Mitogen-activated protein kinase kinase kinase 5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	0.69 [1], 37.0 [2], 1000.0 [3]
	Selonsertib	IC50	5.0 [1], 5.01 [2], 6.0 [3]
	Hymenialdisine	IC50	150.0 [1], 7000.0 [2]
	Ethyl 8,15-dioxo-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-16-carboxylate	IC50	3000.0 [1]
	Ethyl 8,15-dioxo-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-16-carboxylate	Ki	500.0 [1]
	4-Tert-Butyl-N-[6-(1h-Imidazol-1-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamide	IC50	14.0 [1]
	2-Fluoro-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide	IC50	50.12 [1], 55.0 [2]
	5-(4-Cyclopropylimidazol-1-yl)-2-fluoro-4-methyl-N-pyridin-2-ylbenzamide	IC50	6000.0 [1], 6309.57 [2]
	3-((1-Methyl-1H-indol-3-yl)methylene)indolin-2-one	IC50	82700.0 [1], 100000.0 [2]
	2-Methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-5-sulfamoylbenzamide	IC50	1.5 [1], 736.0 [2]
	4-Methoxy-1-N-methyl-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamide	IC50	2.4 [1], 272.0 [2]
	4-Methoxy-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamide	IC50	1.0 [1], 94.0 [2]
	2-Methoxy-4-methyl-5-methylsulfonyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide	IC50	4.0 [1], 73.0 [2]
	5-(Ethylsulfonylamino)-2-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide	IC50	0.32 [1], 41.0 [2]
	2-Methoxy-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-5-sulfamoylbenzamide	IC50	0.1 [1], 84.0 [2]
	2-Methoxy-5-methylsulfonyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide	IC50	5.0 [1], 140.0 [2]
	4-Methoxy-6-methyl-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamide	IC50	0.42 [1], 28.0 [2]
	2-[(5Z)-5-[[5-(3,4-Dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid	IC50	650.0 [1]
	2-[(5Z)-5-[[5-(3,4-Dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid	Ki	340.0 [1]
	4-[4-(1-Benzothiophen-4-yloxy)-3-chloroanilino]-N-(2-hydroxyethyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamide	IC50	10000.0 [1]
	N-(3-Chloro-1-cyclopropylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamide	IC50	4.0 [1], 6.0 [2]
	N-(3-Bromo-1-cyclopropylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamide	IC50	2.0 [1], 7.0 [2]
	N-(3-Chloro-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamide	IC50	11.0 [1], 18.0 [2]
	N-(2,3-Dichloro-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamide	IC50	60.0 [1], 146.0 [2]
	N-(3-Chloro-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2S)-1,2-dihydroxypropan-2-yl]benzamide	IC50	9.0 [1], 12.0 [2]
	N-[1-(Cyclopropylmethyl)pyrrolo[3,2-c]pyridin-6-yl]-4-(2-hydroxypropan-2-yl)benzamide	IC50	81.0 [1], 237.0 [2]
	N-[3-Bromo-1-(cyclopropylmethyl)pyrrolo[3,2-c]pyridin-6-yl]-4-(2-hydroxypropan-2-yl)benzamide	IC50	3.0 [1], 62.0 [2]
	N-(3-Bromo-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamide	IC50	3.0 [1], 8.0 [2]
	N-(1-Ethyl-3-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamide	IC50	7.0 [1], 20.0 [2]
	4-[(2R)-1,2-Dihydroxypropan-2-yl]-N-(1-ethylpyrrolo[3,2-c]pyridin-6-yl)benzamide	IC50	55.0 [1], 64.0 [2]
	N-(3-Chloro-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamide	IC50	6.0 [1], 16.0 [2]
	N-(3-Bromo-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamide	IC50	5.0 [1], 10.0 [2]
	N-(3-Bromo-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamide	IC50	7.0 [1], 20.0 [2]
	N-(1-Cyclopropylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamide	IC50	69.0 [1], 214.0 [2]
	4-[(2R)-1,2-Dihydroxypropan-2-yl]-N-(1-ethyl-3-methylpyrrolo[3,2-c]pyridin-6-yl)benzamide	IC50	14.0 [1], 17.0 [2]
	N-(1,3-Dimethylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamide	IC50	19.0 [1], 29.0 [2]
	N-(3-Bromo-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamide	IC50	2.0 [1], 10.0 [2]
	Doramapimod	IC50	30000.0 [1]
	Anilinoquinazoline	IC50	10000.0 [1]
	6-O-Cyclohexylmethyl guanine	IC50	25100.0 [1]
	Tak-285	IC50	10000.0 [1]
	CID 46215815	IC50	27542.0 [1]
	6-Methylthioguanine	IC50	13300.0 [1]
	6-(Piperidin-1-yl)-9H-purine	IC50	17000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	(5Z)-5-(Furan-2-ylmethylidene)-3-pyridin-3-yl-2-sulfanylidene-1,3-thiazolidin-4-one	IC50	33000.0 [1]
	6-Anilinopurine	IC50	10000.0 [1]
	N,N-Dipropyl-9H-purin-6-amine	IC50	25800.0 [1]
	1-Acetyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione	IC50	15000.0 [1]
	N-(5-(Cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide	IC50	93.0 [1]
	1-(2-Hydroxy-ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione	IC50	25000.0 [1]
	5-(3-Pyridylmethylene)rhodanine	IC50	33000.0 [1]
	N-(3-Chlorophenyl)-7H-purin-6-amine	IC50	10000.0 [1]
