NAD-dependent deacetylase sirtuin 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	280.0 [1]
	Nicotinamide	IC50	88000.0 [1]
	Sirtinol	IC50	82500.0 [1]
	Cambinol	IC50	56000.0 [1]
	2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-	IC50	50000.0 [1]
	(2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone	IC50	2800.0 [1], 283500.0 [2], 421400.0 [3], 491100.0 [4], 550400.0 [5]
	(2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone	Ki	800.0 [1], 174400.0 [2], 218700.0 [3], 252500.0 [4], 253800.0 [5]
	Suramin	IC50	600.0 [1]
	N-[3-[(2-Oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide	IC50	43000.0 [1]
	Tenovin-6	IC50	29700.0 [1]
	3-(2-Furyl)-6-(2-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	IC50	3500.0 [1], 44000.0 [2], 87900.0 [3], 132800.0 [4]
	3-(2-Furyl)-6-(2-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Ki	600.0 [1], 24100.0 [2], 39100.0 [3], 58900.0 [4]
	Bisindolylmaleimide IX	IC50	3500.0 [1], 5100.0 [2], 25000.0 [3]
	2-(Phenylamino)benzamide	IC50	17000.0 [1], 56000.0 [2]
	10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11-dione	IC50	8400.0 [1], 9800.0 [2]
	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	IC50	50000.0 [1], 100000.0 [2], 140000.0 [3]
	(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate	IC50	2700.0 [1], 9900.0 [2], 140000.0 [3]
	Bisindolylmaleimide i	IC50	23000.0 [1], 50000.0 [2]
	Bisindolylmaleimide v	IC50	15700.0 [1], 50000.0 [2]
	2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide	IC50	124.0 [1], 180.0 [2], 652.0 [3]
	2,3,4,9-Tetrahydro-1H-carbazole-1-carboxamide	IC50	1470.0 [1], 3300.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid	IC50	310.0 [1], 330.0 [2], 10000.0 [3]
	5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamide	IC50	12000.0 [1], 52700.0 [2]
	(4S)-4-[[(2S,3R)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]hexanoyl]amino]-6-(1-sulfanylethylideneamino)hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-5-(carboxymethylamino)-5-oxopentanoic acid	IC50	1700.0 [1], 2000.0 [2]
	Sodium	IC50	300.0 [1], 32000.0 [2]
	N-Phenylanthranilic acid	IC50	68000.0 [1]
	Surfactin	IC50	600000.0 [1]
	Splitomicin	IC50	96200.0 [1], 500000.0 [2]
	8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid	IC50	297.0 [1], 2800.0 [2]
	Paullone	IC50	8000.0 [1], 50000.0 [2]
	5-{3-[(Furan-2-carbonyl)-amino]-benzoylamino}-2-hydroxy-benzoic acid	IC50	1578000.0 [1]
	6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	205.0 [1], 2500.0 [2]
	5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide	IC50	6560.0 [1]
	5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide	Ki	5000.0 [1]
	2-Phenoxybenzamide	IC50	100000.0 [1]
	Para-sirtinol	IC50	13000.0 [1], 48100.0 [2]
	2-(3-Phenoxyphenylamino)benzamide	IC50	58000.0 [1]
	8-Bromo-2-phenyl-1,2-dihydrobenzo[f]chromen-3-one	IC50	5000.0 [1]
	Meta-sirtinol	IC50	58600.0 [1], 59000.0 [2]
	2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dione	IC50	50500.0 [1], 51000.0 [2]
	2-(2-Chlorobenzoyl)-1H-benzo[f]chromen-3(2H)-one	IC50	89800.0 [1]
	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	IC50	100000.0 [1]
	2,4-Dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	IC50	314000.0 [1]
	(S)-2-((S)-2-((S)-2-Acetamidopropanamido)-6-ethanethioamidohexanamido)propanoic acid	IC50	240.0 [1]
	N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide	IC50	50000.0 [1], 100000.0 [2]
	6-Hydroxy-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	15000.0 [1]
	5-(1H-Indol-2-ylmethylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione	IC50	5900.0 [1], 6000.0 [2]
	(E)-4-((2-Hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzenesulfonamide	IC50	40300.0 [1], 44100.0 [2]
	1-((3-(2-Phenylpropylthio)phenylimino)methyl)naphthalen-2-ol	IC50	40300.0 [1]
	2-Phenylsulfanylbenzamide	IC50	78000.0 [1]
	6-(4-Bromophenyl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-sulfanylidene-1H-pyrimidin-4-one	IC50	12700.0 [1], 13000.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2,6-Diaminohexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoic acid	IC50	570.0 [1]
