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Metabotropic glutamate receptor 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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EglumetadKi125.6 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC50895.0 [1], 1070.0 [2], 7690.0 [3]
(1R,2S,4R,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi138.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC503370.0 [1], 6710.0 [2]
(1R,2S,4S,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi272.0 [1]
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-AlanineIC5010.0 [1], 14.0 [2]
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-AlanineKi14.0 [1]
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acidKi4.6 [1], 5.8 [2], 1040.0 [3]
CID 6324634IC5030000.0 [1]
CID 6324634Ki30000.0 [1]
(1r,2s,4r,5r,6r)-2-Amino-4-(1h-1,2,4-Triazol-3-Ylsulfanyl)bicyclo[3.1.0]hexane-2,6-Dicarboxylic AcidIC502730.0 [1], 25200.0 [2]
(1r,2s,4r,5r,6r)-2-Amino-4-(1h-1,2,4-Triazol-3-Ylsulfanyl)bicyclo[3.1.0]hexane-2,6-Dicarboxylic AcidKi156.0 [1]
(1S,2S,4R,5R,6S)-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC501050.0 [1], 3420.0 [2]
(1S,2S,4R,5R,6S)-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi302.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-(2H-triazol-4-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC502380.0 [1], 5510.0 [2]
(1R,2S,4R,5R,6R)-2-Amino-4-(2H-triazol-4-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi259.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC503100.0 [1], 4260.0 [2]
(1R,2S,4S,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi126.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC50859.0 [1], 12500.0 [2]
(1R,2S,4R,5R,6R)-2-Amino-4-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi157.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-[[5-(difluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC50154.0 [1], 459.0 [2]
(1R,2S,4R,5R,6R)-2-Amino-4-[[5-(difluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi63.2 [1]
Glutamic acidKi57.54 [1], 9000.0 [2]
CID 9886034IC5024.0 [1]
CID 9886034Ki4.5 [1]
(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acidKi4.7 [1]
CID 11158623IC50270.0 [1]
[(3R)-3-(Hydroxymethyl)piperidin-1-yl]-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanoneIC50660.0 [1], 1479.11 [2]
(S)-(2,4-Dichlorobenzyl)-[1-(5-bromopyrimidin-2-yl)-pyrrolidin-3-yl]-amineIC50190.0 [1], 4200.0 [2]
2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acidIC506100.0 [1]
2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acidKi6100.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-3-phenylpropyl)cyclopropane-1-carboxylic acidIC50650.0 [1]
(1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic AcidIC509830.0 [1]
(1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic AcidKi146.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(3-phenylpropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC502050.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(3-phenylpropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi281.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(cyclohexanecarbonylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC509990.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-(cyclohexanecarbonylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi757.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-[(2-cyclohexylacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC5025000.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-[(2-cyclohexylacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi425.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[[5-(difluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC50244.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[[5-(difluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi57.5 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC502350.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi82.7 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC503590.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi79.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC50528.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi56.7 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC503870.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi69.0 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC5094.7 [1]
(1R,2S,4R,5R,6R)-2-Amino-4-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi58.3 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-(2H-triazol-4-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC502790.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-(2H-triazol-4-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi65.1 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidIC50624.0 [1]
(1R,2S,4S,5R,6R)-2-Amino-4-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi43.1 [1]
Quisqualic acidKi40000.0 [1]
2-Methyl-6-(phenylethynyl)pyridineKi100000.0 [1]
2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acidIC5016.0 [1]
(2S)-2-Amino-4-phosphonobutanoic acidKi1000000.0 [1]
(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycineKi440.0 [1]
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acidKi410.0 [1]
2-Methyl-6-(2-phenylethenyl)pyridineKi100000.0 [1]
6-Methyl-2-(phenylazo)-3-pyridinolKi100000.0 [1]
(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxideKi92.0 [1]
(+)-(1R,2R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2-oxideKi447.0 [1]
(RS)-PpgKi200000.0 [1]
TalaglumetadKi10000.0 [1]
CID 10058694Ki7.6 [1]
N-Pyridin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amineIC5010000.0 [1]
1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazoleKi100000.0 [1]
1-Adamantyl-[4-(1,3-thiazol-2-yl)piperazin-1-yl]methanoneIC5030000.0 [1]
N-Methyl-5-(phenylethynyl)pyrimidin-2-amineIC5010000.0 [1]
2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acidKi1000000.0 [1]
(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acidKi52000.0 [1]
(1S,2S)-2-[(1R)-1-Amino-1-carboxy-3,3-diphenylpropyl]cyclopropane-1-carboxylic acidIC50280.0 [1]
(1S,2S,4S,5R,6S)-2,4-Diaminobicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi284.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi511.0 [1]
3,4-Dimethoxy-N-[2-(1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl]benzamideIC5010000.0 [1]
1-Benzyl-APDCIC50300000.0 [1]
(2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glutamic acidIC501000000.0 [1]
(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-[2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acidKi200.0 [1]
N-Pyrimidin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amineIC5010000.0 [1]
(3-Hydroxypiperidin-1-yl)-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanoneIC502454.71 [1]
(1S,2S,4S,5R,6S)-4-Acetamido-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi177.0 [1]
(2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidine-2,4-dicarboxylic acidIC508580.0 [1]
(1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)-cyclopropanecarboxylic acidIC5080.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-2-cyclohexylethyl)cyclopropane-1-carboxylic acidIC501400.0 [1]
(1S,2S)-2-[3-(1-Adamantyl)-1-amino-1-carboxypropyl]cyclopropane-1-carboxylic acidIC50760.0 [1]
(1S,2S)-2-(1-Amino-1-carboxypropyl)cyclopropane-1-carboxylic acidIC502500.0 [1]
(1S,2S)-2-((S)-1-Amino-1-carboxy-3,3-diphenyl-propyl)-cyclopropanecarboxylic acidIC50170.0 [1]
(1S,2S)-2-[1-Amino-1-carboxy-3-(1-methylindol-3-yl)propyl]cyclopropane-1-carboxylic acidIC501200.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-5-phenylpentyl)cyclopropane-1-carboxylic acidIC502800.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-3-thiophen-3-ylpropyl)cyclopropane-1-carboxylic acidIC50570.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-4-phenylbutyl)cyclopropane-1-carboxylic acidIC50550.0 [1]
3-[3-Amino-3-carboxy-3-[(1S,2S)-2-carboxycyclopropyl]propyl]benzoic acidIC5080.0 [1]
(1S,2S)-2-(1-Amino-1-carboxy-3-naphthalen-1-ylpropyl)cyclopropane-1-carboxylic acidIC50470.0 [1]
(1S,2S,4S,5R,6S)-2-Amino-4-benzamidobicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi6.75 [1]
(1R,2R,4S,5S,6R)-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acidKi100000.0 [1]
1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanoneIC5012500.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Metabotropic glutamate receptor 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Metabotropic glutamate receptor 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-3-inhibitors-ic50-ki.
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