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MAP kinase-interacting serine/threonine-protein kinase MNK1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamineIC50850.0 [1], 870.0 [2]
N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamineKi1010.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC502670.0 [1]
4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]PyridineIC50646.0 [1], 5500.0 [2]
4-(7H-Purin-6-ylamino)benzamideIC5060.0 [1], 160.0 [2]
3-(Pyridin-4-yl)imidazo[1,2-b]pyridazineIC501800.0 [1], 3800.0 [2]
Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateIC50590.0 [1]
Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amineIC50530.0 [1]
DorsomorphinIC5011.0 [1]
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amineIC50630.0 [1]
N4-(3-Bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamineIC501700.0 [1]
Ast-487IC501760.0 [1]
Aigialomycin DIC5040000.0 [1]
TomivosertibIC502.4 [1]
2,6-Dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenolIC50120.0 [1]
2-(2-Quinolin-3-Ylpyridin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-OneIC505700.0 [1]
N-(3-Bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amineIC502800.0 [1]
2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC5010000.0 [1]
N-(3-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501090.0 [1]
N-[3-[[5-Cyclopropyl-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamideIC5019000.0 [1]
CID 44814409IC5010000.0 [1]
N-(4-Bromophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501560.0 [1]
pi3K|A Inhibitor C52IC5066.0 [1]
4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholineIC50130.0 [1]
N-(Naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501350.0 [1]
3-(1H-Benzimidazol-2-yl)-5-phenylpyridin-2-amineIC50120.0 [1]
(9Ar)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamideKi507.0 [1]
STO-609 acetateIC50120.0 [1]
4-(2-Amino-5-phenylpyridin-3-yl)benzamideIC505150.0 [1]
7H-ADENINE, N-(p-FLUOROPHENYL)-IC501030.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC506700.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
Methyl 4-(7H-purin-6-ylamino)benzoateIC50850.0 [1]
(4-Methylpiperazin-1-yl)-[4-[3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]methanoneIC50574.0 [1]
[4-[3-(4-Chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanoneIC50331.0 [1]
12-Fluoro-15,18-dioxa-4,6,8,25-tetrazapentacyclo[18.3.1.13,23.02,7.09,14]pentacosa-1(23),2,4,6,9(14),10,12-heptaen-19-oneIC503540.0 [1]
N-Ethyl-4-[(6-methoxy-1H-indazol-5-yl)amino]-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole-6-carboxamideIC506.0 [1]
4-(4-Fluoro-2-methylanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acidKi10000.0 [1]
CID 118598634IC503.3 [1]
N-[6-[(8-Chloro-1,5-dioxospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamideIC500.51 [1]
N-[6-[(3,3-Dimethyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamideIC502.7 [1]
3,3-Dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dioneIC5060.0 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dioneIC500.65 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-4',4'-difluoro-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dioneIC501.4 [1]
3,3,8-Trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dioneIC5010.0 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-8-chloro-3,3-dimethyl-2H-imidazo[1,5-a]pyridine-1,5-dioneIC502.2 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclopentane]-1,5-dioneIC500.88 [1]
N-[6-[[8-Chloro-3-(3-chlorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamideIC501.6 [1]
8-Fluoro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dioneIC506.5 [1]
Methyl 4-[(1,5-dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
Methyl 4-[[1-(2-methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acidKi4820.0 [1]
4-[[1-(2-Methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acidKi2060.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi10000.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N,5-dimethylthieno[2,3-d]pyrimidine-6-carboxamideKi10000.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-ethyl-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi10000.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi5400.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-(3-methoxypropyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi5000.0 [1]
