Mitogen-activated protein kinase kinase kinase 11 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3,9-Bis((ethylthio)methyl)-K-252a	IC50	6.0 [1], 23.0 [2], 23.1 [3], 64.0 [4]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	724.0 [1]
	6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one	IC50	49.0 [1]
	K252a	IC50	13.0 [1]
	Methyl (15S,16R)-10,23-bis(ethylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	20.0 [1]
	CID 53469448	IC50	1140.0 [1]
	RepSox	IC50	16000.0 [1]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	14.0 [1]
	CID 72547959	IC50	602.0 [1]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-10-one	IC50	1000.0 [1]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-8-one	IC50	1000.0 [1]
	2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile	IC50	10000.0 [1]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21,23-decaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	58.0 [1]
	3,13-Diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-12-one	IC50	87.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	2-Methoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol[2,1-a]pyrrolo[3,4-c]carbazole-5-one	IC50	55.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	CID 46236221	IC50	3.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	5-[1-(Cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine	IC50	10000.0 [1]
	3,13-Diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	40.0 [1]
	2-Isopropoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol[2,1-a]pyrrolo[3,4-c]carbazole-5-one	IC50	65.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-10,23-bis(hydroxymethyl)-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	11.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-10,23-bis(prop-2-enylsulfanylmethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	94.0 [1]
	Methyl (15S,16R,18R)-10,23-bis(butylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	143.0 [1]
	Methyl (15S,16R,18R)-10,23-bis[2-(dimethylamino)ethylsulfanylmethyl]-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	123.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-10,23-bis(methoxymethyl)-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	11.0 [1]
	Methyl (15S,16R,18R)-10,23-bis(ethoxymethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	11.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-10,23-bis(propylsulfanylmethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	56.0 [1]
	3-Oxa-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-14-one	IC50	270.0 [1]
	3,13-Diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Oxa-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-14-one	IC50	171.0 [1]
	3-Oxa-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	1106.0 [1]
	3-(2-Hydroxyethyl)-7-(propan-2-yloxymethyl)-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaen-12-one	IC50	7.0 [1]
	4-Phenyl-2,6-dihydro-1H-pyrrolo[3,4-c]carbazol-3-one	IC50	10000.0 [1]
	4-Phenyl-3,6-dihydro-2H-pyrrolo[3,4-c]carbazol-1-one	IC50	1200.0 [1]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-12-one	IC50	22.0 [1]
	13-Azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	157.0 [1]
	3-Thia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-12-one	IC50	110.0 [1]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione	IC50	12.0 [1]
	3,23-Dithia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3,23-Dithia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	10000.0 [1]
	20-Methoxy-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	274.0 [1]
	20-Propan-2-yloxy-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	159.0 [1]
	3-(2-Hydroxyethyl)-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	1000.0 [1]
	3-(3-Hydroxypropyl)-20-methoxy-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	87.0 [1]
	3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzyl]-benzamide	IC50	10000.0 [1]
	7-Chloro-1-(3,4-dichlorophenyl)-6-methoxy-3,4-dihydroisoquinoline	IC50	10000.0 [1]
	7-Chloro-1-(3-chlorophenyl)-6-methoxy-3,4-dihydroisoquinoline	IC50	10000.0 [1]
	Methyl (15S,16R,18R)-10-(ethylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20,22,24,26-nonaene-16-carboxylate	IC50	21.0 [1]
	Methyl (15S,16R,18R)-23-(ethylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20(25),21,23,26-nonaene-16-carboxylate	IC50	44.0 [1]
	5-[3-(1H-Indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyrimidin-2-amine	IC50	78.0 [1]
	5-[3-(1H-Indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-amine	IC50	19.0 [1]
	5-[5-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine	IC50	7.0 [1]
	5-[5-(3,4,5-Trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-yl]pyrimidine-2-amine	IC50	9.0 [1]
	1-(1H-Indol-5-yl)-6-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one	IC50	40.0 [1]
	5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrrolo[2,3-b]pyridine	IC50	21.0 [1]
	Dlk-IN-1	IC50	10000.0 [1]
	3-Thia-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	26.0 [1]
	13-Azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	277.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-10,23-bis(propan-2-ylsulfanylmethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	31.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 65 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Mitogen-activated protein kinase kinase kinase 11 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-11-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Mitogen-activated protein kinase kinase kinase 11 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-11-inhibitors-ic50-ki.
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