Mitogen-activated protein kinase kinase kinase kinase 4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-[4-(4-Chlorophenyl)pyrazol-1-yl]benzamide	IC50	248.0 [1], 10000.0 [2], 30000.0 [3]
	4-[5-(4-Cyclopropyloxyphenyl)pyridin-3-yl]benzamide	IC50	48.0 [1], 6200.0 [2], 9800.0 [3]
	4-[5-(4-Chlorophenyl)-1,3-Oxazol-2-Yl]benzamide	IC50	94.0 [1], 6300.0 [2], 10000.0 [3]
	5-(6-Aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine	IC50	3.7 [1], 160.0 [2]
	6-(3-Fluorophenyl)quinazolin-4-amine	IC50	58.0 [1]
	4-{6-Amino-5-[4-(Methylsulfonyl)phenyl]pyridin-3-Yl}phenol	IC50	21.0 [1], 2900.0 [2]
	4-[5-(4-Methoxyphenyl)pyridin-3-yl]benzamide	IC50	45.0 [1], 600.0 [2]
	4-[6-Amino-5-(4-methylsulfonylphenyl)pyridin-3-yl]benzamide	IC50	64.0 [1], 4200.0 [2]
	5-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]-1H-pyridin-2-one	IC50	96.0 [1], 2900.0 [2]
	4-[5-(4-Chlorophenyl)pyridin-3-yl]benzamide	IC50	46.0 [1], 7500.0 [2]
	4-[1-(4-Chlorophenyl)imidazol-4-yl]benzamide	IC50	270.0 [1], 30000.0 [2]
	4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]-1H-pyridin-2-one	IC50	20.0 [1], 590.0 [2]
	4-[4-(4-Chlorophenyl)pyridin-2-yl]benzamide	IC50	1722.0 [1], 30000.0 [2]
	Map4K4-IN-3	IC50	14.9 [1], 470.0 [2]
	4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]benzamide	IC50	13.0 [1], 360.0 [2]
	4-[4-(4-Chlorophenyl)pyrimidin-2-yl]benzamide	IC50	861.0 [1], 30000.0 [2]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	8-Amino-N-[1-(Cyclopropylcarbonyl)azetidin-3-Yl]-2-(3-Fluorophenyl)-1,7-Naphthyridine-5-Carboxamide	IC50	3.7 [1]
	6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one	Ki	812.4 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	892.0 [1]
	CID 27666048	IC50	100000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	CID 71553154	IC50	18.0 [1]
	8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	1600.0 [1]
	1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	10000.0 [1]
	(13R)-11-(4-Bromophenyl)-13-methyl-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one	IC50	100000.0 [1]
	6-(3-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine	IC50	17.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	1000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	1000.0 [1]
	N-Pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	1600.0 [1]
	6-Bromo-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	150.0 [1]
	Ethyl 4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate	IC50	70.0 [1]
	4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carbonitrile	IC50	710.0 [1]
	[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanol	IC50	160.0 [1]
	2-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]propan-2-ol	IC50	840.0 [1]
	4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide	IC50	300.0 [1]
	N-Ethyl-4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide	IC50	640.0 [1]
	Azetidin-1-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanone	IC50	130.0 [1]
	Morpholin-4-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanone	IC50	180.0 [1]
	Furan-3-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanone	IC50	10.0 [1]
	[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-(2H-tetrazol-5-yl)methanone	IC50	70.0 [1]
	1H-Pyrazol-4-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanone	IC50	10.0 [1]
	6-(2-Fluorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	11000.0 [1]
	6-(2-Methylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	19000.0 [1]
	6-(2-Chlorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	37000.0 [1]
	6-(3-Methylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	7000.0 [1]
	6-(3-Chlorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	23000.0 [1]
	[3-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]methanol	IC50	3000.0 [1]
	6-(4-Fluorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	10000.0 [1]
	[4-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]methanol	IC50	6000.0 [1]
	6-[4-[(Dimethylamino)methyl]phenyl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	1000.0 [1]
	6-(4-Ethylsulfonylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	2000.0 [1]
	N-Methyl-4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]benzenesulfonamide	IC50	2000.0 [1]
	6-[4-(4-Methylpiperazin-1-yl)phenyl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	1000.0 [1]
