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Matrix metalloproteinase 8 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2R)-N-Hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide;hydrochlorideIC504.4 [1]
MarimastatIC500.47 [1], 2.0 [2], 10000.0 [3]
4-[4-(4-Chloro-phenoxy)-benzenesulfonylmethyl]-tetrahydro-pyran-4-carboxylic acid hydroxyamideIC500.1 [1]
Methylamino-phenylalanyl-leucyl-hydroxamic acidIC500.05 [1]
Methylamino-phenylalanyl-leucyl-hydroxamic acidKi1.0 [1], 2.0 [2]
N-(3-Methoxybenzyl)-4-Oxo-3,4-Dihydroquinazoline-2-CarboxamideIC501100.0 [1]
IlomastatIC509.7 [1]
IlomastatKi0.18 [1], 1.0 [2]
N-Hydroxy-4-(4-phenylsulfanylphenyl)sulfonyl-1-prop-2-ynylpiperidine-4-carboxamideIC501.8 [1]
(2R,3R)-3-(Cyclopentylmethyl)-N-hydroxy-2-[[methyl(methylsulfonyl)amino]methyl]-4-oxo-4-piperidin-1-ylbutanamideIC50199.53 [1], 200.0 [2]
(2R)-2-[Benzyl-[4-(2-fluoroethoxy)phenyl]sulfonylamino]-N-hydroxy-3-methylbutanamideIC502.0 [1]
(R)-3-[[[(S)-2-Phenyl-1-(N-methylcarbamoyl)ethyl]amino]carbonyl]-8-phenoxyoctanehydroximic acidKi2.0 [1]
(R)-3-[[[(S)-2-Phenyl-1-(N-methylcarbamoyl)ethyl]amino]carbonyl]-7-(benzyloxy)heptanehydroximic acidKi2.0 [1], 20.0 [2]
(R)-3-[[[(S)-2-Phenyl-1-(N-methylcarbamoyl)ethyl]amino]carbonyl]-7-phenoxyheptanehydroximic acidKi2.0 [1]
PrinomastatIC500.4 [1], 0.54 [2]
N-Hydroxy-N~2~-[(4-Methoxyphenyl)sulfonyl]glycinamideKi59.0 [1], 155.0 [2]
(2R)-2-[Benzyl-(4-methoxyphenyl)sulfonylamino]-N-hydroxy-3-methylbutanamideKi23.0 [1]
(R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamideIC501.6 [1]
2-[(4-Chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-oneIC5040000.0 [1], 100000.0 [2]
CID 6914621Ki257.0 [1]
cis-2-Aminocyclohexylcarbamoylphosphonic acidIC50100000.0 [1]
N1,2-Dibenzyl-N3-hydroxymalonamideKi3090.3 [1], 3100.0 [2]
N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpiperidine-4-carboxamideIC501.7 [1]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC5030000.0 [1], 100000.0 [2]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi10000.0 [1]
2-(Biphenyl-4-ylsulfonamido)-N-hydroxyacetamideIC507.0 [1]
2-(Biphenyl-4-ylsulfonamido)-N-hydroxyacetamideKi9.0 [1]
(2S,3R)-2-(Cyclopropylmethylamino)-N-hydroxy-N'-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(3-hydroxyphenyl)methyl]butanediamideKi171.0 [1]
N-Hydroxy-2-[(4-nitro-benzyl)-pentafluorobenzenesulfonyl-amino]-acetamideKi0.1 [1]
N1-Hydroxy-2-isobutyl-N3-(3-phenylpropyl)malonamideKi537.03 [1], 540.0 [2]
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-CarboxylateIC5030000.0 [1], 100000.0 [2]
(8S,11R,12S)-12-N-Hydroxy-8-N-(2-morpholin-4-yl-2-oxoethyl)-2,10-dioxo-11-[[4-[2-(trifluoromethyl)phenyl]phenyl]methyl]-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi126.0 [1], 200.0 [2]
N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-(4-nitro-benzyl)-amino]-acetamideKi21.0 [1]
N-Hydroxy-2-[(4-nitro-benzyl)-(nonafluorobutane-1-sulfonyl)-amino]-acetamideKi2.4 [1]
2-Benzyl-N1-hydroxy-N3-(3-phenylpropyl)malonamideKi560.0 [1], 562.34 [2]
Ethyl 2-benzyl-3-(hydroxyamino)-3-oxopropanoateKi52480.75 [1], 53000.0 [2]
Mmp-8 inhibitor iIC504.0 [1]
(2R)-2-[[4-(4-Methoxyphenyl)phenyl]sulfonylamino]-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]acetic acidIC501.5 [1], 1.51 [2]
(3S)-N-Hydroxy-4-(4-methoxyphenyl)sulfonyl-2,2-dimethyl-1,1-dioxo-1,4-thiazepane-3-carboxamideIC502.4 [1]
(1S)-1-{[(4'-Methoxy-1,1'-biphenyl-4-YL)sulfonyl]amino}-2-methylpropylphosphonic acidIC50810.0 [1]
