Microsomal triglyceride transfer protein large subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Lomitapide	IC50	0.8 [1], 8.0 [2]
	Dirlotapide	IC50	0.01 [1], 2.7 [2], 2.9 [3]
	Unii-0Z473OO6GB	IC50	0.03 [1], 1.0 [2]
	3-Methyl-N-[(2S)-2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	100.0 [1], 2350.0 [2]
	Methyl N-[(2S)-5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	4.3 [1], 70.0 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-yloxyphenyl)benzoyl]amino]quinoline-6-carboxamide	IC50	0.0 [1], 0.77 [2]
	3-Methyl-N-[(2R)-2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	3.5 [1], 410.0 [2]
	Methyl N-[(2R)-5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	0.9 [1], 70.0 [2]
	9-[4-[2-Methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide	IC50	0.15 [1], 1.0 [2]
	9-[4-[2-Propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide	IC50	0.06 [1], 4.0 [2]
	N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]fluorene-9-carboxamide	IC50	0.24 [1], 5.0 [2]
	9-[4-[5-Methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide	IC50	0.02 [1], 1.0 [2]
	2-[[2-(4-Tert-butylphenyl)benzoyl]amino]-N-[(1S)-2-[(4-fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]quinoline-6-carboxamide	IC50	0.0 [1], 1.2 [2]
	2-[[2-(4-Tert-butylphenyl)benzoyl]amino]-N-[(1S)-2-[(4-fluorophenyl)methylamino]-2-oxo-1-phenylethyl]quinoline-6-carboxamide	IC50	0.0 [1], 1.2 [2]
	N-[(1S)-2-Amino-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide	IC50	0.34 [1], 1.5 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-methylphenyl)benzoyl]amino]quinoline-6-carboxamide	IC50	0.01 [1], 2.2 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]benzoyl]amino]quinoline-6-carboxamide	IC50	0.06 [1], 4.3 [2]
	2-[[2-(4-Tert-butylphenyl)benzoyl]amino]-N-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]quinoline-6-carboxamide	IC50	0.02 [1], 0.56 [2]
	2-[4-[2-[[6-[[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]carbamoyl]quinolin-2-yl]carbamoyl]phenyl]phenoxy]propanoic acid	IC50	0.48 [1], 22.0 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-ylphenyl)benzoyl]amino]quinoline-6-carboxamide	IC50	0.0 [1], 0.6 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]benzoyl]amino]quinoline-6-carboxamide	IC50	0.03 [1], 1.1 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(1-hydroxypropan-2-yloxy)phenyl]benzoyl]amino]quinoline-6-carboxamide	IC50	0.12 [1], 9.4 [2]
	1-Methyl-N-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide	IC50	0.38 [1], 1.8 [2]
	2-[4-[2-[[6-[[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]carbamoyl]quinolin-2-yl]carbamoyl]phenyl]phenyl]-2-methylpropanoic acid	IC50	0.07 [1], 7.5 [2]
	2-[4-[2-[[6-[[(1S)-2-[(4-Fluorophenyl)methylamino]-2-oxo-1-phenylethyl]carbamoyl]quinolin-2-yl]carbamoyl]phenyl]phenyl]-2-methylpropanoic acid	IC50	0.25 [1], 12.0 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]quinoline-6-carboxamide	IC50	0.0 [1], 0.74 [2]
	N-[(1S)-2-(Methylamino)-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-yloxyphenyl)benzoyl]amino]quinoline-6-carboxamide	IC50	0.1 [1], 0.63 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-hydroxyphenyl)benzoyl]amino]quinoline-6-carboxamide	IC50	0.1 [1], 11.0 [2]
	N-[(1S)-2-[(4-Fluorophenyl)methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-yloxyphenyl)benzoyl]amino]quinoline-6-carboxamide	IC50	0.01 [1], 1.21 [2]
	Benzyl N-[2-oxo-2-[4-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]butyl]-1,3,2lambda5-dioxaphosphinan-5-yl]carbamate	IC50	14.0 [1], 210.0 [2]
	Jnj-31020028	IC50	710.0 [1]
	N-[4-[4-[2-(Diethylamino)-2-oxo-1-phenylethyl]piperidin-1-yl]-3-fluorophenyl]-3,5-dimethyl-1,2-oxazole-4-carboxamide	IC50	10000.0 [1]
	9-(4-Dibutoxyphosphorylbutyl)-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide	IC50	22.0 [1]
