Nerve growth factor receptor Trk-A Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	0.5 [1], 1.29 [2], 1.7 [3], 3.1 [4], 8.3 [5]
	N-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide	IC50	47.0 [1], 85.4 [2], 119.3 [3], 287.2 [4], 662.0 [5]
	Antibiotic K 252a	IC50	2.4 [1], 13.0 [2]
	Methyl (15S,16S,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate	IC50	1.2 [1], 5.0 [2]
	AZ-23	IC50	3.2 [1], 8.9 [2], 9.9 [3]
	1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one	IC50	2.0 [1], 3.0 [2]
	1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-((2-hydroxyethyl)amino)-5-nitro-	IC50	3720.0 [1], 5880.0 [2], 149000.0 [3]
	(R)-3-((6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-yl)thio)-5-ureidoisothiazole-4-carboxamide	IC50	1.0 [1], 7.0 [2]
	1-[(3S,4R)-4-(3,4-Difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenylpyrazol-3-yl)urea	IC50	2.7 [1], 6.0 [2], 37163.3 [3]
	2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid	IC50	1.0 [1]
	1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol	IC50	3.0 [1], 4.0 [2], 10.0 [3]
	5-[[2-Chloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-(3-hydroxycyclobutyl)-1-phenylpyrazole-3-carboxamide	IC50	61.8 [1], 75.8 [2], 82.2 [3]
	Crizotinib	IC50	1.0 [1], 580.0 [2]
	Purvalanol B	IC50	51.0 [1], 1710.0 [2]
	Larotrectinib	IC50	9.7 [1]
	Entrectinib	IC50	1.0 [1], 3.0 [2]
	JNJ-28312141 free base	IC50	15.0 [1], 150.0 [2]
	4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol	IC50	1.67 [1]
	2-Amino-1-[4-[5-[[2-[(6-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl]sulfanyl]-2-methylbenzoyl]piperazin-1-yl]ethanone	IC50	0.6 [1]
	CID 59627005	IC50	1.4 [1], 3.0 [2]
	1-Propan-2-yl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethoxy)phenyl]urea	IC50	3.0 [1], 11.0 [2]
	3-{[(4-Chlorophenyl)methyl]sulfanyl}-5-(pyridin-3-ylamino)-1,2-thiazole-4-carboxamide	IC50	19.0 [1], 581.0 [2]
	3-{[(4-Chlorophenyl)methyl]sulfanyl}-5-[(6-methoxypyridin-3-yl)amino]-1,2-thiazole-4-carboxamide	IC50	179.0 [1], 1000.0 [2]
	(15S,16S,18R)-16-Hydroxy-15,16-dimethyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaen-3-one	IC50	3.0 [1], 10.0 [2]
	5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-methylsulfonylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamide	IC50	30.0 [1], 500.0 [2]
	3-{[(4-Chlorophenyl)methyl]sulfanyl}-5-(pyridin-2-ylamino)-1,2-thiazole-4-carboxamide	IC50	33.0 [1], 756.0 [2]
	3-{[(4-Chlorophenyl)methyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide	IC50	7.0 [1], 300.0 [2]
	3-{[1-(4-Chlorophenyl)ethyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide	IC50	3.0 [1], 96.0 [2]
	3-{[1-(4-Chlorophenyl)propyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide	IC50	9.0 [1], 70.0 [2]
	3-{[(1R)-1-(4-Chlorophenyl)propyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide	IC50	4.0 [1], 46.0 [2]
	3-{[(1S)-1-(4-Chlorophenyl)propyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide	IC50	52.0 [1], 978.0 [2]
