Mitogen-activated protein kinase kinase kinase 14 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	NIK Inhibitor C33	IC50	40.0 [1], 67.0 [2]
	NIK Inhibitor C33	Ki	0.3 [1], 0.47 [2]
	NIK Inhibitor C32	IC50	102.0 [1], 199.0 [2]
	NIK Inhibitor C32	Ki	0.4 [1], 3.0 [2]
	Nik smi1	IC50	34.0 [1], 70.0 [2]
	Nik smi1	Ki	0.23 [1]
	4-{3-[2-Amino-5-(2-Methoxyethoxy)pyrimidin-4-Yl]-1h-Indol-5-Yl}-2-Methylbut-3-Yn-2-Ol	IC50	20.0 [1], 40.0 [2], 70.0 [3]
	9-Fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	IC50	156.0 [1]
	9-Fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	0.3 [1]
	6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazine-2-carboxamide	IC50	170.0 [1]
	6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazine-2-carboxamide	Ki	1.3 [1]
	6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide	IC50	80.0 [1]
	6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide	Ki	0.42 [1]
	4-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrimidine-2-carboxamide	IC50	355.0 [1]
	4-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrimidine-2-carboxamide	Ki	2.0 [1]
	2-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxypyrimidine-4-carboxamide	IC50	69.0 [1]
	2-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxypyrimidine-4-carboxamide	Ki	0.59 [1]
	3-Amino-6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide	IC50	16.0 [1]
	3-Amino-6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide	Ki	0.07 [1]
	3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]isoquinoline-1-carboxamide	IC50	10.0 [1]
	3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]isoquinoline-1-carboxamide	Ki	0.07 [1]
	3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide	IC50	500.0 [1]
	3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide	Ki	4.7 [1]
	1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]-4,5,6,7-tetrahydroindazole-3-carboxamide	IC50	84.0 [1]
	1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]-4,5,6,7-tetrahydroindazole-3-carboxamide	Ki	0.86 [1]
	5-Cyclopropyl-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide	IC50	2100.0 [1]
	5-Cyclopropyl-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide	Ki	16.0 [1]
	5-Amino-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide	IC50	4300.0 [1]
	5-Amino-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide	Ki	9.4 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazolo[3,4-b]pyridine-3-carboxamide	IC50	38.0 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazolo[3,4-b]pyridine-3-carboxamide	Ki	0.23 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-3-carboxamide	IC50	15.0 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-3-carboxamide	Ki	0.18 [1]
	1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide	IC50	20000.0 [1]
	1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide	Ki	28.0 [1]
	1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide	IC50	33.0 [1]
	1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide	Ki	0.08 [1]
	5-Fluoro-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide	IC50	220.0 [1]
	5-Fluoro-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide	Ki	0.17 [1]
	5-Fluoro-1-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide	IC50	39.0 [1]
	5-Fluoro-1-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide	Ki	0.27 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-5-methoxypyrazolo[3,4-b]pyridine-3-carboxamide	IC50	21.0 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-5-methoxypyrazolo[3,4-b]pyridine-3-carboxamide	Ki	0.13 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide	IC50	29.0 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide	Ki	0.23 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxyimidazo[1,5-a]pyridine-3-carboxamide	IC50	4.7 [1]
	1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxyimidazo[1,5-a]pyridine-3-carboxamide	Ki	0.05 [1]
	3-[[4-[(3R)-7-Cyano-3-(hydroxymethyl)-3-methyl-1,2-dihydroindol-5-yl]pyrimidin-2-yl]amino]-N,4-dimethylbenzamide	IC50	1.8 [1], 2.2 [2]
	(3R)-5-[2-[5-Cyano-2-(4-fluoro-1-methylpyrrolidin-3-yl)oxyanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	4.6 [1], 21.4 [2]
	3-[[4-[(3R)-7-Cyano-3-(hydroxymethyl)-3-methyl-1,2-dihydroindol-5-yl]pyrimidin-2-yl]amino]-N-methyl-4-propan-2-yloxybenzamide	IC50	5.5 [1], 19.5 [2]
	(3R)-5-[2-(5-Cyano-4-fluoro-2-methylanilino)pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	1.8 [1], 6.0 [2]
	(3R)-5-[2-[5-Cyano-2-(2-hydroxy-2-methylpropoxy)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	4.1 [1], 25.7 [2]
	(3R)-5-[2-[4-Fluoro-5-(hydroxymethyl)-2-methylanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	2.3 [1], 7.8 [2]
	(3R)-5-[2-[5-Cyano-2-(hydroxymethyl)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	1.3 [1], 6.3 [2]
	(3R)-3-(Hydroxymethyl)-5-[2-[5-(hydroxymethyl)-2-propan-2-yloxyanilino]pyrimidin-4-yl]-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	1.4 [1], 6.6 [2]
	(3R)-5-[2-(5-Cyano-2-cyclopropyloxyanilino)pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	7.4 [1], 11.5 [2]
	(3R)-5-[2-(5-Cyano-2-methylanilino)-5-fluoropyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	1.2 [1], 3.9 [2]
	(3R)-5-[2-[5-Cyano-2-methyl-4-(2-morpholin-4-ylethyl)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	1.3 [1], 1.8 [2]
	7-Ethoxy-3-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide	IC50	380.0 [1]
	7-Ethoxy-3-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide	Ki	5.9 [1]
	(3R)-5-[2-[5-[Dideuterio(hydroxy)methyl]-2-methylanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile	IC50	0.8 [1], 2.2 [2]
	11-Bromo-5,6,7,8-Tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-B]indol-2-Amine	IC50	100.0 [1], 4600.0 [2]
	4-(4-Amino-3,5,12-triazatetracyclo[9.7.0.02,7.013,18]octadeca-1(11),2,4,6,13(18),14,16-heptaen-16-yl)-2-methylbut-3-yn-2-ol	IC50	41.0 [1], 170.0 [2]
	3-Cyclopropyl-9-fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	37.0 [1], 41.0 [2]
	9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	25.0 [1], 35.5 [2]
	3-Cyano-9-fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	172.0 [1], 201.0 [2]
	10-(3-Methyl-3-Oxidanyl-But-1-Ynyl)-5,6-Dihydroimidazo[1,2-D][1,4]benzoxazepine-2-Carboxamide	Ki	310.0 [1], 319.0 [2]
	9-(3-Hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-[1]benzoxepino[5,4-d]thiazole-2-carboxamide	Ki	28.0 [1], 33.0 [2]
	9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	34.0 [1], 36.0 [2]
	4-Hydroxy-9-(3-hydroxy-3-methylbut-1-ynyl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole-2-carboxamide	Ki	93.0 [1], 101.0 [2]
	9-Fluoro-10-[2-(1-hydroxycyclobutyl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	10.0 [1], 20.2 [2]
	9-Fluoro-3-[(2-fluorophenyl)methyl]-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	7.5 [1], 12.0 [2]
	4,4-Difluoro-9-(3-hydroxy-3-methylbut-1-ynyl)-5H-[1]benzoxepino[5,4-d][1,3]thiazole-2-carboxamide	Ki	40.0 [1], 57.0 [2]
	9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-(1H-pyrazol-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	5.4 [1], 7.0 [2]
	9-Fluoro-10-(3-hydroxy-3-pyridazin-3-ylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	3.2 [1], 4.0 [2]
	9-Fluoro-10-[3-hydroxy-3-(1,3-thiazol-2-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	1.5 [1], 2.0 [2]
	10-[4-(Dimethylamino)-3-hydroxy-3-methyl-4-oxobut-1-ynyl]-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	721.0 [1], 986.0 [2]
	9-Fluoro-10-[2-(3-hydroxy-1-methyl-2-oxopiperidin-3-yl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	3.0 [1], 5.0 [2]
	9-Fluoro-10-(4-fluoro-3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	8.0 [1], 8.7 [2]
	9-Fluoro-10-[2-(3-hydroxyoxetan-3-yl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	3600.0 [1], 4282.0 [2]
	9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-[(2-methylpyrazol-3-yl)methyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	7.8 [1], 9.9 [2]
	9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-N,3-N-dimethyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide	Ki	2000.0 [1], 2503.0 [2]
	(6R)-10-(3-Hydroxy-3-methylbut-1-ynyl)-6-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	620.0 [1], 1164.0 [2]
	9-Fluoro-10-[2-[(3S)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	210.0 [1], 405.0 [2]
	9-Fluoro-10-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	0.8 [1], 210.0 [2]
	(6S)-10-(3-Hydroxy-3-methylbut-1-ynyl)-6-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide	Ki	547.0 [1], 620.0 [2]
	9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-N-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide	Ki	2.0 [1], 3.0 [2]
	10-(3-Hydroxy-3-methylbut-1-ynyl)-5,6,7,12-tetrahydro-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide	Ki	20.0 [1], 22.0 [2]
	Staurosporine	IC50	2300.0 [1]
	Plumbagin	IC50	100000.0 [1]
	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide	IC50	100000.0 [1]
	N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide	IC50	100000.0 [1]
	4-(1H-Indol-3-yl)pyrimidin-2-amine	IC50	41000.0 [1]
	Isoquinoline-1,3(2H,4H)-dione	IC50	51000.0 [1]
	CID 11634725	Ki	5000.0 [1]
	3-Methyl-4-phenyl-1H-pyrazol-5-amine	IC50	100000.0 [1]
	4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine	IC50	61100.0 [1]
	4-(Ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione	IC50	50000.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	8400.0 [1]
	4-(2-Methylimidazo[1,2-a]pyridin-3-yl)-2-pyrimidinamine	IC50	80000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Mitogen-activated protein kinase kinase kinase 14 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-14-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Mitogen-activated protein kinase kinase kinase 14 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-14-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan