 | Nociceptin | IC50 | 2.1 [1] |
| Nociceptin | Ki | 0.18 [1] |
 | CompB | IC50 | 1.5 [1], 2.3 [2], 2.4 [3], 5.6 [4] |
| CompB | Ki | 0.4 [1], 2.3 [2] |
 | Benzimidazole analogue, 7e | IC50 | 0.72 [1], 2.1 [2] |
 | N-Methyl-2-[2-oxo-3-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]benzimidazol-1-yl]acetamide | IC50 | 2.6 [1], 59.0 [2] |
| N-Methyl-2-[2-oxo-3-[1-(4-propan-2-ylcyclohexyl)piperidin-4-yl]benzimidazol-1-yl]acetamide | Ki | 0.7 [1], 1.7 [2], 31.0 [3] |
 | (1S,2S,6R,14R,15S,16R)-5-(Cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol | Ki | 77.0 [1], 77.4 [2], 212.0 [3] |
 | (3R)-3-Methyl-4-[5-chloro-2-(tert-butylthio)-1H-benzoimidazole-6-yl]-1-piperazineethanol | IC50 | 0.65 [1], 2.6 [2] |
 | 2-(4-(6-Chloro-2-(3-methylpentan-3-ylthio)-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol | IC50 | 0.66 [1], 1.2 [2] |
 | 2-(4-(6-Chloro-2-(pentan-3-ylthio)-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol | IC50 | 3.3 [1], 9.7 [2] |
 | 1-(1-(3-(5-Methoxy-2-methylphenoxy)-4-methylpentyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | IC50 | 38.0 [1], 677.0 [2] |
| 1-(1-(3-(5-Methoxy-2-methylphenoxy)-4-methylpentyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | Ki | 4.0 [1], 47.0 [2] |
 | 2-(4-(2-(Tert-butylthio)-6-chloro-3H-benzo[d]imidazol-5-yl)piperazin-1-yl)ethanol | IC50 | 17.0 [1], 21.0 [2] |
 | (1S,3R)-N-[[1-(3-Chloropyridin-2-yl)-5-(5-fluoro-6-methylpyridin-3-yl)-4-methylpyrazol-3-yl]methyl]-3-fluorocyclopentan-1-amine | IC50 | 0.31 [1], 0.52 [2] |
 | (1S,2S,6R,14R,15R,16R)-5-(Cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-phenylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol | Ki | 43.2 [1] |
 | JTC-801 free base | IC50 | 30.0 [1] |
| JTC-801 free base | Ki | 8.2 [1] |
 | Nociceptin(1-13)NH2 | IC50 | 0.35 [1] |
| Nociceptin(1-13)NH2 | Ki | 0.35 [1], 0.62 [2] |
 | Ac-RYYRIK-NH2 | IC50 | 0.77 [1], 0.79 [2], 1.04 [3] |
 | 1-Benzyl-N-[3-(1'h,3h-Spiro[2-Benzofuran-1,4'-Piperidin]-1'-Yl)propyl]-D-Prolinamide | IC50 | 0.15 [1], 0.27 [2] |
| 1-Benzyl-N-[3-(1'h,3h-Spiro[2-Benzofuran-1,4'-Piperidin]-1'-Yl)propyl]-D-Prolinamide | Ki | 0.24 [1] |
 | 3-(1-Benzylpiperidin-4-yl)-1H-benzimidazol-2-one | IC50 | 200.0 [1], 10000.0 [2] |
 | 1-Benzhydryl-4-phenylpiperidin-4-ol | Ki | 13.0 [1] |
 | 1-(1-Benzylpiperidin-4-YL)-1,3-dihydro-indol-2-one | Ki | 201.0 [1], 201.3 [2] |
 | 1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 6000.0 [1] |
 | 2-[3-[1-[3-(5-Methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide | IC50 | 10.0 [1] |
| 2-[3-[1-[3-(5-Methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide | Ki | 1.0 [1] |
 | 1-(1-Cyclooctylpiperidin-4-yl)-3H-indol-2-one | Ki | 1.39 [1], 1.4 [2] |
 | 1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-dihydro-indol-2-one | Ki | 3.96 [1], 71.2 [2] |
 | Benzimidazole analogue, 7h | IC50 | 0.81 [1], 1.3 [2] |
 | 1-(2-Methoxyethyl)-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one | IC50 | 60.0 [1] |
| 1-(2-Methoxyethyl)-3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]benzimidazol-2-one | Ki | 4.0 [1], 4.07 [2] |
 | trans-(+)-7-((4-o-Tolylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | IC50 | 9.0 [1], 10000.0 [2] |
| trans-(+)-7-((4-o-Tolylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | Ki | 4.5 [1] |
 | (2S)-6-Amino-2-[[(2S,3S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(3-methylbutanoylamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]pentanoyl]amino]-3-methylpentanoyl]amino]hexanamide | IC50 | 0.03 [1], 2.15 [2], 8.51 [3] |
