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Metabotropic glutamate receptor 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
EglumetadIC505.6 [1]
EglumetadKi84.7 [1]
Glutamic acidKi1200.0 [1], 1819.7 [2], 6400.0 [3], 11000.0 [4], 12000.0 [5]
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-AlanineIC502.9 [1], 21.0 [2], 23.0 [3], 200.0 [4]
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-AlanineKi21.0 [1]
CID 6324634IC50400.0 [1], 50000.0 [2]
CID 6324634Ki50000.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC507000.0 [1], 7020.0 [2], 12500.0 [3]
(1R,2S,4R,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi420.0 [1]
alpha-Methyl-4-carboxyphenylglycineIC5050000.0 [1], 340000.0 [2]
alpha-Methyl-4-carboxyphenylglycineKi340000.0 [1]
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acidKi2.7 [1], 14.1 [2], 2000.0 [3]
(2S)-2-Amino-4-phosphonobutanoic acidKi129000.0 [1], 1000000.0 [2]
CID 11158623IC5014.0 [1], 296.0 [2]
2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acidIC503000.0 [1], 18000.0 [2]
2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acidKi18000.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC5012500.0 [1], 15300.0 [2]
(1R,2S,4S,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi1230.0 [1]
Quisqualic acidKi113000.0 [1], 1000000.0 [2]
(RS)-4-Carboxy-3-hydroxyphenylglycineIC5048000.0 [1]
(RS)-4-Carboxy-3-hydroxyphenylglycineKi20000.0 [1]
CID 9886034IC5020.0 [1]
CID 9886034Ki2.2 [1]
(S)-3,5-DihydroxyphenylglycineKi1000000.0 [1]
2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-IC5068.0 [1]
2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-Ki180.0 [1]
3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acidIC50300000.0 [1]
3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acidKi300000.0 [1]
(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acidKi40.6 [1]
3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridineIC5015.0 [1]
3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridineKi15.0 [1]
(S)-(2,4-Dichlorobenzyl)-[1-(5-bromopyrimidin-2-yl)-pyrrolidin-3-yl]-amineIC5012500.0 [1], 17000.0 [2]
1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazoleIC50533.0 [1]
1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazoleKi110.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-3-phenylpropyl)cyclopropane-1-carboxylic acidIC50850.0 [1]
1-Benzyl-APDCIC50300000.0 [1]
1-Benzyl-APDCKi200000.0 [1]
(7E)-7-Hydroxyimino-N-(4-methylphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamideIC501500.0 [1]
(7E)-7-Hydroxyimino-N-(4-methylphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamideKi600.0 [1]
(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-(9H-xanthen-9-ylmethyl)cyclopropane-1-carboxylic acidIC506400.0 [1]
(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-(9H-xanthen-9-ylmethyl)cyclopropane-1-carboxylic acidKi2700.0 [1]
(1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic AcidIC501750.0 [1]
(1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic AcidKi983.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(3-phenylpropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC505540.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(3-phenylpropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi595.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(cyclohexanecarbonylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC5012000.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(cyclohexanecarbonylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi1520.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-[(2-cyclohexylacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC507660.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-[(2-cyclohexylacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi627.0 [1]
(7E)-N-(4-Chlorophenyl)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamideIC50800.0 [1]
(7E)-N-(4-Chlorophenyl)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamideKi1000.0 [1]
(7E)-7-Hydroxyimino-N-(4-methoxyphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamideIC501000.0 [1]
(7E)-7-Hydroxyimino-N-(4-methoxyphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamideKi800.0 [1]
4-[2-Chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]anilino]cyclohexan-1-olKi2.19 [1], 9.33 [2]
4-[2-Chloro-4-[8-chloro-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenoxy]cyclohexan-1-olKi11.48 [1], 32.36 [2]
(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-[2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acidIC50200.0 [1]
(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-[2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acidKi85.0 [1]
Ibotenic acidKi110000.0 [1]
2-Methyl-6-(phenylethynyl)pyridineKi100000.0 [1]
(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acidKi5000.0 [1]
(S)-McpgIC504300.0 [1]
2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acidIC50200.0 [1]
Dcg-IVKi110.0 [1]
AidaKi1000000.0 [1]
L-Homocysteic acidKi300000.0 [1]
(S)-4-((1-Carboxyethyl)amino)benzoic acidIC50339000.0 [1]
(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycineKi490.0 [1]
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acidKi450.0 [1]
CPCCOEtKi100000.0 [1]
4-CarboxyphenylglycineIC50577000.0 [1]
2-Methyl-6-(2-phenylethenyl)pyridineKi100000.0 [1]
6-Methyl-2-(phenylazo)-3-pyridinolKi100000.0 [1]
2,2,2-Trifluoro-N-(4-(2-methoxyphenoxy)phenyl)-N-(pyridin-3-ylmethyl)ethanesulfonamideIC50100000.0 [1]
(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxideKi149.0 [1]
(+)-(1R,2R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2-oxideKi508.0 [1]
L-2-Aminoadipic acidKi35000.0 [1]
Biphenylindanone AKi60.26 [1]
(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycineIC50300000.0 [1]
Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-Ki10000.0 [1]
CID 25125217Ki371.54 [1]
(RS)-PpgKi300000.0 [1]
(S)-4-CarboxyphenylglycineKi577000.0 [1]
13-(Dimethylamino)-5-(4-ethylphenyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-oneIC5010000.0 [1]
4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamideIC5010000.0 [1]
TalaglumetadKi10000.0 [1]
2-Amino-2-(4-phosphonophenyl)propanoic acidKi11000.0 [1]
(S)-2-Amino-5-phosphonopentanoic acidKi205000.0 [1]
CID 10058694Ki3.9 [1]
4-Methylene-L-glutamic acidKi230.0 [1]
[(3R)-3-(Hydroxymethyl)piperidin-1-yl]-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanoneIC5010000.0 [1]
(S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-butyric acidKi23000.0 [1]
DfmtiIC5010000.0 [1]
(2S,4S)-4-Methylglutamic acidKi2000.0 [1]
1-(Cyclopropylmethyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrileKi26.3 [1]
(S)-HiboKi1000000.0 [1]
4-[(S)-Amino(carboxy)methyl]cubane-1-carboxylic acidKi55000.0 [1]
N-Pyridin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amineIC5010000.0 [1]
(RS)-ApicaKi30000.0 [1]
(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycineKi84000.0 [1]
(1r,2s,4r,5r,6r)-2-Amino-4-(1h-1,2,4-Triazol-3-Ylsulfanyl)bicyclo[3.1.0]hexane-2,6-Dicarboxylic AcidKi144.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Metabotropic glutamate receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Metabotropic glutamate receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-2-inhibitors-ic50-ki.
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