MAP kinase signal-integrating kinase 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine	IC50	1530.0 [1], 1600.0 [2]
	N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine	Ki	340.0 [1], 880.0 [2]
	Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate	IC50	4.0 [1], 60.0 [2]
	Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate	Ki	4050.0 [1]
	(9Ar)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamide	IC50	11.0 [1]
	(9Ar)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamide	Ki	79.0 [1]
	N-[3-(Dimethylamino)propyl]-4-(4-fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	IC50	6.0 [1]
	Staurosporine	IC50	27.12 [1]
	Sorafenib	IC50	262.0 [1]
	Ceritinib	IC50	2240.0 [1]
	4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid	IC50	13.0 [1]
	Bms-777607	IC50	500.0 [1]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	171.0 [1]
	Ast-487	IC50	20.0 [1]
	Aigialomycin D	IC50	450.0 [1]
	CID 58539301	IC50	600.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	Tomivosertib	IC50	1.0 [1]
	CID 59604787	IC50	10000.0 [1]
	CID 44814409	IC50	10000.0 [1]
	CID 73442760	IC50	760000.0 [1]
	4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]Pyridine	IC50	575.0 [1]
	2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide	IC50	10000.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	9350.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol	IC50	1100.0 [1]
	3-(1H-Benzimidazol-2-yl)-5-phenylpyridin-2-amine	IC50	720.0 [1]
	(4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	10000.0 [1]
	9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine	IC50	3200.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	(4-Methylpiperazin-1-yl)-[4-[3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]methanone	IC50	389.0 [1]
	[4-[3-(4-Chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone	IC50	217.0 [1]
	4-(4-Fluoro-2-methylanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid	Ki	500.0 [1]
	CID 118598634	IC50	1.2 [1]
	N-[6-[(8-Chloro-1,5-dioxospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	1.8 [1]
	N-[6-[(3,3-Dimethyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	2.3 [1]
	3,3-Dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione	IC50	57.0 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione	IC50	0.68 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-4',4'-difluoro-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione	IC50	1.0 [1]
	3,3,8-Trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione	IC50	19.0 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-8-chloro-3,3-dimethyl-2H-imidazo[1,5-a]pyridine-1,5-dione	IC50	0.14 [1]
	6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclopentane]-1,5-dione	IC50	0.13 [1]
	N-[6-[[8-Chloro-3-(3-chlorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	1.2 [1]
	6-[(6-Amino-5-chloropyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione	IC50	0.36 [1]
	8-Fluoro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione	IC50	2.6 [1]
	3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-ol	IC50	10000.0 [1]
	Methyl 4-[(1,5-dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylate	Ki	10000.0 [1]
	Methyl 4-[[1-(2-methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylate	Ki	10000.0 [1]
	4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid	Ki	350.0 [1]
	4-[[1-(2-Methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid	Ki	240.0 [1]
	4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	10000.0 [1]
	4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N,5-dimethylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	9050.0 [1]
	4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-ethyl-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	5990.0 [1]
	4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	3170.0 [1]
	4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-(3-methoxypropyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	2630.0 [1]
	4-[[1-(2-Methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	340.0 [1]
	Methyl 5-methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxylate	Ki	10000.0 [1]
	5-Methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxylic acid	Ki	900.0 [1]
	5-Methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamide	Ki	1600.0 [1]
	4-(4-Fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	110.0 [1]
	4-(4-Fluoro-2-propan-2-yloxyanilino)-N,5-dimethylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	18.0 [1]
	N-Ethyl-4-(4-fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	18.0 [1]
	4-(4-Fluoro-2-propan-2-yloxyanilino)-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	31.0 [1]
	4-(4-Fluoro-2-propan-2-yloxyanilino)-N-(3-methoxypropyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide	Ki	164.0 [1]
	(4-Methylpiperazin-1-yl)-[4-(3-phenylimidazo[1,2-a]pyrazin-6-yl)phenyl]methanone	IC50	1430.0 [1]
	3-[6-Amino-5-(1H-benzimidazol-2-yl)pyridin-3-yl]-N,N-dimethylbenzamide	IC50	34.0 [1]
	3-[6-Amino-5-(4-piperazin-1-yl-1H-benzimidazol-2-yl)pyridin-3-yl]-N,N-dimethylbenzamide	IC50	2.0 [1]
	3-[5-Amino-6-(4-piperazin-1-yl-1H-benzimidazol-2-yl)pyrazin-2-yl]-N,N-dimethylbenzamide	IC50	20.0 [1]
	3-[5-Amino-6-(1-methyl-7-piperazin-1-ylbenzimidazol-2-yl)pyrazin-2-yl]-N,N-dimethylbenzamide	IC50	1.0 [1]
	3-[5-Amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylbenzamide	IC50	0.7 [1]
	2-[5-Amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylpyridine-4-carboxamide	IC50	3.0 [1]
	N-[4-[(1-Ethylpiperidin-4-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamide	IC50	10000.0 [1]
	N-[3-Cyclopropyl-4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-2-(4-pyridin-3-ylphenoxy)acetamide	IC50	130.0 [1]
	N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)propanamide	IC50	10000.0 [1]
	N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-[4-[2-(methylamino)pyridin-4-yl]oxyphenyl]acetamide	IC50	8.0 [1]
	2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-N-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]acetamide	IC50	760.0 [1]
	N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-4-yloxyphenyl)acetamide	IC50	10.0 [1]
	N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-2-ylphenoxy)acetamide	IC50	10000.0 [1]
	5-[4-[2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethoxy]phenyl]-N-methylpyridine-2-carboxamide	IC50	6860.0 [1]
	2-Methyl-N-[5-[4-[[2-oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]propanamide	IC50	130.0 [1]
	N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-4-ylphenoxy)acetamide	IC50	1910.0 [1]
	N-[4-[(4-Ethylpiperidin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamide	IC50	82.0 [1]
	3-Methyl-5-(pyrimidin-4-ylamino)-2,3-dihydroisoindol-1-one	IC50	45.0 [1]
	3,3-Dimethyl-5-(pyrimidin-4-ylamino)-2H-isoindol-1-one	IC50	61.0 [1]
	N-[6-[(1-Oxo-2,3-dihydroisoindol-5-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide	IC50	5.7 [1]
	1-[4-[4-Amino-3-[4-(2-morpholin-4-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	IC50	61.0 [1]
	1-Quinolin-6-yl-8-thiophen-3-ylimidazo[4,5-c][1,7]naphthyridine	IC50	1400.0 [1]
	2-Pyridinamine, 3-(1H-benzimidazol-2-yl)-	IC50	900.0 [1]
	[4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-morpholin-4-ylmethanone	IC50	113.0 [1]
	N-Hydroxy-4-[6-[4-(4-methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide	IC50	31.0 [1]
	(4-(3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone	IC50	140.0 [1]
	1-[4-(3-Bromoanilino)quinazolin-6-yl]-3-(3-chlorophenyl)thiourea	IC50	2700.0 [1]
	3-(3-Isoquinolin-6-ylimidazo[1,2-b]pyridazin-6-yl)oxycyclobutan-1-amine	IC50	7.8 [1]
	[4-[3-(4-Methylphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone	IC50	410.0 [1]
	4-(6-Phenylimidazo[1,2-a]pyrazin-3-yl)phenol	IC50	415.0 [1]
	N-(2,4-Dimethoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine	Ki	110.0 [1]
	N-(2,4-Dimethoxyphenyl)-4-[4-methyl-2-(2-morpholin-4-ylethylsulfanyl)-1,3-thiazol-5-yl]pyrimidin-2-amine	Ki	2500.0 [1]
	N-(2,4-Dimethoxyphenyl)-4-(1-ethylindol-3-yl)pyrimidin-2-amine	Ki	430.0 [1]
	N-(2,4-Dimethoxyphenyl)-4-[2-(2-methoxyethoxy)-4-methyl-1,3-thiazol-5-yl]pyrimidin-2-amine	Ki	860.0 [1]
	4-(2-Butoxy-4-methyl-1,3-thiazol-5-yl)-N-(2,4-dimethoxyphenyl)pyrimidin-2-amine	Ki	560.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ MAP kinase signal-integrating kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/map-kinase-signal-integrating-kinase-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ MAP kinase signal-integrating kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-signal-integrating-kinase-2-inhibitors-ic50-ki.
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