Neurogenic locus notch homolog protein 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide	IC50	64.1 [1]
	(2S,3R)-N'-[(3S)-7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-prop-2-enylbutanediamide	IC50	42.4 [1]
	(2S,3R)-3-(2-Methylpropyl)-N'-[(3S)-2-oxo-5-phenyl-1-propyl-3H-1,4-benzodiazepin-3-yl]-2-prop-2-enylbutanediamide	IC50	12.3 [1]
	(2S,3R)-2-Butyl-N'-[(3S)-5-(4-chlorophenyl)-1-methyl-2-oxo-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide	IC50	5.1 [1]
	Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate	IC50	2510.0 [1]
	(2S,3R)-3-(2,2-Dimethylpropyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-pentan-3-ylbutanediamide	IC50	3.0 [1]
	(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-pentan-3-yl-3-(3,3,3-trifluoropropyl)butanediamide	IC50	1.0 [1]
	(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-propyl-3-(2,2,2-trifluoroethyl)butanediamide	IC50	13.0 [1]
	(2R,3R)-2-(1,2,4-Oxadiazol-3-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	1190.0 [1]
	(2R,3R)-2-(1,3-Oxazol-4-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	231.0 [1]
	(2R,3R)-2-(1,2-Oxazol-4-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	32.0 [1]
	(2R,3R)-2-(5-Methyl-1,2,4-oxadiazol-3-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	169.0 [1]
	(2R,3R)-2-(5-Methyl-1,2-oxazol-3-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	54.0 [1]
	(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-(3-methylphenyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.0 [1]
	(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-[3-(trifluoromethyl)phenyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	1.0 [1]
	(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-[3-(trifluoromethoxy)phenyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.0 [1]
	(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-(3-methylsulfonylphenyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2060.0 [1]
	(2R,3R)-2-(4-Methoxyphenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	9.0 [1]
	(2R,3R)-2-(3,4-Difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.0 [1]
	(2R,3R)-2-(2,4-Difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	1.0 [1]
	(2R,3R)-2-(3,5-Difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 2,7,7-trimethyl-5-oxo-4-(3-propan-2-ylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	3320.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 2,7,7-trimethyl-5-oxo-4-quinolin-2-yl-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	330.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl] 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	10000.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 2,7,7-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	10000.0 [1]
	(4-Tert-butylphenyl)methyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	4270.0 [1]
	Cyclohexyl 4-(3-cyanophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	43200.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	1520.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 4-(4-bromo-2-fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	10000.0 [1]
	2-[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]ethyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	2950.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl (4S)-4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	2590.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 2,7,7-trimethyl-5-oxo-4-[3-(trifluoromethyl)phenyl]-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	760.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 4-[3-(1H-indol-5-yl)phenyl]-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	770.0 [1]
	Pyrazin-2-ylmethyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	860.0 [1]
	1-Adamantyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	10000.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	10000.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 4-(3-cyanophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	220.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	360.0 [1]
	[(1R)-2-Cyano-1-phenylethyl] 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	10000.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl 4-(3,5-dichlorophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	640.0 [1]
	[1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]methyl (4R)-4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	130.0 [1]
	Cyclohexyl 2,7,7-trimethyl-5-oxo-4-[3-(trifluoromethyl)phenyl]-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	14700.0 [1]
	Cyclohexyl 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate	IC50	12300.0 [1]
	Cyclohexyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate	IC50	4150.0 [1]
	(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-pentan-3-ylbutanediamide	IC50	2.0 [1]
	(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-phenyl-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.0 [1]
	Unii-lsk1L593UU	IC50	7.8 [1]
	(2R,3R)-2-(4-Fluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.0 [1]
	(2R,3R)-2-(3-Methyl-1,2-oxazol-4-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.0 [1]
	(2S,3R)-N'-[(3S)-9-Aminooxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(3-fluoropropyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	7.0 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.0 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.5 [1]
	(2S,3R)-2-(4,4-Difluorocyclohexyl)-N'-[(3S)-9-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	7.0 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-5-(3-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4-difluorocyclohexyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.2 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[4-(trifluoromethyl)cyclohexyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	11.9 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4-difluorocyclohexyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.4 [1]
	(2S,3R)-2-(3,3-Difluorocyclobutyl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	14.0 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.9 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-9-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.9 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	1.7 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	5.6 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(3,3-difluorocyclobutyl)methyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.8 [1]
	(2S,3R)-2-[(3,3-Difluorocyclobutyl)methyl]-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.4 [1]
	(2S,3R)-2-(3-Fluoropropyl)-N'-[(3S)-8-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	5.8 [1]
	(2S,3R)-2-(2,2-Difluoropropyl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.7 [1]
	(2S,3R)-N'-[(3S)-9-Fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(2S)-3,3,3-trifluoro-2-methylpropyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	2.9 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(3-fluoropropyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	10.8 [1]
	(2S,3R)-2-(3,3-Difluorobutyl)-N'-[(3S)-9-methoxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	7.5 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(2R)-3,3,3-trifluoro-2-methylpropyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.2 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-[(2S)-3,3,3-trifluoro-2-methylpropyl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	5.1 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(3,3-difluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.9 [1]
	(2S,3R)-2-[(1-Fluorocyclobutyl)methyl]-N'-[(3S)-9-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamide	IC50	3.8 [1]
	(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-ethyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.9 [1]
	(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-2-oxo-9-propan-2-yl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	1.8 [1]
	(2S,3R)-N'-[(3S)-9-Ethyl-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	7.2 [1]
	(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.4 [1]
	(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	6.0 [1]
	(2S,3R)-N'-[(3S)-5-(3-Methylphenyl)-2-oxo-9-(trifluoromethyl)-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	8.2 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(3,5-dimethylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	2.5 [1]
	(2S,3R)-N'-[(3S)-5-(3-Methylphenyl)-2-oxo-9-propan-2-yl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	3.0 [1]
	(2S,3R)-N'-[(3S)-2-Oxo-5-phenyl-9-propan-2-yl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	3.4 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	7.7 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.4 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	5.8 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	5.7 [1]
	(2S,3R)-N'-[(3S)-9-Methyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamide	IC50	4.6 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.8 [1]
	(2S,3R)-N'-[(3S)-9-Methyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	1.6 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(2-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	3.3 [1]
	(2S,3R)-N'-[(3S)-5-(4-Fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	3.1 [1]
	(2S,3R)-N'-[(3S)-9-Methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.7 [1]
	(2S,3R)-N'-[(3S)-9-Cyclopropyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	1.4 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(3-cyclopropylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	1.7 [1]
	(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-methoxy-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	3.7 [1]
	(2S,3R)-N'-[(3S)-5-(4-Chlorophenyl)-9-methoxy-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	2.8 [1]
	(2S,3R)-N'-[(3S)-9-Chloro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.8 [1]
	(2S,3R)-N'-[(3S)-9-Methoxy-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	3.9 [1]
	(2S,3R)-N'-[(3S)-5-[4-(Hydroxymethyl)phenyl]-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	4.8 [1]
	(2S,3R)-N'-[(3S)-5-(2-Methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	2.8 [1]
	(2S,3R)-N'-[(3S)-5-(3-Methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide	IC50	6.4 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Neurogenic locus notch homolog protein 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/neurogenic-locus-notch-homolog-protein-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Neurogenic locus notch homolog protein 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neurogenic-locus-notch-homolog-protein-1-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan