NAD-dependent deacetylase sirtuin 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamide	IC50	29700.0 [1], 44200.0 [2]
	5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamide	Ki	45.0 [1], 131.0 [2], 165.0 [3]
	2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-	IC50	50000.0 [1], 52800.0 [2], 91000.0 [3]
	Nicotinamide	IC50	6200.0 [1], 14000.0 [2], 30000.0 [3], 377000.0 [4]
	6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	48700.0 [1], 49000.0 [2], 50000.0 [3], 128000.0 [4]
	Cambinol	IC50	12900.0 [1], 200000.0 [2], 300000.0 [3]
	Tenovin-6	IC50	25700.0 [1], 82650.0 [2]
	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	IC50	100000.0 [1], 140000.0 [2]
	2-(Phenylamino)benzamide	IC50	235000.0 [1]
	5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide	IC50	1870.0 [1]
	5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide	Ki	5400.0 [1]
	(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate	IC50	100000.0 [1]
	(3Z)-6,7-Dichloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one	IC50	23600.0 [1], 24000.0 [2]
	5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	IC50	2400.0 [1]
	5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Ki	7200.0 [1]
	5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	IC50	13400.0 [1]
	5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Ki	3400.0 [1]
	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	66400.0 [1]
	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Ki	100000.0 [1]
	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-2-[[(2S)-2,5-diacetamidopentanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	4300.0 [1]
	(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamide	IC50	213500.0 [1]
	Bisindolylmaleimide IX	IC50	3700.0 [1]
	Panobinostat	Ki	10000.0 [1]
	Quisinostat	Ki	10000.0 [1]
	8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid	IC50	200000.0 [1]
	N-[3-[(2-Oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide	IC50	16700.0 [1]
	N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide	IC50	850.0 [1]
	3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-ol	IC50	25100.0 [1]
	3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide	IC50	50000.0 [1]
	5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	IC50	50000.0 [1]
	6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	IC50	100000.0 [1]
	4-Methylnicotinamide	IC50	23000.0 [1]
	2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide	IC50	100000.0 [1]
	3-(1H-1,2,3-Triazol-4-yl)pyridine	IC50	38000.0 [1]
	2,3,4,9-Tetrahydro-1H-carbazole-1-carboxamide	IC50	100000.0 [1]
	Bisindolylmaleimide IX mesylate	IC50	3700.0 [1]
	5-[4-(Benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	IC50	29300.0 [1]
	2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dione	IC50	40300.0 [1]
	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	IC50	100000.0 [1]
	(2S)-8-Bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-one	IC50	200000.0 [1]
	N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide	IC50	100000.0 [1]
	N-[4-[[3-[[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide	IC50	300000.0 [1]
	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide	IC50	57200.0 [1]
	2-((3-Phenethoxyphenyl)Amino)Benzamide	IC50	300000.0 [1]
	2-[3-(3-Fluorophenethyloxy)phenylamino]benzamide	IC50	300000.0 [1]
	CID 71654771	IC50	3.2 [1]
	5-[5-[(4-Methylbenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamide	IC50	33500.0 [1]
	5-[5-[(3-Nitrobenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamide	IC50	19300.0 [1]
	5-(5-Benzamidonaphthalen-2-yl)oxypyridine-3-carboxamide	IC50	18300.0 [1]
	5-[5-[(4-Methylbenzoyl)amino]naphthalen-2-yl]oxypyridine-3-carboxamide	IC50	22900.0 [1]
	5-[5-[(3-Nitrobenzoyl)amino]naphthalen-2-yl]oxypyridine-3-carboxamide	IC50	10400.0 [1]
	5-[5-[(4-Methyl-3-nitrobenzoyl)amino]naphthalen-2-yl]oxypyridine-3-carboxamide	IC50	4370.0 [1]
	5-(1-Naphthylthio)nicotinamide	IC50	30100.0 [1]
	5-[5-[(4-Methyl-3-nitrobenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamide	IC50	232000.0 [1]
	5-(2-Naphthylamino)nicotinamide	IC50	12300.0 [1]
	5-(2-Naphthyloxy)nicotinamide	IC50	2140.0 [1]
	5-(1-Naphthyloxy)nicotinamide	IC50	16600.0 [1]
	5-(1-Naphthylamino)nicotinamide	IC50	9000.0 [1]
	5-{4-[(2-Chlorobenzyl)oxy]-3-methoxybenzylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	IC50	46400.0 [1]
	Sirt2-IN-1	IC50	100000.0 [1]
	5-((1-Benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	IC50	116300.0 [1]
	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamide	IC50	50000.0 [1]
	2-Cyano-N-(quinolin-8-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide	IC50	50000.0 [1]
	2-Cyano-N-(5-quinolinyl)-3-(5-(3-(trifluoromethyl)phenyl)-2-furyl)acrylamide	IC50	50000.0 [1]
	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide	IC50	50000.0 [1]
	2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide	IC50	50000.0 [1]
	5-Naphthalen-2-ylsulfanylpyridine-3-carboxamide	IC50	27900.0 [1]
	5-[5-(Pyridine-4-carbonylamino)naphthalen-1-yl]oxypyridine-3-carboxamide	IC50	32500.0 [1]
	5-[5-(Pyridine-3-carbonylamino)naphthalen-1-yl]oxypyridine-3-carboxamide	IC50	33600.0 [1]
	N-(4-Bromopyridin-3-yl)-3-naphthalen-2-ylbenzamide	IC50	100000.0 [1]
	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-[(4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	IC50	177400.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxohexan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	980.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxopentan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	480.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxobutan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	1100.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-3-(1-benzothiophen-3-yl)-1-oxopropan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	1400.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxo-4-phenylbutan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	320.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	2100.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-(4-phenylphenyl)propan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	3200.0 [1]
	(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	1910.0 [1]
	(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2,3-diacetamidopropanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	1800.0 [1]
	(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-(4-phenylphenyl)propanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	1620.0 [1]
	(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-(1-benzothiophen-3-yl)propanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	1750.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,3-diacetamidopropanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	1000.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamidohexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	450.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamidopentanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	2100.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamidobutanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	890.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1-benzothiophen-3-yl)propanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	1440.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-4-phenylbutanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	800.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	1290.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-phenylphenyl)propanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamide	IC50	480.0 [1]
	(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-3-acetamido-1-amino-1-oxopropan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamide	IC50	360.0 [1]
	5-[(3-Benzamidophenyl)methoxy]pyridine-3-carboxamide	IC50	11500.0 [1]
	5-[[3-[(4-Piperidin-1-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	3330.0 [1]
	5-[[3-[[(E)-3-Pyridin-3-ylprop-2-enoyl]amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	2700.0 [1]
	5-[[3-[(2-Fluorobenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	2940.0 [1]
	5-[[3-[(4-Phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	200000.0 [1]
	5-[[3-[(2,4-Difluorobenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	15500.0 [1]
	5-[[3-[(4-Cyclohexylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	IC50	3500.0 [1]
	N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-6-(furan-2-yl)pyridine-3-carboxamide	IC50	7120.0 [1]
	N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-1H-indole-6-carboxamide	IC50	1390.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ NAD-dependent deacetylase sirtuin 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ NAD-dependent deacetylase sirtuin 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-3-inhibitors-ic50-ki.
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