(1S)-1-{[(4'-Methoxy-1,1'-biphenyl-4-YL)sulfonyl]amino}-2-methylpropylphosphonic acidKi700.0 [1]
(1R)-1-{[(4'-Methoxy-1,1'-biphenyl-4-YL)sulfonyl]amino}-2-methylpropylphosphonic acidIC501.4 [1]
(1R)-1-{[(4'-Methoxy-1,1'-biphenyl-4-YL)sulfonyl]amino}-2-methylpropylphosphonic acidKi0.6 [1]
N-[4-[2-(Hydroxyamino)-2-oxoethyl]oxan-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi3100.0 [1]
2-[Methyl[4-(2-butynyloxy)phenylsulfonyl]amino]acetohydroximic acidKi43.0 [1], 800.0 [2]
(S)-N-Hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dimethyl-1,4-thiazepane-3-carboxamideIC501.4 [1]
(2R)-1-N-Hydroxy-2-N-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-5-N-(2-phenylethyl)pentane-1,2,5-tricarboxamideKi32.0 [1]
(2R,3R)-3-(Cyclopentylmethyl)-2-[[dimethylsulfamoyl(methyl)amino]methyl]-N-hydroxy-4-oxo-4-piperidin-1-ylbutanamideIC5010.0 [1]
2-[1-(2-Methoxyethoxycarbonyl)piperidin-4-yl]-2-[[4-(4-methylsulfanylphenyl)phenyl]sulfonylamino]acetic acidIC501.8 [1], 1.82 [2]
2-[1-(2-Methoxyethoxycarbonyl)piperidin-4-yl]-2-[[4-(4-methoxyphenyl)phenyl]sulfonylamino]acetic acidIC503.39 [1], 3.4 [2]
N-(5-Adamantan-1-yl-6H-[1,3,4]thiadiazin-2-yl)-2-benzenesulfonylamino-propionamideKi15000.0 [1]
(4'-Methoxy-biphenyl-4-sulfonylamino)-[1-(morpholine-4-carbonyl)-piperidin-4-yl]-acetic acidIC503.0 [1], 3.02 [2]
(R)-3-[[[(S)-2-Phenyl-1-(N-methylcarbamoyl)ethyl]amino]carbonyl]-7-hydroxyheptanehydroximic acidKi7.0 [1]
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiolIC504.0 [1]
N1-Hydroxy-2-phenethyl-N3-(3-phenylpropyl)malonamideKi489.78 [1], 490.0 [2]
(R)-3-[[[(S)-2-Phenyl-1-(N-methylcarbamoyl)ethyl]amino]carbonyl]-8-hydroxyoctanehydroximic acidKi4.0 [1]
(2R)-1-N-Hydroxy-2-N-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-5-N-propylpentane-1,2,5-tricarboxamideKi2.0 [1]
(R)-3-[[[(S)-2-Phenyl-1-(N-methylcarbamoyl)ethyl]amino]carbonyl]-6-(benzyloxy)hexanehydroximic acidKi1.0 [1]
(2R)-5-N-Benzyl-1-N-hydroxy-2-N-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]pentane-1,2,5-tricarboxamideKi30.0 [1]
(3R)-N-Hydroxy-2-(4-methoxyphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxamideIC503.0 [1]
(3S,5R,14S)-14-(Methylcarbamoyl)-2,8-dioxo-3-(2-phenylethyl)-1,4,9-triazacyclotetradecane-5-carboxylic acidKi17.0 [1]
2-Benzyl-N-hydroxy-3-morpholino-3-oxopropanamideKi50000.0 [1], 50118.72 [2]
(3R)-N-Hydroxy-2-(4-morpholin-4-ylphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxamideIC5070.0 [1]
N1,2-Dihydroxy-N3-(3-phenylpropyl)malonamideKi2290.87 [1], 2300.0 [2]
N1-Benzyl-N3-hydroxy-2-phenethylmalonamideKi2290.87 [1], 2300.0 [2]
(3R)-2-(4-Phenoxyphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylic acidIC50100.0 [1]
(3R)-N-Hydroxy-2-(4-phenoxyphenyl)sulfonyl-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxamideIC507.0 [1], 8.0 [2]
Ethyl 3-(hydroxyamino)-3-oxo-2-phenylpropanoateKi97723.72 [1], 98000.0 [2]
Ethyl 2-(hydroxycarbamoyl)-4-phenylbutanoateKi189000.0 [1], 190546.07 [2]
(6R)-N-Hydroxy-5-(4-methoxyphenyl)sulfonyl-1-methyl-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxamideIC503.0 [1]
2-[1-(2-Methoxyethoxycarbonyl)piperidin-4-yl]-2-[[4-(4-methoxyphenyl)phenyl]sulfonyl-methylamino]acetic acidIC503.6 [1], 3.63 [2]
2-(1-Ethoxycarbonylpiperidin-4-yl)-2-[[4-(4-methoxyphenyl)phenyl]sulfonylamino]acetic acidIC502.69 [1], 2.7 [2]
2-[[4-(4-Methoxyphenyl)phenyl]sulfonylamino]-2-(1-propan-2-yloxycarbonylpiperidin-4-yl)acetic acidIC501.5 [1], 1.51 [2]
