 | N-[6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide | IC50 | 5.5 [1], 43.0 [2], 85.0 [3], 872.0 [4] |
| N-[6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide | Ki | 5.5 [1], 38.0 [2] |
 | N-(4-Methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 25.0 [1], 29.0 [2] |
 | 8-(Cyclohexylmethoxy)quinolin-2-amine | IC50 | 90.0 [1] |
 | 6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 0.5 [1], 16.0 [2], 89.13 [3] |
| 6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-one | Ki | 2.8 [1] |
 | 7-Fluorochromone-2-carboxamide | IC50 | 3.0 [1], 29.0 [2] |
 | N-[6-[3-(Methylamino)pyrrolidin-1-yl]pyridin-3-yl]-4-phenylbenzamide | IC50 | 12.0 [1] |
| N-[6-[3-(Methylamino)pyrrolidin-1-yl]pyridin-3-yl]-4-phenylbenzamide | Ki | 2.3 [1], 5.2 [2], 61.0 [3], 122.0 [4] |
 | (E)-N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide | IC50 | 16.0 [1], 19.0 [2], 144.0 [3] |
 | TC-MCH 7c | IC50 | 5.6 [1], 23.0 [2] |
 | 2-(4-(Benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-6-yl)acetamide | IC50 | 1.4 [1], 11.0 [2] |
 | 2-(3-Chlorophenoxy)-N-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamide | IC50 | 29.0 [1], 32.0 [2] |
 | MCH-1 antagonist 1 | IC50 | 14.0 [1] |
| MCH-1 antagonist 1 | Ki | 2.6 [1] |
 | 4-(4-Fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide | IC50 | 0.54 [1], 2.8 [2] |
 | 8-(1,3,3-Trimethyl-butoxy)-quinolin-2-ylamine | IC50 | 41.0 [1], 50.0 [2], 210.0 [3], 211.0 [4] |
 | 2-(2,4-Dichlorophenoxy)-N-[4-methyl-2-(4-methylpiperazino)-6-quinolyl]acetamide | IC50 | 6.4 [1], 10.0 [2], 24.0 [3], 89.0 [4] |
 | N-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-chloro-benzamide | IC50 | 0.4 [1], 3.0 [2], 7.0 [3] |
 | N-(4-Methyl-2-morpholin-4-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 1.6 [1], 12.0 [2], 50.0 [3], 82.0 [4] |
 | N-(1-(3-Fluoro-4-methoxybenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide | IC50 | 24.0 [1], 168.0 [2] |
 | 8-[3-(4-Chloro-3-trifluoromethyl-benzylamino)-propoxy]-quinolin-2-ylamine | IC50 | 5.0 [1], 220.0 [2] |
 | 4-(4-Fluorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide | IC50 | 1.9 [1], 7.9 [2], 17.0 [3] |
 | 4-Bromo-N-[[4-[[[4-(dimethylamino)quinazolin-2-yl]amino]methyl]cyclohexyl]methyl]-2-(trifluoromethoxy)benzenesulfonamide | IC50 | 140.0 [1], 160.0 [2], 200.0 [3] |
 | 1-[4-(3-Cyanophenyl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea | Ki | 1.8 [1], 8.9 [2] |
 | 1-[(1S,2R,5S)-5-(4-Cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea | Ki | 2.7 [1] |
 | 2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamide | IC50 | 50.0 [1], 58.0 [2], 71.0 [3] |
 | 1-[4-[2-(Aminomethyl)-1,3-thiazol-5-yl]cyclohex-3-en-1-yl]-3-(3-chloro-4-fluorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea | Ki | 13.0 [1] |
 | 3-(3-Chloro-4-fluorophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea | Ki | 7.9 [1], 9.0 [2] |
 | 4-[(4-Chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one | IC50 | 23.0 [1], 26.0 [2] |
 | N-(4-Methyl-2-(pyrrolidin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethyl)phenoxy)acetamide | IC50 | 10.0 [1], 15.0 [2] |
 | 2-(4-(Benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)acetamide | IC50 | 558.0 [1], 10000.0 [2] |
 | N-[1-(1,3-Benzodioxol-5-ylmethyl)piperidin-4-yl]-7-methoxy-4-oxo-4H-chromene-2-carboxamide | IC50 | 6.0 [1], 11.0 [2], 73.0 [3] |
 | 2-(4-(Benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-4-yl)acetamide | IC50 | 24.5 [1], 25.0 [2], 71.0 [3] |
 | MCHr1 antagonist 2 | IC50 | 4.0 [1], 65.0 [2], 196.0 [3] |
 | (4Ar,11R,11aS)-11-methyl-2-[3-(oxan-4-yl)propyl]-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazole | IC50 | 0.5 [1], 6.0 [2] |
 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-5-chloro-2-[(thiazol-2-ylmethyl)amino]benzamide | IC50 | 2.0 [1], 16.0 [2] |
 | N-[1-(1,3-Benzodioxol-5-ylmethyl)piperidin-4-yl]-6,7-dichloro-4-oxochromene-2-carboxamide | IC50 | 3.0 [1], 83.0 [2] |
 | (3S)-N-[(3R)-1-(4,4-Dimethylcyclohexyl)pyrrolidin-3-yl]-N-methyl-3-[methyl-[5-[4-(trifluoromethyl)phenyl]thiophene-2-carbonyl]amino]pyrrolidine-1-carboxamide | IC50 | 12.0 [1] |
| (3S)-N-[(3R)-1-(4,4-Dimethylcyclohexyl)pyrrolidin-3-yl]-N-methyl-3-[methyl-[5-[4-(trifluoromethyl)phenyl]thiophene-2-carbonyl]amino]pyrrolidine-1-carboxamide | Ki | 2.0 [1], 1125.0 [2] |
 | N-(1-(Benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)-5-chloro-1H-indazol-3-amine | IC50 | 16.0 [1], 20.0 [2], 260.0 [3] |
 | N-(1-(4-Acetamidobenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide | IC50 | 1690.0 [1], 1700.0 [2], 10000.0 [3] |
 | 1-[(2S)-6-(Diethylaminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-[2-(4-fluorophenyl)ethyl]piperazin-2-one | IC50 | 10.0 [1] |
| 1-[(2S)-6-(Diethylaminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-[2-(4-fluorophenyl)ethyl]piperazin-2-one | Ki | 3.0 [1], 15.0 [2] |
 | AMG-076 free base | IC50 | 0.6 [1], 1.2 [2] |
| AMG-076 free base | Ki | 0.6 [1] |
 | N-[2-(2,5-Diazabicyclo[2.2.1]heptan-2-yl)-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 1.9 [1], 9.7 [2], 16.0 [3] |
 | N-[2-(4-Amino-piperidin-1-yl)-4-methyl-quinolin-6-yl]-2-(4-trifluoromethoxy-phenoxy)-acetamide | IC50 | 1.5 [1], 3.5 [2], 14.0 [3] |
 | (R)-N-(4-Methyl-2-(3-methylpiperazin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 4.1 [1], 18.0 [2], 100.0 [3] |
 | 2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1-yl-quinolin-6-yl)-acetamide | IC50 | 5.0 [1], 16.0 [2], 74.0 [3] |
 | (E)-N-(2-[1,4]Diazepan-1-yl-4-methyl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide | IC50 | 6.1 [1], 23.0 [2], 65.0 [3] |
 | N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide | IC50 | 50.0 [1], 150.0 [2], 260.0 [3] |
 | (E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide | IC50 | 4.0 [1], 65.0 [2], 88.0 [3] |
 | (E)-N-[2-[2-Hydroxyethyl(methyl)amino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide | IC50 | 0.9 [1], 5.2 [2], 41.0 [3] |
 | 2-(2,4-Dichlorophenoxy)-N-[2-[2-hydroxyethyl(methyl)amino]-4-methylquinolin-6-yl]acetamide | IC50 | 2.1 [1], 11.0 [2], 43.0 [3] |
 | 2-(2,4-Dichlorophenoxy)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]acetamide | IC50 | 5.9 [1], 9.4 [2], 66.0 [3] |
 | 2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-acetamide | IC50 | 85.0 [1], 180.0 [2], 1480.0 [3] |
 | N-[4-Methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 1.5 [1], 7.1 [2], 7.5 [3] |
 | (E)-N-[2-[(3R,5S)-3,5-Dimethylpiperazin-1-yl]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide | IC50 | 100.0 [1], 409.0 [2], 1160.0 [3] |
 | N-[2-[(1-Ethylpyrrolidin-2-yl)methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 8.7 [1], 21.0 [2], 109.0 [3] |
 | N-[2-(3-Dimethylamino-propylamino)-4-methyl-quinolin-6-yl]-2-(4-trifluoromethoxy-phenoxy)-acetamide | IC50 | 2.7 [1], 3.8 [2], 16.0 [3] |
 | N-[2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 1.7 [1], 5.0 [2], 23.0 [3] |
 | N-(4-Methyl-2-(2-morpholinoethylamino)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 1.3 [1], 9.6 [2], 16.0 [3] |
 | (E)-N-[2-[1-(Dimethylamino)propan-2-ylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide | IC50 | 4.3 [1], 22.0 [2], 98.0 [3] |
 | (E)-N-[2-[2-(Dimethylamino)ethylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide | IC50 | 3.0 [1], 13.0 [2], 42.0 [3] |
 | 2-[[6-[[2-(2,4-Dichlorophenoxy)acetyl]amino]-4-methylquinolin-2-yl]-methylamino]ethyl acetate | IC50 | 2.3 [1], 14.0 [2], 29.0 [3] |
 | N-(4-Methyl-2-piperidin-1-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 0.92 [1], 19.0 [2], 97.0 [3] |
 | 2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-morpholin-4-yl-quinolin-6-yl)-acetamide | IC50 | 5.5 [1], 15.4 [2], 59.0 [3] |
 | 2-(3,4-Difluorophenyl)-N-ethyl-N-[3-(5-fluorospiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)propyl]-2-(4-methyl(35S)sulfonyl-2-oxopiperazin-1-yl)acetamide | IC50 | 0.36 [1], 3.0 [2] |
| 2-(3,4-Difluorophenyl)-N-ethyl-N-[3-(5-fluorospiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)propyl]-2-(4-methyl(35S)sulfonyl-2-oxopiperazin-1-yl)acetamide | Ki | 0.42 [1] |
 | N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethyl-phenyl)-ureido]-benzamide | IC50 | 20.0 [1], 50.0 [2], 170.0 [3] |
 | N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-benzamide | IC50 | 140.0 [1], 720.0 [2], 880.0 [3] |
 | 2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-methylamino-ethyl)-amino]-quinolin-6-yl}-acetamide | IC50 | 6.1 [1], 6.9 [2], 28.0 [3] |
 | N-(2-(1,4-Diazepan-1-yl)-4-methylquinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 2.0 [1], 12.0 [2], 71.0 [3] |
 | N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)-3-p-tolylacrylamide | IC50 | 17.0 [1], 48.0 [2], 478.0 [3] |
 | N-(4-Methyl-2-(4-methyl-1,4-diazepan-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 3.7 [1], 20.0 [2], 244.0 [3] |
 | 2-(4-Chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)acetamide | IC50 | 33.0 [1], 83.0 [2], 807.0 [3] |
 | N-[2-[[3-(Dimethylamino)-2,2-dimethylpropyl]amino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 4.7 [1], 16.0 [2], 192.0 [3] |
 | N-(2-(1-Benzylpiperidin-4-ylamino)-4-methylquinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 13.0 [1], 40.0 [2], 91.0 [3] |
 | N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]propanamide | IC50 | 14.0 [1], 40.0 [2], 724.0 [3] |
 | N-(4-Methyl-2-(2-(piperidin-1-yl)ethylamino)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | IC50 | 0.91 [1], 5.3 [2], 33.0 [3] |
 | N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-4-[4-(trifluoromethyl)phenyl]benzamide | IC50 | 10.0 [1], 63.0 [2], 474.0 [3] |
 | N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-4-phenylbenzamide | IC50 | 5.7 [1], 25.0 [2], 42.0 [3] |
 | 4-(4-Chlorophenyl)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]cyclohexane-1-carboxamide | IC50 | 23.0 [1], 393.0 [2], 423.0 [3] |
 | N-[2-[3-(Dimethylamino)pyrrolidin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 2.4 [1], 6.2 [2], 82.0 [3] |
 | N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide | IC50 | 2.3 [1], 18.0 [2], 31.0 [3] |
 | 2-[2-[4-[(Dimethylamino)methyl]-2-methylphenyl]-2-oxoethyl]-5-[(5-methoxypyridin-2-yl)methoxy]pyridazin-3-one | IC50 | 22.0 [1], 28.0 [2] |
| 2-[2-[4-[(Dimethylamino)methyl]-2-methylphenyl]-2-oxoethyl]-5-[(5-methoxypyridin-2-yl)methoxy]pyridazin-3-one | Ki | 14.0 [1] |
 | Methyl (4S)-3-[3-[4-(3-acetamidophenyl)piperidin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate | IC50 | 3.0 [1], 15.0 [2] |
 | ATC-0175 free base | IC50 | 3.4 [1], 7.2 [2] |
 | N-(1-(Naphthalen-2-ylmethyl)piperidin-4-yl)benzamide | IC50 | 948.0 [1] |
| N-(1-(Naphthalen-2-ylmethyl)piperidin-4-yl)benzamide | Ki | 347.0 [1] |
 | CID 57521365 | IC50 | 1.1 [1], 2.9 [2] |
 | 6-(4-Chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one | IC50 | 13.0 [1], 16.0 [2] |
 | 1-[[4-(3-Cyanophenyl)phenyl]methyl]-3-(1-hydroxy-2-methylpropan-2-yl)-1-[2-[1-[(4-methylphenyl)methyl]piperidin-4-yl]ethyl]urea | Ki | 43.65 [1] |
 | N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide | IC50 | 109.0 [1] |
| N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide | Ki | 125.0 [1] |
 | 4-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-ylamino)-6-chloro-chromen-2-one | IC50 | 2.0 [1], 28.0 [2] |
 | 4-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-ylamino)-6-methoxy-chromen-2-one | IC50 | 2.0 [1], 11.0 [2] |
 | 1-[4-(3-Cyanophenyl)phenyl]-1-(1-cyclopentylpiperidin-4-yl)-3-(3,5-dichlorophenyl)urea | Ki | 2.5 [1], 2.6 [2] |
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