 | (5S,7R)-1-Methyl-7-[[4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol | IC50 | 10.0 [1], 10000.0 [2] |
| (5S,7R)-1-Methyl-7-[[4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol | Ki | 6.0 [1] |
 | (1S,2S,6R,14R,15R,16R)-5-(Cyclopropylmethyl)-16-[(1S)-1-hydroxy-1-thiophen-2-ylethyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol | Ki | 34.5 [1], 75.0 [2] |
 | [6-Chloro-5-(4-ethylpiperazin-1-yl)-1H-benzimidazol-2-yl]-(4-hydroxy-1,4-dimethylcyclohexyl)methanone | IC50 | 1.3 [1], 1.4 [2], 27.0 [3] |
 | (5S,7S)-7-[[4-(2,6-Dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol | Ki | 0.25 [1] |
 | 1-Phenyl-8-(acenaphthen-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one | Ki | 0.52 [1], 0.63 [2] |
 | 1-(1-Bicyclo[3.3.1]non-9-yl-piperidin-4-yl)-1,3-dihydro-indol-2-one | Ki | 7.49 [1] |
 | 3-[5-(3,5-Difluorophenyl)-3-[[[(1S,3R)-3-fluorocyclopentyl]amino]methyl]-4-methylpyrazol-1-yl]propanenitrile | IC50 | 4.6 [1], 8.2 [2] |
 | 1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-indol-2-one | Ki | 6.0 [1], 6.04 [2] |
 | 8-[(1R,3Ar)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 4.4 [1] |
| 8-[(1R,3Ar)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Ki | 0.39 [1] |
 | 1-[1-[1-(2-Chlorophenyl)ethyl]piperidine-4-yl]-1H-benzimidazole-2(3H)-one | IC50 | 5.9 [1], 10000.0 [2] |
 | (6R,8S)-6-[[(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxypiperidin-1-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-ol | IC50 | 12.0 [1] |
| (6R,8S)-6-[[(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxypiperidin-1-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-ol | Ki | 11.0 [1] |
 | 1-(3,3-Diphenylpropyl)-4-[3-(trifluoromethyl)phenyl]piperidine-4-ol | Ki | 116.0 [1] |
 | 8-(Diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Ki | 23.0 [1] |
 | (4R,7S,10S,13S,16R)-7-(4-Aminobutyl)-16-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-10-[3-(diaminomethylideneamino)propyl]-13-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide | IC50 | 0.83 [1] |
| (4R,7S,10S,13S,16R)-7-(4-Aminobutyl)-16-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-10-[3-(diaminomethylideneamino)propyl]-13-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide | Ki | 0.83 [1] |
 | 8-[(2,6-Dichlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Ki | 2.3 [1] |
 | 8-(4,4-Dimethyl-2,3-dihydro-1H-naphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Ki | 1.3 [1] |
 | N-[[(1S,5R)-8-[Bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-yl]methyl]acetamide | Ki | 20.0 [1] |
 | N-[[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]methyl]cyclopentanamine | IC50 | 28.0 [1] |
 | 1-(3,3-Diphenylpropyl)-4-[3-(trifluoromethyl)-4-chlorophenyl]piperidine-4-ol | Ki | 225.0 [1] |
 | 4-[[4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl]methyl]benzonitrile | Ki | 10000.0 [1] |
 | 4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen-2-ylmethyl-piperidin-4-ol | Ki | 879.0 [1] |
 | 4-[4-Chloro-3-(trifluoromethyl)phenyl]-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-ol | Ki | 1194.0 [1] |
 | 1-Phenyl-8-[(1R,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 300.0 [1], 310.0 [2] |
 | (2S)-2-[(2-Fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-propan-2-ylpropanamide | Ki | 0.23 [1] |
 | (2S)-2-[(2-Fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide | Ki | 0.11 [1] |
 | (2S)-2-[(2-Fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methyl-N-propan-2-ylpropanamide | Ki | 0.14 [1] |
