Multidrug resistance-associated protein 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Verlukast	IC50	400.0 [1], 3300.0 [2], 5220.0 [3]
	Verlukast	Ki	600.0 [1], 134700.0 [2], 139600.0 [3]
	Cyclosporin A	IC50	2700.0 [1], 2810.0 [2], 2970.0 [3], 3530.0 [4], 4780.0 [5]
	Cyclosporin A	Ki	5000.0 [1]
	Verapamil	IC50	3500.0 [1], 6800.0 [2], 9660.0 [3]
	Verapamil	Ki	13200.0 [1], 13400.0 [2]
	4-(2-Phenylethylamino)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 4980.0 [2], 6300.0 [3], 8370.0 [4]
	Daunorubicin	IC50	8000.0 [1]
	Daunorubicin	Ki	70.0 [1], 950.0 [2]
	Mitoxantrone	IC50	1.5 [1], 1.9 [2]
	Myricetin	IC50	20000.0 [1]
	Myricetin	Ki	2400.0 [1], 13300.0 [2]
	4-[[4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-6,8-dinitro-5H-pyrimido[5,4-b]indol-2-yl]methyl]morpholine	IC50	19.0 [1], 118.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-9-carboxamide	IC50	65.0 [1], 183.0 [2], 250.0 [3]
	4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile	IC50	197.0 [1], 370.0 [2], 690.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-pyridin-4-yl-5H-pyrimido[5,4-b]indole-9-carboxamide	IC50	250.0 [1], 650.0 [2], 708.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-(pyridin-4-ylmethyl)pyrimido[5,4-b]indole-9-carboxamide	IC50	20.0 [1], 250.0 [2], 270.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,13-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	94.0 [1], 250.0 [2], 270.0 [3]
	Ethyl 2-[4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-nitropyrimido[5,4-b]indol-5-yl]acetate	IC50	78.0 [1], 138.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-methyl-5H-pyrimido[5,4-b]indole	IC50	250.0 [1], 632.0 [2], 1235.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8,13-dimethyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	21.0 [1], 33.0 [2], 250.0 [3]
	13-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	41.0 [1], 130.0 [2], 250.0 [3]
	8-Benzyl-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	48.0 [1], 250.0 [2], 545.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-N-(pyridin-2-ylmethyl)-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-amine	IC50	15.0 [1], 106.0 [2], 250.0 [3]
	4-[[13-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl]methyl]morpholine	IC50	17.0 [1], 90.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indol-9-amine	IC50	250.0 [1], 708.0 [2], 1900.0 [3]
	Methyl 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-8-carboxylate	IC50	59.0 [1], 113.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5-(pyridin-4-ylmethyl)pyrimido[5,4-b]indole	IC50	13.7 [1], 80.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5-(2-phenylethyl)pyrimido[5,4-b]indole	IC50	40.9 [1], 222.0 [2], 250.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N,8-dimethyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-amine	IC50	28.0 [1], 115.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5H-pyrimido[5,4-b]indole	IC50	59.0 [1], 183.0 [2], 250.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-13-carboxamide	IC50	12.0 [1], 110.0 [2], 250.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N,N,8-trimethyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-amine	IC50	12.0 [1], 166.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-methyl-9-nitropyrimido[5,4-b]indole	IC50	147.0 [1], 231.0 [2], 250.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-4-(morpholin-4-ylmethyl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-13-carboxamide	IC50	10.0 [1], 97.0 [2], 250.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	24.0 [1], 44.0 [2], 250.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-13-carbonitrile	IC50	45.0 [1], 250.0 [2], 355.0 [3]
	9-Chloro-4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole	IC50	167.0 [1], 250.0 [2], 367.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-9-carbonitrile	IC50	169.0 [1], 250.0 [2], 277.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methoxy-5H-pyrimido[5,4-b]indole	IC50	250.0 [1], 608.0 [2], 820.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-methyl-2-(morpholin-4-ylmethyl)pyrimido[5,4-b]indole-9-carboxamide	IC50	29.0 [1], 230.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methoxy-9-nitro-5H-pyrimido[5,4-b]indole	IC50	78.0 [1], 156.0 [2], 250.0 [3]
	11-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene	IC50	87.0 [1], 250.0 [2], 1200.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-13-methoxy-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	63.0 [1], 172.0 [2], 250.0 [3]
	13-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-4-(methoxymethyl)-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	13.0 [1], 244.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5-(pyridin-3-ylmethyl)pyrimido[5,4-b]indole	IC50	26.5 [1], 250.0 [2], 621.0 [3]
	4-[6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-yl]morpholine	IC50	10.0 [1], 71.0 [2], 250.0 [3]
	4-[[4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-nitro-5H-pyrimido[5,4-b]indol-2-yl]methyl]morpholine	IC50	107.0 [1], 250.0 [2], 672.0 [3]