	N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]propyl]fluorene-9-carboxamide	IC50	10.0 [1]
	9-[4-[2-Propyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide	IC50	2.0 [1]
	2-(4-Chlorophenyl)-N-[7-(methanesulfonamido)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-3-methylbenzamide	IC50	90.0 [1]
	2-(4-Chlorophenyl)-3-methyl-N-[2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]benzamide	IC50	120.0 [1]
	2-(4-Fluorophenyl)-N-[2-(methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methylbenzamide	IC50	170.0 [1]
	N-[(2R)-2-(Methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	34.0 [1]
	Methyl N-[3-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]carbamate	IC50	20.0 [1]
	N-(2-Acetamido-2,3-dihydro-1H-inden-5-yl)-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	80.0 [1]
	N-[(2S)-2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	650.0 [1]
	2-(4-Chlorophenyl)-N-[2-(methanesulfonamidomethyl)-2,3-dihydro-1H-inden-5-yl]-3-methylbenzamide	IC50	500.0 [1]
	Methyl N-[[5-[[2-(4-chlorophenyl)-3-methylbenzoyl]amino]-2,3-dihydro-1H-inden-2-yl]methyl]carbamate	IC50	100.0 [1]
	N-[2-(Benzylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	4800.0 [1]
	N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-cyanophenyl)-3-methylbenzamide	IC50	120.0 [1]
	[(R)-5-[2-[4-(Trifluoromethyl)phenyl]benzoylamino]-2-indanyl]carbamic acid methyl ester	IC50	110.0 [1]
	N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-chlorophenyl)-3-methylbenzamide	IC50	100.0 [1]
	N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-chlorophenyl)-3-methoxybenzamide	IC50	110.0 [1]
	Methyl N-[[5-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]methyl]carbamate	IC50	40.0 [1]
	N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-fluorophenyl)-3-methylbenzamide	IC50	240.0 [1]
	N-[2-(Dimethylcarbamoylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	80.0 [1]
	Methyl N-[(2R)-5-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	90.0 [1]
	Methyl N-[3-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]carbamate	IC50	20.0 [1]
	2-(4-Fluorophenyl)-3-methyl-N-[2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]benzamide	IC50	50.0 [1]
	Methyl 4-[(2S)-5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]piperazine-1-carboxylate	IC50	40.0 [1]
	3,5-Dimethyl-N-[(2R)-2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	20.0 [1]
	2-(4-Chlorophenyl)-N-[2-(methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methylbenzamide	IC50	100.0 [1]
	N-[2-(Methanesulfonamidomethyl)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	150.0 [1]
	N-[7-(Methanesulfonamido)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	80.0 [1]
	Methyl N-[(2S)-5-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	70.0 [1]
	[(S)-5-[2-[4-(Trifluoromethyl)phenyl]benzoylamino]-2-indanyl]carbamic acid methyl ester	IC50	68.0 [1]
	3-Methyl-N-[7-(thiophen-2-ylsulfonylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	140.0 [1]
	2-(4-Chlorophenyl)-N-[2-(methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methoxybenzamide	IC50	70.0 [1]
	Methyl N-[2-[5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]ethyl]carbamate	IC50	70.0 [1]
	N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-phenylbenzamide	IC50	710.0 [1]
	Methyl N-[[5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]methyl]carbamate	IC50	24.0 [1]
	3-Methyl-N-[2-[(thiophen-2-ylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	14.0 [1]
	Methyl N-[3-[[2-(4-chlorophenyl)-3-methylbenzoyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]carbamate	IC50	80.0 [1]
	N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-(4-methylphenyl)benzamide	IC50	93.0 [1]
	2-[1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)carbamoylamino]-2-fluorophenyl]piperidin-4-yl]-N-ethyl-2-phenylacetamide	IC50	10000.0 [1]
	2-[1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)carbamoylamino]-2-fluorophenyl]piperidin-4-yl]-N,N-diethyl-2-phenylacetamide	IC50	10000.0 [1]
	N-[(2S)-2-(Furan-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	150.0 [1]
	3-Methyl-N-[(2S)-2-(thiophen-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	140.0 [1]
	3-Methyl-N-[(2R)-2-(1,3-thiazol-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	0.6 [1]
	Methyl N-[(2S)-5-[[5-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	170.0 [1]
	Methyl N-[5-[[2-(4-chlorophenyl)-3,5-dimethylbenzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	120.0 [1]
	3-Methyl-N-[(2R)-2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	50.0 [1]
	Methyl N-[(2S)-5-[[5-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	410.0 [1]
	Methyl N-[(2S)-5-[[3-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate	IC50	50.0 [1]
	N-[2-Oxo-2-[4-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]butyl]-1,3,2lambda5-dioxaphosphinan-5-yl]-1-phenylpiperidine-2-carboxamide	IC50	9.0 [1]
	Unii-71G1A1S0OG	IC50	5.0 [1]
	N-[(1S)-2-Oxo-1-phenyl-2-(propylamino)ethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamide	IC50	5.53 [1]
	N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamide	IC50	26.8 [1]
	N-[(1S)-2-Oxo-1-phenyl-2-piperidin-1-ylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamide	IC50	29.0 [1]
	N-[(1S)-2-Oxo-1-phenyl-2-pyrrolidin-1-ylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamide	IC50	14.9 [1]
	N-[(1S)-2-[Ethyl(propyl)amino]-2-oxo-1-phenylethyl]-6-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]pyridine-3-carboxamide	IC50	13.29 [1]
	N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide	IC50	3.85 [1]
	3-Methoxy-N-[(1S)-2-oxo-1-phenyl-2-piperidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide	IC50	6.38 [1]
	3-Methyl-N-[(1S)-2-oxo-1-phenyl-2-(propylamino)ethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide	IC50	1.64 [1]
	N-[(1S)-2-Morpholin-4-yl-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamide	IC50	72.7 [1]
	N-[(1S)-2-[Butyl(methyl)amino]-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamide	IC50	85.5 [1]
	N-[4-[2-[[(1S)-2-[Butyl(methyl)amino]-2-oxo-1-phenylethyl]amino]-2-oxoethyl]sulfanylphenyl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	17.27 [1]
	N-[4-[2-Oxo-2-[[(1S)-2-oxo-1-phenyl-2-(propylamino)ethyl]amino]ethyl]sulfanylphenyl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	35.92 [1]
	N-[4-[[2-[[(1S)-2-[Butyl(methyl)amino]-2-oxo-1-phenylethyl]amino]-2-oxoethyl]carbamoyl]phenyl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	100.0 [1]
	N-[4-[[2-Oxo-2-[[(1S)-2-oxo-1-phenyl-2-(propylamino)ethyl]amino]ethyl]carbamoyl]phenyl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	100.0 [1]
	N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]piperidine-4-carboxamide	IC50	69.52 [1]
	N-[[4-[[(1S)-2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]carbamoyl]phenyl]methyl]-2-[4-(trifluoromethyl)phenyl]benzamide	IC50	4.11 [1]
	3-Methoxy-N-[(1S)-2-oxo-1-phenyl-2-pyrrolidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide	IC50	1.75 [1]
	N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide	IC50	3.5 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Microsomal triglyceride transfer protein large subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/microsomal-triglyceride-transfer-protein-large-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ Microsomal triglyceride transfer protein large subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/microsomal-triglyceride-transfer-protein-large-subunit-inhibitors-ic50-ki.
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