NAD-dependent protein deacetylase sirtuin-6 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,4-Dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	IC50	106000.0 [1], 136000.0 [2]
	Nicotinamide	IC50	184000.0 [1], 200000.0 [2]
	Trichostatin A	Ki	2000.0 [1], 450000.0 [2]
	5-{3-[(Furan-2-carbonyl)-amino]-benzoylamino}-2-hydroxy-benzoic acid	IC50	89000.0 [1]
	1,3-Dimethyl-2,4-dioxo-N-[4-(pyridin-4-ylmethyl)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	IC50	38000.0 [1], 49000.0 [2]
	N-(4-{[4-(Pyridin-3-yloxy)phenyl]sulfamoyl}phenyl)acetamide	IC50	242000.0 [1], 297000.0 [2]
	3-Methyl-2-oxo-N-(4-pyridin-3-yloxyphenyl)-1,3-benzothiazole-6-sulfonamide	IC50	77000.0 [1], 102000.0 [2]
	2,4-Dioxo-N-(2-phenylphenyl)-1H-quinazoline-6-sulfonamide	IC50	137000.0 [1]
	2,4-Dioxo-N-[3-(2-pyridin-4-ylethyl)phenyl]-1H-quinazoline-6-sulfonamide	IC50	37000.0 [1], 55000.0 [2]
	2-Oxo-N-(4-pyridin-3-yloxyphenyl)-3,4-dihydro-1H-quinoline-6-sulfonamide	IC50	270000.0 [1], 275000.0 [2]
	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	IC50	200000.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid	IC50	78000.0 [1]
	AKK(thioAc)LM21	IC50	47000.0 [1]
	(S)-Benzyl 6-ethaneselenoamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate	IC50	285000.0 [1]
	3-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]propanoic acid	IC50	2400000.0 [1]
	(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanamide	IC50	307000.0 [1]
	2-({[4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]carbonyl}amino)-5-hydroxybenzoic acid	IC50	20000.0 [1]
	Thiomyristoyl	IC50	200000.0 [1]
	(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,14,21-tetraoxo-1,4,7,13-tetrazacyclohenicosane-8-carboxamide	IC50	1000000.0 [1]
	(2S,5S,8S)-2-Butyl-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamide	IC50	4000000.0 [1]
	(2S,5S,8S)-5-[4-(Ethanethioylamino)butyl]-2-(naphthalen-2-ylmethyl)-3,6,12,19-tetraoxo-1,4,7,11-tetrazacyclononadecane-8-carboxamide	IC50	4000000.0 [1]
	(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,12,19-tetraoxo-1,4,7,11-tetrazacyclononadecane-8-carboxamide	IC50	1000000.0 [1]
	(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamide	IC50	2000000.0 [1]
	N-[4-[[3-[[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]-1-methylpyrazole-4-carboxamide	IC50	100000.0 [1]
	(2S)-6-Amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(decylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid	IC50	250000.0 [1]
	(2S)-6-Amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-oxo-4-(tridecylamino)butyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid	IC50	20000.0 [1]
	2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-6-(tetradecanethioylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]acetic acid	IC50	2800.0 [1]
	(2S)-6-Amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-[4-(octylamino)-4-oxobutyl]sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoic acid	IC50	500000.0 [1]
	N-(1-Methylindol-5-yl)-2,4-dioxo-1H-quinazoline-6-sulfonamide	IC50	82000.0 [1]
	4-(3-{[Amino(phenylimino)methyl]sulfanyl}-2,5-dioxo-1-pyrrolidinyl)benzoic acid	IC50	181000.0 [1]
	N-[4-(Pyridin-3-yloxy)phenyl]benzenesulfonamide	IC50	300000.0 [1]
	N-[(3-Pyridin-3-yl-1H-1,2,4-triazol-5-yl)methyl]pyrazine-2-carboxamide	IC50	1339000000.0 [1]
	N-(1-Benzylpyrrolidin-3-yl)-2,4-dioxo-1H-quinazoline-6-sulfonamide	IC50	517000.0 [1]
	N-[4-(Imidazol-1-ylmethyl)phenyl]-2,4-dioxo-1H-quinazoline-6-sulfonamide	IC50	60000.0 [1]
	4-(2-Oxopyrrolidin-1-yl)-N-(4-pyridin-3-yloxyphenyl)benzenesulfonamide	IC50	441000.0 [1]
	N-({3-[(1H-Imidazol-1-yl)methyl]phenyl}methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	IC50	2872000.0 [1]
	4-[4-(Furan-2-amido)benzamido]-2-hydroxybenzoic acid	IC50	22000.0 [1]
	Chembl4128630	IC50	20900.0 [1]
	2,4-Dioxo-N-(4-phenoxyphenyl)-1H-quinazoline-6-sulfonamide	IC50	127000.0 [1]
	5-[4-(Furan-2-amido)benzamido]-2-hydroxybenzoic acid	IC50	34000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 40 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ NAD-dependent protein deacetylase sirtuin-6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/nad-dependent-protein-deacetylase-sirtuin-6-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ NAD-dependent protein deacetylase sirtuin-6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-protein-deacetylase-sirtuin-6-inhibitors-ic50-ki.
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