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Mineralocorticoid receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DexamethasoneIC5033.0 [1]
DexamethasoneKi0.36 [1], 7.2 [2]
MifepristoneIC501000.0 [1], 1155.0 [2], 6000.0 [3]
MifepristoneKi640.0 [1], 851.0 [2], 10000.0 [3]
EplerenoneIC50135.0 [1], 240.0 [2]
SpironolactoneIC5011.0 [1]
SpironolactoneKi2.32 [1]
PrednisoloneIC5011.0 [1], 18.0 [2], 44.0 [3]
PrednisoloneKi0.29 [1], 37.0 [2]
ProgesteroneIC5014.0 [1], 30.0 [2]
6-((2R,5R)-2-Methyl-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-oneIC5033.0 [1], 44.0 [2], 44.4 [3]
6-((2R,5R)-2-Methyl-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-oneKi6.3 [1]
[4-(2-o-Tolyl-ethyl)-pyridin-2-yl]-ureaIC507.1 [1], 19.0 [2]
FinerenoneIC5016.0 [1], 18.0 [2], 58.0 [3]
6-(1-(4-Fluoro-2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-oneIC5041.0 [1], 43.0 [2]
6-[4-(4-Fluorophenyl)-2-methyl-5-oxo-1,2-dihydropyrrol-3-yl]-8-methyl-4H-1,4-benzoxazin-3-oneIC5043.0 [1], 83.0 [2]
Medroxyprogesterone acetateIC501197.0 [1]
OnapristoneIC50470.0 [1], 1000.0 [2]
Unii-34zku73FU3IC509.0 [1], 9.2 [2]
6-(7-Phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-4H-1,4-benzoxazin-3-oneIC50510.0 [1]
4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamideIC507.94 [1], 130.0 [2]
(R)-N-(3-(1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl)-1H-indol-7-yl)methanesulfonamideIC50306.0 [1]
(R)-N-(3-(1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl)-1H-indol-7-yl)methanesulfonamideKi1.51 [1], 2.25 [2]
(S)-N-(3-(1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl)-1H-indol-7-yl)methanesulfonamideIC5027.2 [1]
(S)-N-(3-(1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl)-1H-indol-7-yl)methanesulfonamideKi0.32 [1], 0.49 [2]
6-((2R,5R)-2-Methyl-5-phenylmorpholino)-2H-benzo[b][1,4]oxazin-3(4H)-oneIC5013.0 [1], 24.0 [2]
(R)-6-(3-Phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-oneIC501181.0 [1], 1969.0 [2], 1970.0 [3]
[4-[2-(2-Methylphenyl)propyl]pyridin-2-yl]ureaIC5011.0 [1], 43.0 [2]
{4-[2-(4-Fluoro-2-methyl-phenyl)-ethyl]-pyridin-2-yl}-ureaIC504.7 [1], 31.0 [2]
[4-(2-p-Tolyl-ethyl)-pyridin-2-yl]-ureaIC50480.0 [1], 2800.0 [2]
[4-[2-(4-Chlorophenyl)pyrazol-3-yl]pyridin-2-yl]ureaIC509.4 [1], 110.0 [2]
[4-(2,2-Diphenylethyl)pyridin-2-yl]ureaIC5013.0 [1], 44.0 [2]
N-[[4-(2,4-Dimethylimidazol-1-yl)phenyl]methyl]-2,5-difluorobenzenesulfonamideIC50556.0 [1], 1311.0 [2]
N-[[4-(2,4-Dimethylimidazol-1-yl)phenyl]methyl]-2,5-difluorobenzenesulfonamideKi113.0 [1]
AldosteroneIC500.3 [1], 9.27 [2]
E-GuggulsteroneIC501000.0 [1]
E-GuggulsteroneKi39.0 [1]
GuggulsteroneIC501880.0 [1]
GuggulsteroneKi37.0 [1]
AsoprisnilIC501600.0 [1]
MebudipineIC50126.0 [1]
EsaxerenoneIC502.4 [1], 1000.0 [2]
ZK-216348IC5038.0 [1], 79.43 [2]
Ethyl (4R)-5-acetyl-2,6-dimethyl-4-(2-methyl-4-oxochromen-8-yl)-1,4-dihydropyridine-3-carboxylateIC5028.0 [1]
Unii-6C9ukz0cyeIC50130.0 [1], 240.0 [2]
(3R,4S)-5,7-Difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-olKi1518.0 [1], 1520.0 [2]
1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1H-indol-2-ylmethyl)-4-methylpentan-2-olIC50380.0 [1], 383.0 [2]
6-(5-Fluoro-2-methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinolineIC502000.0 [1]
5-[(E)-(3-Fluoro-6H-benzo[c][1]benzoxepin-11-ylidene)methyl]-1,3-dihydrobenzimidazol-2-oneKi12.0 [1]
N-(1-(1H-Indol-3-yl)propan-2-yl)-2,4,6-trichlorobenzenesulfonamideIC50130.0 [1]
5-Chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolineKi21.0 [1]
CID 11640164IC50580.0 [1]
N-[(2S)-1-(1H-Indol-3-yl)propan-2-yl]-2,4,6-trimethylbenzenesulfonamideIC50290.0 [1], 1000.0 [2]
4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamideIC501.26 [1], 41.0 [2]
4-(5-Fluoro-2-hydroxyphenyl)-4-methyl-1-(2-methylquinolin-5-ylamino)-2-(trifluoromethyl)-pentan-2-olIC501000.0 [1]
Rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-tolylpropan-1-oneIC5010000.0 [1]
Rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-tolylpropan-1-oneKi10000.0 [1]
Tert-butyl 4-(2-chloro-4-fluorophenyl)-5-cyano-2,6-dimethyl-1,4-dihydropyridine-3-carboxylateIC5059.0 [1]
3-[(7R,8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-7-yl]-6-[(E)-(3-fluoro-6H-benzo[c][1]benzoxepin-11-ylidene)methyl]-1H-benzimidazol-2-oneKi9.0 [1]
