Maternal embryonic leucine zipper kinase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	1-Methyl-4-[4-(4-{3-[(Piperidin-4-Yl)methoxy]pyridin-4-Yl}-1h-Pyrazol-1-Yl)phenyl]piperazine	IC50	2.0 [1], 5.0 [2], 140.0 [3]
	Otssp167	IC50	0.41 [1], 0.6 [2], 1.1 [3]
	CID 73442760	IC50	37.0 [1], 23000.0 [2]
	[6-(3-Chloro-4-hydroxy-5-methoxyphenyl)-4-[[4-(diethylamino)cyclohexyl]amino]quinolin-3-yl]-cyclopropylmethanone	IC50	2.6 [1], 3.1 [2], 3.2 [3]
	7-[3-[4-(Piperazin-1-ylmethyl)-3-(trifluoromethyl)phenoxy]prop-1-ynyl]isoquinoline	IC50	7.6 [1], 300.0 [2]
	1-Methyl-4-(4-{4-[3-(2-Methylpropoxy)pyridin-4-Yl]-1h-Pyrazol-1-Yl}phenyl)piperazine	IC50	9.0 [1], 410.0 [2]
	1-[4-[4-(3-Fluoropyridin-4-yl)pyrazol-1-yl]phenyl]-4-methylpiperazine	IC50	70.0 [1], 5000.0 [2]
	1-Methyl-4-[4-(4-pyridin-4-ylpyrazol-1-yl)phenyl]piperazine	IC50	80.0 [1], 5000.0 [2]
	4-[[4-[1-[4-(4-Methylpiperazin-1-yl)phenyl]pyrazol-4-yl]pyridin-3-yl]oxymethyl]cyclohexan-1-amine	IC50	1.0 [1], 57.0 [2]
	1-Methyl-4-[4-[4-[3-(pyridin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazine	IC50	25.0 [1], 1440.0 [2]
	1-Methyl-4-[4-[4-(3-piperidin-4-yloxypyridin-4-yl)pyrazol-1-yl]phenyl]piperazine	IC50	6.0 [1], 260.0 [2]
	1-[4-[4-(3-Cyclohexyloxypyridin-4-yl)pyrazol-1-yl]phenyl]-4-methylpiperazine	IC50	4.0 [1], 150.0 [2]
	4-[4-[4-[3-(Piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]morpholine	IC50	6.0 [1], 210.0 [2]
	N-[(Pyridin-2-Yl)methyl]-4-[4-(Pyridin-4-Yl)-1h-Pyrazol-1-Yl]benzamide	IC50	180.0 [1], 18800.0 [2]
	N-Methyl-7-[3-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenoxy]prop-1-ynyl]isoquinolin-3-amine	IC50	19.0 [1], 20.0 [2]
	7-[3-[3-Methoxy-4-(piperazin-1-ylmethyl)phenoxy]prop-1-ynyl]isoquinoline	IC50	520.0 [1], 720.0 [2]
	1-[6-(3-Chloro-5-fluoro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone	IC50	1.1 [1], 1.3 [2]
	{4-(cis-4-Aminocyclohexylamino)-6-(4-hydroxy-3-methoxyphenyl)quinolin-3-yl}(cyclopropyl)methanone	IC50	1.9 [1], 7.0 [2]
	[4-(cis-4-Aminocyclohexylamino)-6-(3,5-difluoro-4-hydroxyphenyl)quinolin-3-yl](cyclopropyl)methanone	IC50	2.6 [1], 23.0 [2]
	Cyclopropyl-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]quinolin-3-yl]methanone	IC50	0.85 [1], 2.1 [2]
	[4-[[4-(Aminomethyl)cyclohexyl]amino]-6-(3-chloro-5-fluoro-4-hydroxyphenyl)quinolin-3-yl]-cyclopropylmethanone	IC50	3.4 [1], 46.0 [2]
	[6-(3-Chloro-4-hydroxy-5-methoxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]quinolin-3-yl]-cyclopropylmethanone	IC50	2.0 [1], 11.0 [2]
	Nintedanib	Ki	5.6 [1]
	Tozasertib	IC50	420.0 [1]
	Pyridone 6	IC50	330.0 [1]
	Entrectinib	IC50	10000.0 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	685.0 [1]
	Hesperadin	IC50	225.0 [1]
	5-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide	IC50	760.0 [1]
	CC-401	IC50	340.0 [1]
	Nms-P937 (nms1286937)	IC50	744.0 [1]
	5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-Carboxamide	IC50	10.0 [1]
	2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylic acid	Ki	149.0 [1]
	2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide	IC50	10000.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	N-[2-Hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]-2,2-dimethylpropanamide	IC50	2800.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-ol	IC50	10000.0 [1]
