010000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2900.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[4-[(Z)-[1-(3-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-phenylacetamideIC5065.0 [1]
2-[4-[(Z)-[1-(3-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-(2-methylphenyl)acetamideIC5043.0 [1]
2-[4-[(Z)-[1-(3-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-(3-methylphenyl)acetamideIC5020.0 [1]
2-[4-[(Z)-[1-(3-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-(4-methylphenyl)acetamideIC5025.0 [1]
N-(2-Methoxyphenyl)-2-[4-[(Z)-[1-(3-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5046.0 [1]
N-(3-Methoxyphenyl)-2-[4-[(Z)-[1-(3-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5057.0 [1]
N-(4-Methoxyphenyl)-2-[4-[(Z)-[1-(3-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5076.0 [1]
N-(2-Chlorophenyl)-2-[4-[(Z)-[1-(3-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5087.0 [1]
N-(3-Chlorophenyl)-2-[4-[(Z)-[1-(3-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5089.0 [1]
N-(4-Chlorophenyl)-2-[4-[(Z)-[1-(3-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5095.0 [1]
2-[4-[(Z)-[1-(4-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-phenylacetamideIC5023.0 [1]
2-[4-[(Z)-[1-(4-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-(2-methylphenyl)acetamideIC5032.0 [1]
2-[4-[(Z)-[1-(4-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-(3-methylphenyl)acetamideIC5089.0 [1]
2-[4-[(Z)-[1-(4-Methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]-N-(4-methylphenyl)acetamideIC5023.0 [1]
N-(2-Methoxyphenyl)-2-[4-[(Z)-[1-(4-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5043.0 [1]
N-(3-Methoxyphenyl)-2-[4-[(Z)-[1-(4-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5021.0 [1]
N-(4-Methoxyphenyl)-2-[4-[(Z)-[1-(4-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5023.0 [1]
N-(2-Chlorophenyl)-2-[4-[(Z)-[1-(4-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5024.0 [1]
N-(3-Chlorophenyl)-2-[4-[(Z)-[1-(4-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5035.0 [1]
N-(4-Chlorophenyl)-2-[4-[(Z)-[1-(4-methoxyphenyl)-5-oxo-2-phenylimidazol-4-ylidene]methyl]phenoxy]acetamideIC5047.0 [1]
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[2-methyl-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]ureaIC503100.0 [1]
3-(2-Methylpyridin-4-yl)-N-[(2,3,5-trichloropyridin-4-yl)methyl]-1H-indazole-5-carboxamideIC5016.7 [1]
N-[(3-Chlorophenyl)methyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5074.2 [1]
N-[1-(3-Chlorophenyl)ethyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC50154.0 [1]
N-[1-(3-Chlorophenyl)propyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5078.7 [1]
N-[(1S)-1-(3-Chlorophenyl)-2-hydroxyethyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5026.3 [1]
N-[(1R)-1-(3-Chlorophenyl)-2-hydroxyethyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC50833.0 [1]
N-[(1S)-1-(2,6-Dichlorophenyl)ethyl]-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamideIC5019.4 [1]
N-[1-(2-Chlorophenyl)ethyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5035.9 [1]
N-[(2-Chlorophenyl)methyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5046.3 [1]
N-[(2,4-Dichloro-3-fluorophenyl)methyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5029.2 [1]
N-[1-(3-Chlorophenyl)-2-hydroxyethyl]-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5072.4 [1]
N-[1-(3-Chlorophenyl)-2-hydroxyethyl]-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamideIC5053.4 [1]
N-(3-Phenylpropyl)-3-pyridin-4-yl-1H-indazole-5-carboxamideIC5042.9 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase ERK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/map-kinase-erk1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ MAP kinase ERK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-erk1-inhibitors-ic50-ki.
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