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Methionyl-tRNA synthetase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(Z)-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]methyl]azetidine-2-carboxamideIC5070.0 [1], 730.0 [2], 100000.0 [3]
1-(2-Pyridinyl)-5-(2',4'-dichloro-4-biphenylyl)-1H-pyrazole-3-carboxylic acidIC50630.0 [1], 1930.0 [2], 100000.0 [3]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-pyridin-3-yl-N-(2H-tetrazol-5-ylmethyl)pyrazole-3-carboxamideIC50130.0 [1], 3700.0 [2], 13800.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]propyl]azetidine-2-carboxamideIC5018.0 [1], 3510.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]butyl]azetidine-2-carboxamideIC5040.0 [1], 3520.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]propyl]pyrrolidine-2-carboxamideIC50180.0 [1], 1280.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]butyl]pyrrolidine-2-carboxamideIC50760.0 [1], 3110.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]ethyl]pyrrolidine-2-carboxamideIC501670.0 [1], 100000.0 [2]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]butyl]azetidine-2-carboxamideIC5087.0 [1], 100000.0 [2]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]ethyl]pyrrolidine-2-carboxamideIC50340.0 [1], 6630.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]butyl]pyrrolidine-2-carboxamideIC50170.0 [1], 99000.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(Z)-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]methyl]azetidine-2-carboxamideIC50510.0 [1], 1400.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(Z)-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]-phenylmethyl]pyrrolidine-2-carboxamideIC50810.0 [1], 6140.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(Z)-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]-phenylmethyl]pyrrolidine-2-carboxamideIC50430.0 [1], 27400.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(Z)-[2-(2,4-dichlorophenyl)-5-oxo-1,3-oxazol-4-ylidene]methyl]pyrrolidine-2-carboxamideIC50680.0 [1], 14000.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]propyl]pyrrolidine-2-carboxamideIC50850.0 [1], 5930.0 [2], 100000.0 [3]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(1Z)-1-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]propyl]azetidine-2-carboxamideIC50170.0 [1], 99000.0 [2], 100000.0 [3]
1-(2,4-Dichlorophenyl)-5-(2',4'-dichloro-4-biphenylyl)-1H-pyrazole-3-carboxylic acidIC504880.0 [1], 8990.0 [2], 11900.0 [3]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-(2-hydroxyethyl)pyrazole-3-carboxylic acidIC504460.0 [1], 11400.0 [2], 100000.0 [3]
3-[5-[4-(2,4-Dichlorophenyl)phenyl]-3-(tetrazol-1-yl)pyrazol-1-yl]pyridineIC50130.0 [1], 7000.0 [2], 10600.0 [3]
2-[5-[4-(2,4-Dichlorophenyl)phenyl]-3-(tetrazol-1-yl)pyrazol-1-yl]pyridineIC50150.0 [1], 1790.0 [2], 25000.0 [3]
1-(3-Carboxyphenyl)-5-[4-(2,4-dichlorophenyl)phenyl]pyrazole-3-carboxylic acidIC501190.0 [1], 6340.0 [2], 100000.0 [3]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-[4-(trifluoromethoxy)phenyl]pyrazole-3-carboxylic acidIC5047400.0 [1], 100000.0 [2]
(2S)-N-[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(Z)-[2-(4-bromophenyl)-5-oxo-1,3-oxazol-4-ylidene]methyl]pyrrolidine-2-carboxamideIC501100.0 [1], 48000.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-ethylpyrazole-3-carboxylic acidIC501020.0 [1], 46400.0 [2]
1-Benzyl-5-[4-(2,4-dichlorophenyl)phenyl]pyrazole-3-carboxylic acidIC503940.0 [1], 29900.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-(4-methoxyphenyl)pyrazole-3-carboxylic acidIC5010500.0 [1], 100000.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-(2-methoxyphenyl)pyrazole-3-carboxylic acidIC501510.0 [1], 17800.0 [2]