	4-(1H-Pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide	IC50	410.0 [1]
	[4-(3-Isoquinolin-7-ylprop-2-ynoxy)phenyl]methanamine	IC50	24000.0 [1]
	[4-(3-Isoquinolin-7-ylprop-2-ynoxy)-2-methoxyphenyl]methanamine	IC50	5100.0 [1]
	N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamide	IC50	160.0 [1]
	4-[1-(2-Fluorophenyl)-1h-Pyrazol-4-Yl]-3-[(Piperidin-4-Yl)methoxy]pyridine	IC50	13.0 [1]
	3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride	IC50	900.0 [1]
	1-N,1-N-Diethyl-4-N-[6-methoxy-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazolin-4-yl]pentane-1,4-diamine	IC50	6100.0 [1]
	1-Methyl-4-[4-(3-phenyl-1H-pyrazol-5-yl)phenyl]piperazine	IC50	670.0 [1]
	4-[1-(4-Methylsulfonylphenyl)pyrazol-4-yl]phenol	IC50	520.0 [1]
	1-[4-[4-(3-Methoxypyridin-4-yl)pyrazol-1-yl]phenyl]-4-methylpiperazine	IC50	64.0 [1]
	4-(1-Phenylpyrazol-4-yl)-3-(piperidin-4-ylmethoxy)pyridine	IC50	36.0 [1]
	4-[3-Fluoro-4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]morpholine	IC50	0.3 [1]
	5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamide	IC50	10.0 [1]
	Drak2-IN-1	IC50	10000.0 [1]
	5-[2,4-Dihydroxy-6-[4-(propan-2-ylamino)phenoxy]phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamide	IC50	10.0 [1]
	Nintedanib impurity E	Ki	0.47 [1]
	5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-[1-(1,4-dioxaspiro[4.5]decan-8-yl)piperidin-4-yl]-1,2-oxazole-3-carboxamide	IC50	10.0 [1]
	N-[2-Hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]butanamide	IC50	1000.0 [1]
	Melk-IN-1	Ki	0.39 [1]
	2-Hydroxy-N-methyl-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxamide	Ki	2.3 [1]
	N-[3-(Dimethylamino)propyl]-2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxamide	Ki	358.0 [1]
	N-(3-Aminopropyl)-2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxamide	Ki	650.0 [1]
	N-[4-[[(5-Fluoro-2-hydroxy-1H-indol-3-yl)-phenylmethylidene]amino]phenyl]-N-methyl-2-(4-methylpiperazin-1-yl)acetamide	Ki	3.1 [1]
	2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxylic acid	Ki	0.68 [1]
	N-[4-[[(5-Acetyl-2-hydroxy-1H-indol-3-yl)-phenylmethylidene]amino]phenyl]-N-methyl-2-(4-methylpiperazin-1-yl)acetamide	Ki	46.0 [1]
	N-(2-Anilino-2-oxoethyl)-4-[2-(methylamino)-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamide	IC50	120.0 [1]
	4-N-(3-Morpholin-4-ylpropyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]quinazoline-4,6-diamine	IC50	3500.0 [1]
	N-(1H-Benzimidazol-2-ylmethyl)-4-[2-(methylamino)-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamide	IC50	9.2 [1]
	4-N-[1-(Diethylamino)propan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine	IC50	3700.0 [1]
	N-[(E)-(6-Bromo-7aH-inden-1-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride	IC50	400.0 [1]
	4-N-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]quinazoline-4,6-diamine	IC50	6800.0 [1]
	2-Hydroxy-N,N-dimethyl-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxamide	Ki	8.8 [1]
	N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-4-[4-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamide	IC50	1.5 [1]
	N-(2-Anilino-2-oxoethyl)-4-[2-anilino-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamide	IC50	8.8 [1]
	4-N-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-[2-(trifluoromethyl)phenyl]ethenyl]quinazoline-4,6-diamine	IC50	8900.0 [1]
	4-[2-Anilino-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]-N-(1H-benzimidazol-2-ylmethyl)benzamide	IC50	1.1 [1]
	(8Z)-8-(1H-Imidazol-5-ylmethylidene)-6H-pyrrolo[3,2-e][1,3]benzothiazol-7-one	IC50	720.0 [1]
	4-N-[4-(Diethylamino)butan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine	IC50	2600.0 [1]
	4-N-[5-(Diethylamino)pentan-2-yl]-2-[2-[4-(trifluoromethyl)phenyl]ethyl]quinazoline-4,6-diamine	IC50	1300.0 [1]
	4-[2-Anilino-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]-N-[(6-methoxy-1H-benzimidazol-2-yl)methyl]benzamide	IC50	0.15 [1]
	4-N-[4-(Diethylamino)butyl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine	IC50	2100.0 [1]
	N-(2-Anilino-2-oxoethyl)-4-[4-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamide	IC50	740.0 [1]
	N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-4-[2-(methylamino)-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamide	IC50	1.5 [1]
	N-(1H-Benzimidazol-2-ylmethyl)-4-[4-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamide	IC50	12.0 [1]
	4-N-[5-(Diethylamino)pentan-2-yl]-2-[2-(2,4,6-trichlorophenyl)ethyl]quinazoline-4,6-diamine	IC50	7700.0 [1]
	HA 1004, Dihydrochloride	IC50	440.0 [1]
	1-(4-Methylsulfonylphenyl)-4-phenylpyrazole	IC50	20000.0 [1]
	4-[1-(4-Methylsulfonylphenyl)pyrazol-4-yl]pyridine	IC50	400.0 [1]
	2-{[2-Amino-5-(1,3-Benzodioxol-5-Ylmethyl)[1,2,4]triazolo[1,5-C]quinazolin-8-Yl]amino}ethanol	IC50	10000.0 [1]
	5-(1,3-Benzodioxol-5-ylmethyl)-[1,2,4]triazolo[1,5-c]quinazoline-2,8-diamine	IC50	10000.0 [1]
	5-(1,3-Benzodioxol-5-Ylmethyl)-10-Fluoro[1,2,4]triazolo[1,5-C]quinazolin-2-Amine	IC50	10000.0 [1]
	5-(1,3-Benzodioxol-5-ylmethyl)-10-fluoro-8-(4-methylpiperazin-1-yl)-[1,2,4]triazolo[1,5-c]quinazolin-2-amine	IC50	10000.0 [1]
	N-[6-Fluoro-2-methyl-3-[5-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1H-pyridazin-3-yl]phenyl]-1-benzothiophene-2-carboxamide	IC50	10000.0 [1]
	N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine	IC50	1400.0 [1]
	4-Fluoro-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide	IC50	160000.0 [1]
	2-[(4S)-7-(3-Chlorophenyl)-1-oxo-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-4-yl]-N-[(1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl]acetamide	IC50	10000.0 [1]
	4-(3-Hydroxy-5-methoxyanilino)-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide	IC50	2100.0 [1]
	4-Bromo-N-(2,3,4,5-Tetrahydro-1h-3-Benzazepin-7-Yl)benzamide	IC50	31000.0 [1]
	3-(Isoquinolin-7-Yl)prop-2-Yn-1-Ol	IC50	3100.0 [1]
	2-(3-Aminopropoxy)-4-(3-hydroxy-5-methoxyanilino)-N-phenylbenzamide	IC50	4200.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Maternal embryonic leucine zipper kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/maternal-embryonic-leucine-zipper-kinase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Maternal embryonic leucine zipper kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/maternal-embryonic-leucine-zipper-kinase-inhibitors-ic50-ki.
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