 | Unii-dqy244459T | Ki | 0.15 [1], 0.17 [2] |
 | (2R)-2-[(2-Fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-propan-2-ylpropanamide | Ki | 4.51 [1], 4.54 [2] |
 | (2R)-2-[(2-Fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanamide | Ki | 5.61 [1] |
 | N,N-Dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine;hydrochloride | Ki | 0.1 [1], 0.3 [2] |
 | 8-[Bis(2-chlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Ki | 6.8 [1] |
 | 1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one | Ki | 1.4 [1], 2.1 [2] |
 | 8-Indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | Ki | 0.7 [1], 1.2 [2] |
 | 3-[1-[3-(2,5-Dimethylphenoxy)-4-methylpentyl]piperidin-4-yl]-1H-benzimidazol-2-one | IC50 | 131.0 [1] |
| 3-[1-[3-(2,5-Dimethylphenoxy)-4-methylpentyl]piperidin-4-yl]-1H-benzimidazol-2-one | Ki | 11.0 [1] |
 | 2-[4-[6-Chloro-2-(2-methylbutan-2-ylsulfanyl)-1H-benzimidazol-5-yl]piperazin-1-yl]ethanol | IC50 | 2.5 [1], 5.6 [2] |
 | 1-[1-[3-(5-Methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(2-methylsulfanylethyl)benzimidazol-2-one | IC50 | 42.0 [1] |
| 1-[1-[3-(5-Methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-3-(2-methylsulfanylethyl)benzimidazol-2-one | Ki | 1.0 [1] |
 | 1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-dihydro-benzoimidazol-2-one | IC50 | 6.8 [1], 20.0 [2] |
 | 1-[1-(Cyclooctylmethyl)piperidine-4-yl]-1H-benzimidazole-2(3H)-one | IC50 | 6.8 [1], 20.0 [2] |
 | (7R,9S)-7-[[(3S,4R)-3-Methyl-4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | IC50 | 5.7 [1] |
| (7R,9S)-7-[[(3S,4R)-3-Methyl-4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | Ki | 3.5 [1] |
 | (7R,9S)-7-[[(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxypiperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | IC50 | 5.0 [1] |
| (7R,9S)-7-[[(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxypiperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | Ki | 4.4 [1] |
 | (7R,9S)-7-[[(3S,4R)-3-(Hydroxymethyl)-4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | IC50 | 7.3 [1] |
| (7R,9S)-7-[[(3S,4R)-3-(Hydroxymethyl)-4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | Ki | 4.3 [1] |
 | (7R,9S)-7-[[(3S,4S)-3-Hydroxy-4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | IC50 | 18.0 [1] |
| (7R,9S)-7-[[(3S,4S)-3-Hydroxy-4-(2-methylphenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol | Ki | 10.0 [1] |
 | (2R)-1-Benzyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide | IC50 | 0.12 [1], 0.22 [2] |
 | 5-Chloro-3-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-8-ol | IC50 | 21.3 [1] |
| 5-Chloro-3-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-8-ol | Ki | 2.2 [1] |
 | (2S)-1-Benzyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide | IC50 | 42.0 [1], 47.0 [2] |
 | 3-(Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-8-ol | IC50 | 53.9 [1] |
| 3-(Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-8-ol | Ki | 2.4 [1] |
 | 3-(Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | IC50 | 227.0 [1] |
| 3-(Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | Ki | 10.2 [1] |
 | 2-Phenoxy-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)benzamide | IC50 | 4.0 [1], 8.2 [2] |
 | 2-Phenylmethoxy-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)benzamide | IC50 | 83.0 [1], 110.0 [2] |
 | 1'-(1,2,3,4-Tetrahydroisoquinolin-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine] | IC50 | 248.0 [1] |
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