Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nicotine	IC50	84.8 [1]
	3-[(2s)-Azetidin-2-Ylmethoxy]-5-[(1s,2r)-2-(2-Methoxyethyl)cyclopropyl]pyridine	IC50	9.7 [1]
	(3S)-3-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-4-[(2S)-2-[[(1R,6R,9S,12S,15S,21S,24S,27S,30S,33R,36S,39S,45S,48S,53R)-21,45-bis(2-amino-2-oxoethyl)-12-(3-amino-3-oxopropyl)-9-[(2S)-butan-2-yl]-6-carbamoyl-30-[(1R)-1-hydroxyethyl]-48-(hydroxymethyl)-24-(1H-imidazol-5-ylmethyl)-8,11,14,20,23,26,29,32,35,38,44,47,50,52-tetradecaoxo-27,36-di(propan-2-yl)-3,4,55,56-tetrathia-7,10,13,19,22,25,28,31,34,37,43,46,49,51-tetradecazatetracyclo[31.17.7.015,19.039,43]heptapentacontan-53-yl]carbamoyl]pyrrolidin-1-yl]-4-oxobutanoic acid	IC50	0.95 [1]
	1-(Cyclopropylcarbonyl)piperazine	Ki	26000.0 [1]
	(3S)-3-Amino-4-[(2S)-2-[[(2R)-1-[[(2R)-1-[[(2S)-1-[[(2S)-4-amino-1-[(2S)-2-[[(2S)-1-[[(2R)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxobutanoic acid	IC50	1.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1S,2S)-2-fluorocyclopropyl]methanone	Ki	55.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1S,2R)-2-fluorocyclopropyl]methanone	Ki	43.0 [1]
	1-(3,6-Diazabicyclo[3.1.1]heptan-3-yl)-2-methylpropan-1-one	Ki	580.0 [1]
	Cyclopropyl(3,6-diazabicyclo[3.1.1]heptan-3-yl)methanone	Ki	21.0 [1]
	Ethanone, 1-(3,6-diazabicyclo[3.1.1]hept-3-yl)-	Ki	610.0 [1]
	7-(5-Propan-2-yloxypyridin-3-yl)-3-azabicyclo[3.3.1]non-6-ene	Ki	2.6 [1]
	7-(5-Phenoxypyridin-3-yl)-3-azabicyclo[3.3.1]non-6-ene	Ki	4.8 [1]
	1-(3,6-Diazabicyclo[3.1.1]heptan-3-yl)propan-1-one	Ki	190.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1R,2R)-2-fluorocyclopropyl]methanone	Ki	27.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1R,2S)-2-fluorocyclopropyl]methanone	Ki	490.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1S,2S)-2-methylcyclopropyl]methanone	Ki	310.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-(2,2-difluorocyclopropyl)methanone	Ki	75.0 [1]
	2-Cyclopent-2-en-1-yl-1-(3,6-diazabicyclo[3.1.1]heptan-3-yl)ethanone	Ki	2500.0 [1]
	(1S,5R)-7-Pyridin-3-yl-3-azabicyclo[3.3.1]non-6-ene	Ki	0.95 [1]
	3-Methyl-7-(5-propan-2-yloxypyridin-3-yl)-3-azabicyclo[3.3.1]non-6-ene	Ki	690.0 [1]
	(1R,5S)-3-Methyl-7-pyridin-3-yl-3-azabicyclo[3.3.1]non-6-ene	Ki	320.0 [1]
	(1S,5R)-3-Methyl-7-pyridin-3-yl-3-azabicyclo[3.3.1]non-6-ene	Ki	300.0 [1]
	(1R,5S)-7-Pyridin-3-yl-3-azabicyclo[3.3.1]non-6-ene	Ki	1.0 [1]
	3-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]-5-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]pyridine;2,2,2-trifluoroacetic acid	IC50	23.9 [1]
	3-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]-5-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine;2,2,2-trifluoroacetic acid	IC50	223.0 [1]
	3-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]-5-[[(3R)-pyrrolidin-3-yl]methoxy]pyridine;2,2,2-trifluoroacetic acid	IC50	8.3 [1]
	Cyclopropyl(2,5-diazabicyclo[2.2.1]heptan-2-yl)methanone	Ki	10000.0 [1]
	Cyclopropyl(3,8-diazabicyclo[3.2.1]octan-3-yl)methanone	Ki	7200.0 [1]
	Cyclopent-3-en-1-yl(3,6-diazabicyclo[3.1.1]heptan-3-yl)methanone	Ki	1100.0 [1]
	Cyclopentyl(3,6-diazabicyclo[3.1.1]heptan-3-yl)methanone	Ki	2900.0 [1]
	Cyclobutyl(3,6-diazabicyclo[3.1.1]heptan-3-yl)methanone	Ki	240.0 [1]
	1-(3,6-Diazabicyclo[3.1.1]heptan-3-yl)butan-1-one	Ki	350.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-(2,2-dimethylcyclopropyl)methanone	Ki	250.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1S,2R)-2-methylcyclopropyl]methanone	Ki	92.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1R,2S)-2-methylcyclopropyl]methanone	Ki	170.0 [1]
	3,6-Diazabicyclo[3.1.1]heptan-3-yl-[(1R,2R)-2-methylcyclopropyl]methanone	Ki	14.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 36 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha3-alpha6-beta2-beta3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha3-alpha6-beta2-beta3-inhibitors-ic50-ki.
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