1-(Carboxymethyl)-5-[4-(2,4-dichlorophenyl)phenyl]pyrazole-3-carboxylic acidIC503420.0 [1], 100000.0 [2]
5-Biphenyl-4-yl-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acidIC5040900.0 [1], 44300.0 [2]
1-[5-[4-(2,4-Dichlorophenyl)phenyl]-1-(2-methoxyphenyl)pyrazol-3-yl]tetrazoleIC50530.0 [1], 20000.0 [2]
5-[4-(3-Chloro-4-fluorophenyl)phenyl]-1-(2,4-dichlorophenyl)pyrazole-3-carboxylic acidIC5017200.0 [1], 20900.0 [2]
5-[4-(3-Carboxyphenyl)phenyl]-1-(2,4-dichlorophenyl)pyrazole-3-carboxylic acidIC5040900.0 [1], 41300.0 [2]
1-(2,4-Dichlorophenyl)-5-[4-[4-(trifluoromethyl)phenyl]phenyl]pyrazole-3-carboxylic acidIC5033500.0 [1], 33900.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-(pyridin-4-ylmethyl)pyrazole-3-carboxylic acidIC50500.0 [1], 26200.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-2-(pyridin-3-ylmethyl)pyrazole-3-carboxylic acidIC501090.0 [1], 19900.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-2-(pyridin-2-ylmethyl)pyrazole-3-carboxylic acidIC502680.0 [1], 22300.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-(pyridin-3-ylmethyl)pyrazole-3-carboxylic acidIC50660.0 [1], 100000.0 [2]
1-(2-Pyridinylmethyl)-5-(2',4'-dichloro-4-biphenylyl)-1H-pyrazole-3-carboxylic acidIC501340.0 [1], 42500.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-2-(pyridin-4-ylmethyl)pyrazole-3-carboxylic acidIC50910.0 [1], 17300.0 [2]
2-[[5-[4-(2,4-Dichlorophenyl)phenyl]-1-pyridin-3-ylpyrazole-3-carbonyl]amino]acetic acidIC50300.0 [1], 20000.0 [2]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-pyridin-2-ylpyrazole-3-carboxamideIC502950.0 [1], 100000.0 [2]
1-(3-Pyridinyl)-5-(2',4'-dichloro-4-biphenylyl)-1H-pyrazole-3-carboxylic acidIC50300.0 [1], 47000.0 [2]
1-(2,4-Dichlorophenyl)-5-[4-(4-fluorophenyl)phenyl]pyrazole-3-carboxylic acidIC5041300.0 [1], 43200.0 [2]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC505000.0 [1]
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylsulfanylbutanoyl]sulfamateIC507.0 [1]
2-(3-(3,4-Dichlorobenzylamino)propylamino)quinolin-4(1H)-oneIC50500.0 [1]
[(2R,3S,4R,5S)-5-[(6-Aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC503600.0 [1]
[(2R,3S,4R,5S)-5-[2-(6-Aminopurin-9-yl)ethyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC508300.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[(6-aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5026000.0 [1]
[(2R,3S,4R,5S)-5-[[6-(Benzylamino)purin-9-yl]methyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5016500.0 [1]
2-[3-[(6-Ethyl-8-iodo-1,2,3,4-tetrahydroquinolin-4-yl)amino]propylamino]-1H-quinolin-4-oneIC5012.0 [1]
2-[3-[(6,8-Dibromo-1,2,3,4-tetrahydroquinolin-4-yl)amino]propylamino]-1H-quinolin-4-oneIC501.0 [1]
[(4R)-2-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5039000.0 [1]
[(4S)-2-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5033500.0 [1]
[3-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5058000.0 [1]
3-[4-(2,4-Dichlorophenyl)phenyl]-1H-pyrazole-5-carboxylic acidIC503280.0 [1]
5-[4-(2,4-Dichlorophenyl)phenyl]-1-phenylpyrazole-3-carboxylic acidIC505470.0 [1]
2-[Hydroxy-(3-hydroxy-4-methoxybenzoyl)amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC5072000.0 [1]
2-[(3-Hydroxy-4-methoxybenzoyl)amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC5078000.0 [1]
[(2R,3S,4R,5S)-5-[2-[6-(Benzylamino)purin-9-yl]ethyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5033200.0 [1]
[(2R,3S,4R,5S)-3,4-Dihydroxy-5-[2-(5-phenyltetrazol-2-yl)ethyl]oxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC50256000.0 [1]
2-[[2-(3-Hydroxy-4-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC50163500.0 [1]
2-[Hydroxy-[2-(4-hydroxy-3-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC50128500.0 [1]
[3-(3-Hydroxy-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5047000.0 [1]
2-[[2-(4-Hydroxy-3-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC5094000.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[[6-(benzylamino)purin-9-yl]methyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5063000.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5S)-3,4-dihydroxy-5-[2-(5-phenyltetrazol-2-yl)ethyl]oxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5034000.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[2-(6-aminopurin-9-yl)ethyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5056000.0 [1]
2-[(4-Hydroxy-3-methoxybenzoyl)amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC5060000.0 [1]
2-[Hydroxy-(4-hydroxy-3-methoxybenzoyl)amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC5032500.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5027000.0 [1]
2-[Hydroxy-[2-(3-hydroxy-4-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-4-methylsulfanylbutanoateIC5087000.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5S)-3,4-dihydroxy-5-[(5-phenyltetrazol-2-yl)methyl]oxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5017000.0 [1]
[(2R,3S,4R,5S)-3,4-Dihydroxy-5-[(5-phenyltetrazol-2-yl)methyl]oxolan-2-yl]methyl (2S)-2-amino-4-methylsulfanylbutanoateIC5012200.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[2-[6-(benzylamino)purin-9-yl]ethyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-4-methylsulfanylbutanamideIC5023000.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-hydroxysulfamoyl]-4-methylsulfanylbutanamideIC50106000.0 [1]
[(2R,3S,4R)-3,4-Dihydroxy-5-[2-iodo-6-(methylamino)purin-9-yl]oxolan-2-yl]methyl N-[(2S)-2-amino-4-methylsulfanylbutanoyl]sulfamateIC50191000.0 [1]
[(2R,3S,4R)-5-(6-Amino-2-iodopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylsulfanylbutanoyl]sulfamateIC501200.0 [1]
(2S)-2-Amino-N-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxysulfamoyl]-4-methylsulfanylbutanamideIC5019700.0 [1]
[(2R,3S,4R)-5-(6-Amino-2-ethynylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylsulfanylbutanoyl]sulfamateIC501100.0 [1]
[(2R,3S,4R)-5-(6-Amino-2-hex-1-ynylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylsulfanylbutanoyl]sulfamateIC501900.0 [1]
[(2R,3S,4R)-5-(6-Amino-2-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylsulfanylbutanoyl]sulfamateIC507400.0 [1]
1-{3-[(3,5-Dichlorobenzyl)amino]propyl}-3-PhenylureaIC5010000.0 [1]
1-{3-[(3-Chloro-5-Methoxybenzyl)amino]propyl}-3-PhenylureaIC508348.0 [1]
1-{3-[(3,5-Dichlorobenzyl)amino]propyl}-3-(2-Hydroxyphenyl)ureaIC503720.0 [1]
1-{3-[(3,5-Dichlorobenzyl)amino]propyl}-3-(3-Hydroxyphenyl)ureaIC505430.0 [1]
1-[3-[(3,5-Dichlorophenyl)methylamino]propyl]-3-(3-fluorophenyl)ureaIC504246.0 [1]
1-{3-[(3,5-Dichlorobenzyl)amino]propyl}-3-Thiophen-3-YlureaIC504349.0 [1]
1-{3-[(3-Chloro-5-Methoxybenzyl)amino]propyl}-3-Thiophen-3-YlureaIC506591.0 [1]
1-[3-[(3,5-Dichlorophenyl)methylamino]propyl]-3-thiophen-2-ylureaIC503056.0 [1]
Items per page: 1 - 10 of 91
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References

This online tool may be cited as follows

MLA

"Quest Database™ Methionyl-tRNA synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/methionyl-trna-synthetase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Methionyl-tRNA synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/methionyl-trna-synthetase-inhibitors-ic50-ki.
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