Melanin-concentrating hormone receptor 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	1-[4-(3-Cyanophenyl)cyclohexyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	3-[[(1R)-1-Acetamidospiro[1,2-dihydroindene-3,4'-piperidine]-1'-yl]methyl]carbazole-9-carboxamide	IC50	1.0 [1]
	3-[[(1R)-1-Acetamidospiro[1,2-dihydroindene-3,4'-piperidine]-1'-yl]methyl]carbazole-9-carboxamide	Ki	13.0 [1]
	1-[4-(3-Cyanophenyl)-4-methylcyclohexyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	2-Methoxy-N-(3-morpholin-4-yl-propyl)-4-[3-(3-phenoxy-phenyl)-ureido]-benzamide	IC50	100000.0 [1]
	2-Methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide	IC50	10000.0 [1], 100000.0 [2]
	N-(2-Diethylamino-ethyl)-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide	IC50	100000.0 [1]
	[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy]azetidin-1-yl]methanone	IC50	40000.0 [1]
	1-[4-(3-Cyanophenyl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	3-(3-Chloro-4-fluorophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	2-(2,4-Dichlorophenoxy)-N-[4-methyl-2-(4-methylpiperazino)-6-quinolyl]acetamide	IC50	10.0 [1]
	N-(4-Methyl-2-morpholin-4-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide	IC50	10.0 [1]
	3-(3-Chloro-4-fluorophenyl)-1-[(1R,3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	2-(3,4-Difluorophenyl)-N-(2-fluoroethyl)-N-[3-(6-fluorospiro[1H-furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)propyl]-2-pyrazol-1-ylacetamide	IC50	1000.0 [1]
	1'-[[6-[(Z)-C-(3,4-Difluorophenyl)-N-ethoxycarbonimidoyl]pyridin-3-yl]methyl]-5-methylspiro[3H-furo[3,4-c]pyridine-1,4'-piperidine]-6-one	IC50	10.0 [1]
	AMG-076 free base	IC50	10000.0 [1]
	N-[2-(2,5-Diazabicyclo[2.2.1]heptan-2-yl)-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide	IC50	6.8 [1]
	1-[3-(Spiro[indene-1,4'-piperidine]-1'-ylmethyl)carbazol-9-yl]propan-1-one	IC50	100.0 [1]
	N-[2-(4-Amino-piperidin-1-yl)-4-methyl-quinolin-6-yl]-2-(4-trifluoromethoxy-phenoxy)-acetamide	IC50	4.7 [1]
	3-(Spiro[indene-1,4'-piperidine]-1'-ylmethyl)carbazole-9-carboxamide	IC50	4.0 [1]
	1'-(9H-Carbazol-3-ylmethyl)spiro[indene-1,4'-piperidine]	IC50	100.0 [1]
	(2R)-1'-(9H-Carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-2-ol	IC50	10.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[4-[4-(4-chlorophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-[3-(trifluoromethyl)phenyl]phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(2,5-dichlorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	2-[[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-methylamino]-N-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-[3-(trifluoromethoxy)phenyl]phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-pyrrolidin-1-ylacetamide	Ki	3000.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-[(3R)-3-hydroxypyrrolidin-1-yl]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3-fluorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[4-[4-(4-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-methylamino]acetamide	Ki	3000.0 [1]
	N-[[4-(3-Cyanophenyl)phenyl]methyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-[(3S)-3-hydroxypyrrolidin-1-yl]acetamide	Ki	3000.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]propan-2-yl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-pyrrolidin-1-ylacetamide	Ki	3000.0 [1]
	(E)-N-[4-(Cyclobutylamino)-2-propylquinolin-6-yl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide	IC50	960.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-(4-phenylphenyl)piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	2-[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]oxy-N-(3,5-dichlorophenyl)acetamide	Ki	3000.0 [1]
	N-[[4-(3-Cyanophenyl)phenyl]methyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-pyrrolidin-1-ylacetamide	Ki	3000.0 [1]
	2-[(3R)-3-Acetamidopyrrolidin-1-yl]-N-[2-[4-(3-cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]acetamide	Ki	3000.0 [1]
	1-[(1S,2R,5S)-5-(4-Cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-(3,5-dichlorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea	Ki	3000.0 [1]
	2-[[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]-N-(3,5-difluorophenyl)acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(2-fluorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3-formylphenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	2-[[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]-N-(3,5-dichlorophenyl)acetamide	Ki	3000.0 [1]
	2-[[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-methylamino]-N-(3,5-dichlorophenyl)acetamide	Ki	3000.0 [1]