	6-(4-Morpholin-4-ylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	2000.0 [1]
	6-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	2000.0 [1]
	6-(6-Morpholin-4-ylpyridin-3-yl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	2000.0 [1]
	6-[4-[1-(2-Morpholin-4-ylethyl)pyrazol-4-yl]phenyl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine	IC50	6000.0 [1]
	2-[4-[4-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]ethanol	IC50	3000.0 [1]
	2-Methyl-1-[4-[4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]propan-2-ol	IC50	5000.0 [1]
	N-Methyl-2-[4-[4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]acetamide	IC50	10000.0 [1]
	N,2-Dimethyl-2-[4-[4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]propanamide	IC50	8000.0 [1]
	3-(4-Chlorophenyl)-5-phenylpyridin-2-amine	IC50	84.0 [1]
	N-[4-[(4-Phenylpiperazin-1-yl)methyl]phenyl]-1H-indazole-3-carboxamide	IC50	410.0 [1]
	4-[5-(4-Chlorophenyl)-1-methylimidazol-2-yl]benzamide	IC50	1509.0 [1]
	(13S)-13-Methyl-11-(4-phenylphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one	IC50	100000.0 [1]
	N-[4-[(13S)-13-Methyl-14-oxo-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-11-yl]phenyl]acetamide	IC50	100000.0 [1]
	(13S)-11-(4-Bromophenyl)-13-propan-2-yl-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one	IC50	44000.0 [1]
	(13S)-11-(4-Bromophenyl)-13-[(2-methylpropan-2-yl)oxymethyl]-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one	IC50	5600.0 [1]
	(13S)-11-(2,4-Dichlorophenyl)-13-methyl-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-one	IC50	100000.0 [1]
	8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-one	Ki	1000.0 [1]
	5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one	IC50	10000.0 [1]
	N-[(Pyridin-2-Yl)methyl]-4-[4-(Pyridin-4-Yl)-1h-Pyrazol-1-Yl]benzamide	IC50	5000.0 [1]
	4-[1-Ethynyl-4-(4-fluorophenyl)-5-pyridin-4-ylimidazol-2-yl]but-3-yn-1-ol	IC50	4200.0 [1]
	4-Amino-6-(4-fluorophenyl)-quinazoline	IC50	381.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	1000.0 [1]
	2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	10000.0 [1]
	N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-Diamine	IC50	9430.0 [1]
	2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	10000.0 [1]
	6-(3-Aminophenyl)quinazolin-4-amine	IC50	189.0 [1]
	2-(3,5-Dichloroanilino)-4-[[4-(dimethylamino)cyclohexyl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide	IC50	120.0 [1]
	2-(3,5-Dichloroanilino)-4-[[(3R,4S)-4-hydroxyoxolan-3-yl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide	IC50	2480.0 [1]
	CID 71657853	IC50	1.4 [1]
	1-Amino-7-(3-fluorophenyl)isoquinoline-4-carboxamide	IC50	18.0 [1]
	1-Amino-N-(cyanomethyl)-7-(3-fluorophenyl)isoquinoline-4-carboxamide	IC50	46.0 [1]
	1-Amino-N-cyclopropyl-7-(3-fluorophenyl)isoquinoline-4-carboxamide	IC50	16.0 [1]
	N-(1-Acetylazetidin-3-yl)-1-amino-7-(3-fluorophenyl)isoquinoline-4-carboxamide	IC50	32.0 [1]
	1-Amino-7-(3-fluorophenyl)-N-[1-(methylcarbamoyl)azetidin-3-yl]isoquinoline-4-carboxamide	IC50	15.0 [1]
	1-Amino-7-(3-fluorophenyl)-N-(3-hydroxycyclobutyl)isoquinoline-4-carboxamide	IC50	41.0 [1]
	(2S)-N-[5-(6-Aminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]-4,4,4-trifluoro-2-methylbutanamide	IC50	8000.0 [1]
	6-(3-Chlorophenyl)quinazolin-4-Amine	IC50	77.0 [1]
	6-(3,5-Difluorophenyl)quinazolin-4-amine	IC50	132.0 [1]
	6-Phenyl-N-(Pyridin-4-Yl)pyrrolo[2,1-F][1,2,4]triazin-4-Amine	IC50	8.0 [1]
	6-(3-Amino-5-fluoro-phenyl)quinazolin-4-amine	IC50	60.0 [1]
	1-Amino-N-(azetidin-3-yl)-7-(3-fluorophenyl)isoquinoline-4-carboxamide	IC50	401.0 [1]
	8-Amino-2-(3-fluorophenyl)-N-(1-propanoylazetidin-3-yl)-1,7-naphthyridine-5-carboxamide	IC50	3.5 [1]
	8-Amino-2-(3-fluorophenyl)-N-[1-(methylcarbamoyl)azetidin-3-yl]-1,7-naphthyridine-5-carboxamide	IC50	1.6 [1]
	8-Amino-2-(3-fluorophenyl)-N-(3-hydroxycyclobutyl)-1,7-naphthyridine-5-carboxamide	IC50	3.7 [1]
	6-(2-Methoxyphenyl)quinazolin-4-amine	IC50	546.0 [1]
	6-(4-Methoxyphenyl)quinazolin-4-amine	IC50	689.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Mitogen-activated protein kinase kinase kinase kinase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-kinase-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Mitogen-activated protein kinase kinase kinase kinase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-kinase-4-inhibitors-ic50-ki.
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