Mitogen-activated protein kinase kinase kinase kinase 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Bosutinib	IC50	9.9 [1]
	Pluripotin	IC50	5.0 [1]
	CID 44219749	IC50	50000.0 [1]
	CID 11478363	IC50	8.0 [1]
	CID 59604787	IC50	10000.0 [1]
	(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	60.0 [1]
	N-[3-(7-Amino-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	28.0 [1]
	7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrile	Ki	6516.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	Ripk1-IN-7	IC50	387.0 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	115.0 [1]
	N-(3-(2-(Pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide	IC50	50000.0 [1]
	CID 27666048	IC50	100000.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	3-[7-[4-[(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol	IC50	4100.0 [1]
	N-[3-(7-Anilino-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	47.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	3000.0 [1]
	1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	10000.0 [1]
	N-[3-[7-(Cyclopropylamino)-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	42.0 [1]
	N-[3-[7-[4-(4-Ethylpiperazin-1-yl)anilino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	8.0 [1]
	N-[3-[7-(2-Hydroxyethylamino)-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	33.0 [1]
	N-[3-[7-[[6-(4-Ethylpiperazin-1-yl)pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	7.0 [1]
	N-[4-Methyl-3-[1-methyl-7-[(1-methylpyrazol-4-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide	IC50	6.0 [1]
	N-[3-[7-[[6-(4-Acetylpiperazin-1-yl)pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	1.0 [1]
	5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one	IC50	2940.0 [1]
	N-[4-Methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-4-pyrrol-1-yl-3-(trifluoromethyl)benzamide	IC50	24.0 [1]
	3-(4-Methylimidazol-1-yl)-N-[4-methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-5-(trifluoromethyl)benzamide	IC50	27.0 [1]
	N-[4-Methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)benzamide	IC50	10.0 [1]
	4-Methyl-N-[4-methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide	IC50	39.0 [1]
	N-[3-[1-Cyclopropyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-4-methyl-3-(trifluoromethyl)benzamide	IC50	63.0 [1]
	N-[4-Methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]benzamide	IC50	1080.0 [1]
	4-[[3-(Dimethylamino)pyrrolidin-1-yl]methyl]-N-[3-[7-[[6-(4-ethylpiperazine-1-carbonyl)pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	14.0 [1]
	4-[[3-(Dimethylamino)pyrrolidin-1-yl]methyl]-N-[3-[7-[(2,5-dimethylpyrazol-3-yl)amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	17.0 [1]
	N-[3-[1-Cyclohexyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-4-methyl-3-(trifluoromethyl)benzamide	IC50	497.0 [1]
	N-[4-Methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-morpholin-4-yl-5-(trifluoromethyl)benzamide	IC50	45.0 [1]
	4-Methyl-N-[4-methyl-3-[7-[(6-methylpyridin-3-yl)amino]-2-oxo-1-phenyl-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide	IC50	55.0 [1]
	N-[3-[7-[[6-(4-Acetylpiperazin-1-yl)pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-4-[[3-(dimethylamino)pyrrolidin-1-yl]methyl]-3-(trifluoromethyl)benzamide	IC50	16.0 [1]
	4-[[3-(Dimethylamino)pyrrolidin-1-yl]methyl]-N-[4-methyl-3-[1-methyl-7-[(1-methylpyrazol-4-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide	IC50	8.0 [1]
	N-[3-[1-Ethyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-4-methyl-3-(trifluoromethyl)benzamide	IC50	34.0 [1]
	N-[4-Methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide	IC50	5.0 [1]
	3-(4-Hydroxypiperidin-1-yl)-N-[4-methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-5-(trifluoromethyl)benzamide	IC50	72.0 [1]
	N-[3-[7-[[6-(4-Ethylpiperazine-1-carbonyl)pyridin-3-yl]amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	2.0 [1]
	N-[3-[1-Benzyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-4-methyl-3-(trifluoromethyl)benzamide	IC50	165.0 [1]
	4-[[3-(Dimethylamino)pyrrolidin-1-yl]methyl]-N-[4-methyl-3-[1-methyl-7-[(6-methylpyridin-3-yl)amino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]phenyl]-3-(trifluoromethyl)benzamide	IC50	2.0 [1]
	5-[(E)-4-[(3R)-3-Aminopiperidin-1-yl]but-1-enyl]-4-[(4-methyl-1H-indol-5-yl)amino]pyridine-3-carbonitrile	IC50	2600.0 [1]
	N-(2-Hydroxyethyl)-4-[3-[(Z)-(4-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-1-methylpyrrolo[2,3-b]pyridin-4-yl]benzamide	IC50	50000.0 [1]
	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	IC50	50000.0 [1]
	Tert-butyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate	IC50	50000.0 [1]
	Atropisomer 1	Ki	340.0 [1]
	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	IC50	1300.0 [1]
	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	IC50	50000.0 [1]
	CID 46179972	IC50	24.0 [1]
	1-[4-[4-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-(oxan-4-yl)-1,3,5-triazin-2-yl]phenyl]-3-[4-(4-propan-2-ylpiperazine-1-carbonyl)phenyl]urea	IC50	50000.0 [1]
	N-[3-[7-(Cyclohexylamino)-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	925.0 [1]
	2-{3-[3-(Piperidin-4-Yl)propoxy]phenyl}-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamide	IC50	5000.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	2500.0 [1]
	2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	4760.0 [1]
	N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-Diamine	IC50	6240.0 [1]
	2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	1570.0 [1]
	(2R)-N-[5-(6-Aminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]-4,4,4-trifluoro-2-methylbutanamide	IC50	9700.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 62 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Mitogen-activated protein kinase kinase kinase kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-kinase-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Mitogen-activated protein kinase kinase kinase kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-kinase-2-inhibitors-ic50-ki.
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