	2-[[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]-N-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide	Ki	3000.0 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]oxyacetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3-methoxyphenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3,4-dichlorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-3-pyrrolidin-1-ylpropanamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(4-fluorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	2-[[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-methylamino]-N-(3,5-difluorophenyl)acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[4-[4-(2-chlorophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(2,6-dichlorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3,5-dichlorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-[[4-(3-Cyanophenyl)phenyl]methyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-[(3R)-3-hydroxypyrrolidin-1-yl]acetamide	Ki	3000.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-3-[(3S)-3-hydroxypyrrolidin-1-yl]propanamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-3-[(3R)-3-hydroxypyrrolidin-1-yl]propanamide	Ki	3000.0 [1]
	3-(3-Chloro-4-fluorophenyl)-1-[4-(3-cyanophenyl)cyclohex-3-en-1-yl]-1-(2-pyrrolidin-1-ylethyl)urea	Ki	3000.0 [1]
	3-(3-Chloro-4-fluorophenyl)-1-[(3R,6R)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3,5-difluorophenyl)phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-(3-Chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-[4-(trifluoromethyl)phenyl]phenyl]piperidin-4-yl]amino]acetamide	Ki	3000.0 [1]
	N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-methylamino]acetamide	Ki	3000.0 [1]
	N-[2-(Dimethylamino)ethyl]-2-methoxy-4-[(4-phenylbenzoyl)amino]benzamide	IC50	100000.0 [1]
	2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1-yl-quinolin-6-yl)-acetamide	IC50	3.7 [1]
	N-[(1R)-1'-(9H-Carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide	IC50	0.1 [1]
	N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide	IC50	100000.0 [1]
	2-Methoxy-4-[3-(3-phenylamino-phenyl)-ureido]-N-(3-piperidin-1-yl-propyl)-benzamide	IC50	10000.0 [1]
	N,N-Dimethyl-3-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)carbazole-9-carboxamide	IC50	4.0 [1]
	(E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide	IC50	10.0 [1]
	3-[4-[[(5-Chloro-6-fluoro-1H-benzimidazol-2-yl)methylamino]-[1-(cyclopropylmethyl)piperidin-4-yl]methyl]phenyl]benzonitrile	Ki	3000.0 [1]
	(E)-N-[2-[2-Hydroxyethyl(methyl)amino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide	IC50	6.4 [1]
	3-[4-[[(5-Chloro-6-fluoro-1H-benzimidazol-2-yl)methylamino]-piperidin-4-ylmethyl]phenyl]benzonitrile	Ki	3000.0 [1]
	3-[4-[[(5-Chloro-6-fluoro-1H-benzimidazol-2-yl)methylamino]-(1-cyclopentylpiperidin-4-yl)methyl]phenyl]benzonitrile	Ki	3000.0 [1]
	3-[4-[1-(1-Benzylpiperidin-4-yl)-3-(4,6-dichloro-1H-benzimidazol-2-yl)propyl]phenyl]benzonitrile	Ki	3000.0 [1]
	2-(2,4-Dichlorophenoxy)-N-[2-[2-hydroxyethyl(methyl)amino]-4-methylquinolin-6-yl]acetamide	IC50	10.0 [1]
	2-(2,4-Dichlorophenoxy)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]acetamide	IC50	4.5 [1]
	2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-acetamide	IC50	8.7 [1]
	N-[4-Methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide	IC50	6.3 [1]
	N-[2-[(1-Ethylpyrrolidin-2-yl)methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide	IC50	10.0 [1]
	N-[2-(3-Dimethylamino-propylamino)-4-methyl-quinolin-6-yl]-2-(4-trifluoromethoxy-phenoxy)-acetamide	IC50	7.1 [1]
	N-[(5-Chloro-6-oxo-1H-pyridin-3-yl)-(4-fluorophenyl)methyl]-2-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamide	IC50	4600.0 [1]
	N-[2-[4-(3-Cyanophenyl)phenyl]ethyl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-[(3S)-3-hydroxypyrrolidin-1-yl]acetamide	Ki	3000.0 [1]
	(E)-N-[2-[2-(Dimethylamino)ethylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide	IC50	8.4 [1]
	2-[[6-[[2-(2,4-Dichlorophenoxy)acetyl]amino]-4-methylquinolin-2-yl]-methylamino]ethyl acetate	IC50	10.0 [1]
	3-(3-Chloro-4-fluorophenyl)-1-[(1S,3R,6R)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea	Ki	3000.0 [1]
	(Z)-5-(4-(Pyrrolidin-1-ylmethyl)benzylidene)-3-(4-phenoxyphenyl)imidazolidine-2,4-dione	Ki	10000.0 [1]
	4-(1-Benzylpiperidin-4-yl)-4-[4-(3-cyanophenyl)phenyl]-N-(3,4-difluorophenyl)butanamide	Ki	3000.0 [1]
	N-[2-[2-(Dimethylamino)ethyl-methylamino]-3-methylbenzimidazol-5-yl]-2-[4-(trifluoromethyl)phenoxy]acetamide	IC50	30000.0 [1]
	N-[1-(6,7-Dihydro-5H-cyclopenta[f][1,3]benzodioxol-7-yl)piperidin-4-yl]-6-fluoro-4-oxochromene-2-carboxamide	IC50	10000.0 [1]
	3-[1-Acetyl-4-[4-(3-cyanophenyl)phenyl]piperidin-4-yl]-N-(3,4-difluorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]-1-cyclobutylpiperidin-4-yl]-N-(3,4-difluorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-N-(3,4-difluorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-N-(3,5-dichlorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-N-(3,5-difluorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]-1-(cyclopropylmethyl)piperidin-4-yl]-N-(3,4-difluorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]-1-methylsulfonylpiperidin-4-yl]-N-(3,4-difluorophenyl)propanamide	Ki	3000.0 [1]
	3-[4-[4-(3-Cyanophenyl)phenyl]piperidin-4-yl]-N-(3,4-difluorophenyl)propanamide	Ki	3000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Melanin-concentrating hormone receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/melanin-concentrating-hormone-receptor-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Melanin-concentrating hormone receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/melanin-concentrating-hormone-receptor-2-inhibitors-ic50-ki.
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