	6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-13-propan-2-yloxy-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene	IC50	27.0 [1], 250.0 [2], 265.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-pyrrolidin-1-ylsulfonyl-5H-pyrimido[5,4-b]indole	IC50	235.0 [1], 250.0 [2], 542.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-nitro-5H-pyrimido[5,4-b]indole	IC50	51.0 [1], 133.0 [2], 250.0 [3]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-methylpyrimido[5,4-b]indole-9-carboxamide	IC50	24.0 [1], 62.0 [2], 250.0 [3]
	Indomethacin	IC50	12000.0 [1], 12600.0 [2]
	Quercetin	Ki	2400.0 [1], 8100.0 [2]
	Apigenin	Ki	2400.0 [1], 4900.0 [2]
	Kaempferol	Ki	2400.0 [1]
	Naringenin	Ki	2400.0 [1], 20800.0 [2]
	Benzbromarone	IC50	4000.0 [1]
	Benzbromarone	Ki	190.0 [1]
	MK-571 sodium	IC50	7570.0 [1], 30000.0 [2]
	Ivermectine	IC50	3800.0 [1]
	Ivermectine	Ki	500.0 [1]
	(5S,6R,7E,9E,11Z,14Z)-6-[(2S)-2-[[(4S)-4-Amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid	Ki	300.0 [1], 530.0 [2]
	6-Methyl-2-[4-[2-[2-[2-[2-[2-[4-(6-methyl-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]chromen-4-one	Ki	190.0 [1], 200.0 [2]
	Unii-73CI11LH7F	IC50	800.0 [1]
	N-(3,4-Dimethoxyphenyl)-2-phenylquinazolin-4-amine	IC50	11180.0 [1]
	Phenyl-[4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-10-yl]methanone	IC50	250.0 [1], 1370.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-pyridin-3-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamide	IC50	76.0 [1], 250.0 [2]
	4-(4-Phenacylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 1850.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	229.0 [1], 250.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-2-pyridin-3-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	218.0 [1], 250.0 [2]
	4-[4-[2-(3-Nitrophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 410.0 [2]
	4-[4-(3-Phenylpropyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 7350.0 [2]
	4-[4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 523.0 [2]
	4-[4-[2-(4-Methoxyphenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 50000.0 [2]
	2-Phenyl-4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 715.0 [2]
	4,5-Dimethyl-2-[4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-10-yl]-1,3-thiazole	IC50	250.0 [1], 533.0 [2]
	2-Iodo-4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 887.0 [2]
	4-(4-Benzylsulfonylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 6650.0 [2]
	4-[4-[2-(3-Chlorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 920.0 [2]
	Methyl 4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxylate	IC50	250.0 [1], 910.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamide	IC50	138.0 [1], 250.0 [2]
	N-[4-[10-Cyano-4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-2-yl]phenyl]acetamide	IC50	250.0 [1], 570.0 [2]
	4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)ethylamino]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 6350.0 [2]
	4-[4-[2-(4-Chlorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 399.0 [2]
	4-(Methyl-phenethyl-amino)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 9000.0 [2]
	1-[4-[4-(2-Phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-10-yl]propan-1-one	IC50	250.0 [1], 2800.0 [2]
	4-[4-[2-(3-Methoxyphenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 2300.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-8-carboxamide	IC50	250.0 [1], 3440.0 [2]
	N-[4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indol-8-yl]acetamide	IC50	250.0 [1], 2710.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-7-methoxy-5H-pyrimido[5,4-b]indole	IC50	250.0 [1], 3150.0 [2]
	N-(10-Cyano-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-4-yl)-1-phenylmethanesulfonamide	IC50	250.0 [1], 20900.0 [2]
	4-[4-(2-Phenylethyl)piperazin-1-yl]-10-pyrimidin-2-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine	IC50	250.0 [1], 675.0 [2]
	4-[4-[2-(2-Nitrophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 1415.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-ethyl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamide	IC50	120.0 [1], 250.0 [2]
	4-[4-[2-(2-Chlorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 955.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-2-(2-methylphenyl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	250.0 [1], 620.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-[(2,3-dimethoxyphenyl)methyl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamide	IC50	43.0 [1], 250.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-7-methoxy-6-nitro-5H-pyrimido[5,4-b]indole	IC50	250.0 [1], 3450.0 [2]
	4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-2-pyridin-4-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile	IC50	105.0 [1], 250.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Multidrug resistance-associated protein 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/multidrug-resistance-associated-protein-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Multidrug resistance-associated protein 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/multidrug-resistance-associated-protein-1-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan