NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Imatinib	IC50	30000.0 [1], 100000.0 [2]
	Bosutinib	IC50	150.0 [1], 200.0 [2], 10000.0 [3], 20000.0 [4]
	6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one	IC50	2500.0 [1], 3000.0 [2], 30000.0 [3]
	N-[2-[2-[4-[4-[(2S)-2-Hydroxypropyl]piperazin-1-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	60.0 [1]
	5-(1,3-Benzodioxol-5-yl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxo-1H-pyridine-3-carboxamide	IC50	3600.0 [1], 6500.0 [2]
	5-(1,3-Benzodioxol-5-yl)-N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-oxo-1H-pyridine-3-carboxamide	IC50	11200.0 [1], 25000.0 [2]
	5-(1,3-Benzodioxol-5-yl)-N-[4-[3-(4-methylpiperazin-1-yl)propyl]phenyl]-2-oxo-1H-pyridine-3-carboxamide	IC50	9400.0 [1], 13700.0 [2]
	5-(1,3-Benzodioxol-5-yl)-N-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]-2-oxo-1H-pyridine-3-carboxamide	IC50	7500.0 [1], 17400.0 [2]
	Ellagic acid	IC50	40000.0 [1]
	Crizotinib	IC50	51.0 [1]
	2-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide	IC50	100.0 [1]
	Azetidin-2-yl-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]methanone	IC50	200.0 [1]
	N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine	IC50	100.0 [1]
	(2S)-1-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperazin-1-yl]propan-2-ol	IC50	100.0 [1]
	(2R)-1-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperazin-1-yl]propan-2-ol	IC50	80.0 [1]
	N-[2-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	200.0 [1]
	N-[2-[2-[4-[4-[(2R)-2-Hydroxypropyl]piperazin-1-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	80.0 [1]
	N-[2-[2-[2-Methoxy-4-(4-morpholin-4-ylpiperidin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	50.0 [1]
	N-[2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperazin-1-yl]phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine	IC50	70.0 [1]
	N-[2-Methoxy-4-(4-morpholin-4-ylpiperazin-1-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine	IC50	85.0 [1]
	N-[2-[2-[5-Fluoro-4-[4-[(2S)-2-hydroxypropyl]piperazin-1-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	200.0 [1]
	N-[2-[2-[4-[1-(2-Hydroxyethyl)piperidin-4-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	60.0 [1]
	N-[2-[2-[4-[1-[(2R)-2-Hydroxypropyl]piperidin-4-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	70.0 [1]
	N-[2-[2-(2-Methoxy-4-piperidin-4-ylanilino)pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamide	IC50	40.0 [1]
	(2R)-1-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]propan-2-ol	IC50	100.0 [1]
	N-[2-Methoxy-4-(1-methylpiperidin-4-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amine	IC50	70.0 [1]
	1-Fluoro-3-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]propan-2-ol	IC50	80.0 [1]
	(2S)-3-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]propane-1,2-diol	IC50	30.0 [1]
	2-Amino-1-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]-2-methylpropan-1-one	IC50	150.0 [1]
	2-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]-N-methylacetamide	IC50	100.0 [1]
	2-[4-[4-[[7-(2,4-Dimethoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]-3-methoxyphenyl]piperidin-1-yl]acetamide	IC50	500.0 [1]
	2-[4-[4-[[7-(2-Cyanophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]-3-methoxyphenyl]piperidin-1-yl]acetamide	IC50	250.0 [1]
	2-[4-[3-Methoxy-4-[[7-(3-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide	IC50	150.0 [1]
	2-[4-[3-Methoxy-4-[[7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide	IC50	80.0 [1]
	2-[4-[3-Methoxy-4-[[5-methyl-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide	IC50	70.0 [1]
	2-[4-[4-[[5-Chloro-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]-3-methoxyphenyl]piperidin-1-yl]acetamide	IC50	70.0 [1]
	8-Bromo-N-phenylpyrimido[1,6-a]benzimidazol-3-amine	IC50	5600.0 [1]
	7-(4-Methoxyphenyl)-4-[(E)-2-phenylethenyl]pyrazino[1,2-a]benzimidazole	IC50	840.0 [1]
	7-Bromo-4-chloropyrazino[1,2-a]benzimidazole	IC50	1100.0 [1]
	8-Bromo-3-(4-methoxyphenyl)pyrimido[1,6-a]benzimidazole	IC50	17000.0 [1]
	4,7-Bis[4-(4-methylpiperazin-1-yl)phenyl]pyrazino[1,2-a]benzimidazole	IC50	340.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/npm-alk-nucleophosmin-alk-tyrosine-kinase-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/npm-alk-nucleophosmin-alk-tyrosine-kinase-receptor-inhibitors-ic50-ki.
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