	2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-one	IC50	1000.0 [1]
	(Z)-2-(5-(Furan-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid	IC50	33000.0 [1]
	3-[(5Z)-5-[[5-(3-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid	IC50	1000.0 [1]
	(5Z)-5-(3-Bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one	IC50	33000.0 [1]
	4-[(5Z)-5-[[5-(3-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid	IC50	350.0 [1]
	(Z)-3-(5-((5-(4-Nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid	IC50	650.0 [1]
	N6-(2,5-Dimethoxyphenyl)-9H-purine-2,6-diamine	IC50	18900.0 [1]
	5-[5-(2-Nitro-phenyl)-furan-2-ylmethylene]-2-thioxo-thiazolidin-4-one	IC50	33000.0 [1]
	4-Tert-Butyl-N-[6-(1h-Pyrazol-4-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamide	IC50	6.3 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-Amine	IC50	5690.0 [1]
	7H-ADENINE, N-(p-FLUOROPHENYL)-	IC50	10000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	1-(Ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione	IC50	10000.0 [1]
	(Z)-2-(5-((5-(2-Fluorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid	IC50	3000.0 [1]
	(Z)-4-(5-((5-(2-Fluorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid	IC50	3000.0 [1]
	(4Z)-5-(4-Chlorophenyl)-1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione	IC50	4200.0 [1]
	(4Z)-5-(4-Tert-butylphenyl)-1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione	IC50	5000.0 [1]
	(4Z)-5-(4-Tert-butylphenyl)-1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dione	IC50	2000.0 [1]
	(4Z)-5-(4-Tert-butylphenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2,3-dione	IC50	4400.0 [1]
	(4Z)-5-(4-Tert-butylphenyl)-1-(6-fluoro-1,3-benzothiazol-2-yl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dione	IC50	7600.0 [1]
	(4Z)-5-(4-Chlorophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2,3-dione	IC50	2900.0 [1]
	(4Z)-4-[(4-Ethoxyphenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2,3-dione	IC50	5500.0 [1]
	(4Z)-4-[(4-Chlorophenyl)-hydroxymethylidene]-1-(4,6-dimethyl-1,3-benzothiazol-2-yl)-5-(4-propan-2-ylphenyl)pyrrolidine-2,3-dione	IC50	6300.0 [1]
	(4Z)-1-(6-Fluoro-1,3-benzothiazol-2-yl)-5-(3-fluorophenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]pyrrolidine-2,3-dione	IC50	17000.0 [1]
	4-[(5Z)-4-Oxo-5-(pyridin-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid	IC50	33000.0 [1]
	2-[(5Z)-5-[[5-(2-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid	IC50	1250.0 [1]
	3-[(5Z)-5-[[5-(2-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid	IC50	750.0 [1]
	2-[4-(Propan-2-Yl)-4h-1,2,4-Triazol-3-Yl]-N-(Pyridin-2-Yl)-1,3-Thiazole-4-Carboxamide	IC50	400.0 [1]
	6-[[(2S)-4-Methylmorpholin-2-yl]methoxy]-2-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-one	IC50	6.31 [1]
	2-[6-[4-[(2R)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-6-propan-2-yloxy-3H-isoindol-1-one	IC50	5.01 [1]
	2-[6-(4-Propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-one	IC50	12.59 [1]
	2-[6-[4-[(2R)-Butan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	50.12 [1]
	2-[6-[4-[(2S)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	31.62 [1]
	3-[3-[6-(3-Oxo-1H-isoindol-2-yl)pyridin-2-yl]-1,2,4-triazol-4-yl]butanenitrile	IC50	19.95 [1]
	2-[6-[4-(1-Fluoropropan-2-yl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	12.59 [1]
	2-[6-[4-(Oxetan-2-ylmethyl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	794.33 [1]
	2-[6-[4-(4-Hydroxybutan-2-yl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	39.81 [1]
	2-[6-[4-[(2S)-Butan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	19.95 [1]
	6-Propan-2-yloxy-2-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-one	IC50	15.85 [1]
	6-(2-Methoxyethoxy)-2-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-one	IC50	7.94 [1]
	2-[6-[4-[(2R)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-6-(2-methoxyethoxy)-3H-isoindol-1-one	IC50	7.94 [1]
	N-[6-(4-Propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide	IC50	398.11 [1]
	2-[6-[4-[(2R)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-one	IC50	10.0 [1]
	4-[(5Z)-5-[[5-(4-Bromophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid	IC50	200.0 [1]
	4-[(5Z)-5-[[5-(2,5-Dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid	IC50	350.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Mitogen-activated protein kinase kinase kinase 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Mitogen-activated protein kinase kinase kinase 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-5-inhibitors-ic50-ki.
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