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Matrix metalloproteinase 14 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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IlomastatIC505.2 [1]
(2R)-N-Hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide;hydrochlorideIC5023.0 [1]
BatimastatIC502.9 [1], 3.0 [2], 4.6 [3], 47.0 [4]
4-[4-(4-Chloro-phenoxy)-benzenesulfonylmethyl]-tetrahydro-pyran-4-carboxylic acid hydroxyamideIC501.1 [1], 14.0 [2]
N-(3-Methoxybenzyl)-4-Oxo-3,4-Dihydroquinazoline-2-CarboxamideIC5010000.0 [1]
N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamideIC50833.0 [1], 2300.0 [2]
CID 10370504IC501900.0 [1]
4-[(4-But-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxy-1-propan-2-ylsulfonylpiperidine-4-carboxamideIC503642.0 [1], 4710.0 [2]
N-Hydroxy-4-(4-phenylsulfanylphenyl)sulfonyl-1-prop-2-ynylpiperidine-4-carboxamideIC508.0 [1], 19.0 [2], 19.1 [3]
(2R,3R)-1-[4-[(2-Chloro-4-fluorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxy-3-methylpiperidine-2-carboxamideIC5083.0 [1], 150.0 [2]
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-CarboxylateIC5030000.0 [1], 100000.0 [2]
MarimastatIC501.82 [1], 10000.0 [2]
2-((4-Phenoxyphenylsulfonyl)methyl)thiiraneKi37.0 [1], 110.0 [2]
Unii-Q56UE7E40YIC50772.0 [1]
(R)-5-(6-Cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamideIC5010000.0 [1]
(R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamideIC509.8 [1]
CID 6914621Ki15872.0 [1]
(3R)-3-[[(2S)-1-[[(1S)-2-Methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acidIC5066900.0 [1]
N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpiperidine-4-carboxamideIC5013.0 [1]
N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpiperidine-4-carboxamideKi14.0 [1]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC5030000.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi10000.0 [1]
2-(Biphenyl-4-ylsulfonamido)-N-hydroxyacetamideIC5070.0 [1]
2-Benzenesulfonylamino-N-[5-(4-fluoro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi330.0 [1], 390.0 [2]
2-Benzenesulfonylamino-N-[5-(4-bromo-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi180.0 [1], 200.0 [2]
2-Benzenesulfonylamino-N-[5-(4-chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi100.0 [1], 210.0 [2]
(8S,11R,12S)-12-N-Hydroxy-8-N-(2-morpholin-4-yl-2-oxoethyl)-2,10-dioxo-11-[[4-[2-(trifluoromethyl)phenyl]phenyl]methyl]-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi2000.0 [1]
(2S)-2-[[4-[4-[(5-Bromo-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5015000.0 [1], 15135.61 [2]
N-(4-(4-(Thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)acetamideKi680.0 [1]
4-(4-(Thiiran-2-ylmethylsulfonyl)phenoxy)phenyl methanesulfonateKi145.0 [1], 150.0 [2]
N-Hydroxy-2-[2-methylpropyl-(4-phenylphenyl)sulfonylamino]acetamideIC50530.0 [1]
N-[4-[2-(Hydroxyamino)-2-oxoethyl]oxan-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi5290.0 [1]
2-Benzenesulfonylamino-N-[5-(5-chloro-thiophen-2-yl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi200.0 [1], 320.0 [2]
2-Benzenesulfonylamino-N-[5-(4-trifluoromethyl-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi390.0 [1], 580.0 [2]
2-Benzenesulfonylamino-N-(5-p-tolyl-6H-[1,3,4]thiadiazin-2-yl)-propionamideKi150.0 [1], 290.0 [2]
N-(5-Adamantan-1-yl-6H-[1,3,4]thiadiazin-2-yl)-2-benzenesulfonylamino-propionamideKi3070.0 [1]
(2S)-2-(Benzenesulfonamido)-N-[5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi240.0 [1], 400.0 [2]
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamideIC50100000.0 [1]
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamideKi100000.0 [1]
(2R)-2-(Benzenesulfonamido)-N-[5-(4-chlorophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi50.0 [1], 210.0 [2]
(2R)-2-(Benzenesulfonamido)-N-[5-(4-chlorophenyl)-6H-1,3,4-thiadiazin-2-yl]-3-methylbutanamideKi330.0 [1], 590.0 [2]
{(S)-4-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-4-hydroxycarbamoyl-butyl}-carbamic acid benzyl esterIC507.7 [1]
(2S)-2-[[4-[4-[(5-Ethyl-4-hydroxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5015800.0 [1], 15848.93 [2]
(2S)-2-[[4-[4-[(5-Chloro-3-methyl-4-propan-2-yloxy-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5050000.0 [1], 50118.72 [2]
(2S)-2-[[4-[4-[(5-Iodo-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5030000.0 [1], 30199.52 [2]
4-[2-[[6-Fluoro-2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-quinazolin-5-yl]oxy]ethyl]benzoic acidIC5010000.0 [1]
3-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-pyridin-2-yl-1,3-thiazol-5-yl]propanoic acidIC5024000.0 [1]
N-[(1R)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamideIC505000.0 [1]
N-[(1S)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamideIC505000.0 [1]
5-[3-Fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2S)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamideIC505000.0 [1]
5-[3-Fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2R)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamideIC505000.0 [1]
4-((4-(But-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(pyridin-4-ylmethyl)piperidine-4-carboxamideIC50784.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi5290.0 [1]
5-(2-Amino-2-oxoethyl)-4-oxo-N-[(3-oxo-4H-1,4-benzoxazin-6-yl)methyl]-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidine-2-carboxamideIC502500.0 [1], 10000.0 [2]
[2-[[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyl]-5-phenylpentyl]-[2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acidKi105.0 [1]
(2S)-2-[[4-[4-[(5-Chloro-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5012302.69 [1], 12400.0 [2]
(2S)-2-[[4-[4-[(4-Methoxy-3,5-dimethyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5015000.0 [1], 15135.61 [2]
(2S)-2-[[4-[4-[(5-Ethyl-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5030000.0 [1], 30199.52 [2]
4-[(4-But-2-ynoxyphenyl)sulfonylmethyl]-N-hydroxy-1-(pyridine-4-carbonyl)piperidine-4-carboxamideIC50553.0 [1], 583.0 [2]
Isobutyl 3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-3-(hydroxycarbamoyl)piperidine-1-carboxylateIC503410.0 [1]
N-Hydroxy-2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]acetamideIC50710.0 [1]
(6S,7S)-N-Hydroxy-5-methyl-6-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC505000.0 [1]
(6S,7S)-N-Hydroxy-5-methyl-6-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideKi67.6 [1]
(2R,3R)-4-[(2R)-2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamideKi1100.0 [1], 1148.0 [2]
N-Hydroxy-2-[(4-phenylmethoxyphenyl)sulfonylamino]acetamideIC50310.0 [1]
Benzyl N-[(4R)-4-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamateIC5068000.0 [1]
2-Benzenesulfonylamino-N-[5-(4-cyano-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi240.0 [1], 400.0 [2]
MMP3 inhibitor 1IC5020100.0 [1]
N-[5-(4-Chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-2-phenylmethanesulfonylamino-propionamideKi180.0 [1], 190.0 [2]
2-Benzenesulfonylamino-N-[5-(4-chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-2-methyl-propionamideKi110.0 [1], 150.0 [2]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC507990.0 [1], 8000.0 [2]
N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamideIC5014870.0 [1], 15000.0 [2]
(2S)-2-Cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamideIC5050000.0 [1], 50200.0 [2]
(2S)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-methyl-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC50100000.0 [1]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamideIC503890.0 [1], 3900.0 [2]
(-)-Epigallocatechin gallateIC506800.0 [1]
Zoledronic acidIC5012600.0 [1]
Tiludronic AcidIC5030500.0 [1]
PrinomastatIC500.3 [1]
N^2^-[(2R)-2-{(1S)-1-[Formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl]-N,3-dimethyl-L-valinamideIC5088.0 [1]
(R)-N1-((S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamideIC501.9 [1]
N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acidIC5013.0 [1]
(2S,3R)-N-Hydroxy-2-methyl-N'-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]-3-(2-methylpropyl)butanediamideIC5056.0 [1]
(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acidIC50240.0 [1]
Epigallocatechin 3-O-(3-O-methyl)gallateIC501700.0 [1]
CipemastatIC5023.0 [1]
CID 9847838IC50499.0 [1]
(2S,3R)-N-Hydroxy-2-methyl-N'-[(2S)-1-(methylamino)-1-oxo-3-(5,6,7,8-tetrahydronaphthalen-1-yl)propan-2-yl]-3-(2-methylpropyl)butanediamideIC502.08 [1]
(Biphenyl-3-ylamino)methylenediphosphonic acidIC5040000.0 [1]
N-Hydroxy-N~2~-[(4-Methoxyphenyl)sulfonyl]glycinamideIC50210.0 [1]
[(2,4-Dichloroanilino)-phosphono-methyl]phosphonic acidIC50100000.0 [1]
(3-Bromophenylamino)Methylenediphosphonic AcidIC50100000.0 [1]
[(4-Phenylanilino)-phosphono-methyl]phosphonic acidIC5033500.0 [1]
[(3-Nitroanilino)-phosphono-methyl]phosphonic acidIC50100000.0 [1]
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamideIC50100000.0 [1]
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrileIC50426579.52 [1]
Grassystatin AIC505000.0 [1]
(4S)-5-Amino-4-[[(2S)-2-[[(2S)-2-[[(4-bromophenyl)-hydroxyphosphoryl]methyl]-3-[3-[4-(3-chlorophenyl)phenyl]-1,2-oxazol-5-yl]propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acidKi140.0 [1]
N-Phenyl-4-[(4h-1,2,4-Triazol-3-Ylsulfanyl)methyl]-1,3-Thiazol-2-AmineIC507500.0 [1]
Cruzain-IN-1IC5072443.6 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Matrix metalloproteinase 14 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/matrix-metalloproteinase-14-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Matrix metalloproteinase 14 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/matrix-metalloproteinase-14-inhibitors-ic50-ki.
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