Myosin light chain kinase, smooth muscle Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Wortmannin	IC50	170.0 [1], 1900.0 [2], 5000.0 [3]
	Staurosporine	IC50	10.0 [1], 40.0 [2]
	Fasudil	IC50	3600.0 [1]
	Fasudil	Ki	36000.0 [1]
	Antibiotic K 252a	IC50	22.0 [1]
	Antibiotic K 252a	Ki	20.0 [1]
	Piceatannol	IC50	12000.0 [1]
	ML-9 free base	Ki	3800.0 [1]
	Nifedipine	IC50	2020.0 [1]
	N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	Ki	28300.0 [1]
	Myricetin	Ki	1700.0 [1]
	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide	Ki	110000.0 [1]
	K252a	Ki	17.0 [1]
	Methyl (15S,16S,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate	IC50	25.0 [1]
	Go-6976	IC50	5800.0 [1]
	1H-1,4-Diazepine, hexahydro-1-((5-iodo-1-naphthalenyl)sulfonyl)-	Ki	300.0 [1]
	N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide	Ki	150000.0 [1]
	(S)-2-Methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine	Ki	10100.0 [1]
	Bisindolylmaleimide xi, HCl	IC50	17800.0 [1]
	3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione	IC50	3700.0 [1]
	N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide	Ki	7400.0 [1]
	Dehydroaltenusin	IC50	690.0 [1]
	5,8-Dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone	IC50	10000.0 [1]
	N-(4,6-Dimethyl-2-pyrimidinyl)-1,3-benzothiazol-2-amine	IC50	100000.0 [1]
	CID 73442760	IC50	1000000.0 [1]
	1-[2-(1,3-Benzothiazol-2-ylamino)-4,6-dimethylpyrimidin-5-yl]ethanone	IC50	100000.0 [1]
	3-[3-(Dimethylamino)-2-hydroxypropyl]-7-methoxy-23-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione	IC50	120.0 [1]
	CID 50898538	IC50	36000.0 [1]
	Ethyl 2-methoxy-6-methyl-3-phenacyl-4-phenyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	4291904.01 [1]
	Ethyl 3-[2-(4-chlorophenyl)-2-oxoethyl]-2-methoxy-6-methyl-4-phenyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	3003032.28 [1]
	Ethyl 2-methoxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-6-methyl-4-phenyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	7518825.4 [1]
	Ethyl 4-(4-chlorophenyl)-2-methoxy-6-methyl-3-phenacyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	3194920.09 [1]
	Ethyl 4-(4-chlorophenyl)-3-[2-(4-chlorophenyl)-2-oxoethyl]-2-methoxy-6-methyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	2421307.79 [1]
	Ethyl 3-[2-(4-chlorophenyl)-2-oxoethyl]-2-methoxy-4-(4-methoxyphenyl)-6-methyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	3300350.01 [1]
	Ethyl 4-(4-hydroxyphenyl)-2-methoxy-6-methyl-3-phenacyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	9803925.45 [1]
	Ethyl 3-[2-(4-chlorophenyl)-2-oxoethyl]-4-(4-hydroxyphenyl)-2-methoxy-6-methyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	6579001.72 [1]
	Ethyl 4-(4-hydroxyphenyl)-2-methoxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-6-methyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	10204224.39 [1]
	Ethyl 2-methoxy-6-methyl-4-(4-methylphenyl)-3-phenacyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	5208348.07 [1]
	Ethyl 3-[2-(4-chlorophenyl)-2-oxoethyl]-2-methoxy-6-methyl-4-(4-methylphenyl)-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	3424680.02 [1]
	Ethyl 2-methoxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-6-methyl-4-(4-methylphenyl)-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	19607851.09 [1]
	Ethyl 2-methoxy-4-(4-methoxyphenyl)-6-methyl-3-phenacyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	13513567.02 [1]
	Ethyl 2-methoxy-4-(4-methoxyphenyl)-3-[2-(4-methoxyphenyl)-2-oxoethyl]-6-methyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	24390460.5 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	4000.0 [1]
	1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-Dioxide	IC50	10000.0 [1]
	1-[4-(4-Chlorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	10989046.22 [1]
	Ethyl 4-(4-chlorophenyl)-2-methoxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-6-methyl-2,4-dihydro-1H-pyrimidine-5-carboxylate	IC50	5494523.05 [1]
	1-[4-(2-Chlorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	10204224.39 [1]
	1-[4-(4-Fluorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	13698720.35 [1]
	1-[4-(2-Hydroxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	23256266.74 [1]
	1-[4-(4-Hydroxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	23753083.75 [1]
	1-[4-(4-Methoxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	46729377.97 [1]
	1-[2-Methyl-4-(3-nitrophenyl)-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	49019626.74 [1]
	1-[2-Methyl-4-(4-nitrophenyl)-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	49023013.01 [1]
	1-[4-[4-(Dimethylamino)phenyl]-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	22883370.91 [1]
	1-[4-(4-Hydroxy-3-methoxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]ethanone	IC50	27248336.88 [1]
	1-[4-(2-Chlorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	9259339.33 [1]
	1-[4-(4-Chlorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	9009070.8 [1]
	1-[4-(4-Fluorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	7518825.4 [1]
	1-[4-(2-Hydroxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	21276980.72 [1]
	1-[4-(4-Hydroxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	16949231.05 [1]
	1-[4-(4-Methoxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	46083982.18 [1]
	1-[2-Methyl-4-(3-nitrophenyl)-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	47620066.77 [1]
	1-[2-Methyl-4-(4-nitrophenyl)-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	32895008.28 [1]
	1-[4-[4-(Dimethylamino)phenyl]-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	13568754.97 [1]
	1-[4-(4-Hydroxy-3-methoxyphenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-3-yl]propan-1-one	IC50	27248336.88 [1]
	1-[2-(1,3-Benzothiazol-2-ylamino)-4-ethyl-6-methylpyrimidin-5-yl]ethanone	IC50	100000.0 [1]
	4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-ium	IC50	10000.0 [1]
	N-[6-Benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]naphthalene-2-sulfonamide	IC50	900.0 [1]
	5-(Methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol;hydrochloride	IC50	17800.0 [1]
	3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride	IC50	3700.0 [1]
	4-Chloro-N-[2-(2-phenylethylamino)pyrimidin-4-yl]benzenesulfonamide	IC50	51000.0 [1]
	(E)-N-[1-(3-Bromoanilino)-4-cyanoisoquinolin-7-yl]-4-(dimethylamino)but-2-enamide	IC50	23600.0 [1]
	N-[1-(3-Bromoanilino)-4-cyanoisoquinolin-7-yl]-4-(dimethylamino)butanamide	IC50	25100.0 [1]
	N-[1-(3-Bromoanilino)-4-cyanoisoquinolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide	IC50	8700.0 [1]
	1-[(3-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;methanesulfonic acid	IC50	15.63 [1]
	4-(7-Methoxy-23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaen-3-yl)butanenitrile	IC50	32.0 [1]
	23-[3-(Dimethylamino)-2-hydroxypropyl]-19-methoxy-3-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17(22),18,20-nonaen-12-one	IC50	9200.0 [1]
	3-(7-Methoxy-23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaen-3-yl)propanenitrile	IC50	200.0 [1]
	Indolocarbazole deriv. 3b	IC50	1600.0 [1]
	Indolocarbazole deriv. 3c	IC50	30.0 [1]
	Indolocarbazole deriv. 3d	IC50	390.0 [1]
	Indolocarbazole deriv. 3e	IC50	220.0 [1]
	Indolocarbazole deriv. 3f	IC50	310.0 [1]
	Indolocarbazole deriv. 3g	IC50	250.0 [1]
	Indolocarbazole deriv. 3h	IC50	18.0 [1]
	23-[3-(Dimethylamino)-2-hydroxypropyl]-3-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	5500.0 [1]
	Indolocarbazole deriv. 3k	IC50	55.0 [1]
	3-(19-Methoxy-23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17(22),18,20-nonaen-3-yl)propanenitrile	IC50	49.0 [1]
	Indolocarbazole deriv. 3n	IC50	180.0 [1]
	Indolocarbazole deriv. 3p	IC50	120.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Myosin light chain kinase, smooth muscle Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/myosin-light-chain-kinase-smooth-muscle-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Myosin light chain kinase, smooth muscle Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/myosin-light-chain-kinase-smooth-muscle-inhibitors-ic50-ki.
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