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MAP kinase p38 beta Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC5012.0 [1], 78.0 [2], 430.0 [3], 500.0 [4]
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazoleIC509.8 [1], 100.0 [2]
N-[2-Methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamideIC501.5 [1], 2.0 [2]
DoramapimodIC507.0 [1], 10000.0 [2]
LosmapimodKi25.12 [1]
N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-DicarboxamideIC501000.0 [1]
N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-DicarboxamideKi24.0 [1]
7-(1-Tert-butylpiperidin-4-yl)-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)quinolin-2-oneIC500.25 [1], 260.0 [2]
N-[5-(Cyclopropylcarbamoyl)-2-methylphenyl]-5-methyl-1-[3-(trifluoromethyl)pyridin-2-yl]pyrazole-4-carboxamideIC504.0 [1]
N-[3-[4-(Cyclopropylmethylcarbamoyl)phenyl]-4-methylphenyl]-2-piperidin-1-ylpyridine-4-carboxamideIC501000.0 [1], 10000.0 [2]
TofacitinibIC5010000.0 [1]
Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-IC5044.0 [1]
NeflamapimodKi220.0 [1]
TalmapimodIC5098.0 [1]
3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamideKi40.0 [1]
3-(Dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamideIC502000.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
MilciclibIC5010000.0 [1]
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-IC50200.0 [1]
Bms-582949IC5062.0 [1]
2-{4-[5-(4-Chlorophenyl)-4-Pyrimidin-4-Yl-1h-Pyrazol-3-Yl]piperidin-1-Yl}-2-OxoethanolIC503450.0 [1]
IKK-3 InhibitorIC5015848.93 [1]
6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3-oneIC5036.0 [1]
PF-03715455IC5023.0 [1]
N-(Furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamideIC506309.57 [1]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC500.1 [1]
N-Ethyl-4-[5-(methoxycarbamoyl)-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamideIC5015.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC504000.0 [1]
N-(Cyclopropylmethyl)-2'-Methyl-5'-(5-Methyl-1,3,4-Oxadiazol-2-Yl)biphenyl-4-CarboxamideKi440.0 [1]
Cyclapolin 9IC50100000.0 [1]
1-(2,6-Dichlorophenyl)-6-(2,4-difluorophenylthio)-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidine-2-oneIC50250.0 [1]
6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
1-[4-(4-Pyridinylmethyl)phenyl]-3-(1-methyl-3-tert-butyl-1H-pyrazole-5-yl)ureaIC50110.0 [1]
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamideIC50100.0 [1]
3-[[4-[2,2-Dimethylpropyl(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl]amino]-N-methoxy-4-methylbenzamideIC5022.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
N-Cyclopropyl-3-[1-(2,6-difluorophenyl)-7-methyl-6-oxopyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamideKi2.5 [1]
1-(2,6-Dichlorophenyl)-6-(o-tolylthio)-3,4-dihydropyrido[3,2-d]pyrimidin-2(1H)-oneIC50800.0 [1]
1-(2,6-Dichlorophenyl)-6-(phenylthio)-3,4-dihydropyrido[3,2-d]pyrimidin-2(1H)-oneIC502370.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5050.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
4-[4-[(Z)-[3-[4-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]benzamideIC5030000.0 [1]
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxideIC50100000.0 [1]
CID 9811100IC50572.0 [1]
2-(1-Methyl-4-hydroxy-4-piperidinyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)oxazoleIC502408.0 [1]
p38 MAP Kinase Inhibitor VIC502320.0 [1]
Pyridine, 4-(2-(4-fluorophenyl)-5-(4-(methylsulfinyl)phenyl)-1H-pyrrol-3-yl)-IC508.1 [1]
1-[1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazole-5-yl]-3-(2,3-dichlorophenyl)ureaIC5052.0 [1]
3-[(6-Benzoyl-5-Methylpyrrolo[2,1-F][1,2,4]triazin-4-Yl)amino]-N-Cyclopropyl-4-MethylbenzamideIC5019.0 [1]
N-[(3-Methoxyphenyl)methyl]-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamideKi160.0 [1]
1-[4-[3-(4-Chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-methoxyethanoneIC503250.0 [1]
6-(2-Chloro-4-fluorophenyl)sulfanyl-1-(2,6-dichlorophenyl)-3,4-dihydropyrido[3,2-d]pyrimidin-2-oneIC5057.0 [1]
4-[[2-[4-Chloro-3-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]anilino]-1,3-benzoxazol-5-yl]oxy]-N-methylpyridine-2-carboxamideIC5040000.0 [1]
2-(2-Chloro-6-fluoro-phenyl)-N-(3-(4-fluorophenyl)-4-pyrimidin-4-yl-isoxazol-5-yl)acetamideIC50326.0 [1]
3-[5-Chloro-4-[(2,4-difluorophenyl)methoxy]-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamideIC50249.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-(2-Chloro-N-[1-(2-chlorophenyl)-6-oxopyridazin-3-yl]-4-fluoroanilino)propyl]isoindole-1,3-dioneIC5020.0 [1]
