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Neuropeptide Y receptor type 5 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[[4-[[(4-Aminoquinazolin-2-yl)amino]methyl]cyclohexyl]methyl]naphthalene-1-sulfonamideIC501.3 [1], 2.9 [2]
MK-0557IC501.26 [1], 1.3 [2]
MK-0557Ki1.6 [1]
9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-oneIC5061.0 [1]
9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-oneKi33.0 [1]
3-Oxo-N-(5-phenylpyrazin-2-yl)spiro[2-benzofuran-1,4'-piperidine]-1'-carboxamideIC502.4 [1], 6.1 [2]
3-Oxo-N-(5-phenylpyrazin-2-yl)spiro[2-benzofuran-1,4'-piperidine]-1'-carboxamideKi2.4 [1]
Npy 5RA972IC503.0 [1], 6.0 [2], 37.0 [3]
2-[(4S,5S)-5-(4-Fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridine-4-carbonitrileIC502.0 [1]
2-[(4S,5S)-5-(4-Fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridine-4-carbonitrileKi1.3 [1]
4,4-Bis(4-fluorophenyl)-2-pyrazinyl-2-imidazolineIC502.4 [1], 4.3 [2]
4,4-Bis(4-fluorophenyl)-2-pyrazinyl-2-imidazolineKi4.3 [1]
4'-[6-(5-Methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-2-yl]spiro[2-benzofuran-3,1'-cyclohexane]-1-oneIC503.3 [1], 5.5 [2], 1000.0 [3]
Human Neuropeptide YIC503.0 [1]
Human Neuropeptide YKi2.2 [1]
Neuropeptide Y (24-36) amide, N-acetyl-(leu(28,31))-Ki1000.0 [1]
N-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-2,3-dihydro-1H-indene-2-carboxamideIC5059.0 [1]
N-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-2,3-dihydro-1H-indene-2-carboxamideKi59.0 [1]
4-(Pyridin-2-yl)-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amineKi15.85 [1]
N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-3-yl)-phenyl]-4-methoxy-benzenesulfonamideIC5015.0 [1]
3-[2-[6-[2-[(2-Methylpropan-2-yl)oxy]ethoxy]pyridin-3-yl]-1H-imidazol-5-yl]benzonitrileKi1.2 [1]
N-[[4-[(Naphthalen-2-ylmethylamino)methyl]cyclohexyl]methyl]naphthalene-2-sulfonamideIC5047.0 [1]
N-[[4-[(Naphthalen-2-ylmethylamino)methyl]cyclohexyl]methyl]naphthalene-2-sulfonamideKi32.0 [1]
FR-226928 free baseIC5016.0 [1]
1-(Difluoromethyl)-5-[(4S,5S)-5-(4-fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridin-2-oneIC508.7 [1]
1-(Difluoromethyl)-5-[(4S,5S)-5-(4-fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]pyridin-2-oneKi2.8 [1]
4-Bromo-N-[4-[[4-(dimethylamino)quinazolin-2-yl]amino]cyclohexyl]-2-(trifluoromethoxy)benzenesulfonamideIC5031.0 [1], 880.0 [2]
4-Bromo-N-[[4-[[4-(dimethylamino)quinazolin-2-yl]amino]cyclohexyl]methyl]-2-(trifluoromethoxy)benzenesulfonamideIC50120.0 [1], 150.0 [2]
2-N-[1-[4-Bromo-2-(trifluoromethoxy)phenyl]sulfonylpiperidin-4-yl]-4-N,4-N-dimethylquinazoline-2,4-diamineIC508900.0 [1]
1-Methylsulfonyl-N-(5-phenylpyrazin-2-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC500.97 [1]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminobenzoyl)amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]pentanediamideKi1000.0 [1]
1-Methylsulfonyl-N-(5-phenylpyrimidin-2-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC500.57 [1]
1-Methylsulfonyl-N-(2-phenylpyrimidin-5-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC500.86 [1]
1-Methylsulfonyl-N-(5-phenylpyridin-2-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC500.96 [1]
1-Methylsulfonyl-N-(6-phenylpyridin-3-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC500.82 [1]
N-[[4-[(1,2,3,4-Tetrahydronaphthalen-2-ylmethylamino)methyl]cyclohexyl]methyl]naphthalene-1-sulfonamideIC5038.0 [1]