4-[[1-(2-Methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi2330.0 [1]
Methyl 5-methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
5-Methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxylic acidKi2150.0 [1]
5-Methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamideKi4510.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi1020.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-N,5-dimethylthieno[2,3-d]pyrimidine-6-carboxamideKi106.0 [1]
N-Ethyl-4-(4-fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi933.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi10000.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-N-(3-methoxypropyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi320.0 [1]
(4-Methylpiperazin-1-yl)-[4-(3-phenylimidazo[1,2-a]pyrazin-6-yl)phenyl]methanoneIC502680.0 [1]
3-[6-Amino-5-(1H-benzimidazol-2-yl)pyridin-3-yl]-N,N-dimethylbenzamideIC5036.0 [1]
3-[6-Amino-5-(4-piperazin-1-yl-1H-benzimidazol-2-yl)pyridin-3-yl]-N,N-dimethylbenzamideIC504.0 [1]
3-[5-Amino-6-(4-piperazin-1-yl-1H-benzimidazol-2-yl)pyrazin-2-yl]-N,N-dimethylbenzamideIC5080.0 [1]
3-[5-Amino-6-(1-methyl-7-piperazin-1-ylbenzimidazol-2-yl)pyrazin-2-yl]-N,N-dimethylbenzamideIC502.0 [1]
3-[5-Amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylbenzamideIC501.5 [1]
2-[5-Amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylpyridine-4-carboxamideIC503.0 [1]
N-[4-[(1-Ethylpiperidin-4-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamideIC5010000.0 [1]
N-[3-Cyclopropyl-4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-2-(4-pyridin-3-ylphenoxy)acetamideIC5010000.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)propanamideIC5010000.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-[4-[2-(methylamino)pyridin-4-yl]oxyphenyl]acetamideIC50370.0 [1]
2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-N-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]acetamideIC5010000.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-4-yloxyphenyl)acetamideIC50540.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-2-ylphenoxy)acetamideIC5010000.0 [1]
5-[4-[2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethoxy]phenyl]-N-methylpyridine-2-carboxamideIC5010000.0 [1]
2-Methyl-N-[5-[4-[[2-oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]propanamideIC507700.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-4-ylphenoxy)acetamideIC5010000.0 [1]
N-[4-[(4-Ethylpiperidin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamideIC504510.0 [1]
3-Methyl-5-(pyrimidin-4-ylamino)-2,3-dihydroisoindol-1-oneIC5028.0 [1]
5-(7H-Purin-6-ylamino)-2,3-dihydroisoindol-1-oneIC5023.0 [1]
3,3-Dimethyl-5-(pyrimidin-4-ylamino)-2H-isoindol-1-oneIC50100.0 [1]
N-[6-[(1-Oxo-2,3-dihydroisoindol-5-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamideIC501.9 [1]
2-Pyridinamine, 3-(1H-benzimidazol-2-yl)-IC50700.0 [1]
5H-Pyrazolo[4,3-g]quinazolin-5-one, 1,6-dihydro-IC508170.0 [1]
[4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-morpholin-4-ylmethanoneIC50125.0 [1]
N-Hydroxy-4-[6-[4-(4-methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamideIC5060.0 [1]
(4-(3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanoneIC50284.0 [1]
3-Pyridin-3-ylimidazo[1,2-a]pyridine-8-carboxamideIC506400.0 [1]
3-[(3S)-3-Aminopyrrolidine-1-carbonyl]-5,10-dihydroxy-2-methylnaphtho[2,3-f][1]benzofuran-4,11-dione;methanesulfonic acidIC505000.0 [1]
6-Oxo-5-(pyrimidin-4-ylamino)-1H-pyridine-2-carboxamideIC503000.0 [1]
3,5-Dimethyl-4-(4-pyrrolidin-2-ylphenyl)-1H-pyrazoleIC504700.0 [1]
3-(3-Isoquinolin-6-ylimidazo[1,2-b]pyridazin-6-yl)oxycyclobutan-1-amineIC501.5 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase-interacting serine/threonine-protein kinase MNK1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/map-kinase-interacting-serine-threonine-protein-kinase-mnk1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ MAP kinase-interacting serine/threonine-protein kinase MNK1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-interacting-serine-threonine-protein-kinase-mnk1-inhibitors-ic50-ki.
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