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Mitogen-activated protein kinase kinase kinase 7 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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5Z-7-OxozeaenolIC508.1 [1]
N-[2-[5-Chloro-2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC502.4 [1], 7.6 [2]
N-[2-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC505.1 [1], 360.0 [2]
StaurosporineIC5035.0 [1], 43.11 [2]
N-[2-[[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamideIC5050.0 [1]
[2-[[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl] prop-2-enoateIC503.3 [1]
N-[2-[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC507.3 [1]
N-[2-[5-Chloro-2-[[1-(difluoromethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC507.0 [1]
N-[2-[2-[4-(4-Methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC50950.0 [1]
N-[2-[6-Amino-5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC502750.0 [1]
N-[2-[5-Chloro-2-[[1-(oxan-4-yl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC504.6 [1]
N-[2-[2-[4-(4-Methylpiperazin-1-yl)anilino]pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]prop-2-enamideIC503010.0 [1]
N-[2-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamideIC5083.0 [1]
[2-[[2-[3-(4-Acetylpiperazin-1-yl)anilino]-5-chloropyrimidin-4-yl]amino]phenyl] prop-2-enoateIC501.7 [1]
N-[2-[5-Methoxy-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC5075.0 [1]
[2-[[5-Chloro-2-(3-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl] prop-2-enoateIC503.2 [1]
N-[2-[[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]propanamideIC501630.0 [1]
N-[2-[5-Cyclopropyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC5057.0 [1]
[2-[[5-Chloro-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl] prop-2-enoateIC504.4 [1]
N-[2-[5-Methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC5092.0 [1]
Tak1 inhibitorIC5018.0 [1], 28.0 [2]
HypothemycinIC5033.0 [1]
5E-7-OxozeaenolIC501300.0 [1]
CID 11634725Ki3000.0 [1]
(4S,9S,10S,12E)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dioneIC502600.0 [1]
N-[3-(4-Methylpiperazine-1-carbonyl)-2-propan-2-yloxyphenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC5011.0 [1]
ZeaenolIC5010000.0 [1]
Methyl 6-bromo-2-[(4-methylsulfonylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylateIC5011000.0 [1]
(4S,10E)-16-Hydroxy-18-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),10,15,17-tetraene-2,12-dioneIC5030000.0 [1]
N-[2-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamideIC5010000.0 [1]
1-[4-[4-[7-Amino-2-(1,2-benzothiazol-7-yl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC5044.0 [1]
1-[4-[4-(7-Amino-2-thieno[2,3-c]pyridin-3-ylfuro[2,3-c]pyridin-4-yl)pyrazol-1-yl]piperidin-1-yl]ethanoneIC50110.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-[6-(Hydroxymethyl)-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi1300.0 [1]
N-[1-[4-(Hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi130.0 [1]
N-[5-(2,2-Dimethylpropanoylamino)-1-[4-(hydroxymethyl)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi2500.0 [1]
3-Nitro-N-[1-Phenyl-5-(Piperidin-1-Ylmethyl)-1h-Benzimidazol-2-Yl]benzamideKi800.0 [1]
N-[1-(4-Hydroxycyclohexyl)-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-nitrobenzamideKi15.0 [1]
N-[1-Phenyl-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi2500.0 [1]
N-[1-[4-(Hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-nitrobenzamideKi30.0 [1]
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),16,18-triene-8,14-dioneIC5030000.0 [1]
(2E,5S,9S,11Z,14S)-18-Hydroxy-20-methoxy-7,7,14-trimethyl-6,8,15-trioxatricyclo[15.4.0.05,9]henicosa-1(17),2,11,18,20-pentaene-10,16-dioneIC50380.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2700.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi4000.0 [1]
(2R,4R,6S,7S,9E,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dioneIC50990.0 [1]
(1S,3E,13S,18S)-9,18-Dihydroxy-7-methoxy-13-methyl-12,19-dioxatricyclo[13.3.1.05,10]nonadeca-3,5,7-triene-11,17-dioneIC5030000.0 [1]
(4S,6Z,9S,10S,12E)-15,15-Difluoro-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,16-tetraene-2,8-dioneIC5077.0 [1]
(4S,6Z,9S,10S,12E)-15-Bromo-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dioneIC50360.0 [1]
(4S,6Z,9S,10S,12E)-17-Bromo-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(18),6,12,14,16-pentaene-2,8-dioneIC502600.0 [1]
(4S,6Z,9S,10S,12E)-15,17-Dibromo-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dioneIC508900.0 [1]
Methyl 2-[(1E,4S,5S,7Z,9E)-4,5-dihydroxy-6-oxoundeca-1,7,9-trienyl]-4,6-dimethoxybenzoateIC5030000.0 [1]
N-[4-[[2-[4-(4-Methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamideIC5034.0 [1]
N-[2-Methoxy-4-[3-(4-methylpiperazin-1-yl)propylcarbamoyl]phenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC50260.0 [1]
N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC501300.0 [1]
N-[2-Methoxy-4-(4-methylpiperazine-1-carbonyl)phenyl]thieno[3,2-d]pyrimidine-7-carboxamideIC501600.0 [1]
(1S,2S,4R,6R,7S,11R,12S,13R,16R,18R,19S,22R)-7,19-Dihydroxy-11,22-dimethyl-5,10,17,21-tetraoxaheptacyclo[11.7.2.02,8.02,12.04,6.014,20.016,18]docosa-8,14(20)-diene-3,15-dioneIC5020000.0 [1]
2-Chloro-N-[2-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamideIC5025.0 [1]
N-[5-Acetamido-2-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideIC501640.0 [1]
[2-[[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl] prop-2-enoateIC50342.0 [1]
N-[4-(4-Methylpiperazine-1-carbonyl)-2-phenylphenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC502.3 [1]
N-[2-Methoxy-4-[3-(4-methylpiperazin-1-yl)propylcarbamoyl]phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC5013.0 [1]
N-[2-Methyl-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC5041.0 [1]
N-[2-Cyclohexyl-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC506.7 [1]
N-[2-Chloro-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC505.8 [1]
N-[2-Methoxy-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC5015.0 [1]
1-[4-[4-[7-Amino-2-(4-hydroxyphenyl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC50500.0 [1]
N-[4-(4-Methylpiperazine-1-carbonyl)-2-propan-2-ylphenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC503.5 [1]
N-[2-Fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC50220.0 [1]
N-[2-Bromo-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC507.3 [1]
N-[2-(1-Fluoroethoxy)-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC503.0 [1]
N-[2-(1,1,1,3,3,3-Hexafluoropropan-2-yloxy)-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC505.2 [1]
N-[2-(Dimethylamino)-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC505.0 [1]
N-[2-[Ethyl(methyl)amino]-4-(4-methylpiperazine-1-carbonyl)phenyl]-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamideIC509.3 [1]
3-[(3S)-3-Aminopyrrolidine-1-carbonyl]-5,10-dihydroxy-2-methylnaphtho[2,3-f][1]benzofuran-4,11-dione;methanesulfonic acidIC505000.0 [1]
N-[5-Acetamido-2-[[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamideIC501640.0 [1]
2-Chloro-N-[2-[[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]acetamideIC5025.0 [1]
N-[2-[5-Chloro-2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]propanamideIC501230.0 [1]
5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[4-[4-[[5-chloro-4-[2-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethyl]pentanamideIC5033.0 [1]
N-[1-[4-(2-Hydroxyethyl)phenyl]-5-(piperidin-1-ylmethyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamideKi700.0 [1]
N-[5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideIC5010000.0 [1]
4-[[3-[3-(Trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]amino]cyclohexan-1-olKi4000.0 [1]
N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamideKi860.0 [1]
1-[4-[4-[7-Amino-2-(1H-pyrazol-4-yl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC509100.0 [1]
1-[4-[4-[7-Amino-2-(3-methylsulfonylphenyl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC501100.0 [1]
1-[4-[4-[7-Amino-2-(3-nitrophenyl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC50200.0 [1]
1-[4-[4-[7-Amino-2-(4-methylsulfanylphenyl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC505200.0 [1]
3-[4-[1-(1-Acetylpiperidin-4-yl)pyrazol-4-yl]-7-aminofuro[2,3-c]pyridin-2-yl]benzamideIC503100.0 [1]
1-[4-[4-[7-Amino-2-[3-(trifluoromethoxy)phenyl]furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC501800.0 [1]
1-[4-[4-[7-Amino-2-[4-(trifluoromethoxy)phenyl]furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC508000.0 [1]
1-[4-[4-[7-Amino-2-[3-(aminomethyl)phenyl]furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC504000.0 [1]
1-[4-[4-[7-Amino-2-[3-(2-methoxyethoxy)phenyl]furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC502700.0 [1]
1-[4-[4-[7-Amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC5012.0 [1]
1-[4-[4-[7-Amino-2-(1,3-benzothiazol-7-yl)furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC5010.0 [1]
5-(Hydroxymethyl)-8-(1h-Pyrrol-2-Yl)-2h-[1,2,4]triazolo[4,3-A]quinolin-1-OneIC50650.0 [1]
2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamideIC5010000.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC5010000.0 [1]
1-[4-[4-[7-Amino-2-[2-(hydroxymethyl)phenyl]furo[2,3-c]pyridin-4-yl]pyrazol-1-yl]piperidin-1-yl]ethanoneIC501500.0 [1]
2-Thieno[2,3-c]pyridin-3-yl-4-(1,3,5-trimethylpyrazol-4-yl)furo[2,3-c]pyridin-7-amineIC504400.0 [1]
2-[4-[1-(1-Acetylpiperidin-4-yl)pyrazol-4-yl]-7-aminofuro[2,3-c]pyridin-2-yl]benzamideIC504500.0 [1]
1-[4-[4-(7-Amino-2-phenylfuro[2,3-c]pyridin-4-yl)pyrazol-1-yl]piperidin-1-yl]ethanoneIC50520.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mitogen-activated protein kinase kinase kinase 7 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-7-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Mitogen-activated protein kinase kinase kinase 7 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-7-inhibitors-ic50-ki.
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