N-[[4-[(1,2,3,4-Tetrahydronaphthalen-2-ylmethylamino)methyl]cyclohexyl]methyl]naphthalene-1-sulfonamideKi11.0 [1]
2-Oxo-3-phenyl-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamideKi2.0 [1]
6-[(4S,5S)-5-(4-Fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]-1H-pyridin-2-oneKi1.4 [1]
N-[[4-[(4-Aminoquinazolin-2-yl)amino]cyclohexyl]methyl]naphthalene-1-sulfonamideIC502.7 [1], 3.0 [2]
1-Methylsulfonyl-N-(2-phenylpyrimidin-4-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC507.5 [1]
1-Methylsulfonyl-N-(3-pyridin-4-ylphenyl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC5023.0 [1]
1-Methylsulfonyl-N-(4-phenylpyrimidin-2-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC509.8 [1]
1-Methylsulfonyl-N-(4-pyridin-2-ylphenyl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC503.0 [1]
1-Methylsulfonyl-N-(4-pyridin-3-ylphenyl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC502.1 [1]
1-Methylsulfonyl-N-(6-phenylpyridazin-3-yl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC503.0 [1]
5'-Oxo-N-(5-phenylpyrimidin-2-yl)spiro[cyclohexane-4,7'-furo[3,4-b]pyridine]-1-carboxamideIC502.9 [1]
2-(7-Chloro-2,3-dihydro-1,4-benzoxazin-4-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamideKi0.9 [1], 3.5 [2]
2-(6-Chloro-3,4-dihydro-2H-quinolin-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamideKi0.8 [1], 0.9 [2]
2-(6-Chloro-2-oxo-3,4-dihydroquinolin-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamideKi3.4 [1], 3.9 [2]
2-(7-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamideKi0.3 [1], 1.0 [2]
N-[[4-[(1,2,3,4-Tetrahydronaphthalen-2-ylmethylamino)methyl]cyclohexyl]methyl]naphthalene-2-sulfonamideKi14.0 [1], 32.0 [2]
2-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]-N-(9-oxofluoren-3-yl)acetamideIC500.47 [1]
1-Benzyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-amineIC50900.0 [1], 1000.0 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-(1,3-thiazol-2-yl)piperidine-4-carboxamideIC5053.0 [1]
1-Methylsulfonyl-N-(4-pyridin-4-ylphenyl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamideIC504.1 [1]
3'-Oxo-N-(5-phenylpyrimidin-2-yl)spiro[cyclohexane-4,1'-furo[3,4-c]pyridine]-1-carboxamideIC502.0 [1]
7'-Oxo-N-(5-phenylpyrimidin-2-yl)spiro[cyclohexane-4,5'-furo[3,4-b]pyridine]-1-carboxamideIC502.1 [1]
2-(4-Cyano-2-pyridyl)-4,4-bis(4-fluorophenyl)-2-imidazolineIC502.0 [1]
2-(4-Cyano-2-pyridyl)-4,4-bis(4-fluorophenyl)-2-imidazolineKi2.0 [1]
1'-Oxo-N-(5-phenylpyrimidin-2-yl)spiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamideIC501.8 [1]
5-[(4S,5S)-5-(4-Fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]-1-methoxypyridin-2-oneIC5015.7 [1]
5-[(4S,5S)-5-(4-Fluorophenyl)-5-(6-fluoropyridin-3-yl)-4-methyl-1,4-dihydroimidazol-2-yl]-1-methoxypyridin-2-oneKi2.8 [1]
1'-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]spiro[2-benzofuran-3,4'-piperidine]-1-oneIC503.5 [1], 6400.0 [2]
1-Methyl-1-(1-methylsulfonylpiperidin-4-yl)-3-(4-phenylcyclohexyl)ureaKi52.0 [1], 500.0 [2]
1-(1-Acetylpiperidin-4-yl)-1-methyl-3-(4-phenylcyclohexyl)ureaKi59.0 [1], 1000.0 [2]
1-[4-[[(9-Fluoro-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-2-yl)amino]methyl]piperidin-1-yl]pentan-1-oneIC507.0 [1], 100.0 [2]
1-[(1R,2R)-2-Phenyl-2-hydroxy-1-methylethyl]-1-methyl-3-(4-phenoxyphenyl)ureaIC5045.0 [1]
1-[(1R,2R)-2-Phenyl-2-hydroxy-1-methylethyl]-1-methyl-3-(4-phenoxyphenyl)ureaKi477.0 [1]
3-(4-Benzyloxy-phenyl)-1-(2-hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-ureaIC5020.0 [1]
