Nicotinamide phosphoribosyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Daporinad	IC50	3.0 [1]
	Daporinad	Ki	0.3 [1], 3.0 [2]
	1-(3-Pyridinylmethyl)-3-[4-(3-aza-8-oxabicyclo[3.2.1]octane-3-ylsulfonyl)phenyl]urea	IC50	13.0 [1]
	Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-	IC50	2.0 [1]
	Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-	Ki	3.0 [1]
	1-[(3-Fluorophenyl)methyl]-3-(4-piperidin-1-ylsulfonylphenyl)urea	IC50	39.0 [1]
	Pyridin-3-ylmethyl N-[4-(benzenesulfonyl)phenyl]carbamate	IC50	24.0 [1]
	N-[4-(Benzenesulfonyl)phenyl]-2-pyridin-3-yloxyacetamide	IC50	33.0 [1]
	N-[4-(Benzenesulfonyl)phenyl]-3-pyridin-3-ylpropanamide	IC50	64.0 [1]
	N-[[4-(Benzenesulfonyl)phenyl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	9.0 [1], 15.0 [2]
	1-[(6-Aminopyridin-3-Yl)methyl]-3-[4-(Phenylsulfonyl)phenyl]urea	IC50	3.0 [1], 30.0 [2], 70.0 [3]
	N-{4-[(3,5-Difluorophenyl)sulfonyl]benzyl}imidazo[1,2-A]pyridine-6-Carboxamide	IC50	2.0 [1], 5.0 [2]
	1-(4-(Phenylsulfonyl)phenyl)-3-(pyridin-3-ylmethyl)urea	IC50	3.0 [1], 4.0 [2], 144.0 [3]
	N-[[4-(3,5-Difluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	5.0 [1], 8.0 [2], 10.0 [3]
	N-[[5-(3,5-Difluorophenyl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	5.6 [1], 6.0 [2], 10.0 [3]
	N-[[5-(1-Propan-2-ylpyrazol-4-yl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	11.0 [1], 39.0 [2], 55.5 [3]
	(3-Methyloxetan-3-yl) (2S)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	0.6 [1], 1.5 [2], 3.2 [3], 5.5 [4]
	N-(4-{[3-(Trifluoromethyl)phenyl]sulfonyl}benzyl)-2h-Pyrazolo[3,4-B]pyridine-5-Carboxamide	IC50	4.0 [1], 6.0 [2], 6.1 [3]
	4-[(7-Chloro-3-methyl-4-oxo-1,2,3-benzotriazin-6-yl)methyl-(3-methylbut-2-enyl)amino]-N-(pyridin-3-ylmethyl)benzamide	IC50	0.45 [1], 0.5 [2]
	N-(4-(Phenylsulfonyl)benzyl)-1h-Pyrrolo[3,2-C]pyridine-2-Carboxamide	IC50	20.0 [1], 29.0 [2]
	N-[[4-(Benzenesulfonyl)phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	14.0 [1], 15.0 [2]
	1-[4-(2,8-Diazaspiro[4.5]decan-8-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea	IC50	6.0 [1], 76.0 [2]
	1-[4-(Benzenesulfonyl)phenyl]-3-[(6-methylpyridin-3-yl)methyl]urea	IC50	59.0 [1], 2000.0 [2]
	(1s,2s)-N-[4-(Phenylsulfonyl)phenyl]-2-(Pyridin-3-Yl)cyclopropanecarboxamide	IC50	3.9 [1], 4.0 [2], 6.0 [3]
	N-[[4-(6-Methylpyridin-3-yl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	11.0 [1]
	N-[(4-Cyclohexylsulfonylphenyl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	2.0 [1], 13.0 [2]
	6-Amino-N-[[4-(benzenesulfonyl)phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	74.0 [1], 75.0 [2], 378.0 [3]
	5-Cyano-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	2.99 [1], 8.0 [2]
	5-Cyano-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	4.7 [1]
	5-Methoxy-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	15.4 [1], 22.9 [2]
	5-Methoxy-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	16.0 [1]
	N-[4-(Propylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	146.0 [1], 258.0 [2]
	N-[4-(Propylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	104.0 [1]
	N-[6-(3-Methylbutylcarbamoyl)pyridin-3-yl]-1,3-dihydroisoindole-2-carboxamide	IC50	62.1 [1], 79.4 [2]
	N-[6-(3-Methylbutylcarbamoyl)pyridin-3-yl]-1,3-dihydroisoindole-2-carboxamide	Ki	57.0 [1]
	4-({[(4-Tert-Butylphenyl)sulfonyl]amino}methyl)-N-(Pyridin-3-Yl)benzamide	IC50	19.0 [1], 24.0 [2]
	1-[4-(Piperidin-1-Ylsulfonyl)phenyl]-3-(Pyridin-3-Ylmethyl)thiourea	IC50	7.0 [1], 9.9 [2]
	4-[[2-[[4-(3-Aminopropyl)piperazin-1-yl]methyl]-7-chloro-3-methyl-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide	IC50	0.3 [1]
	1-(4-Morpholin-4-ylsulfonylphenyl)-3-(pyridin-3-ylmethyl)urea	IC50	28.0 [1], 31.0 [2]
	N-[[4-(Benzenesulfonyl)phenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide	IC50	18.0 [1]
	N-[(4-Piperidin-1-ylsulfonylphenyl)methyl]imidazo[1,2-a]pyridine-6-carboxamide	IC50	28.0 [1]
	1-[4-(Benzenesulfonyl)phenyl]-3-(1-pyridin-3-ylethyl)urea	IC50	930.0 [1]
	N-[[4-(3,5-Difluorophenyl)sulfonylphenyl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	14.0 [1]
	N-[[4-(3,5-Difluorophenyl)sulfonylphenyl]methyl]thieno[2,3-c]pyridine-2-carboxamide	IC50	3.0 [1]
	N-[[4-(Benzenesulfonyl)phenyl]methyl]-1,3-dihydroisoindole-2-carboxamide	IC50	12.0 [1]
	N-[[4-(Benzenesulfonyl)phenyl]methyl]-1,3-dihydroisoindole-2-carboxamide	Ki	487.0 [1]
	N-[[5-(1-Propan-2-ylpyrazol-4-yl)sulfonylpyridin-2-yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	84.0 [1], 125.0 [2]
	N-[[5-[3-(Trifluoromethyl)phenyl]sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	6.6 [1], 15.0 [2]
	N-[[5-(6-Methylpyridin-3-yl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	11.3 [1], 34.0 [2]
	N-[[6-(2,4-Dimethyl-1,3-oxazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	1.6 [1], 4.4 [2]
	(3-Methyloxetan-3-yl) 2-[[(1,1,3,3-tetradeuteriopyrrolo[3,4-c]pyridine-2-carbonyl)amino]methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	1.0 [1], 11.9 [2]
	N-[[6-(1,3-Dimethylpyrazole-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	7.5 [1], 41.2 [2]
	N-[[6-(3,3-Dimethylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	1.6 [1], 21.2 [2]
	N-[[6-(3-Methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	4.4 [1], 12.8 [2]
	(1-Methylcyclobutyl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	4.8 [1], 22.2 [2]
	N-[[6-[4-(1-Methylpiperidin-4-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	5.3 [1], 6.1 [2]
	N-[[6-(4,4,4-Trifluorobutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	24.8 [1], 26.5 [2]
	N-[[6-[3-(Oxan-4-yl)propanoyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	5.8 [1], 16.1 [2]
	N-[[6-(2-Pyrimidin-2-ylacetyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	31.2 [1], 41.0 [2]
	N-[(6-Benzoyl-6-azaspiro[2.5]octan-2-yl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	3.5 [1], 21.0 [2]
	(3-Methyloxetan-3-yl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	2.2 [1], 17.1 [2]
	(1-Methoxy-2-methylpropan-2-yl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	1.6 [1], 6.7 [2]
	N-[[6-[2-(3-Methyloxetan-3-yl)acetyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	11.2 [1], 47.8 [2]
	N-[[6-(4-Methylpyridine-3-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	6.5 [1], 27.4 [2]
	N-[[6-(2,4-Dimethyl-1,3-thiazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	3.8 [1], 14.2 [2]
	N-[[6-(Tert-butylcarbamoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	20.7 [1], 48.1 [2]
	N-[[6-[2-(Oxan-4-yl)acetyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	6.9 [1], 21.9 [2]
	N-[[6-[2-(3-Hydroxy-3-methylcyclobutyl)acetyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	13.3 [1], 58.9 [2]
	Tert-butyl (2S)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	1.0 [1], 13.0 [2]
	N-[(4-Methylsulfonylphenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	402.0 [1], 2000.0 [2]
	N-[[4-[[3-(Dimethylcarbamoyl)phenyl]methoxy]phenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	16.0 [1], 21.0 [2]
	N-[[4-(Cyclopentylsulfonylamino)phenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	14.0 [1], 27.0 [2]
	N-[[5-[(S)-(3,5-Difluorophenyl)sulfinyl]pyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamide	IC50	6.0 [1], 10.0 [2]
	N-(2-Methylpropyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	2000.0 [1]
	Tert-butyl (2R)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	34.0 [1], 35.0 [2]
	N-[[4-(Pyrrolidine-1-carbonyl)phenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	423.0 [1], 2000.0 [2]
	N-[[6-(2-Phenylethyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide	IC50	555.4 [1], 753.5 [2]
	N-(Cyclohexylmethyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	2000.0 [1]
	N-[(4-Sulfamoylphenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide	IC50	473.0 [1], 2000.0 [2]
	Tert-butyl 2-[(pyridin-3-ylmethylcarbamoylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylate	IC50	59.0 [1], 2000.0 [2]
	N-[4-(3-Phenylpropylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	12.5 [1]
	N-[4-(3-Phenylpropylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	9.0 [1]
	5-Fluoro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	11.0 [1]
	5-Fluoro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	7.9 [1]
	N-[4-(3-Methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	15.7 [1]
	N-[4-(3-Methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	11.0 [1]
	5-Methyl-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	17.8 [1]
	5-Methyl-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	13.0 [1]
	N-[4-(3,3-Dimethylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	19.7 [1]
	N-[4-(3,3-Dimethylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	14.0 [1]
	4-Chloro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	24.1 [1]
	4-Chloro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	17.0 [1]
	N-[4-(Benzylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	26.7 [1]
	N-[4-(Benzylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	19.0 [1]
	N-[4-(3-Methylbutylcarbamoyl)phenyl]-5-(trifluoromethyl)-1,3-dihydroisoindole-2-carboxamide	IC50	31.9 [1]
	N-[4-(3-Methylbutylcarbamoyl)phenyl]-5-(trifluoromethyl)-1,3-dihydroisoindole-2-carboxamide	Ki	23.0 [1]
	N-[4-(Oxolan-3-ylmethylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	IC50	34.2 [1]
	N-[4-(Oxolan-3-ylmethylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide	Ki	24.0 [1]
	N-(4-Carbamoylphenyl)-1,3-dihydroisoindole-2-carboxamide	IC50	780.0 [1]
	N-(4-Carbamoylphenyl)-1,3-dihydroisoindole-2-carboxamide	Ki	560.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Nicotinamide phosphoribosyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/nicotinamide-phosphoribosyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Nicotinamide phosphoribosyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nicotinamide-phosphoribosyltransferase-inhibitors-ic50-ki.
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