MAP kinase-interacting serine/threonine-protein kinase 1/2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tomivosertib	IC50	6.0 [1]
	(4-Methylpiperazin-1-yl)-[4-[3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]methanone	IC50	1990.0 [1]
	[4-[3-(4-Chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone	IC50	759.0 [1]
	CID 118598634	IC50	73.0 [1]
	N-[6-[(8-Chloro-1,5-dioxospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	0.31 [1]
	N-[6-[(3,3-Dimethyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	12.3 [1]
	3,3-Dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione	IC50	3800.0 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione	IC50	0.79 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-4',4'-difluoro-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione	IC50	24.0 [1]
	3,3,8-Trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione	IC50	160.0 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-8-chloro-3,3-dimethyl-2H-imidazo[1,5-a]pyridine-1,5-dione	IC50	12.0 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclopentane]-1,5-dione	IC50	0.62 [1]
	N-[6-[[8-Chloro-3-(3-chlorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	1.8 [1]
	6-[(6-Amino-5-chloropyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione	IC50	0.08 [1]
	8-Fluoro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione	IC50	580.0 [1]
	(4-Methylpiperazin-1-yl)-[4-(3-phenylimidazo[1,2-a]pyrazin-6-yl)phenyl]methanone	IC50	1920.0 [1]
	2-Methyl-N-[5-[4-[[2-oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]propanamide	IC50	860.0 [1]
	3-Methyl-5-(pyrimidin-4-ylamino)-2,3-dihydroisoindol-1-one	IC50	28000.0 [1]
	3,3-Dimethyl-5-(pyrimidin-4-ylamino)-2H-isoindol-1-one	IC50	4400.0 [1]
	N-[6-[(1-Oxo-2,3-dihydroisoindol-5-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	430.0 [1]
	[4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-morpholin-4-ylmethanone	IC50	130.0 [1]
	N-Hydroxy-4-[6-[4-(4-methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide	IC50	2500.0 [1]
	(4-(3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone	IC50	189.0 [1]
	3-(3-Isoquinolin-6-ylimidazo[1,2-b]pyridazin-6-yl)oxycyclobutan-1-amine	IC50	120.0 [1]
	[4-[3-(4-Methylphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone	IC50	1210.0 [1]
	4-(6-Phenylimidazo[1,2-a]pyrazin-3-yl)phenol	IC50	819.0 [1]
	1-[4-[4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]benzoyl]piperazin-1-yl]ethanone	IC50	2500.0 [1]
	N-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]acetamide	IC50	2500.0 [1]
	4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]benzamide	IC50	1080.0 [1]
	4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzoic acid	IC50	2500.0 [1]
	[4-[3-(3-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone	IC50	1330.0 [1]
	4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide	IC50	2500.0 [1]
	4-(6-(4-(Morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile	IC50	421.0 [1]
	4-(6-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile	IC50	431.0 [1]
	4-(6-(4-(Morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)benzonitrile	IC50	748.0 [1]
	4-[6-[4-(Morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]benzonitrile	IC50	321.0 [1]
	N-[5-[3-Fluoro-4-[[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]amino]phenyl]pyridin-2-yl]cyclopropanecarboxamide	IC50	280.0 [1]
	2-[4-(6-Acetamidopyridin-3-yl)phenoxy]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]acetamide	IC50	680.0 [1]
	2-[4-(6-Acetamidopyridin-3-yl)anilino]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]acetamide	IC50	320.0 [1]
	N-[5-[4-[[2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]amino]phenyl]pyridin-2-yl]cyclopropanecarboxamide	IC50	180.0 [1]
	N-[5-[4-[[2-Oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]cyclopropanecarboxamide	IC50	320.0 [1]
	2-[4-(6-Acetamidopyridin-3-yl)anilino]-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide	IC50	200.0 [1]
	N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamide	IC50	98.0 [1]
	4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile	IC50	229.0 [1]
	[4-[3-[4-(Difluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone	IC50	1630.0 [1]
	4-[6-[4-[4-(Dimethylamino)piperidine-1-carbonyl]phenyl]imidazo[1,2-a]pyrazin-3-yl]benzonitrile	IC50	640.0 [1]
	4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile	IC50	326.0 [1]
	4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzonitrile	IC50	440.0 [1]
	4-(6-(4-(Piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile	IC50	220.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 49 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ MAP kinase-interacting serine/threonine-protein kinase 1/2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/map-kinase-interacting-serine-threonine-protein-kinase-1-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ MAP kinase-interacting serine/threonine-protein kinase 1/2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-interacting-serine-threonine-protein-kinase-1-2-inhibitors-ic50-ki.
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