2-[3-(2-Chloro-N-[1-(2-chlorophenyl)-6-oxopyridazin-3-yl]anilino)propyl]isoindole-1,3-dioneIC5015.0 [1]
3-[4-[(2,4-Difluorophenyl)methoxy]-5-ethyl-6-oxopyrimidin-1-yl]-N-(2-hydroxyethyl)-4-methylbenzamideKi6.0 [1]
6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2-methylpropyl)pyridine-3-carboxamideKi158.49 [1]
6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(cyclopropylmethyl)pyridine-3-carboxamideKi25.12 [1]
4-(3-(4-Fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazol-4-yl)pyridineIC50404.0 [1]
1-(4-(3-(4-Chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-yl)piperidin-1-yl)ethanoneIC503130.0 [1]
1-[4-[3-(4-Chlorophenyl)-4-pyridin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-methoxyethanoneIC503450.0 [1]
4-(5-(1-Methylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)pyridineIC50164.0 [1]
4-(3-(3-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridineIC501050.0 [1]
4-(3-(4-Fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridineIC50510.0 [1]
4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridineIC502680.0 [1]
4-(3-(4-Fluorophenyl)-5-(1-methylpiperidin-3-yl)-1H-pyrazol-4-yl)pyridineIC502520.0 [1]
4-(3-(4-Chlorophenyl)-5-(1-(methylsulfonyl)piperidin-4-yl)-1H-pyrazol-4-yl)pyridineIC503530.0 [1]
4-[3-(1-Acetylpiperidin-4-yl)-5-(4-chlorophenyl)-1H-pyrazol-4-yl]pyrimidineIC503710.0 [1]
1-(4-(3-(4-Fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-yl)piperidin-1-yl)ethanoneIC501680.0 [1]
4-(5-(1-Methylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)pyridineIC503770.0 [1]
1-[4-[3-(4-Chlorophenyl)-4-pyridin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-(dimethylamino)ethanoneIC506720.0 [1]
4-(3-(4-Chlorophenyl)-5-(1-(2-methoxyethyl)piperidin-4-yl)-1H-pyrazol-4-yl)pyridineIC506720.0 [1]
4-(3-(4-Fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridineIC501960.0 [1]
N,4-Dimethyl-3-[[6-(methylamino)-1-phenylpyrazolo[3,4-d]pyrimidin-4-yl]amino]benzamideIC5012.0 [1]
2-(2-Chlorophenyl)-6-[(2-chlorophenyl)amino]-2,3-dihydropyridazin-3-oneIC50990.0 [1]
2-(2-Chlorophenyl)-6-[(2-methylphenyl)amino]-2,3-dihydropyridazin-3-oneIC50450.0 [1]
2-(2-Chlorophenyl)-6-[(2-methoxyphenyl)amino]-2,3-dihydropyridazin-3-oneIC50920.0 [1]
2-(2-Chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,3-dihydropyridazin-3-oneIC50450.0 [1]
2-(4-Chloro-2-methylphenyl)-6-[(2,4-difluorophenyl)sulfanyl]-2,3-dihydropyridazin-3-oneIC50850.0 [1]
6-[(2-Chloro-4-fluorophenyl)(2-hydroxyethyl)amino]-2-(2-chlorophenyl)-2,3-dihydropyridazin-3-oneIC50135.0 [1]
6-[(3-Aminopropyl)(2-chlorophenyl)amino]-2-(2-chlorophenyl)-2,3-dihydropyridazin-3-oneIC50211.0 [1]
2-(2-Chlorophenyl)-6-[2-chloro-N-[3-[(2,3,4-trimethoxyphenyl)methylamino]propyl]anilino]pyridazin-3-oneIC50600.0 [1]
2-Amino-N-[3-(2-chloro-N-[1-(2-chlorophenyl)-6-oxopyridazin-3-yl]anilino)propyl]acetamideIC5041.0 [1]
N-[3-(2-Chloro-N-[1-(2-chlorophenyl)-6-oxopyridazin-3-yl]anilino)propyl]-2-(methylamino)acetamideIC5029.0 [1]
N-[3-(2-Chloro-N-[1-(2-chlorophenyl)-6-oxopyridazin-3-yl]anilino)propyl]piperidine-4-carboxamideIC5029.0 [1]
N-[3-(2-Chloro-N-[1-(2-chlorophenyl)-6-oxopyridazin-3-yl]anilino)propyl]-4-(trifluoromethyl)cyclohexane-1-carboxamideIC502.0 [1]
5-(4-Chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]thiophene-2-carboxamideIC50270.0 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
5-(2-Chlorophenyl)-N-[5-(Cyclopropylcarbamoyl)-2-Methylphenyl]thiophene-2-CarboxamideIC50265.0 [1]
N-[5-(Cyclopropylcarbamoyl)-2-methylphenyl]-5-[4-(morpholine-4-carbonyl)phenyl]thiophene-2-carboxamideIC5081.0 [1]
N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalazin-6-yl)-benzo[d]isoxazol-3-amineKi1.8 [1]
3,5-Dichloro-N-[2-(dimethylamino)ethyl]-4-[6-(4-fluorophenyl)sulfanyl-2-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-1-yl]benzamideIC501230.0 [1]
1-(2-Chloro-6-ethylphenyl)-6-(4-fluorophenyl)sulfanyl-3,4-dihydropyrido[3,2-d]pyrimidin-2-oneIC50200.0 [1]
Methyl 3-chloro-4-[6-(4-fluorophenyl)sulfanyl-2-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-1-yl]-5-methylbenzoateIC50250.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase p38 beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/map-kinase-p38-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ MAP kinase p38 beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-p38-beta-inhibitors-ic50-ki.
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