NAD-dependent deacetylase sirtuin 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-	IC50	3500.0 [1]
	Sirtinol	IC50	45900.0 [1]
	6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	19600.0 [1]
	Cambinol	IC50	51000.0 [1]
	Nicotinamide	IC50	11000.0 [1]
	N-[3-[(2-Oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide	IC50	25000.0 [1]
	Tenovin-6	IC50	10000.0 [1]
	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	IC50	140.0 [1], 400.0 [2], 440.0 [3], 3388.44 [4]
	3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide	IC50	15500.0 [1], 16000.0 [2]
	SIRT2 Inhibitor II, AK-1	IC50	10800.0 [1], 12500.0 [2]
	10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11-dione	IC50	12300.0 [1], 191200.0 [2]
	Bisindolylmaleimide IX	IC50	800.0 [1], 1100.0 [2]
	2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dione	IC50	8700.0 [1]
	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	IC50	170.0 [1], 1450.0 [2]
	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	Ki	620.0 [1]
	Bisindolylmaleimide i	IC50	7300.0 [1], 11700.0 [2]
	8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid	IC50	1150.0 [1], 13000.0 [2], 14000.0 [3]
	Paullone	IC50	10000.0 [1], 42800.0 [2]
	Bisindolylmaleimide v	IC50	24100.0 [1], 33000.0 [2]
	1,4-Bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione	IC50	56700.0 [1], 57000.0 [2]
	2-(Phenylamino)benzamide	IC50	74000.0 [1], 100000.0 [2]
	(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate	IC50	15000.0 [1], 23000.0 [2]
	5-[[2-[(3,5-Dichloro-2-hydroxyphenyl)methylideneamino]phenyl]sulfanylmethyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol	IC50	74000.0 [1], 74300.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid	IC50	6300.0 [1], 6400.0 [2], 10000.0 [3]
	N-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-4-[[(E)-3-[4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enoyl]amino]piperidine-4-carboxamide	IC50	51000.0 [1]
	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide	IC50	57200.0 [1], 159100.0 [2]
	N-Caffeoyltryptophan	IC50	8700.0 [1]
	N-Caffeoyltryptophan	Ki	5300.0 [1], 9800.0 [2]
	3-(4-Bromophenyl)-5-(3-bromopropyl)-1,2,4-oxadiazole	IC50	1500.0 [1]
	3-(4-Bromophenyl)-5-(3-bromopropyl)-1,2,4-oxadiazole	Ki	2180.0 [1], 2220.0 [2]
	Sodium	IC50	1200.0 [1]
	Suramin	IC50	1100.0 [1], 1200.0 [2]
	5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	IC50	35000.0 [1]
	5-{3-[(Furan-2-carbonyl)-amino]-benzoylamino}-2-hydroxy-benzoic acid	IC50	751000.0 [1]
	5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide	IC50	16.7 [1]
	5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide	Ki	73.0 [1]
	Para-sirtinol	IC50	25900.0 [1], 29900.0 [2]
	Meta-sirtinol	IC50	34500.0 [1], 35700.0 [2]
	CID 2248572	IC50	2818.38 [1], 9700.0 [2]
	2-(2-Chlorobenzoyl)-1H-benzo[f]chromen-3(2H)-one	IC50	9400.0 [1]
	2,4-Dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	IC50	114000.0 [1]
	(S)-2-((S)-2-((S)-2-Acetamidopropanamido)-6-ethanethioamidohexanamido)propanoic acid	IC50	9800.0 [1]
	(2S)-8-Bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-one	IC50	1500.0 [1]
	5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamide	IC50	48.3 [1]
	N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide	IC50	3750.0 [1]
	N-[5-[(7-Chloronaphthalen-1-yl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide	IC50	180.0 [1]
	(E)-4-((2-Hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzenesulfonamide	IC50	22600.0 [1]
	1-((3-(2-Phenylpropylthio)phenylimino)methyl)naphthalen-2-ol	IC50	19200.0 [1]
	(S)-N-(1-(2-(1H-Indol-3-yl)ethylamino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide	IC50	47000.0 [1]
	(1R)-8-Methyl-1-(4-methylphenyl)-1,2-dihydrobenzo[f]chromen-3-one	IC50	1000.0 [1]
	8-Bromo-1-phenyl-1,2-dihydrobenzo[f]chromen-3-one	IC50	1000.0 [1], 5200.0 [2]
	2-Pentyl-6-chloro-8-bromo-2,3-dihydro-4H-1-benzopyran-4-one	IC50	4300.0 [1]