2-(1-Methoxycarbonylpiperidin-4-yl)-2-[[4-(4-methoxyphenyl)phenyl]sulfonylamino]acetic acidIC506.7 [1], 6.76 [2]
2-[[4-(4-Methoxyphenyl)phenyl]sulfonylamino]-2-[1-(3-methylbutanoyl)piperidin-4-yl]acetic acidIC505.25 [1], 5.3 [2]
2-[1-(2-Methoxyethoxycarbonyl)piperidin-4-yl]-2-[2-methoxyethyl-[4-(4-methoxyphenyl)phenyl]sulfonylamino]acetic acidIC502.4 [1]
2-[1-(2-Methoxyethoxycarbonyl)piperidin-4-yl]-2-[(4-phenoxyphenyl)sulfonylamino]acetic acidIC5025.7 [1], 25.8 [2]
(2S)-2-[[4-(4-Methoxyphenyl)phenyl]sulfonylamino]-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]acetic acidIC503.0 [1], 3.02 [2]
2-[(4-Butoxyphenyl)sulfonylamino]-2-[1-(2-methoxyethoxycarbonyl)piperidin-4-yl]acetic acidIC50294.0 [1], 295.12 [2]
(6R)-5-(4-Methoxyphenyl)sulfonyl-1-methyl-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acidIC501000.0 [1], 10000.0 [2]
Mmp-8 inhibitor i, negative controlIC501000.0 [1]
4-[(Biphenyl-4-sulfonylamino)-carboxy-methyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl esterIC5044.67 [1], 44.8 [2]
4-[2-[[6-Fluoro-2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-quinazolin-5-yl]oxy]ethyl]benzoic acidIC50720.0 [1]
N-[(1R)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamideIC505000.0 [1]
N-[(1S)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamideIC505000.0 [1]
5-[3-Fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2S)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamideIC505000.0 [1]
5-[3-Fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2R)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamideIC505000.0 [1]
3-[4-(Phenylthio)phenylsulfonyl]propane-1-thiolIC5036.0 [1]
N-Hydroxy-4-[4-[3-[(4-methoxybenzoyl)amino]propoxy]phenyl]sulfonyloxane-4-carboxamideIC50900.0 [1]
N-Hydroxy-4-[4-[3-[(4-methoxybenzoyl)amino]propoxy]phenyl]sulfonyloxane-4-carboxamideKi900.0 [1]
3-{[4-(But-2-Yn-1-Yloxy)phenyl]sulfonyl}propane-1-ThiolKi2700.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi3058.0 [1]
[2-[[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyl]-5-phenylpentyl]-[2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acidIC502.5 [1]
[2-[[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyl]-5-phenylpentyl]-[2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acidKi2.5 [1]
2-[(3R)-2-[4-(4-Chlorophenyl)phenyl]sulfonyl-3,4-dihydro-1H-isoquinolin-3-yl]-2-oxoacetic acidIC505.0 [1]
2-[(3S)-2-[4-(4-Fluorophenyl)phenyl]sulfonyl-3,4-dihydro-1H-isoquinolin-3-yl]-2-oxoacetic acidIC504000.0 [1]
2-[(3R)-2-[4-(4-Fluorophenyl)phenyl]sulfonyl-3,4-dihydro-1H-isoquinolin-3-yl]-2-oxoacetic acidIC5020.0 [1]
(2R,3R)-3-(Cyclopentylmethyl)-N-hydroxy-2-[[methylsulfonyl(propan-2-yl)amino]methyl]-4-oxo-4-piperidin-1-ylbutanamideIC50100.0 [1]
(2R,3R)-2-[[[5-(Dimethylamino)naphthalen-1-yl]sulfonyl-methylamino]methyl]-N-hydroxy-5-methyl-3-(piperidine-1-carbonyl)hexanamideIC5010.0 [1]
(2R,3R)-2-[Methyl(methylsulfonyl)aminomethyl]-3-(piperidinocarbonyl)-5-methylhexanehydroximic acidIC50100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Matrix metalloproteinase 8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/matrix-metalloproteinase-8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Matrix metalloproteinase 8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/matrix-metalloproteinase-8-inhibitors-ic50-ki.
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