	3-[1-(4-Chlorophenyl)-2-methylpropyl]sulfanyl-5-(methylcarbamoylamino)-1,2-thiazole-4-carboxamide	IC50	16.0 [1], 290.0 [2]
	3-{[1-(4-Chlorophenyl)butyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide	IC50	35.0 [1], 600.0 [2]
	3-[1-(4-Chlorophenyl)-2,2,2-trifluoroethyl]sulfanyl-5-(methylcarbamoylamino)-1,2-thiazole-4-carboxamide	IC50	110.0 [1], 2870.0 [2]
	3-[(Cyclohexylmethyl)sulfanyl]-5-(pyridin-3-ylamino)-1,2-thiazole-4-carboxamide	IC50	610.0 [1], 1000.0 [2]
	5-(Carbamoylamino)-3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)sulfanyl]-1,2-thiazole-4-carboxamide	IC50	10.0 [1], 110.0 [2]
	3-[(5-Chloro-2,3-dihydro-1H-inden-1-yl)sulfanyl]-5-(methylcarbamoylamino)-1,2-thiazole-4-carboxamide	IC50	8.0 [1], 118.0 [2]
	5-(Carbamoylamino)-3-(1,2,3,4-tetrahydronaphthalen-1-ylsulfanyl)-1,2-thiazole-4-carboxamide	IC50	105.0 [1], 1170.0 [2]
	5-[(Methylcarbamoyl)amino]-3-(1,2,3,4-tetrahydronaphthalen-1-ylsulfanyl)-1,2-thiazole-4-carboxamide	IC50	111.0 [1], 1020.0 [2]
	5-(Carbamoylamino)-3-{6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylsulfanyl}-1,2-thiazole-4-carboxamide	IC50	1.0 [1], 17.0 [2]
	6-[(2R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl]-N-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]pyrido[3,2-d]pyrimidin-4-amine	IC50	1.5 [1], 13.0 [2]
	4-(3-Ethoxyphenyl)-1-[2-[4-(trifluoromethoxy)phenoxy]ethyl]pyrrolo[3,2-c]pyridine-2-carboxylic acid	IC50	59.0 [1], 348.0 [2]
	5-Cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylic acid	IC50	118.0 [1], 150.0 [2]
	5-(1H-Pyrazol-5-yl)-1-[2-[4-(trifluoromethoxy)phenoxy]ethyl]indole-2-carboxylic acid	IC50	29.0 [1], 51.0 [2]
	1-[2-(4-Chlorophenoxy)ethyl]-4-(3-ethoxyphenyl)pyrrolo[3,2-c]pyridine-2-carboxylic acid	IC50	200.0 [1], 653.0 [2]
	4-(3-Ethoxyphenyl)-1-(2-phenoxyethyl)pyrrolo[3,2-c]pyridine-2-carboxylic acid	IC50	109.0 [1], 2070.0 [2]
	1-[2-[4-(Trifluoromethoxy)phenoxy]ethyl]pyrrolo[3,2-c]pyridine-2-carboxylic acid	IC50	12300.0 [1], 15750.0 [2]
	2-[(4S)-7-(3-Chlorophenyl)-1-oxo-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-4-yl]-N-[(1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl]acetamide	IC50	10000.0 [1]
	1-Cyclopropyl-1-[3-(1,3-Thiazol-2-Yl)benzyl]-3-[4-(Trifluoromethoxy)phenyl]urea	IC50	549.0 [1], 4233.0 [2]
	1-Propan-2-yl-1-[[3-(1,3-thiazol-2-yl)phenyl]methyl]-3-[4-(trifluoromethoxy)phenyl]urea	IC50	56.0 [1], 132.0 [2]
	N-(2,2-Dimethylpropyl)-2-(1-oxo-7-thiophen-3-yl-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-4-yl)acetamide	IC50	10000.0 [1]
	6-N-[(3-Chlorophenyl)methyl]-4-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrido[3,2-d]pyrimidine-4,6-diamine	IC50	11.0 [1], 1688.0 [2]
	N-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-2-[4-[4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide	IC50	9.0 [1], 60.0 [2]
	Trk Inhibitor C11	IC50	7.0 [1], 9.0 [2]
	1-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-5-(1-methylpyrazol-4-yl)benzimidazol-2-amine	IC50	0.3 [1], 1.0 [2]