	2-Phenethyl-6-chloro-8-bromo-2,3-dihydro-4H-1-benzopyran-4-one	IC50	6800.0 [1]
	N-(2-(1H-Indol-3-yl)ethyl)-4-(3-(4-(benzyloxy)phenyl)acrylamido)piperidine-4-carboxamide	IC50	63000.0 [1]
	N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-methoxyphenyl)acrylamide	IC50	99000.0 [1]
	N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamide	IC50	50000.0 [1]
	N-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-2-[[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]amino]-2-methylpropanamide	IC50	80000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2,6-Diaminohexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoic acid	IC50	151000.0 [1]
	(3Z)-6,7-Dichloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one	IC50	28000.0 [1], 28400.0 [2]
	(2R)-8-Bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-one	IC50	4500.0 [1]
	SIRT1/2 Inhibitor VII	IC50	9000.0 [1], 10000.0 [2]
	3-[(5-Chloropyridin-2-yl)-methylsulfamoyl]-N-(4-cyanophenyl)benzamide	IC50	6100.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-6-(carbamothioylamino)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	IC50	5400.0 [1], 30400.0 [2]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-(methylcarbamothioylamino)hexanoyl]amino]hexanamide	IC50	1650.0 [1], 2200.0 [2]
	5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	IC50	34.1 [1]
	5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Ki	140.0 [1]
	5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	IC50	193.0 [1]
	5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Ki	260.0 [1]
	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	26.3 [1]
	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Ki	140.0 [1]
	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-2-[[(2S)-2,5-diacetamidopentanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	2900.0 [1]
	(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamide	IC50	190200.0 [1]
	(6R,12R)-6,12-Bis(hydroxymethyl)-6,12-diundecyl-1,7-dioxacyclododecane-2,8-dione	IC50	176.0 [1], 2000.0 [2]
	3-Bromo-4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	4600.0 [1]
	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-2-methylbenzamide	IC50	42500.0 [1], 80700.0 [2]
	3-Bromo-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	21200.0 [1]
	4-Bromo-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	39500.0 [1], 55000.0 [2]
	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-propan-2-ylbenzamide	IC50	5710.0 [1], 32500.0 [2]
	3,4-Dichloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	IC50	31900.0 [1]
	Sunitinib	IC50	122700.0 [1]
	Go-6976	IC50	100000.0 [1]
	Panobinostat	Ki	10000.0 [1]
	Bisindolylmaleimide IV	IC50	4700.0 [1]
	N-Phenylanthranilic acid	IC50	100000.0 [1]
	Hyperforin	IC50	28000.0 [1]
	Kenpaullone	IC50	100000.0 [1]
	Toxoflavin	IC50	14400.0 [1]
	Splitomicin	IC50	112900.0 [1]
	Quisinostat	Ki	10000.0 [1]
	Bisindolylmaleimide II	IC50	8300.0 [1]
	3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-ol	IC50	15600.0 [1]
	Aristoforin	IC50	21000.0 [1]
	(1R,3E,5S,6S,7R)-3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6-methyl-1,5-bis(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trione	IC50	22000.0 [1]
	3H-Naphtho[1,2-d]imidazole-2-thiol	IC50	10000.0 [1]
	6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	11500.0 [1]
	5-((1H-Indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	IC50	20300.0 [1]
	N,N'-Bis(salicylidene)-p-phenylenediamine	IC50	58400.0 [1]
	5-(4-Benzamido-2-methoxy-5-methylphenylamino)-5-oxo-3-phenylpentanoic acid	IC50	1000000.0 [1]
	2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide	IC50	2770.0 [1]
	Bauerine C	IC50	87200.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ NAD-dependent deacetylase sirtuin 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ NAD-dependent deacetylase sirtuin 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-2-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan