Neuronal acetylcholine receptor; alpha9/alpha10 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-[(1R,6R,9S,12S,15S,21S,24S,27S,30S,33R,36S,39S,45S,48S,53R)-53-[(2-Aminoacetyl)amino]-30-(2-amino-2-oxoethyl)-9-[(2S)-butan-2-yl]-36-(3-carbamimidamidopropyl)-6-carbamoyl-24,45-bis(carboxymethyl)-48-(hydroxymethyl)-27-[(4-hydroxyphenyl)methyl]-21-(1H-imidazol-2-ylmethyl)-8,11,14,20,23,26,29,32,35,38,44,47,50,52-tetradecaoxo-3,4,55,56-tetrathia-7,10,13,19,22,25,28,31,34,37,43,46,49,51-tetradecazatetracyclo[31.17.7.015,19.039,43]heptapentacontan-12-yl]propanoic acid	IC50	1000.0 [1]
	2-[(1R,6R,9S,12S,15S,21S,24S,27S,30S,33R,36S,39S,45S,48S,53R)-53-[(2-Aminoacetyl)amino]-9-(4-aminobutyl)-12-(2-amino-2-oxoethyl)-6-carbamoyl-45-(carboxymethyl)-36-[3-(diaminomethylideneamino)propyl]-30,48-bis(hydroxymethyl)-21-(1H-imidazol-2-ylmethyl)-8,11,14,20,23,26,29,32,35,38,44,47,50,52-tetradecaoxo-27-propan-2-yl-3,4,55,56-tetrathia-7,10,13,19,22,25,28,31,34,37,43,46,49,51-tetradecazatetracyclo[31.17.7.015,19.039,43]heptapentacontan-24-yl]acetic acid	IC50	9300.0 [1], 12960.0 [2], 13230.0 [3], 15200.0 [4]
	2-[(1R,6R,9S,12S,15S,21S,24S,27S,30S,33R,36S,39S,45S,48S,53R)-53-[(2-Aminoacetyl)amino]-12,30-bis(2-amino-2-oxoethyl)-9-[(2S)-butan-2-yl]-36-(3-carbamimidamidopropyl)-6-carbamoyl-45-(carboxymethyl)-48-(hydroxymethyl)-27-[(4-hydroxyphenyl)methyl]-21-(1H-imidazol-2-ylmethyl)-8,11,14,20,23,26,29,32,35,38,44,47,50,52-tetradecaoxo-3,4,55,56-tetrathia-7,10,13,19,22,25,28,31,34,37,43,46,49,51-tetradecazatetracyclo[31.17.7.015,19.039,43]heptapentacontan-24-yl]acetic acid	IC50	8590.0 [1], 10240.0 [2], 10790.0 [3], 17540.0 [4]
	Stilonium iodide	IC50	10.0 [1]
	2-[(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-40-[(2-Aminoacetyl)amino]-24-carbamoyl-4,27,33-tris[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-30-[(4-hydroxyphenyl)methyl]-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decazatricyclo[17.16.7.07,11]dotetracontan-13-yl]acetic acid	IC50	248700.0 [1]
	4-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenoxy]butyl-triethylazanium;iodide	IC50	11.9 [1]
	4-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenoxy]butyl-triphenylphosphanium;iodide	IC50	10000.0 [1]
	Triethyl-[6-[4-[(E)-2-phenylethenyl]phenoxy]hexyl]azanium;iodide	IC50	4.8 [1]
	2-[(1R,6R,9S,12S,15S,21S,24S,27S,30S,33R,36S,39S,45S,48S,53R)-53-[(2-Aminoacetyl)amino]-9-(4-aminobutyl)-12-(2-amino-2-oxoethyl)-6-carbamoyl-30,48-bis(hydroxymethyl)-21,45-bis(1H-imidazol-2-ylmethyl)-36-methyl-8,11,14,20,23,26,29,32,35,38,44,47,50,52-tetradecaoxo-27-propan-2-yl-3,4,55,56-tetrathia-7,10,13,19,22,25,28,31,34,37,43,46,49,51-tetradecazatetracyclo[31.17.7.015,19.039,43]heptapentacontan-24-yl]acetic acid	IC50	22200.0 [1]
	Triethyl-[4-[4-[(E)-2-phenylethenyl]phenoxy]butyl]azanium;iodide	IC50	5.0 [1]
	Triethyl-[8-[4-[(E)-2-phenylethenyl]phenoxy]octyl]azanium;iodide	IC50	6.6 [1]
	2-[4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenoxy]ethyl-triethylazanium;iodide	IC50	17.2 [1]
	3-Phenyl-1-[5-[2,4,5-tris[5-(3-phenylpyridin-1-ium-1-yl)pent-1-ynyl]phenyl]pent-4-ynyl]pyridin-1-ium	IC50	1.7 [1]
	1-[3-[4-[4-[3-(3,4-Dimethylpyridin-1-ium-1-yl)prop-1-ynyl]phenyl]phenyl]prop-2-ynyl]-3,4-dimethylpyridin-1-ium;dibromide	IC50	16.0 [1]
	2-[(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-40-[(2-Aminoacetyl)amino]-24-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]-4,27,33-tris[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-30-[(4-hydroxyphenyl)methyl]-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decazatricyclo[17.16.7.07,11]dotetracontan-13-yl]acetic acid	IC50	5.2 [1]
	2-[(1R,4S,7S,13S,16S,19R,24R,27S,30S,33S,40R)-40-[(2-Aminoacetyl)amino]-24-carbamoyl-4,27-bis[3-(diaminomethylideneamino)propyl]-16-(hydroxymethyl)-30-(1H-indol-3-ylmethyl)-33-methyl-3,6,12,15,18,26,29,32,35,41-decaoxo-21,22,37,38-tetrathia-2,5,11,14,17,25,28,31,34,42-decazatricyclo[17.16.7.07,11]dotetracontan-13-yl]acetic acid	IC50	2000.0 [1]
	1-[5-[3,5-Bis[5-(3-phenylpyridin-1-ium-1-yl)pent-1-ynyl]phenyl]pent-4-ynyl]-3-phenylpyridin-1-ium	IC50	670.0 [1]
	1-(5-{3,5-Bis[5-(quinolin-1-ium-1-yl)pentyl]phenyl}pentyl)quinolin-1-ium tribromide	IC50	4.8 [1]
	1-(5-{3,5-Bis[5-(3-phenylpyridin-1-ium-1-yl)pentyl]phenyl}pentyl)-3-phenylpyridin-1-ium tribromide	IC50	0.56 [1]
	2-(5-{3,5-Bis[5-(isoquinolin-2-ium-2-yl)pentyl]phenyl}pentyl)isoquinolin-2-ium tribromide	IC50	3.7 [1]
	1-[3-[4-[4-[3-(3,4-Dimethylpyridin-1-ium-1-yl)propyl]phenyl]phenyl]propyl]-3,4-dimethylpyridin-1-ium	IC50	4.2 [1]
	3-Phenyl-1-[5-[2,4,5-tris[5-(3-phenylpyridin-1-ium-1-yl)pentyl]phenyl]pentyl]pyridin-1-ium	IC50	5.4 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 22 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor; alpha9/alpha10 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha9-alpha10-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Neuronal acetylcholine receptor; alpha9/alpha10 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha9-alpha10-inhibitors-ic50-ki.
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