	2-(3-Biphenylylamino)benzamide	IC50	52000.0 [1]
	2-(M-Tolylamino)Benzamide	IC50	68000.0 [1]
	2-(3-Hydroxymethylphenylamino)benzamide	IC50	60000.0 [1]
	3-[3-(2-Carbamoylphenylamino)phenyl]acrylic acid	IC50	58000.0 [1]
	2-[3-(2-Hydroxyethyl)anilino]benzamide	IC50	72000.0 [1]
	Methyl (E)-3-[3-(2-carbamoylanilino)phenyl]prop-2-enoate	IC50	65000.0 [1]
	(3Z)-6,7-Dichloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one	IC50	40000.0 [1], 40600.0 [2]
	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide	IC50	89500.0 [1]
	2-(Methyl(Phenyl)Amino)Benzamide	IC50	75000.0 [1]
	5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	IC50	2460.0 [1]
	5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Ki	3000.0 [1]
	5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	IC50	18700.0 [1]
	5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Ki	20000.0 [1]
	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	106000.0 [1]
	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Ki	100000.0 [1]
	6-Chloro-2,3,4,4a,9,9a-hexahydro-1H-carbazole-1-carboxamide	IC50	760.0 [1], 100000.0 [2]
	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-2-[[(2S)-2,5-diacetamidopentanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	5900.0 [1]
	(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamide	IC50	290000.0 [1]
	2-[2-[3-[3-[2-(1,3-Dioxobenzo[de]isoquinolin-2-yl)ethylamino]propylamino]propylamino]ethyl]benzo[de]isoquinoline-1,3-dione	IC50	43000.0 [1]
	3-Bromo-4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	18300.0 [1]
	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-2-methylbenzamide	IC50	90000.0 [1]
	3-Bromo-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	39900.0 [1]
	4-Bromo-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	62100.0 [1], 90000.0 [2]
	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-propan-2-ylbenzamide	IC50	42700.0 [1], 64800.0 [2]
	4-Tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamoyl]benzamide	IC50	21700.0 [1], 29000.0 [2]
	4-Tert-butyl-N-[[4-[6-(dimethylamino)hexanoylamino]phenyl]carbamothioyl]benzamide	IC50	16000.0 [1], 16100.0 [2]
	4-Tert-butyl-N-[[4-[[2-[2-[2-[2-[2-[2-(dimethylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]phenyl]carbamothioyl]benzamide	IC50	60000.0 [1]
	3,4-Dichloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	70900.0 [1]
	4-Tert-butyl-N-[[4-[8-(dimethylamino)octanoylamino]phenyl]carbamothioyl]benzamide	IC50	24700.0 [1], 25000.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]octanediamide	IC50	11700.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]octanediamide	Ki	2600.0 [1]
	Entinostat	IC50	100000.0 [1]
	Panobinostat	Ki	10000.0 [1]
	Hyperforin	IC50	15000.0 [1]
	Toxoflavin	IC50	870.0 [1]
	Ricolinostat	IC50	10000.0 [1]
	Quisinostat	Ki	10000.0 [1]
	4-Tert-Butylbenzoic acid	IC50	1000000.0 [1]
	3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-ol	IC50	41600.0 [1]
	3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide	IC50	50000.0 [1]
	5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	IC50	50000.0 [1]
	(2,5-Dimethoxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone	IC50	300000.0 [1]
	6,9-Dimethyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	100000.0 [1]
	6-Chloro-N-ethyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	100000.0 [1]
	3-(1-Oxoisoindolin-2-yl)propanoic acid	IC50	80000.0 [1]
	Aristoforin	IC50	7000.0 [1]
	(1R,3E,5S,6S,7R)-3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6-methyl-1,5-bis(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trione	IC50	9000.0 [1]
	3H-Naphtho[1,2-d]imidazole-2-thiol	IC50	9600.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ NAD-dependent deacetylase sirtuin 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ NAD-dependent deacetylase sirtuin 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-1-inhibitors-ic50-ki.
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