4-[(3R)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,4-dihydropyrazol-5-yl]-2-ethoxybenzoic acidIC506.0 [1], 25.6 [2]
4-[(3R)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,4-dihydropyrazol-5-yl]-2-methoxybenzoic acidIC5014.0 [1], 15.2 [2]
6-[7-(3-Fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-4H-1,4-benzoxazin-3-oneIC50310.0 [1]
6-[7-(4-Fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-4H-1,4-benzoxazin-3-oneIC50270.0 [1]
(5R)-N,3,5-Tribenzyl-2,4-dioxo-1,3-oxazolidine-5-carboxamideIC506000.0 [1]
6-[4-(4-Fluorophenyl)-5-methyl-1,2-oxazol-3-yl]-4H-1,4-benzoxazin-3-oneIC50710.0 [1], 1400.0 [2]
N-(4-Fluorophenyl)-3-oxo-N-(pyridin-3-ylmethyl)-4H-1,4-benzoxazine-6-sulfonamideIC5010.0 [1]
N-(4-Fluorophenyl)-3-oxo-N-(pyridin-3-ylmethyl)-4H-1,4-benzoxazine-6-sulfonamideKi10.0 [1]
[6-[2-(2-Methoxyphenyl)ethyl]pyridin-2-yl]ureaIC5025.0 [1], 97.0 [2]
N-[1-[(2S)-Butan-2-yl]-3-(4-cyanophenyl)indol-6-yl]methanesulfonamideIC509800.0 [1]
N-[1-[(2S)-Butan-2-yl]-3-(4-cyanophenyl)indol-6-yl]methanesulfonamideKi1000.0 [1]
N-[3-(4-Cyano-3-methoxyphenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideIC502420.0 [1]
N-[3-(4-Cyano-3-methoxyphenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideKi1390.0 [1]
N-[3-(4-Cyanophenyl)-1-ethylindol-6-yl]methanesulfonamideIC5010000.0 [1]
N-[3-(4-Cyanophenyl)-1-ethylindol-6-yl]methanesulfonamideKi1770.0 [1]
N-[3-(4-Cyanophenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideIC5010000.0 [1]
N-[3-(4-Cyanophenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideKi1490.0 [1]
N-[1-[(2R)-Butan-2-yl]-3-(4-cyanophenyl)indol-6-yl]methanesulfonamideIC5010000.0 [1]
N-[1-[(2R)-Butan-2-yl]-3-(4-cyanophenyl)indol-6-yl]methanesulfonamideKi1440.0 [1]
6-(1-o-Tolyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-oneIC5080.0 [1], 150.0 [2]
8-Fluoro-6-[2-(4-fluoro-2-methylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]-4H-1,4-benzoxazin-3-oneIC5076.0 [1], 85.0 [2]
6-[2-(4-Fluoro-2-methylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]-8-methyl-4H-1,4-benzoxazin-3-oneIC5015.0 [1], 21.0 [2]
6-[5-(4-Fluorophenyl)-1,3-dimethyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-oneIC50110.0 [1], 160.0 [2]
(R)-6-(1-(4-Cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acidIC501.8 [1], 4.5 [2]
N-[3-(4-Cyano-3-fluorophenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideIC508150.0 [1]
N-[3-(4-Cyano-3-fluorophenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideKi849.0 [1]
N-[3-(4-Cyano-3-methylphenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideIC5010000.0 [1]
N-[3-(4-Cyano-3-methylphenyl)-1-propan-2-ylindol-6-yl]methanesulfonamideKi126.0 [1]
N-[3-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-1H-indol-7-yl]methanesulfonamideIC5064.1 [1]
N-[3-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-1H-indol-7-yl]methanesulfonamideKi0.64 [1]
3-[(4-Methoxyphenyl)Phenylmethyl]IndoleIC5010000.0 [1]
3-[(4-Methoxyphenyl)Phenylmethyl]IndoleKi86.8 [1]
N-[3-(4-Cyanophenyl)-1-methylindol-6-yl]methanesulfonamideIC5010000.0 [1]
N-[3-(4-Cyanophenyl)-1-methylindol-6-yl]methanesulfonamideKi4170.0 [1]
6-[(2R,5R)-5-(4-Fluorophenyl)-2-methylmorpholin-4-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-oneIC5039.0 [1], 105.0 [2]
(R)-6-(2,2-Dimethyl-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-oneIC5086.0 [1], 407.0 [2]
2-((2R,5R)-2-Methyl-5-phenylmorpholino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-oneIC50113.0 [1], 266.0 [2]
7-((2R,5R)-2-Methyl-5-phenylmorpholino)-1H-pyrido[3,4-b][1,4]oxazin-2(3H)-oneIC50109.0 [1], 252.0 [2]
2-[(2R,5R)-4-(3-Oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)-5-phenylmorpholin-2-yl]acetonitrileIC5056.0 [1], 98.0 [2]
6-[(2R,5R)-5-(2-Fluorophenyl)-2-methylmorpholin-4-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-oneIC5013.0 [1], 33.0 [2]
6-[(2R,5R)-5-(3-Fluorophenyl)-2-methylmorpholin-4-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-oneIC5019.0 [1], 55.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mineralocorticoid receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/mineralocorticoid-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Mineralocorticoid receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mineralocorticoid-receptor-inhibitors-ic50-ki.
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