Name: N-lysine methyltransferase SETD8 Inhibitors (IC50, Ki)
Creator: AAT Bioquest
License: https://www.aatbio.com/tou.html

N-lysine methyltransferase SETD8 Inhibitors (IC50, Ki)

Structure	Compound Name	Standard Type	Standard Values (in nM)
	(E)-3-[(1R,2R,4Ar,5R,7R,8R,8aS)-5,7-dihydroxy-3,4a,8-trimethyl-2-[(5S,7R,8S,9S)-5,7,9-trihydroxy-8,10-dimethylundec-2-en-2-yl]-2,5,6,7,8,8a-hexahydro-1H-naphthalen-1-yl]-2-methylprop-2-enoic acid	IC50	6500.0 ^[1]
	(E)-3-[(1R,2R,4Ar,5R,7R,8R,8aS)-5,7-dihydroxy-3,4a,8-trimethyl-2-[(5S,7R,8S,9S)-5,7,9-trihydroxy-8,10-dimethylundec-2-en-2-yl]-2,5,6,7,8,8a-hexahydro-1H-naphthalen-1-yl]-2-methylprop-2-enoic acid	Ki	2000.0 ^[1]
	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	IC50	7300.0 ^[1], 9000.0 ^[2], 37700.0 ^[3]
	(2S)-2-[[(2S)-2-[[(2S)-2-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	IC50	330.0 ^[1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid	Ki	50.0 ^[1]
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References

This online resource may be cited as follows

MLA	"Quest Database™ N-lysine methyltransferase SETD8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 3 Mar. 2026, https://www.aatbio.com/data-sets/n-lysine-methyltransferase-setd8-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2026, March 3). Quest Database™ N-lysine methyltransferase SETD8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/n-lysine-methyltransferase-setd8-inhibitors-ic50-ki.
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