3-(4-Benzyloxy-phenyl)-1-(2-hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-ureaKi101.0 [1]
N-(9-Ethyl-9H-carbazol-3-yl)-3-pyridin-4-yl-propionamideIC502.0 [1], 11.0 [2]
1-[(1R,2S)-1-Hydroxy-1-phenylpropan-2-yl]-1-methyl-3-(4-phenoxyphenyl)ureaIC50127.0 [1]
1-[(1R,2S)-1-Hydroxy-1-phenylpropan-2-yl]-1-methyl-3-(4-phenoxyphenyl)ureaKi515.0 [1]
(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneIC5034.0 [1]
(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneKi14.0 [1]
1'-(6-Phenyl-1H-benzimidazol-2-yl)spiro[2-benzofuran-3,4'-piperidine]-1-oneIC501.8 [1], 2.4 [2]
1-Methylsulfonyl-N-(4-phenylphenyl)spiro[2H-indole-3,4'-cyclohexane]-1'-carboxamideIC501.5 [1], 200.0 [2]
Methyl 2-(3-oxospiro[2-benzofuran-1,4'-piperidine]-1'-yl)-3H-benzimidazole-5-carboxylateIC501.5 [1], 2.7 [2]
1'-(6-Chloro-1H-benzimidazol-2-yl)spiro[2-benzofuran-3,4'-piperidine]-1-oneIC501.2 [1], 6.6 [2]
6-Fluoro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneIC5063.0 [1]
6-Fluoro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneKi29.0 [1]
9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3,6-trimethyl-4,9-dihydro-2H-xanthen-1-oneIC50111.0 [1]
9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3,6-trimethyl-4,9-dihydro-2H-xanthen-1-oneKi36.0 [1]
9-(7-Hydroxy-9-oxospiro[4.5]dec-7-en-8-yl)spiro[4,9-dihydro-2H-xanthene-3,1'-cyclopentane]-1-oneIC5058.0 [1]
9-(7-Hydroxy-9-oxospiro[4.5]dec-7-en-8-yl)spiro[4,9-dihydro-2H-xanthene-3,1'-cyclopentane]-1-oneKi17.0 [1]
6-Chloro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneIC5082.0 [1]
6-Chloro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneKi34.0 [1]
5-Fluoro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneIC5073.0 [1]
5-Fluoro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3,3-dimethyl-4,9-dihydro-2H-xanthen-1-oneKi34.0 [1]
9-(2-Hydroxy-4-oxospiro[5.5]undec-2-en-3-yl)spiro[4,9-dihydro-2H-xanthene-3,1'-cyclohexane]-1-oneIC50109.0 [1]
9-(2-Hydroxy-4-oxospiro[5.5]undec-2-en-3-yl)spiro[4,9-dihydro-2H-xanthene-3,1'-cyclohexane]-1-oneKi24.0 [1]
4'-[6-(2-Methyltetrazol-5-yl)-1H-benzimidazol-2-yl]spiro[2-benzofuran-3,1'-cyclohexane]-1-oneIC505.9 [1], 7.2 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]piperidine-4-carboxamideIC500.59 [1], 0.7 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-(4-phenoxyphenyl)piperidine-4-carboxamideIC500.85 [1], 1.5 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-(2-hydroxy-2-phenylethyl)piperidine-4-carboxamideIC501.1 [1], 1.2 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-[2-(4-sulfamoylphenyl)ethyl]piperidine-4-carboxamideIC506.1 [1], 9.0 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-[4-(2-hydroxyethyl)phenyl]piperidine-4-carboxamideIC501.7 [1], 2.9 [2]
N-(3-Acetylphenyl)-1-[2-(5-chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]piperidine-4-carboxamideIC500.59 [1], 2.0 [2]
1-[2-(5-Chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-(4-hydroxy-2-methylphenyl)piperidine-4-carboxamideIC501.4 [1], 4.7 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neuropeptide Y receptor type 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/neuropeptide-y-receptor-type-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Neuropeptide Y receptor type 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuropeptide-y-receptor-type-5-inhibitors-ic50-ki.
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