	3-(4-Chloro-benzylsulfanyl)-5-(pyridin-4-ylamino)-isothiazole-4-carboxylic acid amide	IC50	45.0 [1], 344.0 [2]
	1-[2-(3-Methylphenyl)-5-(trifluoromethyl)pyridin-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	3.0 [1], 30.0 [2]
	1-[2-[4-[2-(Ethylamino)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]-3-[2-(4-methylphenyl)-5-(trifluoromethyl)pyridin-3-yl]urea	IC50	4.0 [1], 90.0 [2]
	5-[(2,4-Dichloro-5-pyridin-2-ylbenzoyl)amino]-N-(4-hydroxycyclohexyl)-1-phenylpyrazole-3-carboxamide	IC50	6.93 [1], 7.23 [2]
	5-[[2,4-Dichloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-(4-hydroxycyclohexyl)-1-phenylpyrazole-3-carboxamide	IC50	4.03 [1], 4.46 [2]
	5-[[2-Chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-(4-hydroxycyclohexyl)-1-phenylpyrazole-3-carboxamide	IC50	9.71 [1], 12.0 [2]
	N-(3-Aminocyclobutyl)-5-[(2-chloro-4-fluoro-5-pyridin-2-ylbenzoyl)amino]-1-phenylpyrazole-3-carboxamide	IC50	104.0 [1], 126.0 [2]
	5-[[2-Chloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-[3-(hydroxymethyl)cyclobutyl]-1-phenylpyrazole-3-carboxamide	IC50	67.6 [1], 82.6 [2]
	5-[(2-Chloro-4-fluoro-5-pyridin-2-ylbenzoyl)amino]-N-(3-hydroxycyclobutyl)-1-phenylpyrazole-3-carboxamide	IC50	25.9 [1], 28.7 [2]
	5-[(2-Chloro-4-fluoro-5-pyridin-2-ylbenzoyl)amino]-N-[3-(hydroxymethyl)cyclobutyl]-1-phenylpyrazole-3-carboxamide	IC50	25.9 [1], 26.3 [2]
	5-[(2-Chloro-4-fluoro-5-pyridin-2-ylbenzoyl)amino]-N-(4-hydroxycyclohexyl)-1-phenylpyrazole-3-carboxamide	IC50	20.9 [1], 22.0 [2]
	N-(3-Aminocyclobutyl)-5-[[2-chloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-1-phenylpyrazole-3-carboxamide	IC50	196.0 [1], 234.0 [2]
	N-(4-Aminocyclohexyl)-5-[[2-chloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-1-phenylpyrazole-3-carboxamide	IC50	114.0 [1], 164.0 [2]
	5-[[2,4-Dichloro-5-(5-fluoropyridin-2-yl)benzoyl]amino]-N-(4-hydroxycyclohexyl)-1-phenylpyrazole-3-carboxamide	IC50	17.4 [1], 22.0 [2]
	5-[[2,4-Dichloro-5-(5-fluoropyridin-2-yl)benzoyl]amino]-N-(3-hydroxycyclobutyl)-1-phenylpyrazole-3-carboxamide	IC50	24.2 [1], 25.2 [2]
	5-[[2-Chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-(3-hydroxycyclobutyl)-1-phenylpyrazole-3-carboxamide	IC50	11.3 [1], 14.2 [2]
	5-[[2,4-Dichloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-(3-hydroxycyclobutyl)-1-phenylpyrazole-3-carboxamide	IC50	4.69 [1], 5.83 [2]
	5-[(2,4-Dichloro-5-pyridin-2-ylbenzoyl)amino]-N-(3-hydroxycyclobutyl)-1-phenylpyrazole-3-carboxamide	IC50	7.46 [1], 13.1 [2]
	N-(3-Aminocyclobutyl)-5-[(2,4-dichloro-5-pyridin-2-ylbenzoyl)amino]-1-phenylpyrazole-3-carboxamide	IC50	38.1 [1], 46.9 [2]
	N-(3-Aminocyclobutyl)-5-[[2-chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-1-phenylpyrazole-3-carboxamide	IC50	53.1 [1], 81.3 [2]
	N-(3-Aminocyclobutyl)-5-[[2,4-dichloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-1-phenylpyrazole-3-carboxamide	IC50	27.2 [1], 31.5 [2]
	N-(3-Aminocyclobutyl)-5-[[2,4-dichloro-5-(5-fluoropyridin-2-yl)benzoyl]amino]-1-phenylpyrazole-3-carboxamide	IC50	116.0 [1], 142.0 [2]
	5-[[2-Chloro-5-(3-fluoropyridin-2-yl)benzoyl]amino]-N-(4-hydroxycyclohexyl)-1-phenylpyrazole-3-carboxamide	IC50	57.1 [1], 67.1 [2]
	1-[2-[4-[2-(2-Oxopiperidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]-3-[5-(trifluoromethyl)-2-[6-(trifluoromethyl)pyridin-3-yl]pyridin-3-yl]urea	IC50	93.0 [1], 160.0 [2]
	1-[2-[4-[2-(2-Oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]-3-[5-(trifluoromethyl)-2-[6-(trifluoromethyl)pyridin-3-yl]pyridin-3-yl]urea	IC50	12.0 [1], 40.0 [2]
	1-[5-(1,1-Difluoroethyl)-2-(2-methylphenyl)pyrazol-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	18.0 [1], 60.0 [2]
	1-[2-[4-[2-(Ethylamino)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]-3-[2-phenoxy-5-(trifluoromethyl)pyridin-3-yl]urea	IC50	10.0 [1], 120.0 [2]
	1-[2-(2-Methylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	11.0 [1], 50.0 [2]
	1-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	30.0 [1], 33.0 [2]
	1-[2-(3,4-Dimethylphenyl)-5-(trifluoromethyl)pyridin-3-yl]-3-[2-[4-[2-(2-oxoazepan-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	70.0 [1], 190.0 [2]
	Methyl 3-[3-tert-butyl-5-[[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]carbamoylamino]pyrazol-1-yl]benzoate	IC50	10.0 [1], 130.0 [2]
	1-[2-Chloro-5-(trifluoromethyl)phenyl]-3-[2-[4-[2-(propylamino)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	2.0 [1], 20.0 [2]
	1-[2-(3,4-Dimethylphenyl)-5-(trifluoromethyl)pyridin-3-yl]-3-[6-[4-[2-(ethylamino)-1,3-thiazol-5-yl]phenoxy]pyridin-3-yl]urea	IC50	6.0 [1], 180.0 [2]
	1-[5-Tert-butyl-2-(3,4-dimethylphenyl)pyrazol-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	2.0 [1], 80.0 [2]
	N-[4-[3-Tert-butyl-5-[[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]carbamoylamino]pyrazol-1-yl]phenyl]acetamide	IC50	14.0 [1], 80.0 [2]
	1-[5-Tert-butyl-2-(1-methylindazol-5-yl)pyrazol-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	2.0 [1], 30.0 [2]
	1-[5-Tert-butyl-2-(4-sulfamoylphenyl)pyrazol-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	32.0 [1], 50.0 [2]
	1-[2-[4-[2-(2-Oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]-3-[2-phenyl-5-(trifluoromethyl)pyridin-3-yl]urea	IC50	4.0 [1], 40.0 [2]
	1-[5-Tert-butyl-2-(2,3-dihydro-1-benzofuran-5-yl)pyrazol-3-yl]-3-[2-[4-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-5-yl]phenoxy]pyrimidin-5-yl]urea	IC50	4.0 [1], 20.0 [2]
	Amitriptyline	IC50	60000.0 [1]
	Staurosporine HCl	IC50	1.41 [1]
	K252a	IC50	13.0 [1]
	Bosutinib	IC50	22.0 [1]
	Pictilisib	IC50	2850.0 [1]
	Ceritinib	IC50	2727.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Nerve growth factor receptor Trk-A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/nerve-growth-factor-receptor-trk-a-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Nerve growth factor receptor Trk-A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nerve-growth-factor-receptor-trk-a-inhibitors-ic50-ki.
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