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NAD-dependent protein deacylase sirtuin-5, mitochondrial Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SuraminIC5022000.0 [1]
SirtinolIC5048900.0 [1], 100000.0 [2]
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-olIC5019500.0 [1], 97800.0 [2], 200000.0 [3]
NicotinamideIC5046600.0 [1], 100000.0 [2]
AnthralinIC50100.0 [1], 453400.0 [2]
2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-IC50100000.0 [1]
CID 2248572IC502300.0 [1], 25200.0 [2]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[4-[3-[2-[2-[3-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propylamino]-4-oxobutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-naphthalen-2-ylsulfanylpropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidIC5019.1 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[4-[3-[2-[2-[3-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propylamino]-4-oxobutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-naphthalen-2-ylsulfanylpropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi13.6 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[4-[3-[2-[2-[3-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propylamino]-4-oxobutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[(3-carboxy-3-naphthalen-2-ylsulfanylpropanoyl)amino]hexanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidIC5091.1 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[4-[3-[2-[2-[3-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propylamino]-4-oxobutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[(3-carboxy-3-naphthalen-2-ylsulfanylpropanoyl)amino]hexanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi83.2 [1]
Valproic acidIC50100000.0 [1]
VorinostatIC50100000.0 [1]
4-Phenylbutyric acidIC50100000.0 [1]
SplitomicinIC50100000.0 [1]
CambinolIC5042500.0 [1]
5-((1H-Indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5046500.0 [1]
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamideIC50200000.0 [1]
5-[4-(Benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5012600.0 [1]
2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dioneIC5030000.0 [1]
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-oneIC50100000.0 [1]
6-Hydroxy-5-[(Z)-indol-3-ylidenemethyl]-1-methyl-2-sulfanylidenepyrimidin-4-oneIC5027000.0 [1]
5-{[5-(2,3-Dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC503600.0 [1]
5-{4-[(2-Chlorobenzyl)oxy]-3-methoxybenzylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5012400.0 [1]
5-((1-Benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5016600.0 [1]
2-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]acetic acidIC50100000.0 [1]
3-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]propanoic acidIC505000.0 [1]
4-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]butanoic acidIC50100000.0 [1]
Ethyl 3-[[(5S)-6-[[(2S)-6-acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]propanoateIC50100000.0 [1]
(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanamideIC502000000.0 [1]
5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideIC50200000.0 [1]
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideIC50200000.0 [1]
ThiomyristoylIC50200000.0 [1]
(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,14,21-tetraoxo-1,4,7,13-tetrazacyclohenicosane-8-carboxamideIC50200000.0 [1]
(2S,5S,8S)-2-Butyl-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamideIC50400000.0 [1]
(2S,5S,8S)-5-[4-(Ethanethioylamino)butyl]-2-(naphthalen-2-ylmethyl)-3,6,12,19-tetraoxo-1,4,7,11-tetrazacyclononadecane-8-carboxamideIC506000000.0 [1]
(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,12,19-tetraoxo-1,4,7,11-tetrazacyclononadecane-8-carboxamideIC502000000.0 [1]
(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamideIC50300000.0 [1]
N-[4-[[3-[[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]-1-methylpyrazole-4-carboxamideIC50100000.0 [1]
1-Ethyl-6-hydroxy-5-[(Z)-indol-3-ylidenemethyl]-2-sulfanylidenepyrimidin-4-oneIC5055900.0 [1]
5-{4-[(4-Bromobenzyl)oxy]benzylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC506200.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(3,4-dimethylphenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC5046.1 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-[(3-nitrophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC502673.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[(3-carboxy-4-phenylbutanoyl)amino]hexanoyl]amino]-5-oxopentanoic acidKi263.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(2,3-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50714.5 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[(4-chlorophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50893.3 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[3-carboxy-3-(2-pyrazin-2-ylethylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidKi3.5 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(3,4-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501606.9 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[3-carboxy-3-(2-pyridin-2-ylethylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidKi3.5 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(3-phenylpropylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC502060.6 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-[[4-(trifluoromethyl)phenyl]methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC502202.7 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(2,6-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC5012502.6 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(naphthalen-1-ylmethylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50207.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(4-chlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501614.4 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-(3-naphthalen-2-ylsulfanylpropanoylamino)hexanoyl]amino]-5-oxopentanoic acidIC5040000.0 [1]
4-[5-[(E)-2-Cyano-3-(4-cyano-3-fluoroanilino)-3-oxoprop-1-enyl]furan-2-yl]benzoic acidIC505600.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(3,5-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50647.1 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-naphthalen-2-ylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501181.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-[(4-methoxyphenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501111.7 [1]
(2S)-2-Naphthalen-2-ylsulfanyl-4-oxo-4-(3-phenylpropylamino)butanoic acidIC5072560.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidKi3.5 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-[(3,4-dichlorophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50779.8 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(3,4-dimethoxyphenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50325.8 [1]
(2S)-4-Anilino-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acidIC50157200.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[(4-methoxyphenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501047.1 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[[3-(trifluoromethyl)phenyl]methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501124.6 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(naphthalen-1-ylmethylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidKi7.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-cyclohexylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC5014000.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(2,5-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501977.0 [1]
3-[4-[(3S,7S,10S,29S)-10-Acetamido-29-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-7-[3-(diaminomethylideneamino)propyl]-2,5,9,16,23-pentaoxo-1,4,8,15,24-pentazacyclononacos-3-yl]butylcarbamothioylamino]propanoic acidIC507500.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-[(4-tert-butylphenyl)methylsulfanyl]-3-carboxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501235.9 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(2-phenylethylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC502741.6 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-benzylsulfanyl-3-carboxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50335.7 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-[(4-nitrophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC504027.2 [1]
(2S)-4-[[(5S)-6-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-oxohexyl]amino]-2-methyl-2-naphthalen-1-ylsulfanyl-4-oxobutanoic acidIC5059.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(3-chlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501383.6 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(3-phenylpropylsulfanyl)propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501129.8 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(3,5-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC5086.1 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[(2,4-dichlorophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50543.3 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[[4-(trifluoromethyl)phenyl]methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50803.5 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(2,4-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC502013.7 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-cyclohexylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC504000.0 [1]
(2S)-4-[[(5S)-5-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-6-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-6-oxohexyl]amino]-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acidIC50350.4 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(2,6-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50576.8 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(4-chlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50101.9 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-phenylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidKi135.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-[(4-chlorophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501020.9 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-naphthalen-1-ylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC5095.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[(2,4,6-trimethylphenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC505200.0 [1]
(2S)-4-[[(5S)-5-Acetamido-6-amino-6-oxohexyl]amino]-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acidIC507400.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-(3,4-dimethoxyphenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC509078.2 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-naphthalen-2-ylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC5030.3 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-(3-naphthalen-2-ylsulfanylbutanoylamino)hexanoyl]amino]-5-oxopentanoic acidIC5040000.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-carboxy-3-phenylsulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC501798.8 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3R)-3-benzylsulfanyl-3-carboxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50644.1 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(2,4-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50176.6 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-[(3,4-dichlorophenyl)methylsulfanyl]propanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50739.6 [1]
4-[[(5S)-6-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-[[(2S)-2-[[(2S)-2-[[2-(benzylamino)acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-oxohexyl]amino]-2-methyl-4-oxo-2-phenylbutanoic acidIC504300.0 [1]
(2S)-4-[3-(Methylcarbamoyl)anilino]-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acidIC5090000.0 [1]
(4S)-5-[[(2S)-1-[[2-[[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzamidoacetyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-6-[[(3S)-3-carboxy-3-(2,5-dichlorophenyl)sulfanylpropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acidIC50295.1 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ NAD-dependent protein deacylase sirtuin-5, mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/nad-dependent-protein-deacylase-sirtuin-5-mitochondrial-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ NAD-dependent protein deacylase sirtuin-5, mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-protein-deacylase-sirtuin-5-mitochondrial-inhibitors-ic50-ki.
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