Mitogen-activated protein kinase kinase kinase 9 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3,9-Bis((ethylthio)methyl)-K-252a	IC50	1.0 [1], 38.0 [2], 72.0 [3]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	1106.0 [1]
	2-Methoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol[2,1-a]pyrrolo[3,4-c]carbazole-5-one	IC50	103.0 [1], 127.0 [2]
	2-Isopropoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol[2,1-a]pyrrolo[3,4-c]carbazole-5-one	IC50	26.0 [1], 33.0 [2]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-12-one	IC50	46.0 [1], 274.0 [2]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione	IC50	22.0 [1], 90.0 [2]
	20-Propan-2-yloxy-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	66.0 [1], 196.0 [2]
	20-Cyclopentyloxy-3-(2-hydroxyethyl)-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	49.0 [1], 345.0 [2]
	6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one	IC50	138.0 [1]
	K252a	IC50	22.0 [1]
	Doramapimod	IC50	30000.0 [1]
	CID 53469448	IC50	1578.0 [1]
	Apitolisib	IC50	232.0 [1]
	CID 44462758	IC50	60.0 [1]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	19.0 [1]
	CID 58539301	IC50	2100.0 [1]
	Gne-493	IC50	591.0 [1]
	CID 59604787	IC50	10000.0 [1]
	CID 72547959	IC50	67.8 [1]
	2-(2-(2-Amino-4-methylpyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol	IC50	1000.0 [1]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-10-one	IC50	1000.0 [1]
	9,19-Diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13,15,17-hexaen-8-one	IC50	1000.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	1667.0 [1]
	2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile	IC50	10000.0 [1]
	3,13-Diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17,19,21,23-decaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	68.0 [1]
	3,13-Diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-12-one	IC50	167.0 [1]
	Ripk1-IN-7	IC50	52.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	CID 59627005	IC50	44.3 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	CID 71553154	IC50	160.0 [1]
	8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	370.0 [1]
	1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	10000.0 [1]
	5-[1-(Cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine	IC50	3500.0 [1]
	3,13-Diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	69.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-10,23-bis(hydroxymethyl)-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	15.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-10,23-bis(prop-2-enylsulfanylmethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	162.0 [1]
	Methyl (15S,16R,18R)-10,23-bis(butylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	303.0 [1]
	Methyl (15S,16R,18R)-10,23-bis[2-(dimethylamino)ethylsulfanylmethyl]-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	360.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-10,23-bis(methoxymethyl)-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	16.0 [1]
	Methyl (15S,16R,18R)-10,23-bis(ethoxymethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	19.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-10,23-bis(propylsulfanylmethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	90.0 [1]
	3-Oxa-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-14-one	IC50	308.0 [1]
	3,13-Diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Oxa-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-14-one	IC50	1795.0 [1]
	6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamide	IC50	10000.0 [1]
	3-Oxa-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	10000.0 [1]
	3-(2-Hydroxyethyl)-7-(propan-2-yloxymethyl)-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaen-12-one	IC50	13.0 [1]
	4-Phenyl-2,6-dihydro-1H-pyrrolo[3,4-c]carbazol-3-one	IC50	10000.0 [1]
	4-Phenyl-3,6-dihydro-2H-pyrrolo[3,4-c]carbazol-1-one	IC50	2900.0 [1]
	13-Azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3-Thia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-14-one	IC50	482.0 [1]
	3-Thia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4,6,8,11(15),17,19,21-nonaen-12-one	IC50	615.0 [1]
	3,23-Dithia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	300.0 [1]
	3,23-Dithia-13-azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	10000.0 [1]
	4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-ium	IC50	10000.0 [1]
	20-Methoxy-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	188.0 [1]
	3-(3-Hydroxypropyl)-20-methoxy-3,13-diazahexacyclo[14.8.0.02,10.04,9.011,15.017,22]tetracosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-14-one	IC50	101.0 [1]
	Methyl (15S,16R,18R)-10-(ethylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20,22,24,26-nonaene-16-carboxylate	IC50	28.0 [1]
	Methyl (15S,16R,18R)-23-(ethylsulfanylmethyl)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20(25),21,23,26-nonaene-16-carboxylate	IC50	43.0 [1]
	3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-5-[[(4-methylsulfonylphenyl)methylamino]methyl]benzoic acid	IC50	5000.0 [1]
	5-[[[(2S)-2,4-Diamino-4-oxobutanoyl]amino]methyl]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid	IC50	30000.0 [1]
	3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-5-[(E)-[[5-(hydroxymethyl)furan-2-carbonyl]hydrazinylidene]methyl]benzoic acid	IC50	4000.0 [1]
	5-[(E)-[[2-(4-Chlorophenyl)sulfonylacetyl]hydrazinylidene]methyl]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid	IC50	7000.0 [1]
	(2r)-N-[4-[2-[(4-Morpholin-4-Ylphenyl)amino]pyrimidin-4-Yl]phenyl]pyrrolidine-2-Carboxamide	IC50	370.0 [1]
	4-[[(3S,4R)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	IC50	51.0 [1]
	2-(3,5-Dichloroanilino)-4-[[4-(dimethylamino)cyclohexyl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide	IC50	12230.0 [1]
	2-(3,5-Dichloroanilino)-4-[[(3R,4S)-4-hydroxyoxolan-3-yl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide	IC50	13430.0 [1]
	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]urea	IC50	10000.0 [1]
	Dlk-IN-1	IC50	5920.0 [1]
	3-Thia-13,23-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	111.0 [1]
	13-Azahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	1415.0 [1]
	Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-10,23-bis(propan-2-ylsulfanylmethyl)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8(13),9,11,20(25),21,23,26-nonaene-16-carboxylate	IC50	45.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 76 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Mitogen-activated protein kinase kinase kinase 9 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-9-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Mitogen-activated protein kinase kinase kinase 9 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-9-inhibitors-ic50-ki.
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